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SNPs within microRNA binding sites and the prognosis of breast cancer
- Source :
- Aging (Albany NY)
- Publication Year :
- 2021
- Publisher :
- Impact Journals, 2021.
-
Abstract
- Single nucleotide polymorphisms (SNPs) within microRNA binding sites can affect the binding of microRNA to mRNA and regulate gene expression, thereby contributing to cancer prognosis. Here we performed a two-stage study of 2647 breast cancer patients to explore the association between SNPs within microRNA binding sites and breast cancer prognosis. In stage I, we genotyped 192 SNPs within microRNA binding sites using the Illumina Goldengate platform. In stage II, we validated SNPs associated with breast cancer prognosis in another dataset using the TaqMan platform. We identified 8 SNPs significantly associated with breast cancer prognosis in stage I (P
- Subjects :
- Oncology
Adult
Aging
medicine.medical_specialty
Single-nucleotide polymorphism
Breast Neoplasms
Polymorphism, Single Nucleotide
Young Adult
Breast cancer
breast cancer
single nucleotide polymorphism
Internal medicine
Gene expression
microRNA
Genotype
Medicine
Humans
Genetic Association Studies
Aged
Neoplasm Staging
Aged, 80 and over
Binding Sites
business.industry
Kinase
Cell Biology
Middle Aged
medicine.disease
Prognosis
LRRK2
Survival Analysis
Gene Expression Regulation, Neoplastic
MicroRNAs
Female
Lymph
business
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 19454589
- Volume :
- 13
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Aging (Albany NY)
- Accession number :
- edsair.doi.dedup.....e58c79dedbdc85f310fcc8a174a494d7