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An exploration for quantification of overdiagnosis and its effect for breast cancer screening
- Source :
- Chinese Journal of Cancer Research
- Publication Year :
- 2020
- Publisher :
- Chinese Journal of Cancer Research, 2020.
-
Abstract
- Objective To redefine overdiagnosis and reestimate the proportion of overdiagnosis of breast cancer caused by screening based on the Surveillance, Epidemiology, and End Results (SEER, 1973−2015) Program data. Methods The breast cancer diagnosed before 1977 was defined as the no-screening cohort since America had initiated breast cancer screening from 1977. The breast cancer diagnosed in 1999 was defined as the screening cohort due to no increases in both the proportion of early-stage breast cancer until 1999 and the overall survival of early-stage breast cancer diagnosed over the three years since 1999. The magnitude of overdiagnosis was calculated as the difference in the proportions of early-stage breast cancer patients with long-time (15-year) survival to all breast cancer patients between two cohorts. Results Over 23 years before and after widespread screening in America, the proportion of early-stage breast cancer patients increased from 52.1% (16,891/32,443) to 72.7% (16,021/22,025) (P
- Subjects :
- Oncology
End results
Cancer Research
medicine.medical_specialty
overdiagnosis
03 medical and health sciences
Breast cancer screening
Breast cancer
0302 clinical medicine
Internal medicine
Epidemiology
Cancer screening
medicine
Overdiagnosis
skin and connective tissue diseases
Survival rate
medicine.diagnostic_test
business.industry
screening
medicine.disease
030220 oncology & carcinogenesis
Cohort
Original Article
business
Subjects
Details
- ISSN :
- 19930631
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Cancer Research
- Accession number :
- edsair.doi.dedup.....12d30c24c4225db52a8766e7773ae910