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Severe acute abdomen caused by symptomatic Meckel's diverticulum in three children with trisomy 18
- Source :
- American Journal of Medical Genetics Part A. 167:2447-2450
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Meckel's diverticulum (MD) is the most prevalent congenital anomaly of the gastrointestinal tract and often presents a diagnostic challenge. Patients with trisomy 18 frequently have MD, but the poor prognosis and lack of consensus regarding management for neonates has meant that precise information on the clinical manifestations in infants and children with MD is lacking. We describe the cases of three children with trisomy 18 who developed symptomatic MD. Intussusception was diagnosed in Patient 1, intestinal volvulus in Patient 2, and gastrointestinal bleeding in Patient 3. All three patients underwent surgical treatment and only the Patient 1 died due to pulmonary hypertensive crisis. The other two patients experienced no further episodes of abdominal symptoms. In patients with trisomy 18, although consideration of postoperative complications and prognosis after surgical treatment is necessary, symptomatic MD should carry a high index of suspicion in patients presenting with acute abdomen.
- Subjects :
- Pediatrics
medicine.medical_specialty
Gastrointestinal bleeding
Trisomy
Intestinal Volvulus
Intussusception (medical disorder)
Genetics
medicine
Humans
Genetics (clinical)
Abdomen, Acute
Meckel's diverticulum
Gastrointestinal tract
business.industry
Infant, Newborn
Infant
medicine.disease
Meckel Diverticulum
Acute abdomen
Child, Preschool
Female
medicine.symptom
Chromosomes, Human, Pair 18
Gastrointestinal Hemorrhage
business
Intussusception
Trisomy 18 Syndrome
Diverticulum
Subjects
Details
- ISSN :
- 15524825
- Volume :
- 167
- Database :
- OpenAIRE
- Journal :
- American Journal of Medical Genetics Part A
- Accession number :
- edsair.doi.dedup.....f406a72dd5750292e8863073ad26563a