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"Benifuuki" Extract Reduces Serum Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind Placebo-Controlled Randomized Trial.
- Source :
-
Nutrients [Nutrients] 2018 Jul 19; Vol. 10 (7). Date of Electronic Publication: 2018 Jul 19. - Publication Year :
- 2018
-
Abstract
- (1) Background: Arteriosclerosis is associated with high levels of low-density lipoprotein (LDL) cholesterol. O -methylated catechins in "Benifuuki" green tea are expected to reduce cholesterol levels, although there is limited research regarding this topic; (2) Methods: This trial evaluated 159 healthy volunteers who were randomized to receive ice cream containing a high-dose of "Benifuuki" extract including 676 mg of catechins (group H), a low-dose of "Benifuuki" extract including 322 mg of catechins (group L), or no "Benifuuki" extract (group C). Each group consumed ice cream (with or without extract) daily for 12 weeks, and their lipid-related parameters were compared; (3) Results: A significant reduction in the level of lectin-like oxidized LDL receptor-1 ligand containing ApoB (LAB) was detected in group H, compared to groups L and C. No significant differences between the three groups were detected in their levels of total cholesterol, triglycerides, and LDL cholesterol; (4) Conclusions: "Benifuuki" extract containing O -methylated catechins may help prevent arteriosclerosis.
- Subjects :
- Aged
Apolipoprotein B-100 blood
Biomarkers blood
Catechols administration & dosage
Catechols therapeutic use
Double-Blind Method
Female
Food Handling
Food Preferences
Humans
Hyperlipidemias blood
Hypolipidemic Agents therapeutic use
Ice Cream
Intention to Treat Analysis
Japan
Ligands
Male
Middle Aged
Oxidation-Reduction
Plant Extracts therapeutic use
Plant Leaves chemistry
Apolipoprotein B-100 antagonists & inhibitors
Camellia sinensis chemistry
Dietary Supplements
Hyperlipidemias prevention & control
Hypolipidemic Agents administration & dosage
Plant Extracts administration & dosage
Scavenger Receptors, Class E metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 10
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 30029523
- Full Text :
- https://doi.org/10.3390/nu10070924