47 results on '"Takashi, Kusunoki"'
Search Results
2. Fall birth is associated with prolonged elimination in Japanese children with hen's egg allergy: A population-based study
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Takeshi Morimoto, Takashi Kusunoki, Yuie Motoyama, and Jiro Takeuchi
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Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,MEDLINE ,Japan ,Odds Ratio ,medicine ,Humans ,Immunology and Allergy ,Child ,Egg Hypersensitivity ,business.industry ,Parturition ,General Medicine ,RC581-607 ,medicine.disease ,Population based study ,Child, Preschool ,Population Surveillance ,Egg allergy ,Female ,Seasons ,Immunologic diseases. Allergy ,business ,Food Hypersensitivity - Published
- 2021
3. Risk Factors for Cerebral Infarction in Duchenne Muscular Dystrophy: Review With our 2 Cases
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Minoru Shibata, Takashi Kusunoki, Fumihito Nozaki, Tomohiro Kumada, and Tatsuya Fujii
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Adult ,Cardiomyopathy, Dilated ,Male ,medicine.medical_specialty ,Adolescent ,Health Status ,Duchenne muscular dystrophy ,Population ,Infarction ,Risk Assessment ,Ventricular Function, Left ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Mobility Limitation ,Risk factor ,Child ,education ,education.field_of_study ,Ejection fraction ,business.industry ,Cerebral infarction ,Rehabilitation ,Age Factors ,Stroke Volume ,Dilated cardiomyopathy ,Atrial fibrillation ,Cerebral Infarction ,Prognosis ,medicine.disease ,Muscular Dystrophy, Duchenne ,Diffusion Magnetic Resonance Imaging ,Child, Preschool ,cardiovascular system ,Cardiology ,Surgery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Background: Although the incidence of cerebral infarction is higher in Duchenne muscular dystrophy (.75 per 100) than in the general population (7.5-11.4 per 100 000), only 18 cases have been reported, and prevention and management guidelines for infarction in this disorder remain lacking. Patients and Methods: We encountered 2 cases of Duchenne muscular dystrophy with cerebral infarction. To clarify risk factors for such infarction in Duchenne muscular dystrophy, we reviewed 20 cases, including our 2 patients. Results: Age at onset of infarction ranged from 4 to 31 years (n = 19). Most patients were 16-21 years old (14 of 19; 73.7%). Eighteen patients (90%) had dilated cardiomyopathy (DCM), showing a higher frequency than in the age-matched general Duchenne muscular dystrophy population. Left ventricular ejection fraction (LVEF) ranged from 10.2% to 42% (median, 20%; n = 9). Detectable cardiac thrombus and atrial fibrillation were rare (2 of 17; 11.8%, and 1 of 17; 5.9%, respectively). Conclusions: Presence of DCM with low LVEF seems to be the strongest risk factor for cerebral infarction in Duchenne muscular dystrophy.
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- 2019
4. Slow stepwise resolution protocol for children allergic to hen’s egg, milk or wheat
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Jiro Takeuchi, Takashi Kusunoki, Fumihito Nozaki, Kenji Inoue, and Kumiko Mukaida
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,030228 respiratory system ,business.industry ,Family medicine ,medicine ,030212 general & internal medicine ,General Medicine ,business - Published
- 2018
5. Asthma death in Japanese children committee report in 2017
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Takanari Imai, Mizuho Nagao, Yukihiro Ohya, Hironobu Fukuda, Masaki Futamura, Takehiko Matsui, Toshiko Itazawa, Hiroshi Odajima, Akira Akasawa, Takashi Kusunoki, Sankei Nishima, Koichi Arakawa, and Koichi Yoshida
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medicine.medical_specialty ,business.industry ,Committee report ,Family medicine ,medicine ,medicine.disease ,business ,Asthma - Published
- 2018
6. Left ventricular noncompaction cardiomyopathy in a patient with trisomy 13: A report and review of the literature
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Anri Hayashi, Minoru Shibata, Tatsuya Fujii, Fumihito Nozaki, Takashi Kusunoki, Ikuko Hiejima, and Tomohiro Kumada
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medicine.medical_specialty ,Heart disease ,Heart malformation ,business.industry ,030204 cardiovascular system & hematology ,medicine.disease ,Left ventricular noncompaction cardiomyopathy ,Sudden death ,Asymptomatic ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Heart failure ,Genetics ,Cardiology ,medicine ,medicine.symptom ,Trisomy ,business ,Stroke ,030217 neurology & neurosurgery ,Genetics (clinical) - Abstract
Left ventricular noncompaction cardiomyopathy (LVNC) is characterized by prominent trabecular meshwork, and it is thought to result from arrest of the normal compaction process during embryogenesis. Patients with LVNC may be asymptomatic or have symptoms ranging from heart failure to stroke, life-threatening arrhythmias, or sudden death. The frequency of LVNC in children has increased with longer clinical courses. About 80% of patients with trisomy 13 have a congenital cardiac abnormality, but a clinical description of LVNC with trisomy 13 is lacking because of its poor prognosis and lack of awareness about LVNC. We described a patient with trisomy 13 who was diagnosed with LVNC-dilated phenotype and died suddenly, as well as two additional patients with LVNC. All three patients had chronic heart failure without congenital heart disease and were treated with diuretics. To manage trisomy 13 with or without congenital heart disease, cardiac disease such as LVNC may present at any ages, and therefore cardiac evaluation should be considered as a part of their appropriate management.
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- 2017
7. Correction to: Helicobacter cinaedi-Associated Refractory Cellulitis in Patients with X-Linked Agammaglobulinemia
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Kohsuke Imai, Takashi Kusunoki, Tomohiro Morio, Hirokazu Kanegane, Kento Inoue, Takahiro Yasumi, and Saeko Sasaki
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medicine.medical_specialty ,biology ,business.industry ,Immunology ,MEDLINE ,X-linked agammaglobulinemia ,medicine.disease ,biology.organism_classification ,Dermatology ,Helicobacter cinaedi ,Medical microbiology ,Refractory ,Cellulitis ,Immunology and Allergy ,Medicine ,In patient ,business - Published
- 2021
8. ALDH18A1-related cutis laxa syndrome with cyclic vomiting
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Yuto Yamamoto, Tatsuhiko Tsunoda, Nobuhiko Okamoto, Tatsuya Fujii, Takashi Kusunoki, Kenjiro Kosaki, Tomohiro Kumada, Minoru Shibata, Fumihito Nozaki, and Fuyuki Miya
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Male ,0301 basic medicine ,medicine.medical_specialty ,Microcephaly ,Foot Deformities, Congenital ,Arginine ,Vomiting ,030105 genetics & heredity ,Short stature ,Cutis Laxa ,Diagnosis, Differential ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Developmental Neuroscience ,Internal medicine ,medicine ,Citrulline ,Humans ,Child ,business.industry ,Brain ,Syndrome ,General Medicine ,Aldehyde Dehydrogenase ,Ornithine ,medicine.disease ,Hypotonia ,Endocrinology ,chemistry ,Face ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,medicine.symptom ,business ,Hand Deformities, Congenital ,Blood Chemical Analysis ,030217 neurology & neurosurgery ,Cutis laxa - Abstract
Cutis laxa (CL) syndromes are connective tissue disorders characterized by redundant, sagging, inelastic and wrinkled skin, with organ involvement. Here, we describe a patient with ALDH18A1-related CL who developed cyclic vomiting. The patient was a 12-year-old boy who presented with poor postnatal growth, hypotonia, short stature, joint hyperlaxity, microcephaly, strabismus, bilateral cataracts, facial dysmorphism and severe mental retardation. Bone radiographs showed osteopenia and osteoporosis, and magnetic resonance angiography showed marked kinking and tortuosity of the brain vessels. These findings were clinically compatible with ALDH18A1-related CL. Molecular analysis revealed a de novo heterozygous mutation (p.R138Q) in ALDH18A1. No mutations were found in PYCR1 gene. The patient developed cyclic vomiting with decreased blood levels of ornithine, citrulline, arginine and proline without hyperammonemia and other hypoaminoacidemias were also found. ALDH18A1 encodes Δ(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline. Cyclic vomiting has never been reported in other ALDH18A1-related CL patients. This is the first case report of ALDH18A1-related CL with cyclic vomiting associated with amino acid abnormalities.
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- 2016
9. Secondary biotin, carnitine and selenium deficiency caused by long-term use of casein hydrolyzed formula
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Fumihito Nozaki and Takashi Kusunoki
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medicine.medical_specialty ,business.industry ,Family medicine ,Medicine ,business - Published
- 2016
10. Management of food-induced anaphylaxis and ownership of adrenaline autoinjectors among children in nurseries
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Kazuo Nonomura, Akio Kihara, Takashi Kusunoki, Naruo Saito, Seiro Narumiya, Tsuyoshi Ishigami, Yoshitaka Iwai, Tsuneo Hirota, and Yasuyuki Nomura
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,030228 respiratory system ,business.industry ,Food induced anaphylaxis ,Anesthesia ,Emergency medicine ,medicine ,030212 general & internal medicine ,business - Published
- 2016
11. Severe acute abdomen caused by symptomatic Meckel's diverticulum in three children with trisomy 18
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Anri Hayashi, Takashi Kusunoki, Oki Furukawa, Minoru Shibata, Fumihito Nozaki, Ikuko Hiejima, Tatsuya Fujii, and Tomohiro Kumada
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Pediatrics ,medicine.medical_specialty ,Gastrointestinal bleeding ,Trisomy ,Intestinal Volvulus ,Intussusception (medical disorder) ,Genetics ,medicine ,Humans ,Genetics (clinical) ,Abdomen, Acute ,Meckel's diverticulum ,Gastrointestinal tract ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Meckel Diverticulum ,Acute abdomen ,Child, Preschool ,Female ,medicine.symptom ,Chromosomes, Human, Pair 18 ,Gastrointestinal Hemorrhage ,business ,Intussusception ,Trisomy 18 Syndrome ,Diverticulum - Abstract
Meckel's diverticulum (MD) is the most prevalent congenital anomaly of the gastrointestinal tract and often presents a diagnostic challenge. Patients with trisomy 18 frequently have MD, but the poor prognosis and lack of consensus regarding management for neonates has meant that precise information on the clinical manifestations in infants and children with MD is lacking. We describe the cases of three children with trisomy 18 who developed symptomatic MD. Intussusception was diagnosed in Patient 1, intestinal volvulus in Patient 2, and gastrointestinal bleeding in Patient 3. All three patients underwent surgical treatment and only the Patient 1 died due to pulmonary hypertensive crisis. The other two patients experienced no further episodes of abdominal symptoms. In patients with trisomy 18, although consideration of postoperative complications and prognosis after surgical treatment is necessary, symptomatic MD should carry a high index of suspicion in patients presenting with acute abdomen.
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- 2015
12. Fruit intake reduces the onset of respiratory allergic symptoms in schoolchildren
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Mio Sakuma, Takeshi Morimoto, Takashi Kusunoki, Takahiro Yasumi, Ryuta Nishikomori, Akane Higashi, Jiro Takeuchi, and Toshio Heike
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Ragweed ,Male ,Pediatrics ,medicine.medical_specialty ,Immunology ,Diet Surveys ,Food group ,Allergic sensitization ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Internal medicine ,Epidemiology ,medicine ,Odds Ratio ,Prevalence ,Respiratory Hypersensitivity ,Immunology and Allergy ,Humans ,030212 general & internal medicine ,Longitudinal Studies ,Prospective Studies ,Prospective cohort study ,Child ,Asthma ,biology ,business.industry ,Odds ratio ,Protective Factors ,biology.organism_classification ,medicine.disease ,Confidence interval ,Diet ,Logistic Models ,030228 respiratory system ,Fruit ,Pediatrics, Perinatology and Child Health ,Female ,business - Abstract
Background Previous studies have shown that dietary pattern is associated with allergy prevention. Methods We conducted a prospective cohort study on all primary schools in Omihachiman City, Shiga Prefecture, Japan. Questionnaires regarding allergic symptoms and diet were distributed to the parents of all 759 7-year-old schoolchildren for 4 consecutive years, from 2011–2014. Specific immunoglobulin E to inhalant allergens were measured at 10 years of age. Participants were then categorized as low, medium, or high intake during the study period for four food groups (fruits, vegetables, fish and beans). Logistic regression analysis was performed to estimate odds ratios and 95% confidence intervals. Results A total of 520 children (68.5%) whose parents responded to the questionnaires all 4 years were included in the analysis. The prevalence of asthma, rhinitis, and any allergic symptoms at age 10 was significantly decreased with increases in fruit intake. In addition, the onset of any allergic symptoms during the study period was significantly decreased with increases in fruit intake (33.3%, 28.3%, and 14.3% in children with low, medium, and high fruit intake, respectively; P for trend = 0.01). The sensitization rate to ragweed at age 10 was significantly decreased with increases in fruit intake (P for trend = 0.046). No significant effect was observed for the other three food groups, except for the association between fish intake and new onset asthma symptoms. Conclusions These findings suggest that higher intake of fruit can help prevent respiratory allergic symptoms in schoolchildren. This article is protected by copyright. All rights reserved.
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- 2017
13. Organizing pneumonia as an extraintestinal manifestation of Crohn's disease in a child
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Takashi Kusunoki, Tatsuya Fujii, and Kenji Inoue
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Antibiotics ,Disease ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,Internal medicine ,Biopsy ,medicine ,Humans ,Crohn's disease ,Gastrointestinal tract ,medicine.diagnostic_test ,business.industry ,Interstitial lung disease ,Pneumonia ,medicine.disease ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Immunology ,Etiology ,030211 gastroenterology & hepatology ,business ,Tomography, X-Ray Computed - Abstract
Crohn's disease (CD) is a chronic inflammatory disorder with an unknown etiology that commonly involves the gastrointestinal tract, and bronchopulmonary manifestations only occur in 0.4% of cases. There have not been any reports about pulmonary involvement in pediatric CD patients. We experienced a 14-year-old boy with Crohn's disease diagnosed with organizing pneumonia by chest CT-guided biopsy examination. His pneumonia was intractable despite the administration of multiple antibiotics, and steroid therapy was very effective. In pediatric patients with CD whose lung disease does not respond to antibiotics, OP should be considered as a possible diagnosis.
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- 2017
14. Slow stepwise resolution protocol for children allergic to egg, milk, or wheat: comparison between schoolchildren and preschool children
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Kenji Inoue, Takashi Kusunoki, Kumiko Mukaida, Fumihito Nozaki, and Jiro Takeuchi
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Protocol (science) ,Pediatrics ,medicine.medical_specialty ,business.industry ,Immunology ,Resolution (electron density) ,Immunology and Allergy ,Medicine ,business - Published
- 2019
15. Effect of eczema on the association between season of birth and food allergy in Japanese children
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Takashi Kusunoki, Kumiko Mukaida, Toshio Heike, Takeshi Morimoto, Takahiro Yasumi, Ryuta Nishikomori, and Mio Sakuma
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Pediatrics ,medicine.medical_specialty ,Multivariate analysis ,Season of birth ,business.industry ,Confounding ,Retrospective cohort study ,Economic shortage ,Logistic regression ,medicine.disease ,Food allergy ,Pediatrics, Perinatology and Child Health ,Vitamin D and neurology ,Medicine ,business - Abstract
Background Food allergy (FA) in childhood has been shown to be more prevalent in those born in autumn and winter. The mechanisms of this season-of-birth effect remain unclear, although shortage of vitamin D during infancy has been considered one possible mechanism. The purpose of this study was to investigate the effect of eczema on the season-of-birth effect on FA in infancy. Methods A questionnaire survey on the prevalence of allergic diseases was completed by the parents of 14 669 Japanese schoolchildren, aged 7–15 years, in Kyoto City, Japan. Logistic regression models were constructed to compare the prevalence of FA in infancy according to season of birth. Results Those born in autumn and winter had a significantly higher prevalence of FA in infancy compared to those born in spring and summer in a multivariate model (4.8% vs 3.6%, P = 0.001). The difference, however, was no longer significant when eczema before 6 months was included as either an additional or only confounding factor. The difference among those with and without eczema before 6 months was further analyzed, and it was found that, in both groups, there was no difference between those born in spring and summer and those born in autumn and winter. Conclusions The season-of-birth effect on FA in infancy was significantly affected by the existence of eczema before 6 months in Japanese children. Eczema before 6 months may be the factor directly related to the season-of-birth effect on FA in infancy.
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- 2012
16. Association of age and family history with supplement use in pediatric patients with allergy
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Shoko Hamada, Takashi Kusunoki, Ayako Nagai, Takahiro Kiyomasu, Masaru Kubota, Yutaka Suehiro, Yoshihiro Wakazono, Shiro Seto, and Nagisa Mori
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Male ,Parents ,Pediatrics ,medicine.medical_specialty ,Allergy ,Adolescent ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,Chlorella ,Aquatic organisms ,Endocrinology ,Japan ,Surveys and Questionnaires ,Supplement use ,Epidemiology ,Hypersensitivity ,Humans ,Medicine ,Family ,Micronutrients ,Family history ,Child ,Dosage Forms ,Biological Products ,Minerals ,Univariate analysis ,Nutrition and Dietetics ,business.industry ,Probiotics ,Nutritional content ,Age Factors ,Infant ,Vitamins ,medicine.disease ,Cross-Sectional Studies ,Case-Control Studies ,Child, Preschool ,Dietary Supplements ,Female ,Nutrition Therapy ,business - Abstract
This study was conducted to determine the frequency and characteristics of supplement use in pediatric patients with allergic disorders in Japan. A total of 229 patients with various allergic disorders aged between 0 and 15 years were enrolled. Supplements were defined as preparations that provided nutritional content in the form of a tablet, capsule, powder, liquid, or jelly. The parents of each subject were asked to complete a questionnaire on their child's use of supplements over the previous year. Demographic information, parents' perceived view of the child's health status over the previous month, and family history of both allergic disorders, and supplement use were collected. Four hundred eight age- and sex-matched healthy children served as the controls. Twenty-nine (12.7%) patients had used supplements. This frequency was not significantly different from that in the control group (15.0%). The types of supplements most commonly used were vitamins, followed by minerals, probiotics, and chlorella. Univariate analysis revealed that older age and a positive family history of supplement use were associated with patients' supplement use. The types of allergic disorders, health status from the point of view of the parents, and a family history of allergic disorders did not show any significant association. To our knowledge, this is the first cross-sectional study to demonstrate the frequency and the factors affecting supplement use in pediatric patients with allergic disorders.
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- 2012
17. Birth order effect on childhood food allergy
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Kumiko Mukaida, Takahiro Yasumi, Ryuta Nishikomori, Toshio Heike, Takeshi Morimoto, Takashi Kusunoki, and Mio Sakuma
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Allergy ,Pediatrics ,medicine.medical_specialty ,business.industry ,Immunology ,Atopic dermatitis ,medicine.disease ,Allergic conjunctivitis ,Birth order ,Food allergy ,Wheeze ,Pediatrics, Perinatology and Child Health ,Epidemiology ,medicine ,Immunology and Allergy ,medicine.symptom ,business ,Asthma - Abstract
To cite this article: Kusunoki T, Mukaida K, Morimoto T, Sakuma M, Yasumi T, Nishikomori R, Heike T. Birth order effect on childhood food allergy. Pediatric Allergy Immunology 2012: 23: 250–254. Abstract Higher birth order is associated with a smaller risk of allergy (birth order effect). The purpose of this study was to compare the significance of the birth order effect on the prevalence of specific allergic diseases [bronchial asthma (BA), atopic dermatitis (AD), allergic rhinitis (AR), allergic conjunctivitis (AC), and food allergy (FA)] among schoolchildren. A questionnaire survey dealing with the prevalence of allergic diseases was administered to the parents of 14,669 schoolchildren aged 7–15 yr. Based on the data, the prevalence of each allergic disease was compared according to birth order (1st, 2nd, and 3rd or later). Multiple regression analysis was performed to test the significance of the differences. There was no significant difference in the prevalence of BA or AD according to birth order. The prevalence of AR, AC, and FA decreased significantly as birth order increased. The prevalence of FA among those with 1st, 2nd, and 3rd or later birth order was 4.0%, 3.4%, and 2.6%, respectively (p = 0.01). With respect to symptoms in infancy, the prevalence of wheeze increased significantly and that of FA and eczema in infancy decreased significantly as birth order increased. The present data show a significant birth order effect on FA. The effect was also observed for the prevalence of FA and eczema in infancy. These data support the concept of early, non-allergen-specific programming of IgE-mediated immunity.
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- 2012
18. Sports activities enhance the prevalence of rhinitis symptoms in schoolchildren
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Takashi Kusunoki, Takahiro Yasumi, Ryuta Nishikomori, Mio Sakuma, Takeshi Morimoto, Kumiko Mukaida, Toshio Heike, and Jiro Takeuchi
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Intoxicative inhalant ,Male ,medicine.medical_specialty ,Pediatrics ,Allergy ,Immunology ,Population ,Prevalence ,Immunoglobulin E ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Environmental health ,Epidemiology ,Immunology and Allergy ,Medicine ,Humans ,030212 general & internal medicine ,Sports activity ,education ,Child ,Asthma ,education.field_of_study ,biology ,business.industry ,medicine.disease ,Rhinitis, Allergic ,030228 respiratory system ,Pediatrics, Perinatology and Child Health ,biology.protein ,Female ,business ,human activities ,Sports - Abstract
Background To evaluate the association between sports activities and allergic symptoms, especially rhinitis, among schoolchildren. Methods This longitudinal survey of schoolchildren collected data from questionnaires regarding allergic symptoms based on the International Study of Asthma and Allergies in Childhood (ISAAC) program and sports participation that were distributed to the parents of children at all 12 public primary schools in Ohmi-Hachiman City, Shiga Prefecture, Japan. Data were collected annually from 2011 until 2014, when the children reached 10 years of age. Blood samples were obtained in 2014, and the levels of immunoglobulin (Ig)E specific to four inhalant allergens were measured. Results Data from 558 children were analyzed. At 10 years of age, prevalence of asthma and eczema did not differ significantly, while rhinitis was significantly higher (p = 0.009) among children who participated in sports. Prevalence of rhinitis increased as the frequency or duration of sports participation increased (p < 0.01). The prevalence of new-onset rhinitis increased significantly among 10-year-olds with increasing duration of participation in sports (p = 0.03). Among those who participated in continuous sports activities, the prevalence of rhinitis was significantly higher with prolonged eczema (p = 0.006). Sports activities did not increase sensitization to inhalant allergens. Conclusion Sports activities enhance the prevalence of rhinitis in schoolchildren. Prolonged eczema, together with sports participation, further promotes the symptoms. The mechanisms of these novel findings warrant further investigation.
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- 2015
19. Allergic status of schoolchildren with food allergy to eggs, milk or wheat in infancy
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Toshio Heike, Takeshi Morimoto, Tatsutoshi Nakahata, Tatsuya Fujii, Ryuta Nishikomori, and Takashi Kusunoki
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Hypersensitivity, Immediate ,Male ,medicine.medical_specialty ,Allergy ,Adolescent ,Immunology ,Atopy ,Food allergy ,Surveys and Questionnaires ,Environmental health ,Epidemiology ,Prevalence ,medicine ,Animals ,Humans ,Immunology and Allergy ,Child ,Egg Hypersensitivity ,Triticum ,Asthma ,business.industry ,Atopic dermatitis ,Odds ratio ,Allergens ,medicine.disease ,Health Surveys ,Allergic conjunctivitis ,Milk ,Pediatrics, Perinatology and Child Health ,Female ,Milk Hypersensitivity ,business ,Food Hypersensitivity - Abstract
Although children allergic to eggs, milk or wheat in infancy tend to become tolerant by school age, the allergic status of these children at school age has not been well evaluated. To investigate the allergic status of schoolchildren who avoided eggs, milk or wheat because of an immediate-type allergic reaction at
- Published
- 2009
20. Macrophage inflammatory protein-1α (MIP-1α) enhances a receptor activator of nuclear factor κB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways
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Shozo Nishida, Takao Satou, Takashi Kusunoki, Kimiko Fujiwara, Miyuki Manno, Masanobu Tsubaki, Hiroshi Matsuoka, Chisato Kato, Mitsuhiko Ogaki, Yoshihiro Tanimori, and Tatsuki Itoh
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musculoskeletal diseases ,MAPK/ERK pathway ,medicine.medical_specialty ,Stromal cell ,Pyridines ,Morpholines ,Clinical Biochemistry ,Osteoclasts ,Bone Marrow Cells ,Mice ,Phosphatidylinositol 3-Kinases ,chemistry.chemical_compound ,Internal medicine ,Nitriles ,Butadienes ,medicine ,Animals ,LY294002 ,Enzyme Inhibitors ,Phosphorylation ,Extracellular Signal-Regulated MAP Kinases ,Molecular Biology ,Protein kinase B ,Cells, Cultured ,PI3K/AKT/mTOR pathway ,Chemokine CCL3 ,Osteoblasts ,biology ,RANK Ligand ,Imidazoles ,Cell Differentiation ,Osteoblast ,Cell Biology ,General Medicine ,Cell biology ,Oncogene Protein v-akt ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Chromones ,RANKL ,biology.protein ,Bone marrow ,Stromal Cells ,Signal Transduction - Abstract
Osteolytic lesions are rapidly progressive during the terminal stages of myeloma, and the bone pain or bone fracture that occurs at these lesions decreases the patients' quality of life to a notable degree. In relation to the etiology of this bone destruction, it has been reported recently that MIP-1alpha, produced in large amounts in myeloma patients, acts indirectly on osteoclastic precursor cells, and activates osteoclasts by way of bone-marrow stromal cells or osteoblasts, although the details of this process remain obscure. In the present study, our group investigated the mechanism by which RANKL expression is induced by MIP-1alpha and the effects of MIP-1alpha on the activation of osteoclasts. RANKL mRNA and RANKL protein expressions increased in both ST2 cells and MC3T3-E1 cells in a MIP-1alpha concentration-dependent manner. RANKL mRNA expression began to increase at 1 h after the addition of MIP-1alpha; the increase became remarkable at 2 h, and continuous expression was observed subsequently. Both ST2 and MC3T3-E1 cells showed similar levels of increased RANKL protein expression at 1, 2, and 3 days after the addition of MIP-1alpha. After the addition of MIP-1alpha, the amount of phosphorylated ERK1/2 and Akt protein expressions showed an increase, as compared to the corresponding amount in the control group. On the other hand, the amount of phosphorylated p38MAPK protein expression showed a decrease from the amount in the control group after the addition of MIP-1alpha. U0126 (a MEK1/2 inhibitor) or LY294002 (a PI3K inhibitor) was added to ST2 and MC3T3-E1 cells, and was found to inhibit RANKL mRNA and RANKL protein expression in these cells. When SB203580, a p38MAPK inhibitor, was added, RANKL mRNA and RANKL protein expression were increased in these cells. MIP-1alpha was found to promote osteoclastic differentiation of C7 cells, an osteoclastic precursor cell line, in a MIP-1alpha concentration-dependent manner. MIP-1alpha promoted differentiation into osteoclasts more extensively in C7 cells incubated together with ST2 and MC3T3-E1 cells than in C7 cells incubated alone. These results suggested that MIP-1alpha directly acts on the osteoclastic precursor cells and induces osteoclastic differentiation. This substance also indirectly induces osteoclastic differentiation through the promotion of RANKL expression in bone-marrow stromal cells and osteoblasts. The findings of this investigation suggested that activation of the MEK/ERK and the PI3K/Akt pathways and inhibition of p38MAPK pathway were involved in RANKL expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts. This finding may be useful in the development of an osteoclastic inhibitor that targets intracellular signaling factors.
- Published
- 2007
21. Relationship between physique and food avoidance in infants: a study conducted in a community setting in Japan
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Takashi Kusunoki, Kiyoko Odani, Akane Higashi, Hiroaki Asano, Yukari Nishi, Yurika Tanaka, Kiyomi Harada, Sayuri Fukuda, and Ayako Saruwatari
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Hypersensitivity, Immediate ,Male ,Pediatrics ,medicine.medical_specialty ,growth ,maternity passbook ,General Biochemistry, Genetics and Molecular Biology ,Percentile rank ,Child Development ,Japan ,Surveys and Questionnaires ,Weight growth ,Medicine ,Humans ,Longitudinal Studies ,infancy ,Retrospective Studies ,community health ,business.industry ,Body Weight ,Infant ,General Medicine ,Allergens ,Body Height ,Nutrition Assessment ,Child, Preschool ,Community health ,Community setting ,food avoidance ,Female ,business ,Body mass index ,Food Hypersensitivity ,Demography - Abstract
The relationship between food avoidance during infancy and the growth of Japanese infants in a community health setting has not been well evaluated. In order to assess the growth of infants who avoided either of the three major allergen foods in Japan, eggs, milk or wheat, we employed the results of 4 physical checkups recorded in maternity passbooks and administrated a questionnaire on allergic diseases, height and weight at birth to the guardians of 1,132 infants at the age of 3.5 years. Data was obtained from 890 subjects (78.6%) and 662 subjects (58.5%) who met the inclusion criteria were analyzed. The height, weight and body mass index percentile scores of each subject were calculated. Subjects who avoided either of the three foods at 3.5 years had lower weight percentile scores at 1.5 years, lower height and weight percentile scores at 3.5 years, and lower weight growth rates, compared with the subjects who did not avoid any of the three foods at 3.5 years (P=0.02, 0.03, 0.03, 0.01). The results suggested that there was a negative relationship between physique and food avoidance in infants, and that physical and nutritional assessments are important for food avoiders.
- Published
- 2015
22. Somatic mosaicism ofCIAS1 in a patient with chronic infantile neurologic, cutaneous, articular syndrome
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Ryuta Nishikomori, Akihiro Fujisawa, Tatsutoshi Nakahata, Takakazu Yoshioka, Ikuo Okafuji, Naotomo Kambe, Momoko Yoshimoto, Takashi Kusunoki, Toshio Heike, Mami Nakata-Hizume, Katsuyuki Ohmori, Yoshiki Miyachi, and Megumu K. Saito
- Subjects
Mutation ,Pathology ,medicine.medical_specialty ,business.industry ,Point mutation ,Immunology ,Heterologous ,medicine.disease_cause ,medicine.disease ,Peripheral blood mononuclear cell ,Exon ,Rheumatology ,Familial Cold Autoinflammatory Syndrome ,Polymorphism (computer science) ,Immunology and Allergy ,Medicine ,Pharmacology (medical) ,business ,Meningitis - Abstract
Chronic infantile neurologic, cutaneous, articular syndrome (CINCA syndrome) is a severe inflammatory disease that was recently found to be associated with mutations in CIAS1. However, CIAS1 mutations have been detected in only half of CINCA syndrome patients, and it remains unclear which genes are responsible for the syndrome in the remaining patients. We describe here a patient with CINCA syndrome who exhibited CIAS1 somatic mosaicism. We genetically analyzed the CIAS1 gene in various blood cells and the buccal mucosa of the patient. The production of interleukin-1β (IL-1β) by peripheral blood mononuclear cells (PBMCs) was measured by enzyme-linked immunosorbent assay, and the ability of the mutant CIAS1 gene to enhance ASC-dependent NF-κB activation was assessed to confirm that the mutations of CIAS1 found were responsible for the patient's clinical manifestations of the CINCA syndrome. The patient had 1 heterologous single-nucleotide polymorphism, 587G>A (S196N), and 1 heterologous mutation, 1709A>G (Y570C), in exon 3 of CIAS1. The latter mutation was found to occur as somatic mosaicism. The patient's PBMCs produced a large amount of IL-1β in the absence of stimulation, unlike those from controls or from his mother, who also bore the S196N polymorphism. In addition, the Y570C mutation (with or without the S196N polymorphism) increased the ability of CIAS1 to induce ASC-dependent NF-κB activation, unlike the wild-type gene or the gene bearing the S196N polymorphism alone. The findings in this patient indicate that somatic mosaicism is one reason CIAS1 mutations have not been detected in some patients with CINCA syndrome.
- Published
- 2005
23. Fever of unknown origin as the initial manifestation of valproate-induced Fanconi syndrome
- Author
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Kei Murayama, Akira Ohtake, Tomohiro Kumada, Fumihito Nozaki, Takashi Kusunoki, and Tatsuya Fujii
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Adolescent ,Urinary system ,Cytochrome-c Oxidase Deficiency ,Gastroenterology ,Tachypnea ,Asymptomatic ,Fever of Unknown Origin ,Developmental Neuroscience ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Fever of unknown origin ,Hypouricemia ,Enzyme Inhibitors ,business.industry ,Valproic Acid ,nutritional and metabolic diseases ,Fanconi syndrome ,medicine.disease ,Fanconi Syndrome ,Hypokalemia ,Endocrinology ,Neurology ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,medicine.symptom ,business ,Hypophosphatemia - Abstract
Background Valproate-induced Fanconi syndrome is a rare adverse effect of valproate. Severely disabled patients who require tube feeding are reported to be susceptible to valproate-induced Fanconi syndrome. Although most patients with valproate-induced Fanconi syndrome are asymptomatic and detected incidentally with findings such as hypophosphatemia, hypouricemia, increased urinary β2-microglobulin, and generalized hyperaminoaciduria, clinical symptoms such as bone fracture, fever, tachypnea, and edema have been reported. Patient description This 15-year-old, severely disabled, tube-fed, male patient with cytochrome oxidase deficiency had taken valproate for 3 years when he developed fever for 3 weeks. Hypophosphatemia, hypouricemia, hypokalemia, increased urinary β2-microglobulin, and generalized hyperaminoaciduria, as well as hypocarnitinemia, were found, indicating that he had Fanconi syndrome. Valproate was the most likely cause of Fanconi syndrome in this patient. After discontinuation of valproate, the fever resolved immediately, and the laboratory findings normalized. Conclusion Valproate-induced Fanconi syndrome should be considered when individuals taking valproate develop fever of unknown origin.
- Published
- 2014
24. Nasal mupirocin treatment of pharynx-colonized methicillin resistant Staphylococcus aureus: Preliminary study with 10 carrier infants
- Author
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Tadashi Hayashidera, Sachiko Katsura, Takahiro Hayakawa, Takashi Kusunoki, and Kozo Yoneda
- Subjects
Male ,Staphylococcus aureus ,medicine.medical_specialty ,Mupirocin ,macromolecular substances ,Nose ,medicine.disease_cause ,chemistry.chemical_compound ,stomatognathic system ,Internal medicine ,otorhinolaryngologic diseases ,medicine ,Humans ,Administration, Intranasal ,Cross Infection ,Transmission (medicine) ,business.industry ,Pharynx ,Infant, Newborn ,Pharyngeal Diseases ,Staphylococcal Infections ,biochemical phenomena, metabolism, and nutrition ,Methicillin-resistant Staphylococcus aureus ,Surgery ,medicine.anatomical_structure ,chemistry ,Carrier State ,Pediatrics, Perinatology and Child Health ,Female ,Methicillin Resistance ,business - Abstract
Background: Nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection in infants has become a serious concern and a new means of preventing the transmission of MRSA in the community needs to be considered. Methods: We performed nasal mupirocin treatment on 10 infants who were MRSA-positive either in the nose or the pharynx and evaluated the effect of mupirocin on the eradication of MRSA. Results: Eradication of MRSA from the nose was successful in two cases and eradication from the pharynx in six (66.6%) of nine cases. The number of treatments required to achieve eradication varied; within three courses for nose carriers and from one to seven courses for pharynx carriers. Eradication was unsuccessful even after five to seven treatments in three pharynx-limited carriers. Conclusions: These data suggest that the effect of nasal mupirocin treatment on pharynx-colonized MRSA is limited and that repetitive treatment is necessary in some cases. However, in view of the possibility of preferential pharyngeal colonization of Staphylococcus aureus in infancy, nasal mupirocin treatment deserves further evaluation for eradication not only of nose- but also of pharynx-colonized MRSA.
- Published
- 2000
25. Month of birth and prevalence of atopic dermatitis in schoolchildren: Dry skin in early infancy as a possible etiologic factor
- Author
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Susumu Hosoi, Takashi Kusunoki, Kouichi Asai, Masashi Harazaki, and Seigo Korematsu
- Subjects
Aging ,medicine.medical_specialty ,Pediatrics ,Allergy ,Adolescent ,Immunology ,Population ,Skin Diseases ,Dermatitis, Atopic ,Atopy ,Epidemiology ,Prevalence ,medicine ,Humans ,Immunology and Allergy ,Risk factor ,Child ,education ,School Health Services ,education.field_of_study ,business.industry ,Birth Month ,Infant ,Odds ratio ,Atopic dermatitis ,medicine.disease ,Seasons ,business - Abstract
Month of birth has been shown to affect later development of allergic diseases.We sought to evaluate the relationship between month of birth and the prevalence of atopic dermatitis (AD) in a large-scale general population of schoolchildren and to elucidate the possible mechanism for this relationship.Questionnaire data on the prevalence of allergic diseases were obtained for 33,725 schoolchildren aged 7 to 15 years. In a separate study the water-holding capacity of "uninvolved" skin was compared for children with and without AD.We found striking differences in the prevalence of AD according to the month of birth (chi2 = 34.9, P.0001). Overall, those born in autumn showed the highest (7.5%), and those born in spring showed the lowest (5.5%), prevalence of AD. There was little or no such tendency for the prevalence of bronchial asthma (chi2 = 17.2, P =.103) and allergic rhinitis (chi2 = 24, P =.01). We found no statistical variation across birth month in the ratio of AD with no other allergic disease/total AD, indicating that this deviation was observed whatever the allergic predisposition of the subjects. In a separate study a significantly lower water-holding capacity of uninvolved skin was observed in children with AD even from early infancy.These findings lead us to speculate that the climate in early infancy affects the skin condition and that those born in autumn have dry skin in early infancy, which may ultimately result in a higher prevalence of AD among young schoolchildren. This might be at least one of the "nonallergic" etiologic factors of this complex disease.
- Published
- 1999
26. SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis
- Author
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Takashi Kusunoki, Tatsutoshi Nakahata, Toshio Heike, Takakazu Yoshioka, Ryuta Nishikomori, Megumu K. Saito, Manabu Sugai, Akira Shimizu, and Ikuo Okafuji
- Subjects
medicine.medical_specialty ,Disease severity ,business.industry ,Food allergy ,Immunology ,medicine ,Immunology and Allergy ,Atopic dermatitis ,medicine.disease ,business ,Dermatology - Published
- 2005
27. Grisel syndrome as a complication of Kawasaki disease: a case report and review of the literature
- Author
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Fumihito Nozaki, Yoshihide Tomoda, Tomoko Miyajima, Takashi Kusunoki, Tohru Futami, Tatsuya Fujii, Anri Hayashi, Tomohiro Kumada, and Ikuko Hiejima
- Subjects
Pediatrics ,medicine.medical_specialty ,Joint Dislocations ,Mucocutaneous Lymph Node Syndrome ,Cervical lymphadenopathy ,hemic and lymphatic diseases ,medicine ,Paralysis ,Humans ,cardiovascular diseases ,Joint dislocation ,skin and connective tissue diseases ,business.industry ,Atlanto-axial joint ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Atlanto-Axial Joint ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Kawasaki disease ,Female ,medicine.symptom ,business ,Vasculitis ,Complication - Abstract
Grisel syndrome is a non-traumatic atlantoaxial subluxation and a rare complication of any inflammatory condition of the upper neck and otolaryngological procedures. Delayed diagnosis causes neurological impairment, ranging from radiculopathy to paralysis and death. Kawasaki disease is a very frequent and important acute febrile vasculitis of childhood that is seen worldwide, and upper neck involvement (cervical lymphadenopathy) is one of the common symptoms of Kawasaki disease. A case of Grisel syndrome that occurred as a complication of Kawasaki disease is reported. This is the first case report, in English, of Grisel syndrome as a complication of Kawasaki disease. Conclusion: Pediatricians should be aware of Grisel syndrome as a possible complication of Kawasaki disease.
- Published
- 2012
28. Manganese superoxide dismutase content and localization in human thyroid tumours
- Author
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Fumiharu Akai, Takashi Kusunoki, Shozo Nishida, Naoyuki Taniguchi, Shigeo Hashimoto, Hosokawa K, Keiichiro Suzuki, Iwasaki H, and Tamura Tt
- Subjects
Adenoma ,endocrine system ,medicine.medical_specialty ,Pathology ,endocrine system diseases ,Enzyme-Linked Immunosorbent Assay ,Pathology and Forensic Medicine ,Thyroid carcinoma ,Internal medicine ,Carcinoma ,Humans ,Medicine ,Thyroid Neoplasms ,Anaplastic carcinoma ,Chronic thyroiditis ,Manganese ,Superoxide Dismutase ,business.industry ,Thyroid ,medicine.disease ,Immunohistochemistry ,Staining ,medicine.anatomical_structure ,Endocrinology ,business - Abstract
Manganese-containing superoxide dismutase (Mn-SOD) content and its immunohistochemical localization in human thyroid tumours and some other thyroid diseases were examined and compared with adjacent normal thyroid tissue. Enzyme-linked immunosorbent assay (ELISA) was used in this study for the measurement of Mn-SOD. The content of Mn-SOD tended to increase in diffuse hyperplasia, adenomatous goitre, and follicular adenoma. In papillary carcinoma, it was significantly higher than in adjacent normal thyroid tissue. Follicular carcinoma also revealed a markedly high Mn-SOD content. In the immunohistochemical study, adjacent normal thyroid tissue showed granular positive staining of Mn-SOD in the cytoplasm. An increase of Mn-SOD was observed in the papillary proliferative lesion of diffuse hyperplasia and in the follicles adjacent to lymphoid tissue in chronic thyroiditis with hypothyroidism. Strong positive staining of Mn-SOD was observed in papillary and follicular carcinomas, whereas in anaplastic carcinoma staining was markedly less intense. These results indicate that the Mn-SOD content varies according to the degree of differentiation of thyroid carcinomas.
- Published
- 1993
29. Breastfeeding and the prevalence of allergic diseases in schoolchildren: Does reverse causation matter?
- Author
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Tatsuya Fujii, Takahiro Yasumi, Ryuta Nishikomori, Kumiko Mukaida, Takashi Kusunoki, Takeshi Morimoto, Tatsutoshi Nakahata, and Toshio Heike
- Subjects
Adult ,Hypersensitivity, Immediate ,Male ,Allergy ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Immunology ,Prevalence ,Breastfeeding ,Dermatitis, Atopic ,Atopy ,Japan ,Risk Factors ,Wheeze ,Surveys and Questionnaires ,medicine ,Immunology and Allergy ,Humans ,Child ,Asthma ,business.industry ,Atopic dermatitis ,medicine.disease ,Health Surveys ,Breast Feeding ,Pediatrics, Perinatology and Child Health ,Multivariate Analysis ,Female ,medicine.symptom ,business ,Breast feeding ,Food Hypersensitivity - Abstract
Kusunoki T, Morimoto T, Nishikomori R, Yasumi T, Heike T, Mukaida K, Fujii T, Nakahata T. Breastfeeding and the prevalence of allergic diseases in schoolchildren: Does reverse causation matter? Pediatr Allergy Immunol 2010: 21: 60–66. © 2010 John Wiley & Sons A/S Infants at higher risk of allergic diseases might be breastfed for longer periods compared with infants at lower risk in the hope that breastfeeding might reduce the risk of atopic disorders. Therefore, this intention could manifest as an apparent allergy-promoting effect of breastfeeding or reverse causation. To analyze the effect of breast feeding on the prevalence of allergic diseases at school age, a large questionnaire survey was administered to the parents of schoolchildren aged 7–15 yrs. 13,215 parents responded (response rate, 90.1%). Prevalence rates of allergic diseases were compared according to the type of feeding in infancy (either complete breastfeeding, mixed feeding or complete artificial feeding). In both univariate and multivariate analysis, compared with those with complete artificial feeding, those with mixed and complete breastfeeding showed a significantly lower prevalence of bronchial asthma (BA) (p = 0.01 and 0.003, respectively). On the other hand, in univariate analysis, the prevalence of atopic dermatitis (AD) and food allergy (FA) were significantly higher in those with complete breastfeeding (p = 0.04 and 0.01, respectively). There was a significantly higher proportion of complete breastfeeding among those with greater risk of allergic diseases (presence of family history, either eczema or wheeze within 6 months after birth, or FA in infancy). Therefore, our multivariate analysis included these risks as confounding factors, and we found that the promoting effects of breastfeeding on AD and FA disappeared. In conclusion, our data clearly showed the inhibitory effect of breastfeeding on the prevalence of BA at school age. The apparent promoting effect of breastfeeding on the prevalence of AD and FA is most likely because of reverse causation.
- Published
- 2010
30. Correspondence
- Author
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Yamada S, Masashi Akiyama, Takashi Kusunoki, Kozo Yoneda, Morita E, and Yamamoto S
- Subjects
medicine.medical_specialty ,medicine ,Dermatology ,Biology ,Annular epidermolytic ichthyosis - Published
- 1999
31. Obesity and the prevalence of allergic diseases in schoolchildren
- Author
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Susumu Hosoi, Takeshi Morimoto, Masatoshi Ito, Takashi Kusunoki, Ryuta Nishikomori, Toshio Heike, and Tatsutoshi Nakahata
- Subjects
Hypersensitivity, Immediate ,Male ,Allergy ,medicine.medical_specialty ,Adolescent ,Immunology ,Severity of Illness Index ,Childhood obesity ,Body Mass Index ,Atopy ,Sex Factors ,Internal medicine ,Surveys and Questionnaires ,medicine ,Prevalence ,Immunology and Allergy ,Humans ,Obesity ,Child ,Asthma ,business.industry ,Atopic dermatitis ,medicine.disease ,Allergic conjunctivitis ,Pediatrics, Perinatology and Child Health ,Female ,business ,Body mass index - Abstract
Although the association between obesity and bronchial asthma (BA) has been gaining more attention, few studies have been conducted concerning the relationship between obesity and other allergic diseases. The objective of this study was to determine whether and how childhood obesity is associated with allergic diseases other than BA, such as atopic dermatitis (AD), allergic rhinitis (AR), allergic conjunctivitis (AC), and either AR or AC (AR/AC). A questionnaire was administered to the parents of 50,086 Japanese schoolchildren. Associations between childhood obesity and the various allergic diseases were evaluated by univariate and multivariate logistic models. Significant associations were found between higher body mass index (BMI) and AD (p = 0.03), and lower BMI and AC (p < 0.0001), and AR/AC (p < 0.0001). There was a significantly higher prevalence of BA in girls with obesity (p = 0.009) than in those without obesity. Significantly lower prevalence of AC (p = 0.01) and AR/AC (p = 0.002) among children with obesity, and AR (p = 0.04) and AR/AC (p = 0.0004) among boys with obesity were observed than those without obesity. Those who were obese and had AD were significantly more likely to have severe symptoms (p = 0.01). Overall, childhood obesity has positive associations with BA prevalence and AD severity, whereas it has negative associations with AR and AC prevalence, especially among boys. Changes in the immunologic balance accompanied by obesity might have different effects on each type of allergic disease. Exploring the mechanisms by which childhood obesity affects allergic status should lead to new management options for childhood allergy.
- Published
- 2008
32. Nitrogen-containing bisphosphonate, YM529/ONO-5920, inhibits macrophage inflammatory protein 1 alpha expression and secretion in mouse myeloma cells
- Author
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Kimiko Fujiwara, Masanobu Tsubaki, Tatsuki Ito, Chisato Kato, Takao Satou, Takashi Kusunoki, Shozo Nishida, Minori Nishinobo, Yuzuru Yamazoe, and Mitsuhiko Ogaki
- Subjects
MAPK/ERK pathway ,Lipopolysaccharides ,Cancer Research ,medicine.medical_specialty ,Mitogen-Activated Protein Kinase 3 ,Morpholines ,Alpha (ethology) ,Cell Growth Processes ,Biology ,p38 Mitogen-Activated Protein Kinases ,Mice ,Polyisoprenyl Phosphates ,Internal medicine ,Cell Line, Tumor ,Nitriles ,medicine ,Butadienes ,Animals ,RNA, Messenger ,Phosphorylation ,Protein kinase A ,Protein kinase B ,Chemokine CCL3 ,Mitogen-Activated Protein Kinase 1 ,Diphosphonates ,Kinase ,Imidazoles ,General Medicine ,Endocrinology ,Oncology ,Chromones ,Cancer research ,I-kappa B Proteins ,Signal transduction ,Multiple Myeloma ,Proto-Oncogene Proteins c-akt ,Sesquiterpenes - Abstract
Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is detected at high concentrations in patients with multiple myeloma, and it is thought to play an important role in the etiology of multiple myeloma and osteolysis. Thus, we investigated whether or not YM529/ONO-5920, a new bisphosphonate, inhibited MIP-1 alpha mRNA expression in, and MIP-1 alpha secretion from, mouse myeloma cells. When the cells were stimulated by lipopolysaccharide, increased MIP-1 alpha mRNA expression and MIP-1 alpha secretion were observed. YM529/ONO-5920 inhibited MIP-1 alpha mRNA expression and MIP-1 alpha secretion in a concentration-dependent manner. A transient increase in the phosphorylation of extracellular-regulated kinase 1/2 (ERK1/2) and Akt was observed after lipopolysaccharide stimulation. After YM529/ONO-5920 was given, there was no transient increase in the phosphorylation of ERK1/2 or Akt. These results indicated that YM529/ONO-5920 inhibited the expression and secretion of MIP-1 alpha through blocking the signaling pathway of the Ras/mitogen-activated protein kinase kinase/ERK and Ras/phosphatidylinositol-3 kinase/Akt. Accordingly, YM529/ONO-5920 appears to have promise for use in effective future therapy for osteolysis and myeloma cell growth that depends on MIP-1 alpha.
- Published
- 2007
33. p-Nonylphenol induces endoplasmic reticulum stress-mediated apoptosis in neuronally differentiated PC12 cells
- Author
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Soichiro Kishi, Takashi Kusunoki, Toshihiko Ikeuchi, Koji Shimoke, and Satoko Komatsubara
- Subjects
endocrine system ,medicine.medical_specialty ,Programmed cell death ,Cell Survival ,Cellular differentiation ,Estrogen receptor ,Apoptosis ,Biology ,PC12 Cells ,Phenols ,Internal medicine ,Nerve Growth Factor ,medicine ,Animals ,Egtazic Acid ,Heat-Shock Proteins ,Chelating Agents ,Neurons ,Analysis of Variance ,Mitogen-Activated Protein Kinase 3 ,Dose-Response Relationship, Drug ,General Neuroscience ,Endoplasmic reticulum ,Cell Differentiation ,Cell biology ,Rats ,Endocrinology ,Gene Expression Regulation ,Cell culture ,Unfolded protein response ,Phosphorylation ,Molecular Chaperones - Abstract
Endocrine disrupting chemicals (EDCs) induce estrogenic phenotypes in sexual organs and cells by chronic stimulation through binding to estrogen receptors. Although cell death may be induced instead of phenotypic change by EDCs in germ cells, the mechanism of the effect of EDCs in neuronal cells is still obscure. Here we report that p-nonylphenol, one of the EDCs, induced apoptosis with up-regulation of glucose-regulated protein 78 (GRP78) expression and activation of caspase-12, which are involved in endoplasmic reticulum (ER) stress specific phenomena, in NGF-treated neuronally differentiated PC12 cells. Moreover, we observed that p-nonylphenol increased the intracellular Ca(2+) concentration and p-nonylphenol-induced apoptosis was prevented when BAPTA-AM, a membrane-permeable Ca(2+) chelator, was added. Intriguingly, we also discovered that decreased phosphorylation of ERK1/2 was induced by p-nonylphenol in the presence of NGF, whereas p-nonylphenol alone did not induce phosphorylation of ERK1/2. These lines of evidence suggest that p-nonylphenol can induce ER stress-mediated apoptosis via increased intracellular Ca(2+) concentration, and can reduce ERK1/2 phosphorylation to attenuate the cell survival effect of NGF, in neuronally differentiated PC12 cells.
- Published
- 2007
34. Malignancies of human thyroid tumors and dynamic magnetic resonance imaging (MRI)
- Author
-
Kiyotaka Murata, Shozo Nishida, Takashi Kusunoki, Hiroshi Hosoi, Takanori Tomura, and Masaaki Inoue
- Subjects
Gadolinium DTPA ,Pathology ,medicine.medical_specialty ,Contrast Media ,Diagnosis, Differential ,medicine ,Mitotic Index ,Humans ,Thyroid Neoplasms ,medicine.diagnostic_test ,business.industry ,Thyroid ,Washout ,Reproducibility of Results ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,Intensity (physics) ,ErbB Receptors ,medicine.anatomical_structure ,Otorhinolaryngology ,Dynamic contrast-enhanced MRI ,Surgery ,Differential diagnosis ,business ,Calcification - Abstract
Time intensity curves for gadolinium-diethylene triaminepentacetic acid (Gd-DTPA) enhanced magnetic resonance imaging (MRI), namely dynamic MRI, were determined for thyroid diseases and compared with findings of histopathologic examination. Time intensity curves for solid lesions were determined, excluding cases with secondary changes such as calcification, hemorrhage, necrosis and fibrosis. Three different patterns of time intensity curves were observed: rapid washout, delayed washout and no change. In our previous study, malignant grades of thyroid tumors were estimated immunohistochemically by epidermal growth factor receptor (EGFR) antibody. In most of malignant diseases and a few benign diseases that had marked cell proliferative activity with staining EGFR strongly, the time intensity curve displayed a delayed washout pattern, in which intensity was above 1/2-maximal value within 10 min after injection Gd-DTPA. Almost all benign diseases and a few well differentiated carcinomas displayed a rapid washout pastern, in which intensity was decreased to lower than 1/2 of peak grade within 10 min following injection and showed staining EGFR weakly. Benign diseases showing no change of time intensity curve, did not almost show aEGFR positive cell. These findings suggested that the time intensity curve obtained from dynamic MRI might indicate differentiated grades and cell proliferating activity of thyroid tumors.
- Published
- 1998
35. Induction of manganese superoxide dismutase by thyroid stimulating hormone in rat thyroid cells
- Author
-
Takashi Kusunoki, Naoyuki Taniguchi, Shozo Nishida, Kiyotaka Murata, Takanori Tomura, Keiichiro Suzuki, Takayuki Nakano, and Saori Kimoto
- Subjects
Male ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Biophysics ,Thyroid Gland ,Thyrotropin ,Superoxide dismutase induction ,Biochemistry ,Superoxide dismutase ,Rat Thyroid ,Thyroid-stimulating hormone ,Structural Biology ,Thyroid peroxidase ,Thyroid stimulating hormone ,Internal medicine ,Methylthiouracil ,Genetics ,medicine ,Animals ,Rats, Wistar ,Molecular Biology ,Cells, Cultured ,Thyroid ,Manganese containing superoxide dismutase ,biology ,Chemistry ,Superoxide Dismutase ,Interleukin ,Cell Biology ,Manganese Superoxide Dismutase ,Immunohistochemistry ,Rats ,Thyroxine ,Endocrinology ,medicine.anatomical_structure ,Enzyme Induction ,biology.protein ,Tumor necrosis factor alpha ,hormones, hormone substitutes, and hormone antagonists - Abstract
Alterations in the superoxide dismutase (SOD) content of thyroid tissues occurring in association with thyroid dysfunction have been reported. In this study, the Mn-SOD content was found to increase in thyroid tissues of rats administered thyroid stimulating hormone (TSH) and in thyrocytes cultured in medium supplemented with TSH. Furthermore, in the thyroid glands of rats whose serum TSH level was elevated by inhibiting the synthesis of T3 and T4 by 6-methyl-2-thiouracil, the Mn-SOD increased as the TSH concentration increased. In the cultured thyrocytes, the increase in Mn-SOD induced by TSH was inhibited by the C-kinase inhibitor H7. These findings suggest the induction of Mn-SOD by TSH in thyroid cells and point to a role of C-kinase in this process, thereby indicating that a close relationship exists between the serum TSH level and the change in Mn-SOD content in thyrocytes with thyroid dysfunction.
- Published
- 1997
36. Lifestyle Risk Factors for Allergic Rhinitis in Schoolchildren: Are Sports Activities a Negative Factor?
- Author
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Takahiro Yasumi, Ryuta Nishikomori, Jiro Takeuchi, Toshio Heike, Takashi Kusunoki, Takeshi Morimoto, Mio Sakuma, and Kumiko Mukaida
- Subjects
medicine.medical_specialty ,business.industry ,Environmental health ,Immunology ,Physical therapy ,Immunology and Allergy ,Medicine ,Sports activity ,business - Published
- 2013
37. Birth Order Effect on the Prevalence of Childhood Allergy: Comparisons among Different Allergic Diseases
- Author
-
Kumiko Mukaida, Tatsuya Morimoto, Tatsuya Fujii, N. Mito, Toshio Heike, Mio Sakuma, Takashi Kusunoki, Takahiro Yasumi, and Ryuta Nishikomori
- Subjects
Birth order ,Pediatrics ,medicine.medical_specialty ,business.industry ,Immunology ,medicine ,Childhood allergy ,Immunology and Allergy ,business - Published
- 2011
38. DOHaD and Allergic Diseases in Schoolchildren: Does IUGR Affect Risk of Allergic Diseases?
- Author
-
Toshio Heike, Tatsuya Morimoto, Takashi Kusunoki, N. Mito, Takahiro Yasumi, Ryuta Nishikomori, Kumiko Mukaida, Mio Sakuma, and Tatsuya Fujii
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Birth weight ,Immunology ,Gestational age ,Intrauterine growth restriction ,Disease ,Atopic dermatitis ,medicine.disease ,Allergic conjunctivitis ,Food allergy ,medicine ,Immunology and Allergy ,business ,Asthma - Abstract
M O N D A Y 719 DOHaD and Allergic Diseases in Schoolchildren: Does IUGR Affect Risk of Allergic Diseases? K. Mukaida, T. Kusunoki, T. Morimoto, M. Sakuma, N. Mito, T. Yasumi, T. Fujii, R. Nishikomori, T. Heike; Department of Pediatrics, Shiga Medical Center for Children, Shiga, JAPAN, Kumiko Allergy clinic, Kyoto, JAPAN, Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, JAPAN, Center for Medical Education, Graduate School of Medicine, Kyoto University, Kyoto, JAPAN. RATIONALE:Developmental Origins of Health andDisease (DOHaD) is the hypothesis that states that the change in fetal programming in response to preterm birth or intrauterine growth restriction (IUGR) is associated with metabolic diseases later in life. It is not clear whether it is also associated with allergic diseases. Our aim was to determine whether the prevalence of allergic diseases in schoolchildren was affected by DOHaD-related prenatal factors, such as being born late preterm (34-36 weeks) or light for dates (LFD). METHODS: A questionnaire-based survey on the prevalence of allergic diseases, such as bronchial asthma (BA), atopic dermatitis (AD), allergic rhinitis (AR), allergic conjunctivitis (AC), and food allergy (FA), as well as birth weight and gestational age, was administered to more than 13,000 schoolchildren. Multivariate analysis was performed to test the differences in the prevalence of allergic diseases between those with or without DOHaD-related factors. RESULTS: The prevalence of any allergic disease did not differ significantly between those born late preterm and term. On the other hand, the prevalence of those with any allergic diseases was significantly lower among LFD children than among non-LFD children (p50.03). Specifically, the prevalence of FAwas significantly lower in LFD children than in non-LFD children (1.9% vs. 3.9%, p50.004). Although not statistically significant, the prevalence of other allergic diseases was also lower in LFD children. CONCLUSIONS: The present data suggest that the change in fetal programming due to IUGR might suppress allergic diseases, especially food allergy, in schoolchildren. Possible mechanisms are discussed.
- Published
- 2011
39. Total and LDL Cholesterol Are Associated with Atopic Status in Schoolchildren
- Author
-
Tatsuya Morimoto, Takashi Kusunoki, Tatsutoshi Nakahata, Tatsuya Fujii, Kumiko Mukaida, Toshio Heike, Takahiro Yasumi, and Ryuta Nishikomori
- Subjects
Ldl cholesterol ,medicine.medical_specialty ,Endocrinology ,business.industry ,Internal medicine ,Immunology ,medicine ,Immunology and Allergy ,business - Published
- 2010
40. Screening of Untreated Schoolchildren with Allergic Symptoms - How many are left untreated?
- Author
-
Tatsutoshi Nakahata, Takahiro Yasumi, Ryuta Nishikomori, Tatsuya Morimoto, Takashi Kusunoki, Kumiko Mukaida, Tatsuya Fujii, and Toshio Heike
- Subjects
medicine.medical_specialty ,Allergic symptoms ,business.industry ,Immunology ,medicine ,Immunology and Allergy ,business ,Dermatology - Published
- 2010
41. Breast-feeding in Infancy and the Prevalence of Allergic Diseases in Schoolchildren-Does Reverse Causation Matter?
- Author
-
Tatsutoshi Nakahata, Takashi Kusunoki, Toshio Heike, Takahiro Yasumi, Ryuta Nishikomori, Tatsuya Morimoto, Kumiko Mukaida, and Tatsuya Fujii
- Subjects
Pediatrics ,medicine.medical_specialty ,Reverse causation ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,business ,Breast feeding - Published
- 2009
42. Nerve growth factor specifically induces human IgG4 production
- Author
-
Chihiro Ishioka, Haruki Mikawa, Akira Yoshida, Susumu Hosoi, Takashi Kusunoki, and Hajime Kimata
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,T-Lymphocytes ,Immunology ,Receptors, Antigen, B-Cell ,In Vitro Techniques ,Immunoglobulin E ,Immunoglobulin G ,Internal medicine ,parasitic diseases ,medicine ,Immunology and Allergy ,Humans ,Nerve Growth Factors ,Interleukin 5 ,Interleukin 4 ,Cells, Cultured ,B-Lymphocytes ,biology ,Interleukin ,Molecular biology ,Immunoglobulin Isotypes ,Nerve growth factor ,Endocrinology ,Cytokine ,Cell culture ,biology.protein ,Cytokines - Abstract
The effect of nerve growth factor (NGF) on human IgG4 production was studied. NGF specifically enhanced IgG4 production in cultures of human tonsillar mononuclear cells without affecting production of other isotypes or other IgG subclasses. Optimal enhancement of IgG4 production by NGF required the presence of T cells. However, NGF induced significant IgG4 production by small resting B cells in the absence of T cells, and this production was enhanced by stimulation with Staphylococcus aureus Cowan strain I (SAC). In contrast to small B cells, large activated B cells produced IgG4 spontaneously; this production was enhanced by NGF. NGF also enhanced IgM and IgA production by large B cells, while production of IgG1, IgG2, IgG3 and IgE was not affected. The enhancement of IgG4 production was blocked by anti-NGF serum but not by control serum. NGF, T cells and SAC, separately or together, failed to induce IgG4 production by surface (sIgG4+)-depleted B cells. In contrast to NGF, other recombinant human cytokines including interleukin (IL) 1 beta, IL 2, IL 4, IL 5, IL 6, granulocyte-macrophage colony-stimulating factor, interferon alpha and gamma failed to induce IgG4 production. These results suggest that NGF directly and preferentially stimulates activated sIgG4+ B cells to produce IgG4.
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- 1991
43. Childhood Obesity as a Possible Aggravating Factor of Atopic Dermatitis
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Susumu Hosoi, Ryuta Nishikomori, Takashi Kusunoki, Toshio Heike, Moeko Ito, Tatsutoshi Nakahata, and Tatsuya Morimoto
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medicine.medical_specialty ,business.industry ,Immunology ,medicine ,Immunology and Allergy ,Atopic dermatitis ,Aggravating Factor ,business ,medicine.disease ,Dermatology ,Childhood obesity - Published
- 2007
44. Somatic Mosaicism of CIAS1 in a Patient with Chronic Infantile Neurologic, Cutaneous, Articular Syndrome
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Ikuo Okafuji, Toshio Heike, Yoshiki Miyachi, Takakazu Yoshioka, Naotomo Kambe, Akihiro Fujisawa, Momoko Yoshimoto, Tatsutoshi Nakahata, M.N. Hizume, K. Omori, Megumu K. Saito, Takashi Kusunoki, and Ryuta Nishikomori
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Pathology ,medicine.medical_specialty ,Somatic mosaicism ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,business - Published
- 2006
45. SPINK5 polymorphism and disease severity among Japanese children with atopic dermatitis
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Ikuo Okafuji, Tatsutoshi Nakahata, Ryuta Nishikomori, Akira Shimizu, Takashi Kusunoki, Megumu K. Saito, Toshio Heike, Takakazu Yoshioka, and Manabu Sugai
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medicine.medical_specialty ,Disease severity ,business.industry ,Polymorphism (computer science) ,Immunology ,medicine ,Immunology and Allergy ,Atopic dermatitis ,medicine.disease ,business ,Dermatology - Published
- 2005
46. The Effect of Past Food Avoidance Due to Allergic Symptoms on the Growth of Children at School Age
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Tatsutoshi Nakahata, Takeshi Morimoto, Takashi Kusunoki, Kumiko Mukaida, Tatsuya Fujii, Toshio Heike, Takahiro Yasumi, and Ryuta Nishikomori
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lcsh:Immunologic diseases. Allergy ,Percentile ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Eggs ,growth ,Population ,body mass index ,Overweight ,Japan ,Food allergy ,Allergic symptoms ,Epidemiology ,medicine ,Immunology and Allergy ,Animals ,Humans ,Child ,Triticum ,business.industry ,Body Weight ,Infant, Newborn ,Infant ,schoolchildren ,General Medicine ,medicine.disease ,Obesity ,Body Height ,Milk ,food avoidance ,epidemiology ,Growth and Development ,medicine.symptom ,Underweight ,business ,lcsh:RC581-607 ,Body mass index ,Food Hypersensitivity - Abstract
Background The influence of food avoidance due to allergic symptoms in infancy on the growth of children at school age has not been well evaluated. Methods To determine the growth of schoolchildren who avoided eggs, milk, or wheat due to immediate allergic symptoms in infancy (food avoiders in infancy) (FAI), a questionnaire on the presence of allergic diseases, as well as present height and weight, was administered to the parents of 14,669 schoolchildren. 11,473 subjects had available data. The height and weight standard deviation scores (HtSDS and WtSDS) and body mass index percentile (BMI percentile) of each subject were calculated. Results FAI had significantly lower WtSDS than non-FAI ( P = 0.01). Among those with avoidance at age 3 years, those who avoided two or more foods and those who avoided milk had significantly lower HtSDS than their counterparts ( P = 0.02 and 0.04, respectively). FAI had a significantly lower prevalence of obesity ( P = 0.01) and overweight ( P = 0.002), while there was no difference in the prevalence of underweight ( P = 0.58), resulting in a significantly higher prevalence of appropriate weight ( P = 0.01) compared to non-FAI. Significantly lower prevalence of obesity and overweight was observed even among those who terminated the avoidance by age 3 years. Conclusions FAI were less likely to be obese or overweight, resulting in a higher prevalence of appropriate weight at school age. Further investigation should contribute to better management of food allergy and obesity.
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47. Changing Prevalence and Severity of Childhood Allergic Diseases in Kyoto, Japan, from 1996 to 2006
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Toshio Heike, Takashi Kusunoki, Takeshi Morimoto, Takahiro Yasumi, Ryuta Nishikomori, Tatsuya Fujii, and Tatsutoshi Nakahata
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Male ,lcsh:Immunologic diseases. Allergy ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Population ,prevalence ,Severity of Illness Index ,Sex Factors ,Japan ,Surveys and Questionnaires ,Epidemiology ,Hypersensitivity ,medicine ,Humans ,Immunology and Allergy ,Child ,education ,Asthma ,education.field_of_study ,business.industry ,questionnaire ,schoolchildren ,General Medicine ,Atopic dermatitis ,medicine.disease ,Allergic conjunctivitis ,allergic disease ,Disease Progression ,Childhood allergy ,Female ,epidemiology ,lcsh:RC581-607 ,business - Abstract
Background: Published data regarding changes in the prevalence of childhood allergic diseases in Japan have been limited. Methods: To observe changes in the recent trends of the childhood allergy epidemic in Japan, a population- based questionnaire survey of allergic diseases was conducted among 13,215 schoolchildren, aged 7 to 15 years, in Kyoto, Japan in 2006. The results were compared with those obtained in the 1996 survey using the same scale and methods in the same region. Results: The prevalences of bronchial asthma (BA), atopic dermatitis (AD), allergic rhinitis (AR), and allergic conjunctivitis (AC) in 1996 and 2006 were 5.1% and 5.0% (p = 0.58), 4.2% and 5.6% (p < 0.0001), 20.3% and 27.4% (p < 0.0001), and 13.3% and 25.2% (p < 0.0001), respectively. Although the distribution of BA severity improved, the severity distribution of AD, AR, and AC all deteriorated. The lifetime prevalence (present prevalence and past history combined) of BA increased from 6.5% to 7.6% (p < 0.0001). The sex ratio analysis showed that the female predominance in the prevalence of AD observed in 1996 disappeared in 2006, indicating a particular rise in AD prevalence among boys. Conclusions: Overall, the results indicate that the rising trend of allergic diseases, especially in AD, AR, and AC, continues among schoolchildren living in Kyoto, Japan. Special attention should be paid to skin and naso- ocular symptoms.
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