1. "Benifuuki" Extract Reduces Serum Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind Placebo-Controlled Randomized Trial.
- Author
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Miyawaki M, Sano H, Imbe H, Fujisawa R, Tanimoto K, Terasaki J, Maeda-Yamamoto M, Tachibana H, Hanafusa T, and Imagawa A
- Subjects
- Aged, Apolipoprotein B-100 blood, Biomarkers blood, Catechols administration & dosage, Catechols therapeutic use, Double-Blind Method, Female, Food Handling, Food Preferences, Humans, Hyperlipidemias blood, Hypolipidemic Agents therapeutic use, Ice Cream, Intention to Treat Analysis, Japan, Ligands, Male, Middle Aged, Oxidation-Reduction, Plant Extracts therapeutic use, Plant Leaves chemistry, Apolipoprotein B-100 antagonists & inhibitors, Camellia sinensis chemistry, Dietary Supplements, Hyperlipidemias prevention & control, Hypolipidemic Agents administration & dosage, Plant Extracts administration & dosage, Scavenger Receptors, Class E metabolism
- Abstract
(1) Background: Arteriosclerosis is associated with high levels of low-density lipoprotein (LDL) cholesterol. O -methylated catechins in "Benifuuki" green tea are expected to reduce cholesterol levels, although there is limited research regarding this topic; (2) Methods: This trial evaluated 159 healthy volunteers who were randomized to receive ice cream containing a high-dose of "Benifuuki" extract including 676 mg of catechins (group H), a low-dose of "Benifuuki" extract including 322 mg of catechins (group L), or no "Benifuuki" extract (group C). Each group consumed ice cream (with or without extract) daily for 12 weeks, and their lipid-related parameters were compared; (3) Results: A significant reduction in the level of lectin-like oxidized LDL receptor-1 ligand containing ApoB (LAB) was detected in group H, compared to groups L and C. No significant differences between the three groups were detected in their levels of total cholesterol, triglycerides, and LDL cholesterol; (4) Conclusions: "Benifuuki" extract containing O -methylated catechins may help prevent arteriosclerosis.
- Published
- 2018
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