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Antihypertensive effect of Benifuuki tea containing O-methylated EGCG.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2010 Feb 10; Vol. 58 (3), pp. 1903-8. - Publication Year :
- 2010
-
Abstract
- Benifuuki is a tea cultivar with an antiallergic effect stronger than that of Yabukita tea, the most popular green tea cultivar consumed in Japan. The effective compound is (-)-epigallocatechin-3-O-(3-O-methyl)gallate (EGCG3''Me), an O-methylated derivative of EGCG. This study examined the antihypertensive effects of EGCG3''Me and Benifuuki tea. First, it was determined that EGCG3''Me has a significant inhibitory effect on the activity of angiotensin I-converting enzyme (ACE). Second, clinical trials showed that Benifuuki tea suppressed high blood pressure to a greater extent than green tea that did not contain EGCG3''Me after equal amounts of tea catechins were consumed for 8 weeks. The effect of Benifuuki tea on human hypertension is mainly the result of the strong inhibitory effect of EGCG3''Me on ACE activity, its high rate of absorption, and its stability in the blood.
- Subjects :
- Adult
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents chemistry
Blood Pressure drug effects
Catechin administration & dosage
Catechin chemistry
Double-Blind Method
Female
Humans
Hypertension physiopathology
Male
Middle Aged
Peptidyl-Dipeptidase A metabolism
Plant Extracts chemistry
Tea chemistry
Antihypertensive Agents administration & dosage
Camellia sinensis chemistry
Catechin analogs & derivatives
Hypertension drug therapy
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 58
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20078079
- Full Text :
- https://doi.org/10.1021/jf904335g