Back to Search
Start Over
Malignancies of human thyroid tumors and dynamic magnetic resonance imaging (MRI)
- Source :
- Auris, nasus, larynx. 25(4)
- Publication Year :
- 1998
-
Abstract
- Time intensity curves for gadolinium-diethylene triaminepentacetic acid (Gd-DTPA) enhanced magnetic resonance imaging (MRI), namely dynamic MRI, were determined for thyroid diseases and compared with findings of histopathologic examination. Time intensity curves for solid lesions were determined, excluding cases with secondary changes such as calcification, hemorrhage, necrosis and fibrosis. Three different patterns of time intensity curves were observed: rapid washout, delayed washout and no change. In our previous study, malignant grades of thyroid tumors were estimated immunohistochemically by epidermal growth factor receptor (EGFR) antibody. In most of malignant diseases and a few benign diseases that had marked cell proliferative activity with staining EGFR strongly, the time intensity curve displayed a delayed washout pattern, in which intensity was above 1/2-maximal value within 10 min after injection Gd-DTPA. Almost all benign diseases and a few well differentiated carcinomas displayed a rapid washout pastern, in which intensity was decreased to lower than 1/2 of peak grade within 10 min following injection and showed staining EGFR weakly. Benign diseases showing no change of time intensity curve, did not almost show aEGFR positive cell. These findings suggested that the time intensity curve obtained from dynamic MRI might indicate differentiated grades and cell proliferating activity of thyroid tumors.
- Subjects :
- Gadolinium DTPA
Pathology
medicine.medical_specialty
Contrast Media
Diagnosis, Differential
medicine
Mitotic Index
Humans
Thyroid Neoplasms
medicine.diagnostic_test
business.industry
Thyroid
Washout
Reproducibility of Results
Magnetic resonance imaging
General Medicine
medicine.disease
Immunohistochemistry
Magnetic Resonance Imaging
Intensity (physics)
ErbB Receptors
medicine.anatomical_structure
Otorhinolaryngology
Dynamic contrast-enhanced MRI
Surgery
Differential diagnosis
business
Calcification
Subjects
Details
- ISSN :
- 03858146
- Volume :
- 25
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Auris, nasus, larynx
- Accession number :
- edsair.doi.dedup.....412fd0807a913a85b33ab77591d0b036