22 results on '"Yubei Huang"'
Search Results
2. Effect of estradiol as a continuous variable on breast cancer survival by menopausal status: a cohort study in China
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Junxian Li, Chenyang Li, Ziwei Feng, Luyang Liu, Liwen Zhang, Wenjuan Kang, Ya Liu, Baoshan Ma, Haixin Li, Yubei Huang, Hong Zheng, Fangfang Song, Fengju Song, and Kexin Chen
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Cohort Studies ,Cancer Research ,Estradiol ,Premenopause ,Oncology ,Humans ,Breast Neoplasms ,Female ,Menopause - Abstract
BackgroundHigh levels of circulating estradiol (E2) are associated with increased risk of breast cancer, whereas its relationship with breast cancer prognosis is still unclear. We studied the effect of E2 concentration on breast cancer survival among pre- menopausal and post- menopausal patients in China.MethodsWe evaluated this association among 8766 breast cancer cases diagnosed between 2005 and 2017 from the Tianjin Breast Cancer Cases Cohort. Levels of serum E2 were measured in pre-menopausal and post-menopausal women. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) between quartile of E2 levels and overall survival (OS) and progression-free survival (PFS) of breast cancer. The penalized spline was then used to test for non-linear relationships between E2 (continuous variable) and survival endpoints.ResultsA total of 612 deaths and 982 progressions occurred over follow-up through 2017. Compared to women in the quartile 3, the highest quartile of E2 was associated with reduced risk of both PFS in pre-menopausal women (HR=1.79, 95% CI: 1.17-2.75, P=0.008) and OS in post-menopausal women (HR=1.35, 95% CI: 1.04-1.74, P=0.023). OS and PFS in pre-menopausal women exhibited a nonlinear relation (“L-shaped” and “U-shaped”, respectively) with E2 levels. However, there was a linear relationship in post-menopausal women, among whom increasing E2 was associated with escalating risks of death and progression. Moreover, patients with estrogen receptor-negative (ER-negative) breast cancer showed a “U-shaped” relationship with OS and PFS in pre-menopausal women.ConclusionsPre-menopausal breast cancer patients have a plateau stage of prognosis at the intermediate concentrations of E2, whereas post-menopausal patients have no apparent threshold, and ER status may have an impact on this relationship.
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- 2022
3. Development and evaluation of the screening performance of a low-cost high-risk screening strategy for breast cancer
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Ying Zhu, Huan Wang, Yubei Huang, Fengju Song, Peifang Liu, Kexin Chen, Hongji Dai, and Zhangyan Lyu
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Cancer Research ,medicine.medical_specialty ,Population ,Breast Neoplasms ,Asymptomatic ,Breast cancer ,Cancer screening ,medicine ,Humans ,Mass Screening ,Mammography ,Stage (cooking) ,Family history ,education ,Early Detection of Cancer ,Aged ,Ultrasonography ,education.field_of_study ,medicine.diagnostic_test ,Obstetrics ,business.industry ,Middle Aged ,medicine.disease ,Oncology ,Female ,medicine.symptom ,Live birth ,business ,Contraceptives, Oral - Abstract
Objective: To develop and evaluate the screening performance of a low-cost high-risk screening strategy for breast cancer in low resource areas. Methods: Based on the Multi-modality Independent Screening Trial, 6 questionnaire-based risk factors of breast cancer (age at menarche, age at menopause, age at first live birth, oral contraceptive, obesity, family history of breast cancer) were used to determine the women with high risk of breast cancer. The screening performance of clinical breast examination (CBE), breast ultrasonography (BUS), and mammography (MAM) were calculated and compared to determine the optimal screening method for these high risk women. Results: A total of 94 breast cancers were detected among 31,720 asymptomatic Chinese women aged 45–65 years. Due to significantly higher detection rates (DRs) and suitable coverage of the population, high risk women were defined as those with any of 6 risk factors. Among high risk women, the DR for BUS [3.09/1,000 (33/10,694)] was similar to that for MAM [3.18/1,000 (34/10,696)], while it was significantly higher than that for the CBE [1.73/1,000 (19/10,959), P = 0.002]. Compared with MAM, BUS showed significantly higher specificity [98.64% (10,501/10,646) vs. 98.06% (10,443/10,650), P = 0.001], but no significant differences in sensitivity [68.75% (33/48) vs. 73.91% (34/46)], positive prediction values [18.54% (33/178) vs. 14.11% (34/241)], and negative prediction values [99.86% (10,501/10,516) vs. 99.89% (10,443/10,455)]. Further analyses showed no significant difference in the percentages of early stage breast cancer [53.57% (15/28) vs. 50.00% (15/30)], lymph node involvement [22.73% (5/22) vs. 28.00% (7/25)], and tumor size ≥ 2 cm [37.04% (10/27) vs. 29.03% (9/31)] between BUS and MAM. Subgroup analyses stratified by breast densities or age at enrollment showed similar results. Conclusions: The low-cost high-risk screening strategy based on 6 questionnaire-based risk factors was an easy-to-use method to identify women with high risk of breast cancer. Moreover, BUS and MAM had comparable screening performances among high risk women.
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- 2021
4. SNPs within microRNA binding sites and the prognosis of breast cancer
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Kexin Chen, Hong Zheng, Yubei Huang, Fangfang Song, Junxian Li, Haixin Li, Ziwei Feng, Peishan Wang, Xin Wang, Lu Han, Luyang Liu, Fengju Song, and Liwen Zhang
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Oncology ,Adult ,Aging ,medicine.medical_specialty ,Single-nucleotide polymorphism ,Breast Neoplasms ,Polymorphism, Single Nucleotide ,Young Adult ,Breast cancer ,breast cancer ,single nucleotide polymorphism ,Internal medicine ,Gene expression ,microRNA ,Genotype ,Medicine ,Humans ,Genetic Association Studies ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Binding Sites ,business.industry ,Kinase ,Cell Biology ,Middle Aged ,medicine.disease ,Prognosis ,LRRK2 ,Survival Analysis ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,Female ,Lymph ,business ,Research Paper - Abstract
Single nucleotide polymorphisms (SNPs) within microRNA binding sites can affect the binding of microRNA to mRNA and regulate gene expression, thereby contributing to cancer prognosis. Here we performed a two-stage study of 2647 breast cancer patients to explore the association between SNPs within microRNA binding sites and breast cancer prognosis. In stage I, we genotyped 192 SNPs within microRNA binding sites using the Illumina Goldengate platform. In stage II, we validated SNPs associated with breast cancer prognosis in another dataset using the TaqMan platform. We identified 8 SNPs significantly associated with breast cancer prognosis in stage I (P
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- 2021
5. Utility of Preoperative Inflammatory Markers to Distinguish Epithelial Ovarian Cancer from Benign Ovarian Masses
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Liwen Zhang, Hong Zheng, Yubei Huang, Chao Sheng, Jing Tian, Fengju Song, Kexin Chen, Luyang Liu, and Lian Li
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medicine.medical_specialty ,endocrine system diseases ,Predictive capability ,Cancer biomarkers ,Logistic regression ,Gastroenterology ,Benign ovarian masses ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diagnosis ,medicine ,Epithelial ovarian cancer ,Inflammation biomarkers ,030212 general & internal medicine ,Receiver operating characteristic ,business.industry ,Histology ,female genital diseases and pregnancy complications ,Serous fluid ,Oncology ,030220 oncology & carcinogenesis ,Potential biomarkers ,business ,Research Paper - Abstract
Background: Inflammatory markers have been reported to be predictors for the presence of epithelial ovarian cancer (EOC), however, the cut-off value of each marker remains unclear and predictive capability of the markers in different histology types of EOC is still unknown. Methods: A total of 207 patients with benign ovarian masses and 887 EOC patients who underwent surgical resection, and were pathologically diagnosed were included. We compared the difference of preoperative inflammatory markers between benign ovarian masses and EOC patients. Stratified analysis by histology subtype was further conducted. Logistic regression analyses and receiver operating characteristic (ROC) curves was used to evaluate the predictive capability of the markers. Results: Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were significantly associated with all stages and subtypes of EOC (P
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- 2021
6. Tumor markers CA15-3, CA125, CEA and breast cancer survival by molecular subtype: a cohort study
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Fengju Song, Hong Zheng, Yubei Huang, Luyang Liu, Xin Wang, Baoshan Ma, Kexin Chen, Junxian Li, Ziwei Feng, Pengyu Zhang, Haixin Li, Fangfang Song, Hongji Dai, Dezheng Wang, and Liwen Zhang
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Adult ,0301 basic medicine ,Oncology ,CA15-3 ,China ,medicine.medical_specialty ,Adolescent ,Population ,Breast Neoplasms ,GPI-Linked Proteins ,Disease-Free Survival ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Pharmacology (medical) ,Radiology, Nuclear Medicine and imaging ,Breast ,education ,Mastectomy ,Aged ,Tumor marker ,Aged, 80 and over ,education.field_of_study ,Proportional hazards model ,business.industry ,Mucin-1 ,Hazard ratio ,Membrane Proteins ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Carcinoembryonic Antigen ,030104 developmental biology ,Chemotherapy, Adjuvant ,CA-125 Antigen ,030220 oncology & carcinogenesis ,Preoperative Period ,Cohort ,Female ,business ,Follow-Up Studies ,Cohort study - Abstract
The burden of breast cancer has grown rapidly in China during recent decades. However, the association between tumor markers (CA15-3, CA125, and CEA) and breast cancer survival among certain molecular subtypes is unclear; we described this association in a large, population-based study. We conducted a cohort study including 10,836 women according to the Tianjin Breast Cancer Cases Cohort. Demographic and epidemiologic data were collected by a structured face-to-face questionnaire. Clinico-pathological parameters were abstracted from medical records, and follow-up information was obtained once a year by telephone. The primary endpoints were breast cancer-specific survival (BCSS) and disease-free survival (DFS). We utilized the Cox proportional hazard model to calculate hazard ratios (HRs) and 95% confidence intervals (CI). Among all patients, elevated CA15-3 and CEA exhibited consistently and statistically significant reduced BCSS compared with normal ones (CA15-3: HR 1.54, 95% CI 1.01–2.34; CEA: HR 2.45, 95% CI 1.40–4.30). Similar patterns of association were observed for DFS (CA15-3: HR 2.09, 95% CI 1.44–3.02; CEA: HR 2.71, 95% CI 1.71–4.27). Moreover, in luminal A subtype, high CA15-3 and CEA levels were associated with decreased BCSS (CA15-3: HR 4.47, 95% CI 2.04–9.81; CEA: HR 3.79, 95% CI 1.68–8.55) and DFS (CA15-3: HR 4.06, 95% CI 2.29–7.18, CEA: HR 3.41, 95% CI 1.75–6.64). In basal-like subtype, elevated CEA conferred reduction for BCSS (HR 5.13, 95% CI 1.65–15.9). However, no association was observed between CA125 and breast cancer outcome. Preoperative CA15-3 and CEA levels differ in breast cancer molecular subtypes and yield strong prognostic information in Chinese women with breast cancer. Measuring CA15-3 and CEA levels before surgery may have the potential in predicting breast cancer survival and offering patients’ personalized treatment strategy among luminal A and basal-like subtypes.
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- 2020
7. An exploration for quantification of overdiagnosis and its effect for breast cancer screening
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Shengfeng Wang, Yubei Huang, and Lei Yang
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Oncology ,End results ,Cancer Research ,medicine.medical_specialty ,overdiagnosis ,03 medical and health sciences ,Breast cancer screening ,Breast cancer ,0302 clinical medicine ,Internal medicine ,Epidemiology ,Cancer screening ,medicine ,Overdiagnosis ,skin and connective tissue diseases ,Survival rate ,medicine.diagnostic_test ,business.industry ,screening ,medicine.disease ,030220 oncology & carcinogenesis ,Cohort ,Original Article ,business - Abstract
Objective To redefine overdiagnosis and reestimate the proportion of overdiagnosis of breast cancer caused by screening based on the Surveillance, Epidemiology, and End Results (SEER, 1973−2015) Program data. Methods The breast cancer diagnosed before 1977 was defined as the no-screening cohort since America had initiated breast cancer screening from 1977. The breast cancer diagnosed in 1999 was defined as the screening cohort due to no increases in both the proportion of early-stage breast cancer until 1999 and the overall survival of early-stage breast cancer diagnosed over the three years since 1999. The magnitude of overdiagnosis was calculated as the difference in the proportions of early-stage breast cancer patients with long-time (15-year) survival to all breast cancer patients between two cohorts. Results Over 23 years before and after widespread screening in America, the proportion of early-stage breast cancer patients increased from 52.1% (16,891/32,443) to 72.7% (16,021/22,025) (P
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- 2020
8. Interpretation of breast cancer screening guideline for Chinese women
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Yubei Huang, Yehui Shi, Xishan Hao, Peifang Liu, Ying Wang, Wenhua Zhao, Juntian Liu, Fengju Song, Kexin Chen, Lin Gu, Jinpu Yu, Zhongsheng Tong, Huaiyuan Xiao, and Hui Li
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Cancer Research ,medicine.medical_specialty ,Guideline Interpretation ,mammography ,Population ,lcsh:RC254-282 ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Breast cancer screening ,0302 clinical medicine ,Breast cancer ,breast cancer ,medicine ,Mammography ,education ,China ,skin and connective tissue diseases ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,ultrasound ,screening ,Cancer ,Guideline ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Clinical research ,Oncology ,030220 oncology & carcinogenesis ,Family medicine ,business ,guideline - Abstract
Breast cancer is the most common malignant tumor in Chinese women. Early screening is the best way to improve the rates of early diagnosis and survival of breast cancer patients. The peak onset age for breast cancer in Chinese women is considerably younger than those in European and American women. It is imperative to develop breast cancer screening guideline that is suitable for Chinese women. By summarizing the current evidence on breast cancer screening in Chinese women, and referring to the latest guidelines and consensus on breast cancer screening in Europe, the United States, and East Asia, the China Anti-Cancer Association and National Clinical Research Center for Cancer (Tianjin Medical University Cancer Institute and Hospital) have formulated population-based guideline for breast cancer screening in Chinese women. The guideline provides recommendations on breast cancer screening for Chinese women at average or high risk of breast cancer according to the following three aspects: age of screening, screening methods, and screening interval. This article provides more detailed information to support the recommendations in this guideline and to provide more direction for current breast cancer screening practices in China.
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- 2019
9. A Nomogram To Predict The Overall Survival Of Breast Cancer Patients And Guide The Postoperative Adjuvant Chemotherapy In China
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Kexin Chen, Fangfang Song, Jin Zhang, Peishan Wang, Hong Zheng, Yubei Huang, Ping Cui, Hongji Dai, Xuchen Cao, Fengju Song, Haixin Li, Lin Gu, Xin Wang, Ziwei Feng, and Dezheng Wang
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Chemotherapy ,Proportional hazards model ,business.industry ,medicine.medical_treatment ,Hazard ratio ,Area under the curve ,Nomogram ,medicine.disease ,Confidence interval ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Breast cancer ,030220 oncology & carcinogenesis ,Internal medicine ,Propensity score matching ,medicine ,business - Abstract
Purpose We aim to construct a nomogram to predict breast cancer survival and guide postoperative adjuvant chemotherapy in China. Patients and methods A total of 5,504 breast cancer patients from the Tianjin Breast Cancer Cases Cohort were included. Multivariable Cox regression was used to investigate the factors associated with overall survival (OS) and a nomogram was constructed based on these prognostic factors. The nomogram was internal and external validated and the performance was evaluated by area under the curve (AUC) and calibration curve. The partial score was also constructed and stratified them into low, moderate and high-risk subgroups for death according to the tripartite grouping method. Multivariate Cox regression analysis and the propensity score matching method were respectively used to test the association between adjuvant chemotherapy and OS in different risk subgroups. Results Age, diameter, histological differentiation, lymph node metastasis, estrogen, and progesterone receptor were incorporated into the nomogram and validation results showed this nomogram was well-calibrated to predict the 3-year [AUC =74.1%; 95% confidence interval (CI): 70.1-78.0%] and 5-year overall survival [AUC =72.3%; 95% CI: 69.6-75.1%]. Adjuvant chemotherapy was negatively associated with death in high risk subgroup [Hazard Ratio (HR) = 0.54; 95% CI: 0.37-0.77; P
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- 2019
10. Comparison of outcomes between immediate implantbased and autologous reconstruction: 15-year, single-center experience in a propensity score-matched Chinese cohort
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Jian Yin, Shanshan He, Bowen Ding, Gang Li, Shu Wang, Jing Liu, Jingyan Sun, Yubei Huang, Chunyong Han, Qingfeng Huang, and Zhuming Yin
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Cancer Research ,medicine.medical_specialty ,business.industry ,Mammaplasty ,Breast Neoplasms ,medicine.disease ,Single Center ,Confidence interval ,Breast cancer ,Patient satisfaction ,Oncology ,Internal medicine ,Propensity score matching ,Cohort ,medicine ,Humans ,Female ,Implant ,Breast reconstruction ,business ,Propensity Score ,Mastectomy ,Retrospective Studies - Abstract
Objective: The number of immediate breast reconstruction (IBR) procedures has been increasing in China. This study aimed to investigate the oncological safety of IBR, and to compare the survival and surgical outcomes between implant-based and autologous reconstruction. Methods: Data from patients diagnosed with invasive breast cancer who underwent immediate total breast reconstruction between 2001 and 2016 were retrospectively reviewed. Long-term breast cancer-specific survival (BCSS), disease-free survival (DFS), and locoregional recurrence-free survival (LRFS) were evaluated. Patient satisfaction with the breast was compared between the implant-based and autologous groups. BCSS, DFS, and LRFS were compared between groups after propensity score matching (PSM). Results: A total of 784 IBR procedures were identified, of which 584 were performed on patients with invasive breast cancer (implant-based, n = 288; autologous, n = 296). With a median follow-up of 71.3 months, the 10-year estimates of BCSS, DFS, and LRFS were 88.9% [95% confidence interval (CI) (85.1%–93.0%)], 79.6% [95% CI (74.7%–84.8%)], and 94.0% [95% CI (90.3%–97.8%)], respectively. A total of 124 patients completed the Breast-Q questionnaire, and no statistically significant differences were noted between groups (P = 0.823). After PSM with 27 variables, no statistically significant differences in BCSS, DFS, and LRFS were found between the implant-based (n = 177) and autologous (n = 177) groups. Further stratification according to staging, histological grade, lymph node status, and lymph-venous invasion status revealed no significant survival differences between groups. Conclusions: Both immediate implant-based and autologous reconstruction were reasonable choices with similar long-term oncological outcomes and patient-reported satisfaction among patients with invasive breast cancer in China.
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- 2021
11. Prognostic value of pre-treatment peripheral blood markers in pancreatic ductal adenocarcinoma and their association with S100A4 expression in tumor tissue
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De-Jun Zhou, Xiangdong Tian, Yong Xu, Hua Li, Yi Pan, Yubei Huang, and Zhenguo Song
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0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Multivariate analysis ,Pancreatic ductal adenocarcinoma ,medicine.medical_treatment ,pancreatic ductal adenocarcinoma ,03 medical and health sciences ,0302 clinical medicine ,S100 calcium-binding protein A4 ,Internal medicine ,platelet-lymphocyte ratio ,Medicine ,neutrophil-lymphocyte ratio ,prognostic factor ,Univariate analysis ,Chemotherapy ,Oncogene ,business.industry ,fungi ,Cancer ,Articles ,medicine.disease ,Molecular medicine ,Peripheral blood ,030104 developmental biology ,030220 oncology & carcinogenesis ,business ,lymphocyte-monocyte ratio - Abstract
The aims of the present study were to clarify the prognostic value of peripheral blood variables in patients with pancreatic ductal adenocarcinoma (PDAC), including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), and to determine the association between these variables and S100 calcium-binding protein A4 (S100A4) expression in tumor tissue, which is another prognostic factor for PDAC. Patients with PDAC were recruited at the Tianjin Medical University Cancer Institute and Hospital (Tianjin, China) between December 2008 and December 2014. A retrospective analysis was performed based on the recorded pre-treatment hematological parameters and clinical data. The prognostic value of NLR, PLR and LMR was examined. The association between these variables and S100A4 tissue expression was analyzed. Descriptive statistics and χ2 analyses were used in the present study. The median overall survival (OS) time of patients with PDAC was 9 months (range, 1-32 months). Univariate analysis revealed that NLR, LMR, carbohydrate antigen 19-9, surgery, chemotherapy, stage at diagnosis, tumor grade and age significantly affected OS. Although PLR exhibited no significant effects on OS, NLR and LMR were independent prognostic factors according to the multivariate analysis. Unpaired Student's t-test revealed differences between S100A4 expression and NLR, PLR and LMR. The results of the present study indicated that low NLR and high LMR were associated with a favorable prognosis in patients with PDAC. As a simply obtained and widely available index at diagnosis, NLR and LMR may become a novel predictive and classifying marker for PDAC in the clinical setting.
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- 2019
12. Methods of computed tomography screening and management of lung cancer in Tianjin
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Monique D. Dorrius, Zhaoxiang Ye, Matthijs Oudkerk, Yubei Huang, Marjolein A Heuvelmans, Yingru Zhao, Rozemarijn Vliegenthart, Yihui Du, Xiaonan Cui, Xueqian Xie, Geertruida H. de Bock, Grigory Sidorenkov, Harry J.M. Groen, Kexin Chen, Shiyuan Liu, Mieneke Rook, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), and Cardiovascular Centre (CVC)
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Cancer Research ,medicine.medical_specialty ,China ,PULMONARY SUBSOLID NODULES ,FEATURES ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,Cancer screening ,Epidemiology ,medicine ,EPIDEMIOLOGY ,030212 general & internal medicine ,Lung cancer ,Prospective cohort study ,Lung ,business.industry ,STATEMENT ,lung nodules ,screening ,MORTALITY ,Nodule (medicine) ,computed tomography ,Guideline ,respiratory system ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,respiratory tract diseases ,PROBABILITY ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,VOLUME ,Original Article ,Radiology ,medicine.symptom ,business ,Lung cancer screening - Abstract
Objective: European lung cancer screening studies using computed tomography (CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time (VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol (Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT (a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume- and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations.
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- 2019
13. Performance of ultrasonography screening for breast cancer: a systematic review and meta-analysis
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Shengfeng Wang, Lei Yang, Ping Wang, Yubei Huang, Liwen Zhang, Chao Sheng, and Fengju Song
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Oncology ,Cancer Research ,medicine.medical_specialty ,Biopsy ,Breast Neoplasms ,Sensitivity and Specificity ,lcsh:RC254-282 ,03 medical and health sciences ,Breast cancer ,0302 clinical medicine ,Surgical oncology ,Internal medicine ,Genetics ,Screening method ,Humans ,Mass Screening ,Medicine ,Mammography ,Breast ,030212 general & internal medicine ,Early Detection of Cancer ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Cancer ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Supplemental ultrasonography ,030220 oncology & carcinogenesis ,Meta-analysis ,Asymptomatic Diseases ,Screening ,Feasibility Studies ,Female ,Ultrasonography, Mammary ,business ,Research Article - Abstract
Background To investigate the performance of primary ultrasound (P-US) screening for breast cancer, and that of supplemental ultrasound (S-US) screening for breast cancer after negative mammography (MAM). Methods Electronic databases (PubMed, Scopus, Web of Science, and Embase) were systematically searched to identify relevant studies published between January 2003 and May 2018. Only high-quality or fair-quality studies reporting any of the following performance values for P-US or S-US screening were included: sensitivity, specificity, cancer detected rate (CDR), recall rate (RR), biopsy rate (BR), proportion of invasive cancers among screening-detected cancers (ProIC), and proportion of node-negative cancers among screening-detected invasive cancers (ProNNIC). Results Twenty-three studies were included, including 12 studies in which S-US screening was used after negative MAM and 11 joint screening studies in which both primary MAM (P-MAM) and P-US were used. Meta-analyses revealed that S-US screening could detect 96% [95% confidential intervals (CIs): 82 to 99%] of occult breast cancers missed by MAM and identify 93% (95% CIs: 89 to 96%) of healthy women, with a CDR of 3.0/1000 (95% CIs: 1.8/1000 to 4.6/1000), RR of 8.8% (95% CIs: 5.0 to 13.4%), BR of 3.9% (95% CIs: 2.7 to 5.4%), ProIC of 73.9% (95% CIs: 49.0 to 93.7%), and ProNNIC of 70.9% (95% CIs: 46.0 to 91.6%). Compared with P-MAM screening, P-US screening led to the recall of significantly more women with positive screening results [1.5% (95% CIs:0.6 to 2.3%), P = 0.001] and detected significantly more invasive cancers [16.3% (95% CIs: 10.6 to 22.1%), P Conclusions Current evidence suggests that S-US screening could detect occult breast cancers missed by MAM. P-US screening has shown to be comparable to P-MAM screening in women with dense breasts in terms of sensitivity, specificity, cancer detection rate, and biopsy rate, but with higher recall rates and higher detection rates for invasive cancers.
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- 2020
14. Association Study between SNPs within MicroRNA Binding Sites and the Prognosis of Breast Cancer
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Fangfang Song, Junxian Li, Ziwei Feng, Fengju Song, Liwen Zhang, Haixin Li, Kexin Chen, Lu Han, Peishan Wang, Xin Wang, Hong Zheng, Yubei Huang, and Luyang Liu
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Oncology ,medicine.medical_specialty ,Breast cancer ,MicroRNA binding ,business.industry ,Internal medicine ,medicine ,Single-nucleotide polymorphism ,medicine.disease ,business - Abstract
Background: Single nucleotide polymorphisms (SNPs) within microRNA binding sites can affect the binding of microRNA to mRNA and regulate gene expression, thereby contributing to the prognosis of cancer. We performed this study to explore the association between SNPs within microRNA binding sites and the prognosis of breast cancer.Methods: We carried out a two-stage study including 2647 breast cancer patients. In stage I, we genotyped 192 SNPs within microRNA binding sites using the Illumina Goldengate platform. In stage II, we validated SNPs significantly associated with breast cancer prognosis in another dataset using the TaqMan platform. Survival times was calculated, and Kaplan-Meier curves and Cox regression model were used to analyze survival of breast cancer patients with different genotypes.Results: We identified 8 SNPs significantly associated with breast cancer prognosis in stage I (PConclusions: The LRKK2 rs10878441 CC genotype is associated with poor prognosis of breast cancer in a Chinese population, and it could be used as a potential prognostic biomarker for breast cancer. Further studies are warranted.
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- 2020
15. Improved Performance of Adjunctive Ultrasonography After Mammography Screening for Breast Cancer Among Chinese Females
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Xishan Hao, Kexin Chen, Yubei Huang, Fengju Song, Ying Zhu, Peishan Wang, Hongji Dai, Peifang Liu, Henglei Dong, and Jiali Han
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China ,Cancer Research ,medicine.medical_specialty ,Fibrocystic Breast Disease ,Breast imaging ,Biopsy ,Breast Neoplasms ,Malignancy ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,medicine ,Humans ,Mammography ,False Positive Reactions ,Breast ,030212 general & internal medicine ,Early Detection of Cancer ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Oncology ,030220 oncology & carcinogenesis ,Female ,Ultrasonography, Mammary ,Breast disease ,Radiology ,Ultrasonography ,business ,Follow-Up Studies - Abstract
Until now, no studies have investigated whether women other than those with dense breasts are suitable for adjunctive ultrasonography after negative mammography, and investigated whether all women with negative mammography are suitable for adjunctive ultrasonography.Based on the Multi-modality Independent Screening Trial in China, a total of 31,918 women aged 45 to 65 years underwent both ultrasonography and mammography. Physicians performed ultrasonography and mammography separately and were blinded to each other's findings until their interpretations had been recorded. For both ultrasonography and mammography, suspicious results and those highly suggestive of a malignancy were confirmed by pathologic examination, whereas other results were confirmed by 1-year follow-up after initial screening.Based on Breast Imaging Reporting and Data System (BIRADS) assessments, 84 (84.8%) of 99 cancers were identified on mammography (detection rate, 2.6/1000), and 61 (61.6%) of 99 cancers were identified on ultrasonography (detection rate, 1.9/1000). Integrated mammography with ultrasonography identified 94 (95.0%) of 99 cancers, with an increment of 11.9% in cancer detection rate (from 2.6/1000 to 2.9/1000) (P .05). Moreover, among women with BIRADS 3, adjunctive ultrasonography detected no cancers. All 10 additional cancers detected by adjunctive ultrasonography were from women with BIRADS 0 to 2, at a cost of 207 women with false positives. Additionally, dense breasts and benign breast disease were significantly associated with positive ultrasonography after BIRADS 0 to 2 (all P values .05).After negative mammography, adjunctive ultrasonography should only be recommended for BIRADS 0 to 2 but not BIRADS 3, especially for women with dense breasts or benign breast disease.
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- 2018
16. MicroRNA-21 as a potential diagnostic biomarker for breast cancer patients: a pooled analysis of individual studies
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Yubei Huang, Kexin Chen, Li Sun, Hongxi Yang, Yaogang Wang, Shu Li, Qiliang Cai, and Ying Gao
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Databases, Factual ,diagnostic ,Breast Neoplasms ,Likelihood ratios in diagnostic testing ,03 medical and health sciences ,breast cancer ,0302 clinical medicine ,Breast cancer ,Internal medicine ,Epidemiology of cancer ,Biomarkers, Tumor ,medicine ,Humans ,business.industry ,Cancer ,medicine.disease ,meta-analysis ,MicroRNAs ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Meta-analysis ,Diagnostic odds ratio ,biomarker ,Biomarker (medicine) ,Female ,Biostatistics ,business ,Research Paper ,microRNA-21 - Abstract
// Ying Gao 1, 2, * , Qiliang Cai 3, * , Yubei Huang 2, * , Shu Li 1 , Hongxi Yang 1 , Li Sun 1 , Kexin Chen 2 , Yaogang Wang 1 1 Department of Health Service Management, School of Public Health, Tianjin Medical University, Tianjin, 300070, China 2 Department of Cancer Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China 3 Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China * Co-first authors, these authors contributed equally to this work Correspondence to: Yaogang Wang, email: wangyg@tmu.edu.cn Keywords: microRNA-21, breast cancer, diagnostic, biomarker, meta-analysis Received: January 17, 2016 Accepted: April 16, 2016 Published: May 02, 2016 ABSTRACT MicroRNA-21 (miR-21) has been reported as the potential novel diagnostic biomarker for breast cancer in several studies, but their results were inconsistent. Therefore, we conducted a systematic analysis to evaluate the diagnostic value of miR-21 in detecting breast cancer. A comprehensive electronic and manual search was conducted for relevant literatures through several databases up to November 9, 2015. QUADAS-2 was used to assess the quality of the studies included in the study. All statistical analyses were performed using Meta-Disc 1.4 and Stata 12.0. Eleven studies with a total of 918 breast cancer patients and 613 controls were included. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) with their 95% confidence intervals (CIs) were 0.72 (95% CI: 0.69–0.75), 0.80 (95% CI: 0.77–0.83), 3.37 (95% CI: 2.24–5.07), 0.30 (95% CI: 0.19–0.50), and 11.79 (95% CI: 5.23–26.57), respectively. The area under the curve of SROC was 0.8517. In conclusion, our analyses suggested that miR-21 is a promising biomarker in diagnosing breast cancer. For clinical purpose, further large-scale studies are warranted to validate its clinical application.
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- 2016
17. A survey of overall life satisfaction and its association with breast diseases in Chinese women
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Ying Gao, Peishan Wang, Hongji Dai, Xishan Hao, Yubei Huang, Aili Bai, Haixin Li, Xueou Liu, Kexin Chen, and Fengju Song
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detection rate ,lifestyle ,China ,Health Knowledge, Attitudes, Practice ,Cancer Research ,medicine.medical_specialty ,Breast Neoplasms ,Physical examination ,Personal Satisfaction ,physical examination ,Breast Diseases ,03 medical and health sciences ,breast cancer ,0302 clinical medicine ,Breast cancer ,Asian People ,Quality of life ,Risk Factors ,Surveys and Questionnaires ,Epidemiology ,Odds Ratio ,medicine ,Humans ,Mammography ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,skin and connective tissue diseases ,Life Style ,Breast ultrasound ,Original Research ,Gynecology ,medicine.diagnostic_test ,Obstetrics ,business.industry ,Odds ratio ,Benign breast diseases ,medicine.disease ,Oncology ,030220 oncology & carcinogenesis ,Quality of Life ,Female ,overall life satisfaction ,Breast disease ,business ,Cancer Prevention - Abstract
To investigate the association between overall life satisfaction and healthy lifestyle, knowledge of breast cancer, physical examination, and detection rate of breast cancer and benign breast disease in Chinese women. In a multicentered breast disease screening program in China, we enrolled 33,057 women aged 45–65 years without prior diagnosis of breast cancer. After completing an epidemiological questionnaire, all participants were examined by clinical breast examination, breast ultrasound, and mammography independently. All breast cancer cases and a selected sample of benign breast diseases were confirmed pathologically. Univariate and multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association between life satisfaction and lifestyle, knowledge of breast cancer, physical examination, and detection rate of breast diseases. Overall life satisfaction was positively associated with women's healthy lifestyle. Compared with less satisfied women, satisfied women were less likely to be smokers (OR = 0.54; 95% CI: 0.47–0.62), have more exercise (OR = 1.49; 95% CI: 1.26–1.75), eat less fried (OR = 0.60; 95% CI: 0.50–0.71), smoked (OR = 0.54, 95% CI: 0.47–0.63), pickled (OR = 0.66, 95% CI: 0.55–0.79), and grilled (OR = 0.63, 95% CI: 0.54–0.74) foods. Satisfied women were more likely to have knowledge of breast cancer (OR = 1.48, 95% CI: 1.29–1.70), and have regular physical examinations (OR = 1.11, 95% CI: 1.01–1.12). Compared to less satisfied women, we found significantly lower detection rate of benign breast diseases (OR = 0.90, 95% CI: 0.82–0.99), and lower but nonsignificant detection rate of breast cancer (OR = 0.66, 95% CI: 0.35–1.25) in satisfied women. Women with a higher overall life satisfaction are more likely to have healthy lifestyle, knowledge of breast cancer, and regular physical examination, thus resulting in a lower detection rate of breast diseases in screening.
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- 2015
18. Abstract 5295: Screening performance of ultrasonography and mammography among Chinese women at high-risk of developing breast cancer
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Kexin Chen, Fengju Song, and Yubei Huang
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Gynecology ,Cancer Research ,medicine.medical_specialty ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Population ,Cancer ,medicine.disease ,Breast cancer ,Oncology ,medicine ,Mammography ,Breast disease ,business ,education ,Breast carcinoma ,Breast ultrasound ,Breast feeding - Abstract
In order to easily identify high-risk population of breast cancer and to determine the optimal screening modality among Chinese high-risk women, a total of 33234 asymptomatic Chinese women aged 45-65 years underwent breast ultrasound (BUS) and mammography (MAM) screening concurrently. Physicians performed these screening modalities separately and blindly. The number of risk factors of breast cancer, rather than complex risk prediction models, was used to identify potential high-risk women. Initially, a total of 13 factors (age at menarche, menopausal status, age at menopause, number of live birth, age at first pregnancy, breast feeding, duration of breast feeding, abortion, oral contraceptive, hormone replacement therapy, obesity, history of benign breast disease, and family history of breast cancer) were selected. After excluding correlated factors, factors with risk frequency ≥ 20% and factors with missing values ≥ 5%, 6 factors (age at menarche, age at menopause, age at first pregnancy, oral contraceptive, obesity, family history of breast cancer) were selected as risk-evaluating factors. High-risk women was defined as those with ≥ 1 of the abovementioned 6 factors. According to this strategy, the detection rate among high-risk women (4.34/1000) was significantly higher than their counterpart (2.23/1000, p=0.001), and the percent of high-risk women accounted for 34.9% of the whole population. . Among high-risk women, the cancer detection rate on MAM (3.2/1000) was non-significantly different from that on BUS (3.1/1000; p=0.663). Comparisons on screening accuracy showed no significant difference on sensitivities (73.9% vs. 68.8%, p=0.663), positive prediction values (14.1% vs. 18.5%, p=0.221), and negative prediction values (99.9% vs. 99.9%, p=0.574) between MAM and BUS, but significant higher specificity for BUS (98.6%) than MAM (98.0%, p=0.001). Comparisons on cancer characteristics showed no significant difference on breast carcinoma in situ (22.6% vs. 17.2%, p=0.605), lymph-node involvement (24.1% vs. 20.0%, p=0.715), and tumor size ≥ 2 cm (25.0% vs. 35.5%, p=0.350) between MAM-detected cancers and BUS-detected cancers. Subgroup analyses stratified by breast densities (four groups: 0~ 75%) or age at enrolment (four groups: ≤49, 50-54, 55-59, ≥60 years) also showed no significant difference on sensitivities between MAM and BUS across subgroups. In conclusion, high-risk screening strategy based on the number of exposure to risk factors is an easy-to-use method to identify potential high-risk women of breast cancer, and the performance of BUS is very similar to that of MAM among high-risk women. Citation Format: Yubei Huang, Fengju Song, Kexin Chen. Screening performance of ultrasonography and mammography among Chinese women at high-risk of developing breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5295. doi:10.1158/1538-7445.AM2017-5295
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- 2017
19. Association between abortion and breast cancer: an updated systematic review and meta-analysis based on prospective studies
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Juan Yin, Wengang Qin, Zhengqiang Xie, Li Kuang, Yubei Huang, Lei Yang, Shuhong Song, and Jun Guo
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Adult ,Cancer Research ,medicine.medical_specialty ,Breast Neoplasms ,Abortion ,Breast cancer ,Pregnancy ,Risk Factors ,Epidemiology ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,business.industry ,Obstetrics ,Abortion, Induced ,medicine.disease ,Confidence interval ,Parity ,Oncology ,Relative risk ,Meta-analysis ,Case-Control Studies ,Female ,business - Abstract
Although positive association between abortion and breast cancer was frequently reported from case–control studies, results from prospective studies were still unclear. This study aimed to evaluate this association based on prospective studies. PubMed, ISI Web of Knowledge and Embase were systematically searched for prospective studies on the association between abortion and breast cancer up to April 2014, supplemented by manual searches on the references. Two reviewers independently conducted the literature search, study selection, data extraction, and quality assessment of included studies. Random effects models were used to estimate the combined relative risks (RRs) and corresponding 95 % confidence intervals (95 % CIs). Fifteen prospective studies [14 focused on induced abortion (IA), and 12 focused on spontaneous abortion (SA)] were included in the final analysis. The combined RRs (95 % CIs) of breast cancer risk were 1.00 (0.94–1.05) [1.00 (0.92–1.08) for cumulative-incidence data and 1.00 (0.94–1.05) for incidence-rate data] for IA, and 1.02 (0.95–1.09) [1.06 (0.96–1.16) for cumulative-incidence data and 1.01 (0.92–1.09) for incidence-rate data] for SA, respectively. Non-significant associations of breast cancer with IA and SA were also found among nulliparous women, women with abortion before or after the first full-term pregnancy, women with one or ≥2 abortions, and women with first abortion after 30 years old. The current prospective evidences are not sufficient to support the positive association between abortion (including IA and SA) and breast cancer risk.
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- 2014
20. A meta-analysis of the association between induced abortion and breast cancer risk among Chinese females
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Fengju Song, Kexin Chen, Chuan Chen, Yaogang Wang, Weiqin Li, Xueou Liu, Hongji Dai, Ye Yan, Ying Gao, Yubei Huang, Jing Wang, and Xiaoliang Zhang
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Gynecology ,Cancer Research ,medicine.medical_specialty ,China ,business.industry ,Case-control study ,Abortion, Induced ,Breast Neoplasms ,Publication bias ,Odds ratio ,medicine.disease ,Cohort Studies ,Breast cancer ,Oncology ,Risk Factors ,Meta-analysis ,Internal medicine ,Case-Control Studies ,Epidemiology ,medicine ,Humans ,Female ,Risk factor ,business ,Cohort study - Abstract
To evaluate the association between induced abortion (IA) and breast cancer risk among Chinese females. We searched three English databases (PubMed, ScienceDirect, and Wiley) and three Chinese databases (CNKI, WanFang, and VIP) for studies up to December 2012, supplemented by manual searches. Two reviewers independently conducted the literature searching, study selection, and data extraction and quality assessment of included studies. Random effects models were used to estimate the summary odds ratios (ORs) and the 95 % confidence intervals (CIs). A total of 36 articles (two cohort studies and 34 case–control studies) covering 14 provinces in China were included in this review. Compared to people without any history of IA, an increased risk of breast cancer was observed among females who had at least one IA (OR = 1.44, 95 % CI 1.29–1.59, I 2 = 82.6 %, p
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- 2013
21. Abstract 3932: Values of single nucleotide polymorphisms identified from genome-wide association studies on risk prediction, risk reclassification, and population-based screening of breast-cancer
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Fengju Song, Yubei Huang, and Kexin Chen
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Cancer Research ,education.field_of_study ,Receiver operating characteristic ,business.industry ,Population ,Cancer ,Single-nucleotide polymorphism ,Genome-wide association study ,Bioinformatics ,medicine.disease ,Breast cancer ,Oncology ,medicine ,SNP ,business ,education ,Genetic association - Abstract
Background: With an increasing number of single nucleotide polymorphisms (SNPs) being identified from genome-wide association studies (GWAS), it's important to examine whether these SNPs have values in public health. And it's also unclear how to select the targeted SNPs valuable for population-based screening from numerous GWAS-identified SNPs. Methods: Based on the fraction of the genetic risk explained by a SNP, the area under the receiver operating characteristic curve (AUC), integrated discrimination improvement, and net reclassification improvement were used to select targeted SNPs and to evaluate the values of genetic risk score (GRS) with targeted SNPs on risk prediction, risk reclassification, and effects of population-based screening among 2 million simulated Chinese women aged 35-69 years. Results: A total of 11 targeted SNPs from 23 GWAS-identified SNPs would be valuable for population-based screening of breast cancer among Chinese women. After incorporating GRS with targeted SNPs into traditional risk predication based on established risk factors (ERF) of breast cancer, the AUC significantly improved from 65.5% to 67.5% (P Conclusion: GRS based on targeted GWAS-identified SNPs could significantly improve the risk prediction, risk reclassification, and the effects of population-based screening. Further real-world studies are needed to validate this method and these results. Citation Format: Yubei Huang, Fengju Song, Kexin Chen. Values of single nucleotide polymorphisms identified from genome-wide association studies on risk prediction, risk reclassification, and population-based screening of breast-cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3932.
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- 2016
22. Abstract 4045: Urban-rural disparity of overweight/obesity distribution and its potential association with breast cancer among Chinese females
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Peishan Wang, Ying Gao, Henglei Dong, Yubei Huang, Yaogang Wang, Hong Zheng, Fengju Song, Hongji Dai, Kexin Chen, Haixin Li, and Jiali Han
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Gerontology ,Cancer Research ,medicine.diagnostic_test ,business.industry ,Cancer ,Overweight ,medicine.disease ,Obesity ,Breast cancer screening ,Breast cancer ,Oncology ,Medicine ,medicine.symptom ,business ,China ,Developed country ,Body mass index ,Demography - Abstract
Background: Disparity of overweight/obesity distribution had been investigated in developed countries, but rarely been investigated in developing countries, especially for China with rapid socio-economic development in the past decades. Methods: A total of 1 210 762 participants were recruited from the Chinese National Breast Cancer Screening Program. Overweight and obesity were defined as body mass index (BMI) ranged 24.0-27.9 kg/m2 and BMI ≥ 28.0kg/m2, respectively. Results: The prevalence of overweight/obesity for Chinese rural women (35.2%, 29.2% for overweight and 6.0% for obesity) was significantly higher than that for Chinese urban women (33.4%, 27.7% for overweight and 5.7% for obesity) (P Conclusions: There was an obvious urban-rural disparity of overweight/obesity distribution among Chinese females, which could also lead to an obvious disparity of breast cancer distribution. Citation Format: Ying Gao, Yubei Huang, Hongji Dai, Peishan Wang, Haixin Li, Fengju Song, Hong Zheng, Henglei Dong, Jiali Han, Yaogang Wang, Kexin Chen. Urban-rural disparity of overweight/obesity distribution and its potential association with breast cancer among Chinese females. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4045.
- Published
- 2016
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