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New 4-aryl-2-oxo-6-phenyl-3-cyclohexene-1-carboxamides were obtained by the reaction of N-substituted acetoacetic acid amides with benzalacetophenone and 4-methoxybenzalacetophenone in alcohol in the presence of potassium hydroxide. Structure of the prepared compounds was proved using IR, 1H and 13C NMR spectroscopy, mass spectrometry and X-ray analysis data. [ABSTRACT FROM AUTHOR]

Novel hydrazones and hexahydro-1H-indazole-5-carboxamides were obtained via the reaction of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides with tosylhydrazide, 2,4-dinitrophenylhydrazine, and phenylhydrazine, respectively. The structures of the products were proved by IR and 1H and 13C NMR spectroscopy, as well as X-ray diffraction analysis. The synthesized compounds were tested for antinociceptive activity. [ABSTRACT FROM AUTHOR]

The reaction of aroylpyruvic acids methyl esters with aromatic aldehyde and urea (thiourea) in methanol leads to the formation of methyl 6-aryl-5-aroyl-4-hydroxy-2-oxo(thioxo)hexahydropyrimidine-4-carboxylates. Structure of the obtained compounds was established by 1H, 13C NMR spectroscopy and single crystal X-ray diffraction analysis. [ABSTRACT FROM AUTHOR]

4-(3-Acyl-2-aryl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acids were synthesized by three- component reactions of acylpyruvic acid methyl esters, aromatic aldehydes, and 4-aminobenzoic acid (PABA). The structures of the compounds were determined using IR, PMR, and 13C NMR spectroscopy. Pronounced analgesic activity of the synthesized compounds was revealed. An aroyl substituent in the 3-position of the heterocycle was shown to increase the analgesic activity. All studied compounds were practically nontoxic. [ABSTRACT FROM AUTHOR]

Short-term heating of a mixture of tryptamine, aromatic aldehyde, and methyl 4-(4-fluorophenyl)-2,4-dioxobutanoate, followed by keeping for a day at room temperature, leads to the formation of 5-aryl-1-[2-(1H-indol-3-yl)-ethyl]-4-[(4-fluorophenyl)(hydroxy)methylene]pyrrolidine-2,3-diones. Structure of the obtained compounds was confirmed by IR and NMR spectroscopy methods. [ABSTRACT FROM AUTHOR]

Novel hydrazone and 1,2,4-triazole-3-thione derivatives were obtained via the reaction of N1,N3,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with acid hydrazides and thiosemicarbazide, respectively. Structure of the products was proved using IR and 1H NMR spectroscopy methods. Some of the synthesized compounds were tested for antimicrobial activity [ABSTRACT FROM AUTHOR]

The reaction of methyl aroylpyruvate with a mixture of aromatic aldehyde and glycocol in a dioxane–water mixture (1 : 1) leads to the formation of a new series of 5-aryl-4-aroyl-3-hydroxy-1-carboxymethyl-3-pyrroline-2-ones. Structure of the obtained compounds was determined by IR and 1H NMR spectroscopy methods. [ABSTRACT FROM AUTHOR]

The reaction of 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate in ethanol gave 4-aryl-3,6-dihydroxy-6-methyl-4,5,6,7-tetrahydro-2H-indazole-5-carboxamides, the structure of which has been proved by IR spectroscopy, 1H NMR and 13C spectroscopy, as well as X-ray diffraction data. Antimicrobial and analgesic activity of the obtained compounds was studied. [ABSTRACT FROM AUTHOR]

The reaction of unsubstituted acetoacetamide with aromatic aldehydes in ethanol in the presence of piperidine gave 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides and 4-aryl-5-acetyl-2-hydroxy-2-methyl-6-oxopiperidine-3-carboxamides. Structures of the obtained compounds were proved using IR, 1H and 13C NMR spectroscopy methods. The synthesized compounds were tested for antimicrobial and analgesic activities. [ABSTRACT FROM AUTHOR]

A series of novel enamines, bis(enamines), benzisoxazoles, tetrahydroindazoles, benzophenone hydrazones were obtained via reactions of 2-acetyl-5-hydroxy-5-methylcyclohexanone and alkyl 4-hydroxy-4-methyl-2-oxocyclohexanecarboxylates with nucleophilic reagents such as aliphatic and aromatic amines, diamines, hydroxylamine, hydrazine, phenylhydrazine, benzophenone hydrazone. The structures of the compounds obtained were proved by IR and 1H NMR spectroscopy methods. [ABSTRACT FROM AUTHOR]

The reaction of benzoylacetone with aromatic aldehydes under basic catalysis conditions afforded 3-aryl-2,4-dibenzoyl-5-hydroxy-5-methylcyclohexanones. The reaction of benzoylacetone with benzalacetone led to the formation of 2-benzoyl-5-hydroxy-5-methyl-3-phenylcyclohexanone. [ABSTRACT FROM AUTHOR]

Reaction of N-arylacetoacetamides with aromatic aldehydes in the presence of piperidine in ethanol afforded N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides. The latter reacted with p-toluidine leading to the formation of dehydration products. Reactions of N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate and cyanoacetic acid hydrazide gave rise to tetrahydroindazoles. Some of the obtained compounds showed antimicrobial activity. [ABSTRACT FROM AUTHOR]

The reactions of 6-acyl-7-aryl-4,7-dihydrotetrazolo [1,5-a]pyrimidin-5-carboxylates with hydrazine hydrate were used to synthesize 8-methyl-9-aryl-and 8,9-diaryl-4,9-dihydrotetrazolo [1',5':1,2]pyrimidino[4,5-d]pyrazin-5-ones (I – XXX). Compounds I – XXX were found to have moderate antimicrobial activity. [ABSTRACT FROM AUTHOR]

Reaction of the methyl esters of aroylpyruvic acids with mixtures of 4-(2-aminoethyl)benzenesulfonamide and an aromatic aldehyde was used to synthesize 1-[2-(4-aminosulfonylphenyl)ethyl]-5-aryl-4-aroyl-3-hydroxy- 3-pyrrolin-2-ones. The structures of these compounds were verified by IR and H NMR spectroscopy and mass spectrometry. Their antibacterial activity was studied. [ABSTRACT FROM AUTHOR]

6-Aryl-3,4-dimethyl- N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides were synthesized by three-component reactions of acetoacetanilide, aromatic aldehydes, and N-methylurea. The structures of the compounds were confirmed by IR and PMR spectroscopy and mass spectrometry. The antifungal activity of the synthesized compounds was studied. [ABSTRACT FROM AUTHOR]

Reaction of methyl esters of acylpyruvic acids with substituted o-aminophenols led to 6(7)-substituted 3-acylmethylene-1,4-benzoxazin-2-ones. Reaction of substituted o-aminophenols with α-ketoglutaric acid led to 6-substituted 3-carbonyl-1,4-benzoxazin-2-ones. The structures of the synthesized compounds were confirmed by IR and NMR spectroscopy and mass spectrometry. The antibacterial activity of the compounds was studied. [ABSTRACT FROM AUTHOR]

The reaction of substituted methyl aroylpyruvates with 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride in the presence of AcOH gives 3-aroylmethylene-1,6,7,11b-tetrahydro-2H-pyrazino[2,1-a]isoquinolin-4-ones whose structures have been confirmed by IR, 1H NMR, and mass spectrometry. [ABSTRACT FROM AUTHOR]

The article discusses the study of the reactivity of substituted 3-pyrrolin-2-ones in the interaction with arylamines with hydroxylamine, semicarbazide and butylamine. It examines the structure of compounds through nuclear magnetic resonance (NMR) spectroscopy or infrared radiation (IR) and mass spectrometry. It cites the interaction of 4-acetyl-1-(4-hydroxyphenyl)-5-phenyl- 3-hydroxy-3-pyrrolin-2-one with hydroxylamine.

Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl- N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. IR, H NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compounds obtained. Antimicrobial activity of these compounds was investigated. [ABSTRACT FROM AUTHOR]

A series of N,6-diaryl-2-thioxo-4-methyl-1,2,3,6-tetrahydropyrimidine-5-carboxamides were synthesized by a three-component reaction of acetoacetanilide (2-methylacetoacetanilide; 2,4-dimethylacetoacetanilide; 4-chloroacetoacetanilide) with a mixture of aromatic aldehyde and thiourea. All structures are confirmed by IR, PMR, and C NMR spectroscopy and mass spectrometry. All synthesized substances are characterized with respect to antimicrobial activity. [ABSTRACT FROM AUTHOR]

The article discusses the study which examines the reaction of methyl 4-(2-thienyl)-and 4-(2-furyl)-2,4-dioxobutanoates with mixtures of aromatic aldehydes and 5-amino-1-methyltetrazole,3,5-diamino-1,2,4-tetrazole, and ethyl 5-amino-1H-imidazole-4-carboxylate. The IR spectra were recorded on a UR-20 spectrometer from samples dispersed in mineral oil. The 1H NMR spectra were measured on a Bruker DRX-500 instrument at 500.13 MHz in DMSO-d 6.

The reaction in a mixture of 1,3-cyclohexanedione (dimedone), arylaldehyde, and ammonium acetate at 160°C during 10-15 min in the absence of solvent leads to the formation of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2 H,5 H)-diones. The structure of the products has been confirmed by IR and H NMR spectroscopy data. Antimicrobial activity of the obtained compounds has been studied. [ABSTRACT FROM AUTHOR]

The interaction of methyl esters of aroylpyruvic acids with 2-aminophenol was used to form 2-aroylmethylene-6-hydroxy-2,3-dihydroindol-3-ones. The structures of these compounds were verified by IR and H NMR spectroscopy; the antimicrobial activity of the compounds synthesized here was studied. [ABSTRACT FROM AUTHOR]

A series of 4-acyl-3-hydroxyspiro-[2,5-dihydrofuran-5,2′-indan]-2,l′,3′-triones (I–XV) have been synthesized via the interaction of methyl esters of acylpyruvic acids with ninhydrin for 3–4 h in water at a temperature of 50–60°C in the presence of dioxane. The target products were obtained with yields within 39–95%. All compounds have been characterized by IR and 1H NMR spectra, and some of the products were tested for their antimicrobial activity. [ABSTRACT FROM AUTHOR]