Author: "Bueno-de-Mesquita, H.B." / Topic: medicine.medical_specialty - Searchworks@Jio Institute Digital Library Search Results

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51 results on '"Bueno-de-Mesquita, H.B."'

1. Circulating Soluble CD27 and CD30 in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)

Author: Saberi Hosnijeh, F., Portengen, L., Bueno-de-Mesquita, H.B., Heederik, D., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS
Subjects: Male, medicine.medical_specialty, Polychlorinated Dibenzodioxins, CD30, Epidemiology, medicine.medical_treatment, Coronacrisis-Taverne, Ki-1 Antigen, Cohort Studies, Occupational Exposure, Internal medicine, Statistical significance, medicine, Humans, heterocyclic compounds, Aged, Netherlands, Retrospective Studies, business.industry, Cancer, Immunosuppression, medicine.disease, Tumor Necrosis Factor Receptor Superfamily, Member 7, Lymphoma, Occupational Diseases, Cross-Sectional Studies, Cytokine, Interleukin 1 receptor antagonist, Endocrinology, Oncology, Chemical Industry, Cohort, business
Abstract: Previous studies suggest that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure may be associated with non-Hodgkin lymphoma (NHL) but findings remain inconclusive. There is a need for mechanistic studies to evaluate the biologic plausibility of this association. In this cross-sectional study, we investigated changes in plasma levels of interleukin 1 receptor antagonist (IL1RA) and soluble (s)CD27 and sCD30 which have been found to be predictive of lymphoma, among workers of a cohort occupationally exposed to TCDD. Eighty-five workers who had been exposed to TCDD more than 30 years before blood collection were included in the current investigation. Plasma level of the markers was measured by ELISA. Current plasma levels of TCDD were determined by high-resolution gas chromatography/isotope dilution high-resolution mass spectrometry. TCDD blood levels at time of last exposure were estimated using a one-compartment first order kinetic model. Exposure-response analyses showed no significant association between blood levels of sCD27, and sCD30 and current and estimated TCDD levels at time of last exposure. IL1RA showed a borderline significant decrease with increasing plasma TCDD levels (P = 0.07), which reached formal statistical significance when excluding subjects with chronic diseases. In conclusion, no clear dose–response relationship was observed between the measured markers and TCDD level. However, there was a suggestion that markers in particular IL1RA tended to decrease with increasing TCDD levels. This observation is consistent with our earlier observation on decreasing cytokine levels, suggesting immunosuppression, with increasing exposures. These findings possibly provide new insights in the etiology of NHL and the mechanisms through which TCDD can increase lymphoma risk. Cancer Epidemiol Biomarkers Prev; 22(12); 2420–4. ©2013 AACR.
Published: 2013

2. Changes in lymphocyte subsets in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Author: Saberi Hosnijeh, F., Lenters, V.C., Boers, D., Portengen, L., Baeten, E., Bueno de Mesquita, H.B., Heederik, D.J.J., Bloem, A.C., Vermeulen, R.C.H., Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS
Subjects: medicine.medical_specialty, Polychlorinated Dibenzodioxins, Cell, CD4-CD8 Ratio, Coronacrisis-Taverne, Biology, Internal medicine, White blood cell, Occupational Exposure, medicine, Humans, Peripheral blood cell, heterocyclic compounds, B-cell lymphoma, B cell, Aged, B-Lymphocytes, Herbicides, Public Health, Environmental and Occupational Health, Middle Aged, medicine.disease, Lymphocyte Subsets, Blood Cell Count, Occupational Diseases, Haematopoiesis, Endocrinology, medicine.anatomical_structure, Cross-Sectional Studies, Chemical Industry, International, Immunology, Environmental Pollutants, CD8, Lymphocyte subsets
Abstract: Objectives 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to have toxic effects on the haematopoietic system in animals but epidemiological studies in humans have shown inconsistent results. In this cross-sectional study we investigated changes in peripheral blood cell counts and lymphocyte subsets among workers from a Dutch historical cohort occupationally exposed to chlorophenoxy herbicides and contaminants including TCDD. Methods Forty-seven workers who had been exposed to high levels of TCDD in the past and 38 low-exposed workers were included in the current investigation. Complete blood counts and differential and major lymphocyte subsets were analysed. Current plasma levels of TCDD (TCDD current ) were determined by high-resolution gas chromatography/isotope-dilution high resolution mass spectrometry. TCDD blood levels at the time of last exposure (TCDD max ) were estimated using a one-compartment first order kinetic model. Results Cell counts and lymphocyte subsets were similar between high- and low-exposed workers, except for a non-dose dependent increase in CD4/CD8 ratio among high-exposed workers. Interestingly, most lymphocyte subsets, in particular the B cell compartment, showed a decrease with increasing levels of both TCDD current and TCDD max . Conclusions Overall, our study showed that plasma TCDD levels had no effect on white blood cell counts and major subsets. However, a non-significant decrease in most lymphocyte subsets was noted, with the strongest effect for B cells. The latter finding may suggest that dioxin exposure might have an adverse impact on the haematopoietic system and lends some support to B cell lymphoma induction by dioxin.
Published: 2012

3. Cause-specific mortality of Dutch chlorophenoxy herbicide manufacturing workers

Author: Boers, D., Portengen, L., Bueno-de-Mesquita, H.B., Heederik, D., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS
Subjects: Adult, Male, medicine.medical_specialty, Urologic Neoplasms, Population, Occupational medicine, Cohort Studies, Risk Factors, Internal medicine, Cause of Death, Neoplasms, Occupational Exposure, medicine, Humans, education, Netherlands, Retrospective Studies, education.field_of_study, business.industry, 2,4,5-Trichlorophenoxyacetic Acid, Herbicides, Hazard ratio, Public Health, Environmental and Occupational Health, Retrospective cohort study, Middle Aged, medicine.disease, Non-Hodgkin's lymphoma, Occupational Diseases, Cohort, Genital Neoplasms, Male, Population study, 2,4-Dichlorophenoxyacetic Acid, business, Cohort study, Follow-Up Studies
Abstract: Objective: A retrospective cohort study was conducted in two chlorophenoxy herbicide manufacturing factories, producing mainly 2,4,5-trichlorophenoxyacetic acid (factory A) and 4-chloro-2-methylphenoxyacetic acid, 4-chloro-2-methylphenoxy propanoic acid and 2,4-dichlorophenoxyacetic acid (factory B). Previously, we have shown elevated risks for mortality and cancer mortality in this cohort. The purpose of the current, third follow-up, is to provide an updated assessment of cause-specific mortality for both factories. Methods: The study population was defined as all persons working in one of the two factories during 1955–1985 for factory A, or during 1965–1986 for factory B. Analyses were performed using Cox proportional hazard models, using attained age as the timescale. Exposure to phenoxy herbicides and dioxins was expected to be different for factory A and factory B and the factories were therefore analysed separately. Results: Previously reported increased risks for respiratory cancer, non-Hodgkin’s lymphoma and ischaemic heart disease in factory A could not be confirmed in the present analysis. However, increased risks were observed for all cancers in both factory A (hazard ratio (HR) 1.31; 95% CI 0.86 to 2.01) and factory B (HR 1.54; 95% CI 1.00 to 2.37). Increased risks for urinary cancers (HR 4.2; 95% CI 0.99 to 17.89) and genital cancers (HR 2.93; 95% CI 0.61 to 14.15) were observed in factory A, consistent with earlier reported results in this population. More detailed analyses showed that this increased risk for urinary and genital cancers in exposed workers was not due to selection of healthy controls and could not be attributed to specific products or departments. Conclusion: The results of this study showed only slight increases in cancer mortality risk. The increased risk for urinary cancers is noteworthy, but could not be linked to a specific exposure and needs to be confirmed in similar cohorts.
Published: 2010

4. Smoking and risk for amyotrophic lateral sclerosis: analysis of the EPIC cohort

Author: Gallo, V., Bueno de Mesquita, H.B., Vermeulen, R.C.H., Andersen, P.M., Kyrozis, A., Linseisen, J., Kaaks, R., Allen, N.E., Roddam, A.W., Boshuizen, H.C., Peeters, P.H.M., Palli, D., Mattiello, A., Sieri, S., Tumino, R., Jimenez-Martin, J.M., Diaz, M.J., Suarez, L.R., Trichopoulou, A., Agudo, A., Arriola, L., Barricante-Gurrea, A., Bingham, S., Khaw, K.T., Manjer, J., Lindkvist, B., Overvad, K., Bach, F.W., Tjonneland, A., Olsen, A., Bergmann, M.M., Boeing, H., Clavel-Chapelon, F., Lund, E., Hallmans, G., Middleton, L., Vineis, P., Riboli, E., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS
Subjects: Adult, Male, Questionnaires, Risk, medicine.medical_specialty, International Cooperation, Cohort Studies, Sex Factors, Internal medicine, medicine, Humans, ddc:610, Amyotrophic lateral sclerosis, Risk factor, Aged, Proportional Hazards Models, business.industry, Proportional hazards model, Mortality rate, Amyotrophic Lateral Sclerosis, Smoking, Age Factors, Middle Aged, Former Smoker, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Europe, Neurology, Cohort, Physical therapy, Female, Neurology (clinical), business, Cohort study
Abstract: Udgivelsesdato: 2009-Apr OBJECTIVE: Cigarette smoking has been reported as "probable" risk factor for Amyotrophic Lateral Sclerosis (ALS), a poorly understood disease in terms of aetiology. The extensive longitudinal data of the European Prospective Investigation into Cancer and Nutrition (EPIC) were used to evaluate age-specific mortality rates from ALS and the role of cigarette smoking on the risk of dying from ALS. METHODS: A total of 517,890 healthy subjects were included, resulting in 4,591,325 person-years. ALS cases were ascertained through death certificates. Cox hazard models were built to investigate the role of smoking on the risk of ALS, using packs/years and smoking duration to study dose-response. RESULTS: A total of 118 subjects died from ALS, resulting in a crude mortality rate of 2.69 per 100,000/year. Current smokers at recruitment had an almost two-fold increased risk of dying from ALS compared to never smokers (HR = 1.89, 95% C.I. 1.14-3.14), while former smokers at the time of enrollment had a 50% increased risk (HR = 1.48, 95% C.I. 0.94-2.32). The number of years spent smoking increased the risk of ALS (p for trend = 0.002). Those who smoked more than 33 years had more than a two-fold increased risk of ALS compared with never smokers (HR = 2.16, 95% C.I. 1.33-3.53). Conversely, the number of years since quitting smoking was associated with a decreased risk of ALS compared with continuing smoking. INTERPRETATION: These results strongly support the hypothesis of a role of cigarette smoking in aetiology of ALS. We hypothesize that this could occur through lipid peroxidation via formaldehyde exposure.
Published: 2009

5. Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition

Author: Hermann, S., Rohrmann, S., Linseisen, J., Nieters, A., Khan, A., Gallo, V., Overvad, K., Tjonneland, A., Raaschou-Nielsen, O., Bergmann, M.M., Boeing, H., Becker, N., Kaaks, R., Bueno-de-Mesquita, H.B., May, A.M., Vermeulen, R.C.H., Bingham, S, Khaw, K.T., Key, T.J., Travis, R.C., Trichopoulou, A., Georgila, C., Triantafylou, D., Celentano, E., Krogh, V., Masala, G., Tumino, R., Agudo, A., Altzibar, J.M., Ardanaz, E., Martinez-Garcia, C., Arguelles, M.V., Tormo, M.J., Braaten, T., Lund, E., Manjer, J., Zackrisson, S., Hallmans, G., Malmer, B., Boffetta, P., Brennan, P., Slimani, N., Vineis, P., Riboli, E., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Hermann, S., Rohrmann, S., Linseisen, J., Nieters, A., Khan, A., Gallo, V., Overvad, K., Tjønneland, A., Raaschou-Nielsen, O., Bergmann, M.M., Boeing, H., Becker, N., Kaaks, R., Bas Bueno-De-Mesquita, H., May, A.M., Vermeulen, R.C.H., Bingham, S., Khaw, K.-T., Key, T.J., Travis, R.C., Trichopoulou, A., Georgila, C., Triantafylou, D., Celentano, E., Krogh, V., Masala, G., Tumino, R., Agudo, A., Altzibar, J.M., Ardanaz, E., Martínez-García, C., Suárez, M.V.A., Tormo, M.J., Braaten, T., Lund, E., Manjer, J., Zackrisson, S., Hallmans, G., Malmer, B., Boffetta, P., Brennan, P., Slimani, N., Vineis, P., and Riboli, E.
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, lymphoma, European, Risk Assessment, Sex Factors, Risk Factors, immune system diseases, Surveys and Questionnaires, Internal medicine, hemic and lymphatic diseases, Prevalence, medicine, Humans, cancer, Prospective Studies, ddc:610, Risk factor, Prospective cohort study, Proportional Hazards Models, education, business.industry, Incidence, Lymphoma, Non-Hodgkin, Incidence (epidemiology), General Medicine, Middle Aged, medicine.disease, Hodgkin Disease, Leukemia, Lymphocytic, Chronic, B-Cell, Diet, Non-Hodgkin's lymphoma, European Prospective Investigation into Cancer and Nutrition, Lymphoma, Europe, nutrition, Immunology, Educational Status, Female, Lymphoma, Large B-Cell, Diffuse, business, Diffuse large B-cell lymphoma, Cohort study
Abstract: Introduction: Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. Materials and methods: Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk. Results: Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of the cohort. We observed a higher risk of B-NHL (HR = 1.31, 95% CI = 1.02-1.68; n = 583) in women with the highest education level (university) but not in men. Concerning sub-classes of B-NHL, a positive association between education and risk of B cell chronic lymphatic leukaemia (BCLL) was observed only in women. In both genders, the risk of diffuse large B cell lymphoma (DLBCL) was significantly lower for subjects with university degree (HR = 0.46, 95% CI = 0.27-0.79) versus lowest educational level. No association was found for HL. Conclusion: We could not confirm an overall consistent association of education and risk of HL or NHL in this large prospective study; although, education was positively related to the incidence of BCLL and B-NHL (in women) but inversely to incidence of DLBCL. Due to limited number of cases in sub-classes and the large number of comparisons, the possibility of chance findings can not be excluded. © 2009 Springer-Verlag.
Published: 2010

6. Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Author: Rodriguez-Martinez, Andrea, Zhou, Bin, Sophiea, Marisa K, Bentham, James, Paciorek, Christopher J, Iurilli, Maria LC, Carrillo-Larco, Rodrigo M, Bennett, James E, Di Cesare, Mariachiara, Taddei, Cristina, Bixby, Honor, Stevens, Gretchen A, Riley, Leanne M, Cowan, Melanie J, Savin, Stefan, Danaei, Goodarz, Chirita-Emandi, Adela, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Malekzadeh, Reza, Miranda, J Jaime, Moon, Jin Soo, Popovic, Stevo R, Sorensen, Thorkild IA, Soric, Maroje, Starc, Gregor, Zainuddin, Ahmad A, Gregg, Edward W, Bhutta, Zulfiqar A, Black, Robert, Ezzati, Majid, Abarca-Gomez, Leandra, Abdeen, Ziad A, Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F Abdul, Abu-Rmeileh, Niveen M, Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adams, Robert J, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Othman, Amani Rashed, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiri, Parisa, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Angquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Aspelund, Thor, Assah, Felix K, Assuncao, Maria Cecilia F, Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V, Jorgensen, Maja Baeksgaard, Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R, Baran, Joanna, Barbagallo, Carlo M, Barcelo, Alberto, Barkat, Amina, Barros, Aluisio JD, Barros, Mauro Virgilio Gomes, Basit, Abdul, Bastos, Joao Luiz D, Bata, Iqbal, Batieha, Anwar M, Batista, Rosangela L, Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Lele, Elysee Claude Bika, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Bjorkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boeing, Heiner, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Bovet, Pascal, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Brinduse, Lacramioara, Brophy, Sinead, Bruno, Graziella, Bueno-de-Mesquita, H Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, de Leon, Antonio Cabrera, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C, Canete, Felicia, Capanzana, Mario V, Capkova, Nadezda, Capuano, Eduardo, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajus, Jose A, Casanueva, Felipe F, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamukuttan, Snehalatha, Chan, Angelique W, Chan, Queenie, Chaturvedi, Himanshu K, Chaturvedi, Nish, Rahim, Norsyamlina Che Abdul, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Crujeiras, Ana B, Csilla, Semanova, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, D'Arrigo, Graziella, d'Orsi, Eleonora, Dacica, Liliana, Saavedra, Maria Angeles Dal Re, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent, Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Deren, Katarzyna, Deschamps, Valerie, Dhana, Klodian, Dhimal, Meghnath, Di Castelnuovo, Augusto F, Dias-da-Costa, Juvenal Soares, Diaz-Sanchez, Maria Elena, Diaz, Alejandro, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Donati, Maria Benedetta, Donfrancesco, Chiara, Donoso, Silvana P, Doring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Doua, Kouamelan, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Duleva, Vesselka, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eddie, Ricky, Eftekhar, Ebrahim, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Engle-Stone, Reina, Enguerran, Macia, Erasmus, Rajiv T, Erbel, Raimund, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Pena, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Faeh, David, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Sant'Angelo, Victoria Farrugia, Farzadfar, Farshad, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferrer, Eldridge, Ferrieres, Jean, Figueiro, Thamara Hubler, Fijalkowska, Anna, Fink, Gunther, Fischer, Krista, Foger, Bernhard, Foo, Leng Huat, Forsner, Maria, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Franco, Oscar H, Frikke-Schmidt, Ruth, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Galbarczyk, Andrzej, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Garcia-Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K, Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Godos, Justyna, Gogen, Sibel, Goldsmith, Rebecca A, Goltzman, David, Gomez, Santiago F, Gomula, Aleksandra, da Silva, Bruna Goncalves Cordeiro, Goncalves, Helen, Gonzalez-Chica, David A, Gonzalez-Gross, Marcela, Gonzalez-Leon, Margot, Gonzalez-Rivas, Juan P, Gonzalez-Villalpando, Clicerio, Gonzalez-Villalpando, Maria-Elena, Gonzalez, Angel R, Gottrand, Frederic, Graca, Antonio Pedro, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregor, Ronald D, Grodzicki, Tomasz, Groholt, Else Karin, Grontved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Gualdi-Russo, Emanuela, Guallar-Castillon, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc J, Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez-Gonzalez, Enrique, Gutierrez, Laura, Gutzwiller, Felix, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A, Haghshenas, Rosa, Hakimi, Hamid, Halkjaer, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Kumar, Rachakulla Hari, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Jiang, He, Yuan, He, Yuna, Heidinger-Felso, Regina, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Cadena, Leticia Hernandez, Herrala, Sauli, Herrera, Victor M, Herter-Aeberli, Isabelle, Heshmat, Ramin, Hill, Allan G, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Hofman, Albert, Bergh, Ingunn Holden, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hopman, Wilma M, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Thein, Thein Htay, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, Jose Maria, Huhtaniemi, Ilpo Tapani, Petrescu, Constanta Huidumac, Husseini, Abdullatif, Chinh, Nguyen Huu, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Ibarluzea, Jesus M, Ibrahim, Mohsen M, Wong, Norazizah Ibrahim, Ikeda, Nayu, Ikram, M Arfan, Iotova, Violeta, Irazola, Vilma E, Ishida, Takafumi, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Iwasaki, Masanori, Jackson, Rod T, Jacobs, Jeremy M, Jaddou, Hashem Y, Jafar, Tazeen, James, Kenneth, Jamil, Kazi M, Jamrozik, Konrad, Janszky, Imre, Janus, Edward, Jarani, 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Uysal N., Vaitkeviciute J., Valdivia G., Vale S., Valvi D., van Dam R.M., Van der Heyden J., van der Schouw Y.T., Van Herck K., Van Minh H., van Valkengoed I.G., Vanderschueren D., Vanuzzo D., Varbo A., Varela-Moreiras G., Varona-Perez P., Vasan S.K., Vega T., Veidebaum T., Velasquez-Melendez G., Velika B., Veronesi G., Verschuren W.M., Victora C.G., Viegi G., Viet L., Villalpando S., Vineis P., Vioque J., Virtanen J.K., Visser M., Visvikis-Siest S., Viswanathan B., Vladulescu M., Vlasoff T., Vocanec D., Volzke H., Voutilainen A., Voutilainen S., Vrijheid M., Vrijkotte T.G., Wade A.N., Wagner A., Waldhor T., Walton J., Wambiya E.O., Wan Bebakar W.M., Wan Mohamud W.N., Wanderley Junior R.D.S., Wang M.-D., Wang N., Wang Q., Wang X., Wang Y.X., Wang Y.-W., Wannamethee S.G., Wareham N., Weber A., Wedderkopp N., Weerasekera D., Weghuber D., Wei W., Weres A., Werner B., Whincup P.H., Widhalm K., Widyahening I.S., Wiecek A., Wilks R.J., Willeit J., Willeit P., Williams J., Wilsgaard T., Wojtyniak B., Wong-McClure R.A., Wong A., Wong J.E., Wong T.Y., Woo J., Woodward M., Wu F.C., Wu J., Wu L.J., Wu S., Xu H., Xu L., Yaacob N.A., Yamborisut U., Yan W., Yang L., Yang X., Yang Y., Yardim N., Yaseri M., Yasuharu T., Ye X., Yiallouros P.K., Yoosefi M., Yoshihara A., You Q.S., You S.-L., Younger-Coleman N.O., Yusof S.M., Yusoff A.F., Zaccagni L., Zafiropulos V., Zakavi S.R., Zamani F., Zambon S., Zampelas A., Zamrazilova H., Zapata M.E., Zargar A.H., Zaw K.K., Zdrojewski T., Zeljkovic Vrkic T., Zeng Y., Zhang L., Zhang Z.-Y., Zhao D., Zhao M.-H., Zhao W., Zhen S., Zheng W., Zheng Y., Zholdin B., Zhou M., Zhu D., Zocalo Y., Zuniga Cisneros J., Zuziak M., and Ezzati M.
Subjects: Male, body-mass index, ADULTHOOD, Adolescents, pituuskasvu, Pediatrics, Body Mass Index, 0302 clinical medicine, Child Development, nuoret, Public health surveillance, Medicine, Health Status Indicators, 10. No inequality, Child, 11 Medical and Health Sciences, Body mass index, ComputingMilieux_MISCELLANEOUS, education.field_of_study, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, General Medicine, Body mass indexes, kansainvälinen vertailu, 3. Good health, Geography, Health, 030220 oncology & carcinogenesis, Child, Preschool, Medical and Health sciences, purl.org/becyt/ford/3 [https], medicine.medical_specialty, School-aged adolescents, Socio-culturale, lapset (ikäryhmät), Nursing, territories, ravinto, purl.org/becyt/ford/3.3 [https], 03 medical and health sciences, School Children, SDG 3 - Good Health and Well-being, SYSTEMATIC ANALYSIS, Humans, school-aged children and adolescents, Montenegro, education, Science & Technology, Omvårdnad, Health sciences, Medical and Health sciences, Ciências médicas e da saúde, Bayes Theorem, Anthropometry, Adolescent Development, medicine.disease, TRENDS, Height and Body-mass Index, Faculdade de Ciências Sociais, UNDERNUTRITION, Height index trajectories, Height, body mass index, children , epidemiology, risk factors, growth, Stature, Demography, Settore MED/09 - Medicina Interna, Internationality, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Body-mass index trajectories, Epidemiology, Medicine and Health Sciences, risk factors, countries, EPIDEMIOLOGY, height, children, adolescents, BMI, 030212 general & internal medicine, painoindeksi, Child development, 2. Zero hunger, Medicine(all), School age child, obestity children cardiovascular, Population Health, 1. No poverty, Pediatrik, Public Health, Global Health, Social Medicine and Epidemiology, 3142 Public health care science, environmental and occupational health, Pooled analysis, NUTRITION, Female, medicine.symptom, pooled analysis, Life Sciences & Biomedicine, terveys, height, BMI, nutrition, health, children, adolescents, Adolescent, growth, Population, body-mass, Population based, Body-mass index, Young Adult, Medicine, General & Internal, Meta-Analysis as Topic, General & Internal Medicine, parasitic diseases, Weight gain, School-aged childrens, Age trajectories, business.industry, Height, Weight, Body Height, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Malnutrition, ONSET, Ciências da Saúde, Ciências médicas e da saúde, School-aged children, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, business, terveysriskit, Estilos de Vida e Impacto na Saúde
Abstract: BACKGROUND: Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents., METHODS: For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence., FINDINGS: We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls., INTERPRETATION: The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks., Wellcome Trust, AstraZeneca Young Health Programme, EU., peer-reviewed
Published: 2020

7. Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Laure Dossus, Antonio Agudo, Marc J. Gunter, Rudolf Kaaks, Miguel Rodríguez-Barranco, Maria-Dolores Chirlaque, Vittorio Krogh, Petra H.M. Peeters, Hanane Omichessan, Elisabete Weiderpass, Myrto Barrdahl, Ruth C. Travis, Federico Canzian, Antonia Trichopoulou, Laura Baglietto, Gianluca Severi, Hendrik B. Bueno-de-Mesquita, Giuseppe Matullo, Daniele Campa, Aurelia Santoro, Rosario Tumino, Campa, Daniele, Barrdahl, Myrto, Santoro, Aurelia, Severi, Gianluca, Baglietto, Laura, Omichessan, Hanane, Tumino, Rosario, Bueno-de-Mesquita, H.B(as)., Peeters, Petra H., Weiderpass, Elisabete, Chirlaque, Maria-Dolore, Rodríguez-Barranco, Miguel, Agudo, Antonio, Gunter, Marc, Dossus, Laure, Krogh, Vittorio, Matullo, Giuseppe, Trichopoulou, Antonia, Travis, Ruth C., Canzian, Federico, and Kaaks, Rudolf
Subjects: 0301 basic medicine, Oncology, Cancer Research, Mitochondrial copy number, Genome-wide association study, ADN mitocondrial, Cohort Studies, 0302 clinical medicine, Breast cancer, Risk Factors, Epidemiology of cancer, Leukocytes, Copy-number variation, Prospective Studies, Prospective cohort study, Telòmer, Middle Aged, Telomere, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Mitochondrial DNA, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Quartile, 030220 oncology & carcinogenesis, Female, Research Article, Adult, medicine.medical_specialty, DNA Copy Number Variations, Breast Neoplasms, Biology, lcsh:RC254-282, DNA, Mitochondrial, Càncer de mama, 03 medical and health sciences, Cancer epidemiology, Internal medicine, medicine, Humans, Telomere length, Aged, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762, Cancer, Telomere Homeostasis, medicine.disease, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762, 030104 developmental biology, Nutrition Assessment
Abstract: Source at https://doi.org/10.1186/s13058-018-0955-5. Licensed CC BY-NC-ND 4.0. Background: Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC). Methods: To gain a more comprehensive picture on how these markers can modulate BC risk, alone or in conjunction, we performed simultaneous measurements of LTL and mtDNA copy number in up to 570 BC cases and 538 controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. As a first step, we measured LTL and mtDNA copy number in 96 individuals for which a blood sample had been collected twice with an interval of 15 years. Results: According to the intraclass correlation (ICC), we found very good stability over the time period for both measurements, with ICCs of 0.63 for LTL and 0.60 for mtDNA copy number. In the analysis of the entire study sample, we observed that longer LTL was strongly associated with increased risk of BC (OR 2.71, 95% CI 1.58–4.65, p = 3.07 × 10− 4 for highest vs. lowest quartile; OR 3.20, 95% CI 1.57–6.55, p = 1.41 × 10− 3 as a continuous variable). We did not find any association between mtDNA copy number and BC risk; however, when considering only the functional copies, we observed an increased risk of developing estrogen receptor-positive BC (OR 2.47, 95% CI 1.05–5.80, p = 0.04 for highest vs. lowest quartile). Conclusions: We observed a very good correlation between the markers over a period of 15 years. We confirm a role of LTL in BC carcinogenesis and suggest an effect of mtDNA copy number on BC risk.
Published: 2018

8. Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe

Author: Frank Kee, Antonia Trichopoulou, José María Huerta, Heinz Freisling, Christina Bamia, Mazda Jenab, Paolo Boffetta, Anne Tjønneland, Ellen Kampman, Isabelle Romieu, Hendrik B. Bueno-de-Mesquita, Melina Arnold, Vassiliki Benetou, Hermann Brenner, Mark G. O'Doherty, Konstantinos K. Tsilidis, Tom Wilsgaard, Isabelle Soerjomataram, José M Ordóñez-Mena, Michael F. Leitzmann, and Freisling, H. and Arnold, M. and Soerjomataram, I. and O'Doherty, M.G. and Ordóñez-Mena, J.M. and Bamia, C. and Kampman, E. and Leitzmann, M. and Romieu, I. and Kee, F. and Tsilidis, K. and Tjønneland, A. and Trichopoulou, A. and Boffetta, P. and Benetou, V. and Bueno-De-Mesquita, H.B. and Huerta, J.M. and Brenner, H. and Wilsgaard, T. and Jenab, M.
Subjects: Male, cancer hormone therapy, Epidemiology, cancer risk, Body Mass Index, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, prevention, Prospective Studies, comparative study, Cancer, stomach cancer, adult, Incidence, Hazard ratio, kidney cancer, cohort, 3. Good health, Postmenopause, esophagus cancer, priority journal, Oncology, 030220 oncology & carcinogenesis, WAIST CIRCUMFERENCE, ANTHROPOMETRIC FACTORS, medicine.medical_specialty, body fat distribution, Body fat distribution, Article, liver cancer, 03 medical and health sciences, Breast cancer, MASS INDEX, SDG 3 - Good Health and Well-being, GASTRIC ADENOCARCINOMA, Humans, human, Risk factor, VLAG, Aged, Science & Technology, Prevention, nutritional and metabolic diseases, medicine.disease, major clinical study, Ageing, Body mass index, Gerontology, Cancer Research, obesity, Nutrition and Disease, CHANCES consortium, COLORECTAL-CANCER, gallbladder cancer, Waist–hip ratio, Voeding en Ziekte, Neoplasms, 030212 general & internal medicine, Prospective cohort study, Abdominal obesity, 2. Zero hunger, Cohort, ovary cancer, Middle Aged, NIH-AARP DIET, PANCREATIC-CANCER, Europe, waist hip ratio, ABDOMINAL OBESITY, Female, medicine.symptom, Colorectal Neoplasms, Life Sciences & Biomedicine, sex difference, UNITED-STATES, colorectal cancer, Breast Neoplasms, smoking, breast cancer, pancreas cancer, Internal medicine, Journal Article, medicine, follow up, cancer, Obesity, Oncology & Carcinogenesis, hip circumference, Waist-Hip Ratio, business.industry, disease association, endometrium cancer, ageing, DOSE-RESPONSE METAANALYSIS, business, 1112 Oncology And Carcinogenesis, body ma, Follow-Up Studies
Abstract: BACKGROUND: We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obesity, with total obesity-related and site-specific (colorectal and postmenopausal breast) cancer incidence.METHODS: This is a meta-analysis of seven prospective cohort studies participating in the CHANCES consortium including 18 668 men and 24 751 women with a mean age of 62 and 63 years, respectively. Harmonised individual participant data from all seven cohorts were analysed separately and alternatively for each anthropometric indicator using multivariable Cox proportional hazards models.RESULTS: After a median follow-up period of 12 years, 1656 first-incident obesity-related cancers (defined as postmenopausal female breast, colorectum, lower oesophagus, cardia stomach, liver, gallbladder, pancreas, endometrium, ovary, and kidney) had occurred in men and women. In the meta-analysis of all studies, associations between indicators of adiposity, per s.d. increment, and risk for all obesity-related cancers combined yielded the following summary hazard ratios: 1.11 (95% CI 1.02-1.21) for BMI, 1.13 (95% CI 1.04-1.23) for WC, 1.09 (95% CI 0.98-1.21) for HC, and 1.15 (95% CI 1.00-1.32) for WHR. Increases in risk for colorectal cancer were 16%, 21%, 15%, and 20%, respectively per s.d. of BMI, WC, HC, and WHR. Effect modification by hormone therapy (HT) use was observed for postmenopausal breast cancer (PinteractionCONCLUSIONS: BMI, WC, HC, and WHR show comparable positive associations with obesity-related cancers combined and with colorectal cancer in older adults. For postmenopausal breast cancer we report evidence for effect modification by HT use.British Journal of Cancer advance online publication: 25 April 2017; doi:10.1038/bjc.2017.106 www.bjcancer.com.
Published: 2017

9. Self-rated health and all-cause and cause-specific mortality of older adults : individual data meta-analysis of prospective cohort studies in the CHANCES Consortium

Author: Sture Eriksson, Andrzej Pajak, Eleni Klinaki, H. B. Bueno-De-Mesquita, Hermann Brenner, Kai Uwe Saum, Paolo Boffetta, Pagona Lagiou, Dimitrios Trichopoulos, Sofia Malyutina, Julian Gardiner, Philippos Orfanos, Hendrik Juerges, Mette Aadahl, Antonia Trichopoulou, Abdonas Tamosiunas, Ute Mons, Tom Wilsgaard, Roberto Lorbeer, Ruzena Kubinova, Christina Bamia, Charles E. Matthews, Lisette C. P. G. M. de Groot, Anne Peasey, Michael Katsoulis, Ben Schöttker, and Bamia, C. and Orfanos, P. and Juerges, H. and Schöttker, B. and Brenner, H. and Lorbeer, R. and Aadahl, M. and Matthews, C.E. and Klinaki, E. and Katsoulis, M. and Lagiou, P. and Bueno-de-mesquita, H.B. and Eriksson, S. and Mons, U. and Saum, K.-U. and Kubinova, R. and Pajak, A. and Tamosiunas, A. and Malyutina, S. and Gardiner, J. and Peasey, A. and de Groot, L.C. and Wilsgaard, T. and Boffetta, P. and Trichopoulou, A. and Trichopoulos, D.
Subjects: Gerontology, demography, proportional hazards model, Health Status, accounting, health statu, physical activity, cause of death, Elderly, 0302 clinical medicine, cardiovascular mortality, cardiovascular disease, Neoplasms, cancer mortality, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Self-rated health, Geriatrics, anthropometry, 030503 health policy & services, self report, Cardiovascular Disease, Cohort, Obstetrics and Gynecology, health, social psychology, All-cause mortality, medical history, Europe, aged, female, Cardiovascular Diseases, self rated health, Meta-analysis, epidemiology, 0305 other medical science, prospective study, United State, lifestyle, medicine.medical_specialty, alcohol consumption, education, cohort analysi, MEDLINE, European, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, male, medicine, follow up, Humans, controlled study, human, marriage, CHANCES, VLAG, Proportional Hazards Models, Global Nutrition, Wereldvoeding, meta analysi, business.industry, Proportional hazards model, mortality, United States, body regions, Prospective Studie, Ageing, Neoplasm, Self Report, business, body ma, All cause mortality
Abstract: Objectives To evaluate, among the elderly, the association of self-rated health (SRH) with mortality, and to identify determinants of self-rating health as “at-least-good”. Study design Individual data on SRH and important covariates were obtained for 424,791 European and United States residents, ≥60 years at recruitment (1982–2008), in eight prospective studies in the Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES). In each study, adjusted mortality ratios (hazard ratios, HRs) in relation to SRH were calculated and subsequently combined with random-effect meta-analyses. Main outcome measures All-cause, cardiovascular and cancer mortality. Results Within the median 12.5 years of follow-up, 93,014 (22%) deaths occurred. SRH “fair” or “poor” vs. “at-least-good” was associated with increased mortality: HRs 1.46 (95% CI 1·23–1.74) and 2.31 (1.79–2.99), respectively. These associations were evident: for cardiovascular and, to a lesser extent, cancer mortality, and within-study, within-subgroup analyses. Accounting for lifestyle, sociodemographic, somatometric factors and, subsequently, for medical history explained only a modest amount of the unadjusted associations. Factors favourably associated with SRH were: sex (males), age (younger-old), education (high), marital status (married/cohabiting), physical activity (active), body mass index (non-obese), alcohol consumption (low to moderate) and previous morbidity (absence). Conclusion SRH provides a quick and simple tool for assessing health and identifying groups of elders at risk of early mortality that may be useful also in clinical settings. Modifying determinants of favourably rating health, e.g. by increasing physical activity and/or by eliminating obesity, may be important for older adults to “feel healthy” and “be healthy”. © 2017
Published: 2017

10. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer

Author: Stefania Boccia, Wilbert H.M. Peters, Kristina Kjærheim, James McKay, Christopher I. Amos, David I. Conway, Dana Mates, Ana Maria Menezes, Antonio Agudo, Brenda Diergaarde, Rolando Herrero, Valerie Gaborieau, Martin Lacko, Cristina Canova, Neonila Szeszenia-Dąbrowska, Lorenzo Richiardi, Xiangjun Xiao, Victor Wünsch-Filho, Pagona Lagiou, David Zaridze, Maria Paula Curado, H. Bas Bueno-de-Mesquita, Mark C. Weissler, Rayjean J. Hung, Paolo Boffetta, Claire M. Healy, Marcos Brasilino de Carvalho, Fábio Daumas Nunes, Steve Thomas, Devasena Anantharaman, Paul Brennan, Mattias Johansson, Geoffrey Liu, Oxana Shangina, Ariana Znaor, Corina Lesseur, Eleonora Fabianova, Gabriella Cadoni, Andy R Ness, Eloiza H. Tajara, Gary J. Macfarlane, Jennifer R. Grandis, Annika Steffen, Jerry Polesel, Max Robinson, Marta Vilensky, Andrew F. Olshan, Wolfgang Ahrens, Silvia Franceschi, Amelie Chabrier, José Eluf-Neto, Jolanta Lissowska, Ivana Holcatova, Xavier Castellsagué, Nofer Institute of Occupational Medicine, Łódź, Poland, RS: GROW - R2 - Basic and Translational Cancer Biology, MUMC+: MA Keel Neus Oorheelkunde (9), Lesseur, C., Diergaarde, B., Olshan, A.F., Wünsch-Filho, V., Ness, A.R., Liu, G., Lacko, M., Eluf-Neto, J., Franceschi, S., Lagiou, P., Macfarlane, G.J., Richiardi, L., Boccia, S., Polesel, J., Kjaerheim, K., Zaridze, D., Johansson, M., Menezes, A.M., Curado, M.P., Robinson, M., Ahrens, W., Canova, C., Znaor, A., Castellsagué, X., Conway, D.I., Holcátová, I., Mates, D., Vilensky, M., Healy, C.M., Szeszenia-Dabrowska, N., Fabiánová, E., Lissowska, J., Grandis, J.R., Weissler, M.C., Tajara, E.H., Nunes, F.D., De Carvalho, M.B., Thomas, S., Hung, R.J., Peters, W.H.M., Herrero, R., Cadoni, G., Bueno-De-Mesquita, H.B., Steffen, A., Agudo, A., Shangina, O., Xiao, X., Gaborieau, V., Chabrier, A., Anantharaman, D., Boffetta, P., Amos, C.I., McKay, J.D., and Brennan, P.
Subjects: Male, 0301 basic medicine, Epidemiology, Genome-wide association study, Gastroenterology, Genome-wide association studies, INCIDÊNCIA, HLA Antigens, Genetics research, Aged, Case-Control Studies, Female, Genetic Markers, Genetic Variation, Haplotypes, Humans, Middle Aged, Mouth, Mouth Neoplasms, Papillomaviridae, Papillomavirus Infections, Pharyngeal Neoplasms, Genetic Predisposition to Disease, Genome-Wide Association Study, Genetics, Oral cancer, genetic research, 3. Good health, Settore MED/31 - OTORINOLARINGOIATRIA, medicine.medical_specialty, Papillomaviruses, Genome-wide - oral cavity and pharyngeal cancer, Human leukocyte antigen, Biology, Article, 03 medical and health sciences, Internal medicine, medicine, Allele, Papil·lomavirus, Haplotype, Case-control study, Odds ratio, oral cancer, medicine.disease, Càncer de boca, 030104 developmental biology, Nasopharyngeal carcinoma, Immunology, Imputation (genetics)
Abstract: We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers. Genotyping performed at the Center for Inherited Disease Research (CIDR) was funded through the U.S. National Institute of Dental and Craniofacial Research (NIDCR) grant 1X01HG007780-0. Genotyping for shared controls with the Lung OncoArray initiative was funded through the grant X01HG007492-0. Corina Lesseur undertook this work during the tenure of a Postdoctoral Fellowship awarded by the International Agency for Research on Cancer. The funders did not participate in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We acknowledge all of the participants involved in this research and the funders and support. We thank Dr. Leticia Fernandez (Instituto Nacional de Oncologia y Radiobiologia, La Habana, Cuba) for her contribution to the IARC ORC multicenter study. We are also grateful to Sergio Koifman (Escola Nacional de Saúde Pública, Rio de Janeiro, Brazil) for his contribution to the IARC Latin America multicenter study (Sergio Koifman passed away in May 2014) and to Xavier Castellsagué from the ARCAGE Barcelona Center who recently passed away (June 2016). The University of Pittsburgh head and neck cancer case-control study is supported by National Institutes of Health grants P50 CA097190 and P30 CA047904. The Carolina Head and Neck Cancer Study (CHANCE) was supported by the National Cancer Institute (R01-CA90731). The Head and Neck Genome Project (GENCAPO) was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (Grant numbers 04/12054-9 and 10/51168-0). The authors thank all the members of the GENCAPO team. The HN5000 study was funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research scheme (RP-PG-0707-10034), the views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. The Toronto study was funded by the Canadian Cancer Society Research Institute (020214) and the National Cancer Institute (U19 CA148127) and the Cancer Care Ontario Research Chair. The alcohol-related cancers and genetic susceptibility study in Europe (ARCAGE) was funded by the European Commission’s 5th Framework Program (QLK1-2001-00182), the Italian Association for Cancer Research, Compagnia di San Paolo/FIRMS, Region Piemonte, and Padova University (CPDA057222).The Rome Study was supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC) IG 2011 10491 and IG2013 14220 to SB, and Fondazione Veronesi to SB. The IARC Latin American study was funded by the European Commission INCO-DC programme (IC18-CT97-0222), with additional funding from Fondo para la Investigacion Cientifica y Tecnologica (Argentina) and the Fundação de Amparo à Pesquisa do Estado de São Paulo (01/01768-2). The IARC Central Europe study was supported by European Commission’s INCO-COPERNICUS Program (IC15-CT98-0332), NIH/National Cancer Institute grant CA92039, and the World Cancer Research Foundation grant WCRF 99A28.The IARC Oral Cancer Multicenter study was funded by: grant S06 96 202489 05F02 from Europe against Cancer; Grants FIS 97/0024, FIS 97/0662, and BAE 01/5013 from Fondo de Investigaciones Sanitarias, Spain; UICC Yamagiwa-Yoshida Memorial International Cancer Study; National Cancer Institute of Canada; Italian Association for Research on Cancer; and the Pan American Health Organization. The coordination of EPIC study is financially supported
Published: 2016

11. Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)

Author: Manal M. Hassan, Anthony B. Miller, E. A. Holly, Paolo Boffetta, Parviz Ghadirian, William R. Bamlet, Jerry Polesel, Ersilia Lucenteforte, C. La Vecchia, Michelle Cotterchio, Elizabeth T. H. Fontham, Steve Gallinger, Eric J. Duell, J. Su, Donghui Li, Bu Tian Ji, Debra T. Silverman, Paige M. Bracci, Witold Zatonski, R. Talamini, Eva Negri, Yu-Tang Gao, Patrick Maisonneuve, Cristina Bosetti, H. B. Bueno-de-Mesquita, Gloria M. Petersen, Peter A. Baghurst, Lucenteforte, E., La Vecchia, C., Silverman, D., Petersen, G.M., Bracci, P.M., Ji, B.T., Bosetti, C., Li, D., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E., Bamlet, W.R., Holly, E.A., Gao, Y.T., Negri, E., Hassan, M., Cotterchio, M., Su, J., Maisonneuve, P., Boffetta, P., Duell, E.J., International Prevention Research Institute (IPRI), The Tisch Cancer Institute, and Icahn School of Medicine at Mount Sinai [New York] (MSSM)
Subjects: Adult, Male, Oncology, medicine.medical_specialty, Pathology, alcohol drinking, case–control, studies, ethanol, pancreatic cancer, pooled analysis, risk factors, Alcohol, chemistry.chemical_compound, Internal medicine, Pancreatic cancer, Odds Ratio, medicine, Adult Aged Alcohol Drinking/*adverse effects Case-Control Studies Confounding Factors (Epidemiology) Female Humans Logistic Models Male Middle Aged Odds Ratio Pancreatic Neoplasms/*epidemiology/etiology Pancreatitis/complications Risk Factors Smoking/adverse effects, Humans, risk of pancreatic cancer, Aged, business.industry, Smoking, Confounding Factors, Epidemiologic, Original Articles, Hematology, Middle Aged, medicine.disease, Pancreatic Neoplasms, Logistic Models, Pooled analysis, Pancreatitis, chemistry, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, business, Alcohol consumption, heavy alcohol consumptio
Abstract: Lucenteforte, E La Vecchia, C Silverman, D Petersen, G M Bracci, P M Ji, B T Bosetti, C Li, D Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Bamlet, W R Holly, E A Gao, Y T Negri, E Hassan, M Cotterchio, M Su, J Maisonneuve, P Boffetta, P Duell, E J eng CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-CP-05225/CP/NCI NIH HHS/ N01-CP-05227/CP/NCI NIH HHS/ N01-CP-31022/CP/NCI NIH HHS/ N01-CP-51089/CP/NCI NIH HHS/ N01-CP-51090/CP/NCI NIH HHS/ N01-CP-51092/CP/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ Meta-Analysis Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't England 2011/05/04 06:00 Ann Oncol. 2012 Feb;23(2):374-82. doi: 10.1093/annonc/mdr120. Epub 2011 May 2.; International audience; BACKGROUND: Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved. METHODS: To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11,827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models. RESULTS: Compared with abstainers and occasional drinkers (< 1 drink per day), we observed no association for light-to-moderate alcohol consumption (/= 9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area. CONCLUSION: This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.
Published: 2012

12. Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Marina Touillaud, Rudolf Kaaks, Antonia Trichopoulou, Inger T. Gram, Roy Ehrnström, Nina Roswall, Paula Jakszyn, Ellen Kampman, Kay-Tee Khaw, Elio Riboli, H. Bas Bueno-de-Mesquita, Nerea Larrañaga, Marie-Christine Boutron-Ruault, Eva Ardanaz, Carmen Navarro, Kim Overvad, Eiliv Lund, Naomi E. Allen, Carla H. van Gils, Timothy J. Key, Laudina Rodríguez, Martine M. Ros, Paolo Vineis, María José Sánchez, Vicky Benetou, Lambertus A. Kiemeney, Sabina Sieri, Françoise Clavel-Chapelon, A. Naska, Frederike L. Büchner, Rosario Tumino, Lars Egevad, Nicholas J. Wareham, Mazda Jenab, Heiner Boeing, Jonas Manjer, Nadia Slimani, Anne Tjønneland, Petra H.M. Peeters, Fränzel J.B. Van Duijnhoven, Börje Ljungberg, Paolo Boffetta, Steffen Weikert, Domenico Palli, Jenny Chang-Claude, Salvatore Panico, Göran Hallmans, Büchner, F.L., Bueno-De-Mesquita, H.B., Ros, M.M., Kampman, E., Egevad, L., Overvad, K., Tjãnneland, A., Roswall, N., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Touillaud, M., Kaaks, R., Chang-Claude, J., Boeing, H., Weikert, S., Trichopoulou, A., Naska, A., Benetou, V., Palli, D., Sieri, S., Vineis, P., Tumino, R., Panico, S., Van Duijnhoven, F.J.B., Peeters, P.H.M., Van Gils, C.H., Lund, E., Gram, I.T., Sánchez, M.-J., Jakszyn, P., Larrañaga, N., Ardanaz, E., Navarro, C., Rodríguez, L., Manjer, J., Ehrnström, R., Hallmans, G., Ljungberg, B., Key, T.J., Allen, N.E., Khaw, K.-T., Wareham, N., Slimani, N., Jenab, M., Boffetta, P., Kiemeney, L.A.L.M., and Riboli, E.
Subjects: Male, Cancer Research, validity, Nutrition and Disease, Colorectal cancer, pharyngeal cancer, Food group, 0302 clinical medicine, Risk Factors, diet diversity, Voeding en Ziekte, Vegetables, vegetable, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, bladder, risk, 2. Zero hunger, Hazard ratio, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, 030220 oncology & carcinogenesis, food groups, Female, colon-cancer, medicine.medical_specialty, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, Translational research [ONCOL 3], Environmental health, medicine, cancer, Humans, consumption, Risk factor, Life Style, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], VLAG, Gynecology, Bladder cancer, business.industry, cigarette-smoking, questionnaire, colorectal-cancer, Cancer, medicine.disease, Diet, Urinary Bladder Neoplasms, Fruit, business
Abstract: Contains fulltext : 97508.pdf (Publisher’s version ) (Closed access) Recent research does not show an association between fruit and vegetable consumption and bladder cancer risk. None of these studies investigated variety in fruit and vegetable consumption, which may capture different aspects of consumption. We investigated whether a varied consumption of vegetables and fruits is associated with bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Detailed data on food consumption and complete follow-up for cancer incidence were available for 452,185 participants, who were recruited from ten European countries. After a mean follow-up of 8.7 years, 874 participants were diagnosed with bladder cancer. Diet diversity scores (DDSs) were used to quantify the variety in fruit and vegetable consumption. Multivariable Cox proportional hazard models were used to assess the effect of the DDSs on bladder cancer risk. There was no evidence of a statistically significant association between bladder cancer risk and any of the DDSs when these scores were considered as continuous covariates. However, the hazard ratio (HR) for the highest tertile of the DDS for combined fruit and vegetable consumption was marginally significant compared to the lowest (HR = 1.30, 95% confidence interval: 1.00-1.69, p-trend = 0.05). In EPIC, there is no clear association between a varied fruit and vegetable consumption and bladder cancer risk. This finding provides further evidence for the absence of any strong association between fruit and vegetable consumption as measured by a food frequency questionnaire and bladder cancer risk.
Published: 2011

13. Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-Control Study

Author: Peter Boyle, Albert B. Lowenfels, Peter A. Baghurst, Witold Zatonski, H. Bas Bueno-de-Mesquita, Eric J. Duell, Paolo Boffetta, Parviz Ghadirian, Anthony B. Miller, Patrick Maisonneuve, Maisonneuve, P., Lowenfels, A.B., Bueno-de-Mesquita, H.B., Ghadirian, P., Baghurst, P.A., Zatonski, W.A., Miller, A.B., Duell, E.J., Boffetta, P., and Boyle, P.
Subjects: Adult, Male, Canada, medicine.medical_specialty, Epidemiology, Population, Diabete, Allergie, Risk Factors, Internal medicine, Pancreatic cancer, Diabetes Mellitus, Humans, Medicine, Pancreas Cancer, education, Aged, Netherlands, Aged, 80 and over, education.field_of_study, Past medical history, Pancreatiti, business.industry, Smoking, Australia, Past Medical History, Case-control study, Cancer, Odds ratio, Middle Aged, medicine.disease, Multicenter Case-Control Study, Surgery, Pancreatic Neoplasms, Pancreatitis, Case-Control Studies, Female, Poland, business, Risk assessment
Abstract: Purpose: To investigate risk factors that may be linked to pancreatic cancer. Methods: We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland. Results: After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23 - 9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18 - 74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60 - 2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56 - 12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50 - 0.82). Conclusions: Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer. © 2010 Elsevier Inc. All rights reserved.
Published: 2010

14. Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Anne Tjønneland, Carlos González, Ole Raaschou-Nielsen, Marina Touillaud, Sabina Sieri, Françoise Clavel-Chapelon, Salvatore Panico, Lambertus A. Kiemeney, Jonas Manjer, Pagona Lagiou, Rudolf Kaaks, Dimitrios Trichopoulos, Nina Roswall, Andrew W. Roddam, Carla H. van Gils, Inger T. Gram, Steffen Weikert, Frederike L. Büchner, Kim Overvad, Paolo Vineis, Roy Ehrnström, Eva Ardanaz, Nadia Slimani, Martine M. Ros, H. Bas Bueno-de-Mesquita, Sheila Bingham, Traci Mouw, Eiliv Lund, Antonia Trichopoulou, Laudina Rodríguez, Göran Hallmans, Lars Egevad, Ellen Kampman, Rosario Tumino, Carmen Enid Martínez, Heiner Boeing, Kay-Tee Khaw, Marie-Christine Boutron-Ruault, Domenico Palli, Dagrun Engeset, Jenny Chang-Claude, Mazda Jenab, Dominique S. Michaud, Carmen Navarro, Naomi E. Allen, Petra H.M. Peeters, Nerea Larrañaga, Elio Riboli, Alina Vrieling, Börje Ljungberg, Paolo Boffetta, Büchner, F.L., Bueno-De-Mesquita, H.B., Ros, M.M., Kampman, E., Egevad, L., Overvad, K., Raaschou-Nielsen, O., Tjønneland, A., Roswall, N., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Touillaud, M., Chang-Claude, J., Kaaks, R., Boeing, H., Weikert, S., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Vineis, P., Tumino, R., Panico, S., Vrieling, A., Peeters, P.H.M., Van Gils, C.H., Lund, E., Gram, I.T., Engeset, D., Martinez, C., Gonzalez, C.A., Larrañaga, N., Ardanaz, E., Navarro, C., Rodríguez, L., Manjer, J., Ehrnström, R.A., Hallmans, G., Ljungberg, B., Allen, N.E., Roddam, A.W., Bingham, S., Khaw, K.-T., Slimani, N., Boffetta, P., Jenab, M., Mouw, T., Michaud, D.S., Kiemeney, L.A.L.M., Riboli, E., Büchner, Fl, Bueno de Mesquita, Hb, Ros, Mm, Kampman, E, Egevad, L, Overvad, K, Raaschou Nielsen, O, Tjønneland, A, Roswall, N, Clavel Chapelon, F, Boutron Ruault, Mc, Touillaud, M, Chang Claude, J, Kaaks, R, Boeing, H, Weikert, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Sieri, S, Vineis, P, Tumino, R, Panico, Salvatore, Vrieling, A, Peeters, Ph, van Gils, Ch, Lund, E, Gram, It, Engeset, D, Martinez, C, Gonzalez, Ca, Larrañaga, N, Ardanaz, E, Navarro, C, Rodríguez, L, Manjer, J, Ehrnström, Ra, Hallmans, G, Ljungberg, B, Allen, Ne, Roddam, Aw, Bingham, S, Khaw, Kt, Slimani, N, Boffetta, P, Jenab, M, Mouw, T, Michaud, D, and Kiemeney, La
Subjects: Male, Cancer Research, Nutrition and Disease, Aetiology, screening and detection [ONCOL 5], Cohort Studies, 0302 clinical medicine, Risk Factors, Voeding en Ziekte, Vegetables, Epidemiology, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, 2. Zero hunger, carotenoids, Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Oncology, 030220 oncology & carcinogenesis, Female, epidemiology, vitamin-c, Cohort study, Adult, medicine.medical_specialty, prospective cohort, consumption vegetables fruit risk bladder cancer European Prospective Investigation Cancer Nutrition, folate, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, Translational research [ONCOL 3], Environmental health, medicine, Humans, Risk factor, Aged, VLAG, Consumption (economics), Gynecology, Bladder cancer, Hereditary cancer and cancer-related syndromes [ONCOL 1], cigarette-smoking, business.industry, food, Cancer, medicine.disease, Urinary Bladder Neoplasms, Fruit, diet, business, Follow-Up Studies
Abstract: Contains fulltext : 81056.pdf (Publisher’s version ) (Closed access) Previous epidemiologic studies found inconsistent associations between vegetables and fruit consumption and the risk of bladder cancer. We therefore investigated the association between vegetable and fruit consumption and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Data on food consumption and complete follow-up for cancer occurrence was available for a total of 478,533 participants, who were recruited in 10 European countries. Estimates of rate ratios were obtained by Cox proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, duration of smoking and lifetime intensity of smoking. A calibration study in a subsample was used to control for dietary measurement errors. After a mean follow-up of 8.7 years, 1015 participants were newly diagnosed with bladder cancer. Increments of 100 g/day in fruit and vegetable consumption combined did not affect bladder cancer risk (i.e., calibrated HR = 0.98; 95%CI: 0.95-1.01). Borderline statistically significant lower bladder cancer risks were found among never smokers with increased consumption of fruit and vegetables combined (HR = 0.94 95%CI: 0.87-1.00 with increments of 100 g/day; calibrated HR = 0.92 95%CI 0.79-1.06) and increased consumption of apples and pears (hard fruit; calibrated HR = 0.90 95%CI: 0.82-0.98 with increments of 25 g/day). For none of the associations a statistically significant interaction with smoking status was found. Our findings do not support an effect of fruit and vegetable consumption, combined or separately, on bladder cancer risk.
Published: 2009

15. Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition

Author: Göran Hallmanns, Claudia Agnoli, Carlos A. González, H. Bas Bueno-de-Mesquita, Matthias B. Schulze, Thomas Dietrich, Sabine Rohrmann, Petra H.M. Peeters, María Dolores Chirlaque, Jonas Manjer, Domenico Palli, Jakob Stegger, Paolo Vineis, Björn Lindkvist, Elizabeth A Spencer, Esther Molina, Elio Riboli, Eiliv Lund, J. Ramón Quirós, Amalia Mattiello, Kim Overvad, Pilar Amiano, Rosario Tumino, Tobias Pischon, Anne Tjønneland, Heiner Boeing, Anne M. May, Paolo Boffetta, Rudolf Kaaks, Aurelio Barricarte, Jytte Halkjær, Gesthimani Misirli, Sheila Bingham, Roger Stenling, Annika Steffen, Naomi E. Allen, Steffen, A., Schulze, M.B., Pischon, T., Dietrich, T., Molina, E., Chirlaque, M.-D., Barricarte, A., Amiano, P., Quirós, J.R., Tumino, R., Mattiello, A., Palli, D., Vineis, P., Agnoli, C., Misirli, G., Boffetta, P., Kaaks, R., Rohrmann, S., Bueno-de-Mesquita, H.B., Peeters, P.H.M., May, A.M., Spencer, E.A., Allen, N.E., Bingham, S., Tjønneland, A., Halkjær, J., Overvad, K., Stegger, J., Manjer, J., Lindkvist, B., Hallmanns, G., Stenling, R., Lund, E., Riboli, E., Gonzalez, C.A., and Boeing, H.
Subjects: Adult, Male, Risk, medicine.medical_specialty, Waist, Esophageal Neoplasms, Epidemiology, Adenocarcinoma, Gastroenterology, Body Mass Index, Surveys and Questionnaires, Internal medicine, medicine, Humans, Anthropometry esophageal cancer risk European prospective investigation cancer nutrition, Obesity, Prospective Studies, Risk factor, Life Style, Abdominal obesity, Aged, Proportional Hazards Models, Anthropometry, Waist-Hip Ratio, business.industry, nutritional and metabolic diseases, Feeding Behavior, Middle Aged, Confidence interval, Surgery, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Relative risk, Body Composition, Carcinoma, Squamous Cell, Female, medicine.symptom, business, Body mass index, Follow-Up Studies
Abstract: Background: Increasing evidence suggests that general obesity [measured by body mass index (BMI)] is positively associated with risk of esophageal adenocarcinoma (EAC). In contrast, previous studies have shown inverse relations with esophageal squamous cell carcinoma (ESCC). However, it is still unclear whether body fat distribution, particularly abdominal obesity, is associated with each type of esophageal cancer.Methods: We applied multivariable adjusted Cox proportional hazards regression to investigate the association between anthropometric measures and risk of EAC and ESCC among 346,554 men and women participating in the European Prospective Investigation into Cancer and Nutrition. All statistical tests were two sided.Results: During 8.9 years of follow-up, we documented 88 incident cases of EAC and 110 cases of ESCC. BMI, waist circumference, and waist-to-hip ratio (WHR) were positively associated with EAC risk [highest versus lowest quintile; relative risk (RR), 2.60; 95% confidence interval (95% CI), 1.23-5.51; Ptrend < 0.01; RR, 3.07; 95% CI, 1.35-6.98; Ptrend < 0.003; and RR, 2.12; 95% CI, 0.98-4.57; Ptrend < 0.004]. In contrast, BMI and waist circumference were inversely related to ESCC risk, whereas WHR showed no association with ESCC. In stratified analyses, BMI and waist circumference were significantly inversely related to ESCC only among smokers but not among nonsmokers. However, when controlled for BMI, we found positive associations for waist circumference and WHR with ESCC, and these associations were observed among smokers and nonsmokers.Conclusion: General and abdominal obesity were associated with higher EAC risk. Further, our study suggests that particularly an abdominal body fat distribution might also be a risk factor for ESCC. (Cancer Epidemiol Biomarkers Prev 2009;18(7):2079–89)
Published: 2009

16. Cigarette Smoking and Pancreatic Cancer: A Pooled Analysis From the Pancreatic Cancer Cohort Consortium

Author: Patricia Hartge, Charles Kooperberg, Karen C. Johnson, Kathy J. Helzlsouer, Jarmo Virtamo, Geoffrey S. Tobias, Paolo Boffetta, Gilles Thomas, Laudina Rodríguez Suárez, Demetrius Albanes, Elio Riboli, Alan A. Arslan, Sandra Clipp, Federico Canzian, Emily Steplowski, Peter Kraft, H. Bas Bueno-de-Mesquita, Stephen J. Chanock, Kevin B. Jacobs, Elissa Tong, Robert N. Hoover, Rachael Z. Stolzenberg-Solomon, Alina Vrieling, Eric J. Jacobs, Marie-Christine Boutron-Ruault, Sheila Bingham, Jay H. Lubin, Alpa V. Patel, Catherine R. Messina, Julie B. Mendelsohn, Myron D. Gross, Juhua Luo, Laufey T. Amundadottir, Gloria M. Petersen, Xiao-Ou Shu, Andrea Z. LaCroix, Anne Zeleniuch-Jacquette, Anne Tjønneland, Shannon M. Lynch, Domenico Palli, Kai Yu, Dimitrios Trichopoulos, Weimin Ye, Wei Zheng, Lynch, S.M., Vrieling, A., Lubin, J.H., Kraft, P., Mendelsohn, J.B., Hartge, P., Canzian, F., Steplowski, E., Arslan, A.A., Gross, M., Helzlsouer, K., Jacobs, E.J., Lacroix, A., Petersen, G., Zheng, W., Albanes, D., Amundadottir, L., Bingham, S.A., Boffetta, P., Boutron-Ruault, M.-C., Chanock, S.J., Clipp, S., Hoover, R.N., Jacobs, K., Johnson, K.C., Kooperberg, C., Luo, J., Messina, C., Palli, D., Patel, A.V., Riboli, E., Shu, X.-O., Rodriguez Suarez, L., Thomas, G., Tjønneland, A., Tobias, G.S., Tong, E., Trichopoulos, D., Virtamo, J., Ye, W., Yu, K., Zeleniuch-Jacquette, A., Bueno-De-Mesquita, H.B., and Stolzenberg-Solomon, R.Z.
Subjects: Male, Pancreatic disease, Epidemiology, medicine.medical_treatment, Medical and Health Sciences, Mathematical Sciences, Cohort Studies, 80 and over, Medicine, pancreas, Prospective Studies, Cancer, Aged, 80 and over, Smoking, pancreatic neoplasms, Middle Aged, pancreas, pancreatic neoplasms, smoking, tobacco use cessation, Cohort, Female, Cohort study, Adult, Risk, medicine.medical_specialty, Meta- and Pooled Analyses, Adenocarcinoma, smoking, Pancreatic Cancer, Rare Diseases, tobacco use cessation, Internal medicine, Pancreatic cancer, Tobacco, Humans, Risk factor, Aged, Tobacco Smoke and Health, business.industry, Prevention, Odds ratio, medicine.disease, United States, Confidence interval, Surgery, Pancreatic Neoplasms, Case-Control Studies, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Smoking cessation, Smoking Cessation, Digestive Diseases, business
Abstract: Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic cancer is limited. The authors analyzed pooled data from the international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression. Smoking intensity effects were examined with an excess odds ratio model that was linear in pack-years and exponential in cigarettes smoked per day and its square. When compared with never smokers, current smokers had a significantly elevated risk (odds ratio (OR)=1.77, 95% confidence interval (CI): 1.38, 2.26). Risk increased significantly with greater intensity (=30 cigarettes/day: OR=1.75, 95% CI: 1.27, 2.42), duration (=50 years: OR=2.13, 95% CI: 1.25, 3.62), and cumulative smoking dose (=40 pack-years: OR=1.78, 95% CI: 1.35, 2.34). Risk more than 15 years after smoking cessation was similar to that for never smokers. Estimates of excess odds ratio per pack-year declined with increasing intensity, suggesting greater risk for total exposure delivered at lower intensity for longer duration than for higher intensity for shorter duration. This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis. © 2009. Published by the Johns Hopkins Bloomberg School of Public Health.
Published: 2009

17. Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author: Kim Overvad, H. Bas Bueno-de-Mesquita, Zilis Dimosthenes, Elio Riboli, Dominique S. Michaud, Göran Hallmans, Sabina Sieri, Bas A.J. Verhage, Carla H. van Gils, Rudolf Kaaks, Paolo Boffetta, Eric J. Duell, Laudina Rodríguez Suárez, Domenico Palli, Amalia Mattiello, Françoise Clavel-Chapelon, Jonas Manjer, Petra H.M. Peeters, Eiliv Lund, Dagrun Engeset, Weimin Ye, Alina Vrieling, Mazda Jenab, Fränzel J.B. Van Duijnhoven, Sheila Bingham, Björn Lindkvist, Antonia Trichopoulou, Sabine Rohrmann, Anja Olsen, Eva Ardanaz, María José Sánchez, Heiner Boeing, Nerea Larrañaga, Anne Tjønneland, María Dolores Chirlaque, Kay-Tee Khaw, Tountas John, Rosario Tumino, Ute Nöthlings, Paolo Vineis, Paula Jakszyn, Marie-Christine Boutron-Ruault, Timothy J. Key, Andrew W. Roddam, Vrieling, A., Verhage, B.A.J., Van Duijnhoven, F.J.B., Jenab, M., Overvad, K., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Kaaks, R., Rohrmann, S., Boeing, H., Nöthlings, U., Trichopoulou, A., John, T., Dimosthenes, Z., Palli, D., Sieri, S., Mattiello, A., Tumino, R., Vineis, P., Van Gils, C.H., Peeters, P.H.M., Engeset, D., Lund, E., Suárez, L.R., Jakszyn, P., Larrañaga, N., Sánchez, M.-J., Chirlaque, M.-D., Ardanaz, E., Manjer, J., Lindkvist, B., Hallmans, G., Ye, W., Bingham, S., Khaw, K.-T., Roddam, A., Key, T., Boffetta, P., Duell, E.J., Michaud, D.S., Riboli, E., and Bueno-de-Mesquita, H.B.
Subjects: Male, Risk, Cancer Research, medicine.medical_specialty, Nutritional Sciences, Lower risk, Cohort Studies, Environmental health, Internal medicine, Vegetables, medicine, Humans, vegetable, Risk factor, Prospective cohort study, Aged, Proportional Hazards Models, business.industry, Smoking, Hazard ratio, pancreatic cancer risk, Cancer, Middle Aged, medicine.disease, Diet, European Prospective Investigation into Cancer and Nutrition, Europe, Pancreatic Neoplasms, Endocrinology, Oncology, Fruit, Exocrine pancreatic cancer, Female, business, Cohort study
Abstract: Udgivelsesdato: 2008-Nov-7 Many case-control studies have suggested that higher consumption of fruit and vegetables is associated with a lower risk of pancreatic cancer, whereas cohort studies do not support such an association. We examined the associations of the consumption of fruits and vegetables and their main subgroups with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is comprised of over 520,000 subjects recruited from 10 European countries. The present study included 555 exocrine pancreatic cancer cases after an average follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models, stratified by age at recruitment, gender, and study center, and adjusted for total energy intake, weight, height, history of diabetes mellitus, and smoking status. Total consumption of fruit and vegetables, combined or separately, as well as subgroups of vegetables and fruits were unrelated to risk of pancreatic cancer. Hazard ratios (95% CI) for the highest versus the lowest quartile were 0.92 (0.68-1.25) for total fruit and vegetables combined, 0.99 (0.73-1.33) for total vegetables, and 1.02 (0.77-1.36) for total fruits. Stratification by gender or smoking status, restriction to microscopically verified cases, and exclusion of the first 2 years of follow-up did not materially change the results. These results from a large European prospective cohort suggest that higher consumption of fruit and vegetables is not associated with decreased risk of pancreatic cancer. (c) 2008 Wiley-Liss, Inc.
Published: 2009

18. Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition

Author: María Dolores Chirlaque, Rudolf Kaaks, Valentina Gallo, Sara Grioni, Nikolaus Becker, Aneire E. Khan, Martine M. Ros, Anne Tjønneland, Amalia Mattiello, Roel Vermeulen, Naomi E. Allen, Åsa Ågren, Petra H.M. Peeters, Vasiliki Benetou, H. Bas Bueno-de-Mesquita, Nerea Larrañaga, Ole Raaschou-Nielsen, Jakob Linseisen, Kim Overvad, Nadia Slimani, Teresa Norat, Eiliv Lund, Eva Ardanaz, Paula Jakszyn, Hans Erik Johnsen, Giovanna Masala, Elio Riboli, Manuela M. Bergmann, Göran Hallmans, Heiner Boeing, Kay-Tee Khaw, Alexandra Nieters, Göran Berglund, Adamina Losada, Sheila Bingham, Antonia Trichopoulou, Jonas Manjer, Sabine Rohrmann, Theodora Psaltopoulou, Paolo Boffetta, Paolo Vineis, Carmen Martinez-Garcia, Rosario Tumino, Pietro Ferrari, Timothy J. Key, Khan, A.E., Gallo, V., Linseisen, J., Kaaks, R., Rohrmann, S., Raaschou-Nielsen, O., Tjønneland, A., Johnsen, H.E., Overvad, K., Bergmann, M.M., Boeing, H., Benetou, V., Psaltopoulou, T., Trichopoulou, A., Masala, G., Mattiello, A., Grioni, S., Tumino, R., Vermeulen, R.C.H., Peeters, P.H.M., Bueno-de-Mesquita, H.B., Ros, M.M., Lund, E., Ardanaz, E., Chirlaque, M.-D., Jakszyn, P., Larrañaga, N., Losada, A., Becker, N., Nieters, A., Martínez-García, C., Ågren, Å., Hallmans, G., Berglund, G., Manjer, J., Allen, N.E., Key, T.J., Bingham, S., Khaw, K.T., Slimani, N., Ferrari, P., Boffetta, P., Norat, T., Vineis, P., and Riboli, E.
Subjects: Adult, Male, Risk, Oncology, medicine.medical_specialty, Diabetes risk non-Hodgkin's lymphoma multiple myeloma European Prospective Investigation Cancer Nutrition, Nutritional Sciences, Comorbidity, Diabetes Complications, immune system diseases, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Prospective Studies, ddc:610, Risk factor, Prospective cohort study, Multiple myeloma, Aged, Hematology, business.industry, Lymphoma, Non-Hodgkin, Cancer, Middle Aged, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Lymphoma, Non-Hodgkin's lymphoma, Europe, Diabetes Mellitus, Type 2, Immunology, Female, Multiple Myeloma, business, Follow-Up Studies
Abstract: Background: Non-Hodgkin's lymphomas are a heterogeneous group of neoplasms arising from the lymphopoietic system including a wide range of subtypes of either B-cell or T-cell lymphomas. The few established risk factors for the development of these neoplasms include viral infections and immunological abnormalities, but their etiology remains largely unknown. Evidence suggests that certain medical conditions may be linked, through immunosuppression, to the risk of non-Hodgkin's lymphoma. Multiple myeloma is a neoplasm of plasma cells that accounts for approximately 15% of lymphopoietic cancers. Increases in the incidence of non-Hodgkin's lymphoma and multiple myeloma in the past implicate environmental factors as potential causal agents. Design and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,213 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma (594 men; 619 women) were identified during a follow-up of 8.5 years. Cox proportional hazard models were used to explore the association between self-reported diabetes, diagnosed after 30 years of age, and the risk of non-Hodgkin's lymphoma overall and multiple myeloma and various lymphoma subtypes. Results: We found no association between a personal history of diabetes and the risk of non-Hodgkin's lymphoma overall in men (HR: 1.28, 95% CI: 0.89-1.84), in women (HR: 0.71, 95% CI: 0.41-1.24), or in men and women combined (HR: 1.09, 95% CI: 0.80-1.47). Among the B-non-Hodgkin's lymphoma subtypes, we observed a statistically significant increased risk of B-cell chronic lymphocytic leukemia (HR: 2.0, 95% CI: 1.04-3.86) in men, but not in women (HR: 1.07, 95% CI: 0.33-3.43). Conclusions: This prospective study did not provide evidence for a role of self-reported diabetes in the etiology of non-Hodgkin's lymphoma overall or multiple myeloma. We found an increased risk of B-cell chronic lymphocytic leukemia among men with diabetes, but not among women. We hypothesize that diabetes may not play a causal role in the etiology of B-cell chronic lymphocytic leukemia, though the underlying pathogenic mechanisms of both disorders may include shared genetic, host and/or environmental susceptibility factors. ©2008 Ferrata Storti Foundation.
Published: 2008

19. Modified Mediterranean diet and survival after myocardial infarction

Author: Y. T. van der Schouw, Philippos Orfanos, B. Van Guelpen, V. Pala, C. A. Gonzalez, Petra H.M. Peeters, Anne Tjønneland, María José Sánchez, Antonia Trichopoulou, Vassiliki Benetou, S Bingham, Timothy J. Key, S. Rohrmann, Theodora Psaltopoulou, Kay-Tee Khaw, Christina Bamia, Kim Overvad, Erik Berg Schmidt, Concha Moreno, Nerea Larrañaga, F. Clavel-Chapelon, J. Linseisen, Salvatore Panico, J. H. Jansson, M. C. Boutron-Ruault, M-D Chirlaque, Teresa Norat, Giovanna Masala, Jytte Halkjær, Cornelia Weikert, H. Boeing, Paolo Boffetta, Dimitrios Trichopoulos, R. Tumino, Carlotta Sacerdote, Marga C. Ocké, Marie-Noël Vercambre, H. B. Bueno-De-Mesquita, Elio Riboli, E. A. Spencer, Trichopoulou, A, Bamia, C, Norat, T, Overvad, K, Schmidt, Eb, Tjonneland, A, Halkjaer, J, CLAVEL CHAPELON, F, Vercambre, Mn, BOUTRON RUAULT, Mc, Linseisen, J, Rohrmann, S, Boeing, H, Weikert, C, Benetou, V, Psaltopoulou, T, Orfanos, P, Boffetta, P, Masala, G, Pala, V, Panico, Salvatore, Tumino, R, Sacerdote, C, BUENO DE MESQUITA, Hb, Ocke, Mc, Peeters, Ph, VAN DER SCHOUW, Yt, Gonzalez, C, Sanchez, Mj, Chirlaque, Md, Moreno, C, Larranaga, N, VAN GUELPEN, B, Jansson, Jh, Bingham, S, Khaw, Kt, Spencer, Ea, Key, T, Riboli, E, Trichopoulos, D., Trichopoulou, A., Bamia, C., Norat, T., Overvad, K., Schmidt, E.B., Tjønneland, A., Halkjær, J., Clavel-Chapelon, F., Vercambre, M.-N., Boutron-Ruault, M.-C., Linseisen, J., Rohrmann, S., Boeing, H., Weikert, C., Benetou, V., Psaltopoulou, T., Orfanos, P., Boffetta, P., Masala, G., Pala, V., Panico, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, H.B., Ocke, M.C., Peeters, P.H., Van Der Schouw, Y.T., González, C., Sanchez, M.J., Chirlaque, M.D., Moreno, C., Larrañaga, N., Van Guelpen, B., Jansson, J.-H., Bingham, S., Khaw, K.-T., Spencer, E.A., Key, T., Riboli, E., and University of Groningen
Subjects: Male, COUNTRIES, medicine.medical_specialty, Mediterranean diet, Epidemiology, ALCOHOL, Diet, Mediterranean, survival, elderly, Modified Mediterranean diet survival myocardial infarction EPIC-Elderly study, Food group, PEOPLE, medicine, Humans, CORONARY-HEART-DISEASE, COHORT, Prospective Studies, Myocardial infarction, ddc:610, Survival rate, Aged, Proportional Hazards Models, RISK, business.industry, Proportional hazards model, Mortality rate, MORTALITY, Middle Aged, Nutrition Surveys, medicine.disease, CANCER, European Prospective Investigation into Cancer and Nutrition, Surgery, Europe, Survival Rate, Standardized mortality ratio, myocardial infarction, Female, NUTRITION, business, FOLLOW-UP, Demography
Abstract: Mediterranean diet is associated with lower incidence of coronary heart disease, and two randomised trials indicated that it improves prognosis of coronary patients. These trials, however, relied on a total of 100 deaths and evaluated designer diets in the clinical context. We have evaluated the association of adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, with survival among elderly with previous myocardial infarction within the European Prospective Investigation into Cancer and nutrition (EPIC) study. As of December 2003, after a median follow-up of 6.7 years, 2671 EPIC participants from nine countries were 60 years or older and had prevalent myocardial infarction but no stroke or cancer at enrolment, complete information on dietary intakes and important covariates and known survival status. Adherence to the modified Mediterranean diet was assessed through a 10-unit-scale. Mortality ratio in relation to modified Mediterranean diet was estimated through Cox regression controlling for possible confounding. Increased adherence to modified Mediterranean diet by two units was associated with 18% lower overall mortality rate (95% confidence interval 7-27%, fixed effects model). There was no significant heterogeneity by sex, age at enrolment, or country, although the association tended to be less evident among northern Europeans. Associations between food groups contributing to the modified Mediterranean diet and mortality were generally weak. A diet inspired by the Mediterranean pattern that can be easily adopted by Western populations is associated with substantial reduction of total mortality of coronary patients in the community. © 2007 Springer Science+Business Media B.V.
Published: 2007

20. Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Nadia Slimani, Heiner Boeing, Eva Ardanaz, Jonas Manjer, Kim Overvad, Elio Riboli, Göran Berglund, Giovanna Masala, María Dolores Chirlaque, Kay-Tee Khaw, Carla H. van Gils, Hans Erik Johnsen, Nerea Larrañaga, Pietro Ferrari, Petra H.M. Peeters, Sheila Bingham, Martine M. Ros, Theodora Psaltopoulou, Antonia Trichopoulou, Thomas Rüdiger, Rosario Tumino, H. Bas Bueno-de-Mesquita, Eiliv Lund, Teresa Norat, Amalia Mattiello, Timothy J. Key, Vasiliki Benetou, Alexandra Nieters, Adamina Losada, Paolo Vineis, Paula Jakszyn, Jakob Linseisen, Rudolf Kaaks, Naomi E. Allen, Nikolaus Becker, Carmen Martinez-Garcia, Sabine Rohrmann, Anne Tjønneland, Vittorio Krogh, Ole Raaschou-Nielsen, Manuela M. Bergmann, Göran Hallmans, Paolo Boffetta, Åsa Ågren, Rohrmann, S., Becker, N., Linseisen, J., Nieters, A., Rüdiger, T., Raaschou-Nielsen, O., Tjønneland, A., Johnsen, H.E., Overvad, K., Kaaks, R., Bergmann, M.M., Boeing, H., Benetou, V., Psaltopoulou, T., Trichopoulou, A., Masala, G., Mattiello, A., Krogh, V., Tumino, R., Gils, C.H.V., Peeters, P.H.M., Bueno-De-Mesquita, H.B., Ros, M.M., Lund, E., Ardanaz, E., Chirlaque, M.-D., Jakszyn, P., Larrañaga, N., Losada, A., Martínez-García, C., Ågren, Å., Hallmans, G., Berglund, G., Manjer, J., Allen, N.E., Key, T.J., Bingham, S., Khaw, K.T., Slimani, N., Ferrari, P., Boffetta, P., Norat, T., Vineis, P., and Riboli, E.
Subjects: Male, Oncology, Cancer Research, medicine.medical_specialty, Lymphoma, Cohort Studies, Risk Factors, hemic and lymphatic diseases, Internal medicine, Vegetables, Fruit vegetable consumption lymphoma risk European Prospective Investigation Cancer Nutrition (EPIC), Epidemiology, medicine, Humans, ddc:610, Prospective cohort study, business.industry, Incidence, Incidence (epidemiology), Hazard ratio, Feeding Behavior, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Europe, Quartile, Fruit, Immunology, Female, business, Cohort study
Abstract: Introduction: Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology. Material and methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphoma cases were identified in a median follow-up period of 6.4 years. Fruit and vegetable consumption was estimated from validated dietary questionnaires. Cox proportional hazard models were used to examine the association between fruit and vegetable intake with the risk of lymphomas overall and subentities. Results: There was no overall association between total fruit and vegetable consumption and risk of lymphoma [hazard ratio (HR) = 0.95, 95% confidence interval (CI) 0.78-1.15 comparing highest with lowest quartile]. However, the risk of diffuse large B-cell lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR = 0.49, 95% CI 0.23-1.02). Conclusion: In this large prospective study, an inverse associations between fruit and vegetable consumption and risk of lymphomas overall could not be confirmed. Associations with lymphoma subentities such as DLBCL warrant further investigation. © 2007 Springer Science+Business Media B.V.
Published: 2007

21. Lung cancer risk among bricklayers in a pooled analysis of case-control studies

Author: Consonni, Dario, De Matteis, Sara, Pesatori, Angela C, Bertazzi, Pier Alberto, Olsson, Ann C, Kromhout, Hans, Peters, Susan, Vermeulen, Roel Ch, Pesch, Beate, Brüning, Thomas, Kendzia, Benjamin, Behrens, Thomas, Stücker, Isabelle, Guida, Florence, Wichmann, Heinz-Erich, Brüske, Irene, Landi, Maria Teresa, Caporaso, Neil E, Gustavsson, Per, Plato, Nils, Tse, Lap Ah, Yu, Ignatius Tak-Sun, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Merletti, Franco, Richiardi, Lorenzo, Simonato, Lorenzo, Forastiere, Francesco, Siemiatycki, Jack, Parent, Marie-Élise, Tardón, Adonina, Boffetta, Paolo, Zaridze, David, Chen, Ying, Field, John K, 't Mannetje, Andrea, Pearce, Neil, McLaughlin, John, Demers, Paul, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Rudnai, Peter, Fabiánová, Eleonóra, Stanescu Dumitru, Rodica, Bueno-de-Mesquita, Bas, Schüz, Joachim, Straif, Kurt, Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), Consonni, D. and De Matteis, S. and Pesatori, A.C. and Bertazzi, P.A. and Olsson, A.C. and Kromhout, H. and Peters, S. and Vermeulen, R.C.H. and Pesch, B. and Brüning, T. and Kendzia, B. and Behrens, T. and Stücker, I. and Guida, F. and Wichmann, H.-E. and Brüske, I. and Landi, M.T. and Caporaso, N.E. and Gustavsson, P. and Plato, N. and Tse, L.A. and Yu, I.T.-S. and Jöckel, K.-H. and Ahrens, W. and Pohlabeln, H. and Merletti, F. and Richiardi, L. and Simonato, L. and Forastiere, F. and Siemiatycki, J. and Parent, M.-É. and Tardón, A. and Boffetta, P. and Zaridze, D. and Chen, Y. and Field, J.K. and Mannetje, A. and Pearce, N. and McLaughlin, J. and Demers, P. and Lissowska, J. and Szeszenia-Dabrowska, N. and Bencko, V. and Foretova, L. and Janout, V. and Rudnai, P. and Fabiánová, E. and Dumitru, R.S. and Bueno-De-Mesquita, H.B. and Schüz, J. and Straif, K., Courcelles, Michel, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Università degli Studi di Milano = University of Milan (UNIMI), Imperial College London, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Institute for Risk Assessment Sciences, Utrecht University [Utrecht], The University of Western Australia (UWA), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), The Chinese University of Hong Kong [Hong Kong], University Hospital Essen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, University of Bremen, Unit of Cancer Epidemiology, Université de Turin-CERMS and Centre for Oncologic Prevention, Università degli Studi di Padova = University of Padua (Unipd), Azienda Sanitaria Locale [ROMA] (ASL), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), CIBER de Epidemiología y Salud Pública (CIBERESP), International Prevention Research Institute (IPRI), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Institute of Carcinogenesis, Russian Cancer Research Centre, Keele University [Keele], University of Liverpool, London School of Hygiene and Tropical Medicine (LSHTM), Samuel Lunenfeld Research Institute, Mount Sinai Hospital [Toronto, Canada] (MSH), Cancer Care Ontario, The M Sklodowska-Curie Cancer Center and Institute of Oncology, The Nofer Institute of Occupational Medicine, Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-First Faculty of Medicine, Masaryk University [Brno] (MUNI), Department of Optics [Univ Palacký], Faculty of Science [Univ Palacký], Palacky University Olomouc-Palacky University Olomouc, National Institutes of Environmental Health Sciences, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Institute of Public Health, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Grant sponsor: German Social Accident Insurance (DGUV), Grant number: FP 271, Grant sponsors: Canadian Institutes for Health Researchand Guzzo-SRC Chair in Environm ent and Cancer, National Cancer Institute of Canada, Canadian Cancer Society, Occupational Cancer ResearchCentre, Workplace Safety and Insuranc e Boar d, Canadian Cancer Society, and Cancer Care Ontario, Grant sponsor: European Commission’s INCO Copernicus program, Grant number: IC15-CT96-0313, Grant sponsor: European Union Nuclear Fission Safety Program, Grant number:F14P-CT96-0055, Grant sponsors: French Agency of Health Security (ANSES), Fondation de France, French National Research Agency (ANR),National Institute of Cancer (INCA), Fondation pour la Recherche Medicale, French Institute for Public Health Surveillance (InVS), Health Ministry (DGS), Organization for the Research on Cancer (ARC), and French Ministry of work, solidarity, and public function (DGT), Grant sponsor: Federal Ministry of Education, Science, Research, and Technology, Grant number: 01 HK 173/0), Grant sponsor: Federal Ministry of Science, Grant number:01 HK 546/8, Grant sponsor: Ministry of Labour and Social Affairs, Grant number: IIIb7-27/13, Grant sponsor: Research Grants Council of the Hong Kong Special Administrative Region, China, Grant number: CUHK4460/03M, Grant sponsors: Environmental Epidemiology Program of the Lombardy Region, INAIL, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Lazio Region, Health Research Council of New Zealand, New Zealand Department of Labour, Lottery Health Research, Cancer Society of New Zealand, Grant sponsor: Polish State Committee for Scientiﬁc Research, Grant number: SPUB-M-COPERNICUS/P-05/DZ-30/99/2000, Grant sponsors: Instituto Universitario de Oncologia, Universidad de Oviedo, Asturias, Fondo de Investigacion Sanitaria (FIS) and Ciber de Epidemiologia y Salud Publica (CIBERESP), Swedish Council for Work Life Research and Swedish Environmental Protection Agency, Dutch Ministry of Health, Welfare and Sports, National Institute of Public Health and the Environment, and Europe Against Cancer Program, Roy Castle Foundation, and Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), Università degli Studi di Milano [Milano] (UNIMI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Universita degli Studi di Padova, Charles University and General University Hospital-First Faculty of Medicine, and Masaryk Memorial Cancer Institute and Medical Faculty of Masaryk University
Subjects: Male, Epidemiology, control studies, cancer risk, bricklayer, middle aged, occupation, CARCINOGENS, blue collar worker, POPULATION, comparative study, education.field_of_study, MESH: Middle Aged, risk assessment, WORKERS, MEN, MESH: Carcinoma, Squamous Cell, clinical trial, MESH: Follow-Up Studies, Prognosis, MESH: Case-Control Studies, 3. Good health, Occupational Diseases, [SDV] Life Sciences [q-bio], OCCUPATIONAL-EXPOSURE, hospital based case control study, Oncology, priority journal, risk factor, Adenocarcinoma, Carcinoma, Squamous Cell, case, Human, MESH: Occupational Diseases, medicine.medical_specialty, national cancer institute of, additional supporting information may, case–control studies, employment statu, MESH: Prognosis, Article, Follow-Up Studie, MESH: International Agencies, [SDV.CAN] Life Sciences [q-bio]/Cancer, carcinogen, adult, Humans, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, research and guzzo-src chair, education, CRYSTALLINE SILICA DUST, fp 271, Science & Technology, MESH: Humans, Occupational health, MORTALITY, health care facility, Construction Industry, Case-control study, bricklayers, Odds ratio, case control study, medicine.disease, dguv, lung adenocarcinoma, major clinical study, Lung neoplasm, occupational hazard, MESH: Lung Neoplasms, Occupational Disease, occupational cancer, multicenter study, age, Relative risk, small cell lung cancer, Occupational medicine, MESH: Female, population research, Cancer Research, online version of this, [SDV]Life Sciences [q-bio], canada, Medizin, medicine.disease_cause, MESH: Occupational Exposure, grant number, Risk Factors, MESH: Risk Factors, Carcinoma, Small Cell, Medicine (all), international cooperation, grant sponsor, article, canadian institutes for health, MESH: Carcinoma, Small Cell, be found in the, MESH: Construction Industry, female, NORDIC COUNTRIES, International Agencie, canadian cancer society, epidemiology, grant sponsors, Gustavsson, in environment and cancer, Case-Control Studie, Life Sciences & Biomedicine, lifespan, prognosi, Population, UNITED-STATES, [SDV.CAN]Life Sciences [q-bio]/Cancer, lung neoplasms, Asbestos, smoking, building industry, occupational health, Internal medicine, Occupational Exposure, medicine, follow up, controlled study, occupational, Lung cancer, population based case control study, Plato, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, adenocarcinoma, business.industry, case-control studies, Risk Factor, Carcinoma, MESH: Adenocarcinoma, International Agencies, Small Cell, Confidence interval, MESH: Male, human tissue, Surgery, lung cancer, german social accident insurance, Squamous Cell, Bricklayers, Case-control studies, Lung neoplasms, Adenocarcinoma, Case-Control Studies, Female, Follow-Up Studies, Lung Neoplasms, Middle Aged, business, CONSTRUCTION-INDUSTRY, squamous cell lung carcinoma
Abstract: Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case–control studies on lung cancer and the joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals (CI) adjusted for study center, age, lifetime smoking history and employment in occupations with exposures to known or suspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had ever worked as bricklayers (OR: 1.47; 95% CI: 1.28–1.68). In studies using population controls the OR was 1.55 (95% CI: 1.32–1.81, 540/349 cases/controls), while it was 1.24 (95% CI: 0.93–1.64, 155/120 cases/controls) in hospital-based studies. There was a clear positive trend with length of employment (p < 0.001). The relative risk was higher for squamous (OR: 1.68, 95% CI: 1.42–1.98, 309 cases) and small cell carcinomas (OR: 1.78, 95% CI: 1.44–2.20, 140 cases), than for adenocarcinoma (OR: 1.17, 95% CI: 0.95–1.43, 150 cases) (p-homogeneity: 0.0007). ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents. This study provided robust evidence of increased lung cancer risk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in view of the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos. WHAT'S NEW?: In their work, bricklayers can be exposed to various airborne carcinogens, including crystalline silica and asbestos. Previous studies of cancer risk have not accounted for full employment history or smoking status, and failed to establish a firm relationship between bricklaying and lung cancer. In this study, the authors used data from the largest collection of case-control studies on lung cancer with complete occupational and smoking history existing today, the SYNERGY project. They found clear evidence that lung cancer risk increases in proportion to the length of time spent working as a bricklayer, paving the way for better protection and compensation for those in this occupation.
Published: 2015

22. Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author: Maurice P. Zeegers, Herbert Yu, Michelle Cotterchio, Harvey A. Risch, Sara H. Olson, Jerry Polesel, Elizabeth T. H. Fontham, Robert C. Kurtz, Eric J. Duell, Ersilia Lucenteforte, Anthony B. Miller, Witold Zatonski, Steven Gallinger, Rachel E. Neale, Eva Negri, Paige M. Bracci, E. A. Holly, Patrick Maisonneuve, Cristina Bosetti, Paolo Boffetta, C. La Vecchia, Parviz Ghadirian, Yu-Tang Gao, H. B. Bueno-de-Mesquita, R. Talamini, Peter A. Baghurst, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Complexe Genetica, RS: NUTRIM - R4 - Gene-environment interaction, Bosetti, C., Lucenteforte, E., Bracci, P.M., Negri, E., Neale, R.E., Risch, H.A., Olson, S.H., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E., Holly, E.A., Gao, Y.T., Yu, H., Kurtz, R.C., Cotterchio, M., Maisonneuve, P., Zeegers, M.P., Duell, E.J., Boffetta, P., and La Vecchia, C.
Subjects: medicine.medical_specialty, Gastrointestinal Diseases, medicine.medical_treatment, Peptic, pancreatic cancer, Gastroenterology, Risk Factors, Internal medicine, Pancreatic cancer, medicine, Humans, Ulcer, peptic ulcer, Aged, business.industry, Absolute risk reduction, Case-control study, Cancer, case–control study, Original Articles, Hematology, Odds ratio, Middle Aged, anti-ulcer drugs, medicine.disease, Confidence interval, gastrectomy, digestive system diseases, Surgery, Pancreatic Neoplasms, Logistic Models, Oncology, Case-Control Studies, Female, Gastrectomy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, anti-ulcer drugs, case–control study, gastrectomy, pancreatic cancer, peptic ulcer, pooled analysis, pooled analysis, business
Abstract: Bosetti, C Lucenteforte, E Bracci, P M Negri, E Neale, R E Risch, H A Olson, S H Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Holly, E A Gao, Y T Yu, H Kurtz, R C Cotterchio, M Maisonneuve, P Zeegers, M P Duell, E J Boffetta, P La Vecchia, C eng 5R01-CA098870/CA/NCI NIH HHS/ CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ R01 CA97075/CA/NCI NIH HHS/ U01 CA074783/CA/NCI NIH HHS/ U01-CA74783/CA/NCI NIH HHS/ U24 CA074783/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2013/08/24 06:00 Ann Oncol. 2013 Nov;24(11):2903-10. doi: 10.1093/annonc/mdt336. Epub 2013 Aug 22.; International audience; BACKGROUND: Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. METHODS: We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. RESULTS: The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. CONCLUSIONS: This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.
Published: 2013

23. Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author: Robert C. Kurtz, Emmy Ludwig, E. A. Holly, Elizabeth T.H. Fontham, Gloria M. Petersen, Steve Gallinger, Herbert Yu, Albert B. Lowenfels, Patrick Maisonneuve, D. Silverman, Harvey A. Risch, Donghui Li, Paolo Boffetta, Paige M. Bracci, H. B. Bueno-de-Mesquita, Ersilia Lucenteforte, Bu Tian Ji, Eric J. Duell, C. La Vecchia, D. Seminara, Parviz Ghadirian, Sara H. Olson, Duell, E.J., Lucenteforte, E., Olson, S.H., Bracci, P.M., Li, D., Risch, H.A., Silverman, D.T., Ji, B.T., Gallinger, S., Holly, E.A., Fontham, E.H., Maisonneuve, P., Bueno-de-Mesquita, H.B., Ghadirian, P., Kurtz, R.C., Ludwig, E., Yu, H., Lowenfels, A.B., Seminara, D., Petersen, G.M., La Vecchia, C., and Boffetta, P.
Subjects: Male, medicine.medical_specialty, Alcohol Drinking, Population, Case-control studies, Pancreatic cancer, Pancreatitis, Pooled analysis, Risk factors, Adenocarcinoma, Gastroenterology, Diabetes Complications, Risk Factors, Internal medicine, Odds Ratio, Medicine, Humans, Risk factor, education, Aged, education.field_of_study, Hereditary pancreatitis, Pancreatiti, business.industry, General surgery, Smoking, Cancer, Hematology, Odds ratio, Original Articles, Middle Aged, medicine.disease, Pancreatic Neoplasms, medicine.anatomical_structure, Oncology, Case-Control Studies, Female, business, Pancreas
Abstract: Background: Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction. Patients and methods: A pooled analysis of a history of pancreatitis and risk of pancreatic cancer was carried out considering the time interval between diagnoses and potential modification by covariates. Adjusted pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from 10 case-control studies (5048 cases of ductal pancreatic adenocarcinoma and 10 947 controls) taking part in the International Pancreatic Cancer Case-Control Consortium (PanC4). Results: The association between pancreatitis and pancreatic cancer was nearly three-fold at intervals of >2 years between diagnoses (OR: 2.71, 95% CI: 1.96-3.74) and much stronger at intervals of =2 years (OR: 13.56, 95% CI: 8.72-21.90) probably reflecting a combination of reverse causation and antecedent misdiagnosis of pancreas cancer as pancreatitis. The younger (2 years) pancreatitis (OR: 3.91, 95% CI: 2.53-6.04) than the older (=65 years) cases (OR: 1.68, 95% CI: 1.02-2.76; P value for interaction: 0.006). Conclusions: Despite a moderately strong association between pancreatitis (diagnosed before >2 years) and pancreatic cancer, the population attributable fraction was estimated at 1.34% (95% CI: 0.612-2.07%), suggesting that a relatively small proportion of pancreatic cancer might be avoided if pancreatitis could be prevented. © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology.
Published: 2012

24. Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study

Author: Rudolf Kaaks, Catalina Bonet, Kim Overvad, Petra H.M. Peeters, Göran Hallmans, Ingegerd Johansson, Martin Almquist, Rosario Tumino, Antonio Agudo, Eiliv Lund, Christina C. Dahm, Isabelle Romieu, Dimitrios Trichopoulos, Signe Borgquist, Françoise Clavel-Chapelon, Anne Tjønneland, Antonia Trichopoulou, J. Ramón Quirós, Domenico Palli, Eva Ardanaz, Elisabete Weiderpass, Elio Riboli, Annekatrin Lukanova, H. Bas Bueno-de-Mesquita, Pagona Lagiou, Hendriek Boshuizen, Heiner Boeing, María José Sánchez, Sabina Sieri, Inger T. Gram, Noémie Travier, Paolo Boffetta, Frederike L. Büchner, Naomi E. Allen, Kay-Tee Khaw, Jytte Halkjaer, Madlen Schütze, Carmen Navarro, Nicholas J. Wareham, Marie-Christine Boutron-Ruault, Salvatore Panico, Nerea Larrañaga, Timothy J. Key, Paolo Vineis, Carlos A. González, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Agudo, A., Bonet, C., Travier, N., González, C.A., Vineis, P., Bueno-de-Mesquita, H.B., Trichopoulos, D., Boffetta, P., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Kaaks, R., Lukanova, A., Schu?ze, M., Boeing, H., Tjonneland, A., Halkjaer, J., Overvad, K., Dahm, C.C., Quirós, J.R., Sánchez, M.-J., Larrañaga, N., Navarro, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Key, T.J., Allen, N.E., Trichopoulou, A., Lagiou, P., Palli, D., Sieri, S., Tumino, R., Panico, S., Boshuizen, H., Büchner, F.L., Peeters, P.H.M., Borgquist, S., Almquist, M., Hallmans, G., Johansson, I., Gram, I.T., Lund, E., Weiderpass, E., Romieu, I., Riboli, E., Agudo, A, Bonet, C, Travier, N, Gonz?lez, Ca, Vineis, P, Bueno de Mesquita, Hb, Trichopoulos, D, Boffetta, P, Clavel Chapelon, F, Boutron Ruault, Mc, Kaaks, R, Lukanova, A, Sch?tze, M, Boeing, H, Tjonneland, A, Halkjaer, J, Overvad, K, Dahm, Cc, Quir?s, Jr, S?nchez, Mj, Larra?aga, N, Navarro, C, Ardanaz, E, Khaw, Kt, Wareham, Nj, Key, Tj, Allen, Ne, Trichopoulou, A, Lagiou, P, Palli, D, Sieri, S, Tumino, R, Panico, Salvatore, Boshuizen, H, B?chner, Fl, Peeters, Ph, Borgquist, S, Almquist, M, Hallmans, G, Johansson, I, Gram, It, Lund, E, Weiderpass, E, and Romieu, I
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Adolescent, MEDLINE, tobacco related cancer(TRC), cigarette smoking, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Cigarette smoking, Risk Factors, Neoplasms, Surveys and Questionnaires, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Young adult, tobacco smoking, Adolescent Adult Europe/epidemiology Female Humans Male Neoplasms/*epidemiology/etiology Prospective Studies Questionnaires Risk Factors Smoking/*epidemiology Young Adult, Prospective cohort study, Gynecology, business.industry, Smoking, Cancer, medicine.disease, PE&RC, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, 030220 oncology & carcinogenesis, Family medicine, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Cancer risk, International agency
Abstract: Agudo, Antonio Bonet, Catalina Travier, Noemie Gonzalez, Carlos A Vineis, Paolo Bueno-de-Mesquita, H Bas Trichopoulos, Dimitrios Boffetta, Paolo Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine Kaaks, Rudolf Lukanova, Annekatrin Schutze, Madlen Boeing, Heiner Tjonneland, Anne Halkjaer, Jytte Overvad, Kim Dahm, Christina C Quiros, J Ramon Sanchez, Maria-Jose Larranaga, Nerea Navarro, Carmen Ardanaz, Eva Khaw, Kay-Tee Wareham, Nicholas J Key, Timothy J Allen, Naomi E Trichopoulou, Antonia Lagiou, Pagona Palli, Domenico Sieri, Sabina Tumino, Rosario Panico, Salvatore Boshuizen, Hendriek Buchner, Frederike L Peeters, Petra H M Borgquist, Signe Almquist, Martin Hallmans, Goran Johansson, Ingegerd Gram, Inger T Lund, Eiliv Weiderpass, Elisabete Romieu, Isabelle Riboli, Elio eng 11692/Cancer Research UK/United Kingdom G1000143/Medical Research Council/United Kingdom British Heart Foundation/United Kingdom Cancer Research UK/United Kingdom Department of Health/United Kingdom Medical Research Council/United Kingdom Wellcome Trust/United Kingdom Research Support, Non-U.S. Gov't 2012/11/22 06:00 J Clin Oncol. 2012 Dec 20;30(36):4550-7. doi: 10.1200/JCO.2011.41.0183. Epub 2012 Nov 19.; International audience; PURPOSE: Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC). METHODS: The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AF(p)), calculated using the adjusted hazard ratios and 95% CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country. RESULTS: The proportion of all TRC attributable to cigarette smoking was 34.9% (95% CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2% (95% CI, 33.7 to 38.6) using the smoking prevalence from the population. The AF(p) were above 80% for cancers of the lung and larynx, between 20% and 50% for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20% for the remaining TRC. CONCLUSION: Using data on cancer incidence for 2008 and our AF(p) estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark).
Published: 2012

25. Response

Author: Rudolf Kaaks, Aurelio Barricarte, Annekatrin Lukanova, H. Bas Bueno-de-Mesquita, Eiliv Lund, Carlos González, Elisabeth Trepo, Elio Riboli, Isabelle Romieu, Heiner Boeing, J. Ramón Quirós, Malene Outzen, Henk J. van Kranen, Petra H.M. Peeters, Pagona Lagiou, Françoise Clavel-Chapelon, Vassiliki Benetou, Carmen Navarro, Krasimira Aleksandrova, Christina Bamia, Paolo Boffetta, Sara Regnér, Nicholas J. Wareham, Maria-Jose Sanchez Perez, Veronika Fedirko, Shu Chun Chuang, Miren Dorronsoro, Mazda Jenab, Kim Overvad, Anne Tjønneland, Göran Hallmans, Antonia Trichopoulou, Valeria Pala, Neil Murphy, Dimitrios Trichopoulos, Ute Nthlings, Carlotta Sacerdote, Salvatore Panico, Kay-Tee Khaw, Bjoern Lindkvist, Rosario Tumino, Timothy J. Key, Mårten Werner, Dimosthenis Zylis, Tobias Pischon, Domenico Palli, Trichopoulos, D., Bamia, C., Lagiou, P., Fedirko, V., Trepo, E., Jenab, M., Pischon, T., Nöthlings, U., Overvad, K., Tjonneland, A., Outzen, M., Clavel-Chapelon, F., Kaaks, R., Lukanova, A., Boeing, H., Aleksandrova, K., Benetou, V., Zylis, D., Palli, D., Pala, V., Panico, S., Tumino, R., Sacerdote, C., Bueno-De-Mesquita, H.B., Van Kranen, H.J., Peeters, P.H.M., Lund, E., Quirós, J.R., González, C.A., Sanchez Perez, M.-J., Navarro, C., Dorronsoro, M., Barricarte, A., Lindkvist, B., Regnér, S., Werner, M., Hallmans, G., Khaw, K.-T., Wareham, N., Key, T., Romieu, I., Chuang, S.-C., Murphy, N., Boffetta, P., Trichopoulou, A., and Riboli, E.
Subjects: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Response, medicine.disease, digestive system diseases, Internal medicine, Hepatocellular carcinoma, Cohort, Nested case-control study, medicine, business, Disease burden
Abstract: Re : Hepatocellular Carcinoma Risk factors and Disease Burden in a European Cohort: A Nested Case-Control Study Response
Published: 2012

26. Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups

Author: Paul Brennan, Lydia Visser, Dorothy Montgomery, Anne Boland, Marc Maynadié, Eve Roman, Kim Overvad, Kevin Y. Urayama, Gary J. Macfarlane, Silvia de Sanjosé, Petra H.M. Peeters, Yoichiro Kamatani, Ruth C. Travis, Françoise Clavel-Chapelon, Simone Benhamou, Beatrice Melin, Amelie Chabrier, Lesley Shield, Eva Ardanaz, Mark Lathrop, Pierluigi Cocco, Ivana Holcatova, Bengt Glimelius, Carlos González, Henrik Hjalgrim, Tracy Lightfoot, Paolo Boffetta, James McKay, Annette Lake, Lars J. Vatten, Rose-Marie Amini, Ruth F. Jarrett, Anthony Staines, Arjan Diepstra, Sita H. Vermeulen, Kay-Tee Khaw, Anne Tjønneland, Alexandra Nieters, Valerie Gaborieau, Lambertus A. Kiemeney, Federico Canzian, Antonio Agudo, Bjarke Feenstra, Karin E. Smedby, Malcolm Taylor, Elio Riboli, Diana Zelenika, Mads Melbye, José María Huerta, David I. Conway, H. Bas Bueno-de-Mesquita, Ilja M. Nolte, Nikolaus Becker, Anke van den Berg, Lenka Foretova, M. Dorronsoro, Hans-Olov Adami, José Ramón Quirós, Yolanda Benavente, Claire M. Healy, María José Sánchez, Gustaaf W. van Imhoff, Peter Thomson, Urayama, K.Y., Jarrett, R.F., Hjalgrim, H., Diepstra, A., Kamatani, Y., Chabrier, A., Gaborieau, V., Boland, A., Nieters, A., Becker, N., Foretova, L., Benavente, Y., Maynadié, M., Staines, A., Shield, L., Lake, A., Montgomery, D., Taylor, M., Smedby, K.E., Amini, R.-M., Adami, H.-O., Glimelius, B., Feenstra, B., Nolte, I.M., Visser, L., Van Imhoff, G.W., Lightfoot, T., Cocco, P., Kiemeney, L., Vermeulen, S.H., Holcatova, I., Vatten, L., MacFarlane, G.J., Thomson, P., Conway, D.I., Benhamou, S., Agudo, A., Healy, C.M., Overvad, K., Tjønneland, A., Melin, B., Canzian, F., Khaw, K.-T., Travis, R.C., Peeters, P.H.M., González, C.A., Quirós, J.R., Sánchez, M.-J., Huerta, J.M., Ardanaz, E., Dorronsoro, M., Clavel-Chapelon, F., Bueno-De-Mesquita, H.B., Riboli, E., Roman, E., Boffetta, P., De Sanjosé, S., Zelenika, D., Melbye, M., Van Den Berg, A., Lathrop, M., Brennan, P., McKay, J.D., Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Stem Cell Aging Leukemia and Lymphoma (SALL), and Translational Immunology Groningen (TRIGR)
Subjects: Oncology, Cancer Research, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Genome-wide association study, HLA-DR alpha-Chains, Aetiology, screening and detection [ONCOL 5], Aminopeptidases, 0302 clinical medicine, Nodular sclerosis, Risk Factors, CLASS-I, Odds Ratio, POPULATION, RISK, 0303 health sciences, education.field_of_study, PSORIASIS, epstein-barr virus, DISEASE HD, Hodgkin Disease, 3. Good health, 030220 oncology & carcinogenesis, INFECTIOUS-MONONUCLEOSIS, medicine.medical_specialty, GENES, SUSCEPTIBILITY LOCI, Population, ENDOPLASMIC-RETICULUM, Single-nucleotide polymorphism, Biology, Minor Histocompatibility Antigens, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, Internal medicine, Genetic model, medicine, Humans, REED-STERNBERG CELLS, education, 030304 developmental biology, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], Cancer och onkologi, Histocompatibility Antigens Class I, Odds ratio, medicine.disease, classical hodgkin lymphoma, Lymphoma, Logistic Models, Reed–Sternberg cell, Cancer and Oncology, Immunology, Genome-Wide Association Study
Abstract: Item does not contain fulltext BACKGROUND: Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein-Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. METHODS: We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation in an independent replication series, to identify common genetic variants associated with total cHL and subtypes defined by tumor EBV status. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) assuming a log-additive genetic model for the variants. All statistical tests were two-sided. RESULTS: Two novel loci associated with total cHL irrespective of EBV status were identified in the major histocompatibility complex region; one resides adjacent to MICB (rs2248462: OR = 0.61, 95% CI = 0.53 to 0.69, P = 1.3 x 10(-13)) and the other at HLA-DRA (rs2395185: OR = 0.56, 95% CI = 0.50 to 0.62, P = 8.3 x 10(-25)) with both results confirmed in an independent replication series. Consistent with previous reports, associations were found between EBV-positive cHL and genetic variants within the class I region (rs2734986, HLA-A: OR = 2.45, 95% CI = 2.00 to 3.00, P = 1.2 x 10(-15); rs6904029, HCG9: OR = 0.46, 95% CI = 0.36 to 0.59, P = 5.5 x 10(-10)) and between EBV-negative cHL and rs6903608 within the class II region (rs6903608, HLA-DRA: OR = 2.08, 95% CI = 1.84 to 2.35, P = 6.1 x 10(-31)). The association between rs6903608 and EBV-negative cHL was confined to the nodular sclerosis histological subtype. Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x 10(-9)), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear. Notably, one additional psoriasis-associated variant, rs27524 (5q15, ERAP1), showed evidence of an association with cHL in the genome-wide association study (OR = 1.21, 95% CI = 1.10 to 1.33, P = 1.5 x 10(-4)) and replication series (P = .03). CONCLUSION: Overall, these results provide strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive and EBV-negative patients.
Published: 2012

27. Cigarette smoking and pancreatic cancer : an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author: Yu-Tang Gao, Parviz Ghadirian, E. A. Holly, Michelle Cotterchio, C. La Vecchia, Gloria M. Petersen, Steven Gallinger, Donghui Li, Patrick Maisonneuve, Cristina Bosetti, Elizabeth T. H. Fontham, R. Talamini, H. B. Bueno-de-Mesquita, Sara H. Olson, Paola Bertuccio, Paige M. Bracci, Jerry Polesel, Bu Tian Ji, Ersilia Lucenteforte, Debra T. Silverman, William R. Bamlet, J. Su, Witold Zatonski, Paolo Boffetta, Eva Negri, Peter A. Baghurst, Robert C. Kurtz, Manal M. Hassan, Anthony B. Miller, Herbert Yu, Harvey A. Risch, Eric J. Duell, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Bosetti, C., Lucenteforte, E., Silverman, D.T., Petersen, G., Bracci, P.M., Ji, B.T., Negri, E., Li, D., Risch, H.A., Olson, S.H., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E., Bamlet, W.R., Holly, E.A., Bertuccio, P., Gao, Y.T., Hassan, M., Yu, H., Kurtz, R.C., Cotterchio, M., Su, J., Maisonneuve, P., Duell, E.J., Boffetta, P., and La Vecchia, C.
Subjects: medicine.medical_specialty, Multivariate analysis, analysi, pancreatic cancer, cigarette smoking, cancer, Sensitivity and Specificity, PANC4, Cigarette smoking, Internal medicine, Pancreatic cancer, Odds Ratio, medicine, case–control study, pooled analysis, Humans, and pancreatic, Case-Control Studies Humans Logistic Models Multivariate Analysis Odds Ratio Pancreatic Neoplasms/*etiology Sensitivity and Specificity Smoking/*adverse effects, Cigarette, Cancer, Pancreatic, business.industry, Smoking, Case-control study, Original Articles, Hematology, Odds ratio, medicine.disease, Former Smoker, Confidence interval, Surgery, Pancreatic Neoplasms, Case-Control, Logistic Models, Oncology, International, Case-Control Studies, Meta-analysis, Multivariate Analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Corrigendum, business, Consortium
Abstract: Bosetti, C Lucenteforte, E Silverman, D T Petersen, G Bracci, P M Ji, B T Negri, E Li, D Risch, H A Olson, S H Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Bamlet, W R Holly, E A Bertuccio, P Gao, Y T Hassan, M Yu, H Kurtz, R C Cotterchio, M Su, J Maisonneuve, P Duell, E J Boffetta, P La Vecchia, C eng 5R01-CA098870/CA/NCI NIH HHS/ CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-CP-05225/CP/NCI NIH HHS/ N01-CP-05227/CP/NCI NIH HHS/ N01-CP-31022/CP/NCI NIH HHS/ N01-CP-51089/CP/NCI NIH HHS/ N01-CP-51090/CP/NCI NIH HHS/ N01-CP-51092/CP/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ P50 CA102701/CA/NCI NIH HHS/ R01 CA97075/CA/NCI NIH HHS/ Canadian Institutes of Health Research/Canada Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2011/11/23 06:00 Ann Oncol. 2012 Jul;23(7):1880-8. doi: 10.1093/annonc/mdr541. Epub 2011 Nov 21.; International audience; BACKGROUND: To evaluate the dose-response relationship between cigarette smoking and pancreatic cancer and to examine the effects of temporal variables. METHODS: We analyzed data from 12 case-control studies within the International Pancreatic Cancer Case-Control Consortium (PanC4), including 6507 pancreatic cases and 12 890 controls. We estimated summary odds ratios (ORs) by pooling study-specific ORs using random-effects models. RESULTS: Compared with never smokers, the OR was 1.2 (95% confidence interval [CI] 1.0-1.3) for former smokers and 2.2 (95% CI 1.7-2.8) for current cigarette smokers, with a significant increasing trend in risk with increasing number of cigarettes among current smokers (OR=3.4 for >/=35 cigarettes per day, P for trend
Published: 2012

28. Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Miren Dorronsoro, Antonia Trichopoulou, Laudina Rodríguez, Françoise Clavel-Chapelon, Nadia Slimani, Jonas Manjer, Lars Egevad, Georgia Stasinopulou, Elio Riboli, Esther Molina, Nina Roswall, Philippos Orfanos, Inger T. Gram, Maria Dolores Chirlaque, Petra H.M. Peeters, Kim Overvad, Vittorio Krogh, Naomi E. Allen, Martine M. Ros, Ellen Kampman, Amalia Mattiello, Börje Ljungberg, Rosario Tumino, Fränzel J.B. Van Duijnhoven, Frederike L. Büchner, Paolo Boffetta, Nicholas J. Wareham, Anne Tjønneland, Lambertus A. Kiemeney, Steffen Weikert, Heiner Boeing, Katja K.H. Aben, Paolo Vineis, Aurelio Barricarte, Kay-Tee Khaw, Calogero Saieva, Jenny Chang-Claude, Carlos González, Dominique S. Michaud, Eiliv Lund, Roy Ehrnström, H. Bas Bueno-de-Mesquita, Rudolf Kaaks, Andrew W. Roddam, Ros, M.M., Bas Bueno-De-Mesquita, H.B., Büchner, F.L., Aben, K.K.H., Kampman, E., Egevad, L., Overvad, K., Tjãnneland, A., Roswall, N., Clavel-Chapelon, F., Kaaks, R., Chang-Claude, J., Boeing, H., Weikert, S., Trichopoulou, A., Orfanos, P., Stasinopulou, G., Saieva, C., Krogh, V., Vineis, P., Tumino, R., Mattiello, A., Peeters, P.H.M., Van Duijnhoven, F.J.B., Lund, E., Gram, I.T., Chirlaque, M.D., Barricarte, A., Rodríguez, L., Molina, E., Gonzalez, C., Dorronsoro, M., Manjer, J., Ehrnström, R., Ljungberg, B., Allen, N.E., Roddam, A.W., Khaw, K.-T., Wareham, N., Boffetta, P., Slimani, N., Michaud, D.S., Kiemeney, L.A.L.M., and Riboli, E.
Subjects: Male, Cancer Research, Nutrition and Disease, urothelial, food frequency questionnaire, Aetiology, screening and detection [ONCOL 5], carcinoma, Cohort Studies, 0302 clinical medicine, Risk Factors, Voeding en Ziekte, Epidemiology, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, risk, Cancer, disinfection by-products, Hazard ratio, Middle Aged, Prognosis, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Prospective, Oncology, 030220 oncology & carcinogenesis, Female, epidemiology, Fluid, bladder-cancer, intake, Cohort study, Adult, medicine.medical_specialty, life-style, coffee, drinking-water, Drinking, European, Beverages, lower urinary-tract, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, Internal medicine, medicine, Humans, consumption, Risk factor, Aged, VLAG, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], Nutrition, Gynecology, Investigation, business.industry, Proportional hazards model, Feeding Behavior, relative validity, Urinary Bladder Neoplasms, Fluid Therapy, business, EPIC, Relative validity, Follow-Up Studies
Abstract: Contains fulltext : 97923.pdf (Publisher’s version ) (Closed access) Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95%CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95%CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95%CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.
Published: 2011

29. Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Amalia Mattiello, Anne Tjønneland, Leila Lujan-Barroso, Marina Touillaud, Kim Overvad, Roy Ehrnström, Rudolf Kaaks, H. Bas Bueno-de-Mesquita, Ole Raaschou-Nielsen, Traci Mouw, Frederike L. Büchner, Petra H.M. Peeters, Laudina Rodríguez, Martine M. Ros, Domenico Palli, Eva Ardanaz, Guri Skeie, David Ulmert, Nina Roswall, Jenny Chang-Claude, Carlos A. González, Elio Riboli, Timothy J. Key, Naomi E. Allen, Franco Berrino, Andrew W. Roddam, Lars Egevad, Dominique S. Michaud, Börje Ljungberg, Nerea Larrañaga, Carmen Navarro, Paolo Boffetta, Mazda Jenab, Nadia Slimani, Sheila Bingham, Steffen Weikert, Göran Hallmans, Heiner Boeing, María José Sánchez, Antonia Trichopoulou, Inger T. Gram, Paula Jakszyn, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Paolo Vineis, Christine L. Parr, Lambertus A. Kiemeney, Dimosthenis Zylis, Kay-Tee Khaw, Rosario Tumino, Eleni Oikonomou, Jakszyn, P., González, C.A., Luján-Barroso, L., Ros, M.M., Bueno-de-Mesquita, H.B., Roswall, N., Tjønneland, A.M., Büchner, F.L., Egevad, L., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Touillaud, M.S., Chang-Claude, J., Allen, N.E., Kiemeney, L.A., Key, T.J., Kaaks, R., Boeing, H., Weikert, S., Trichopoulou, A., Oikonomou, E., Zylis, D., Palli, D., Berrino, F., Vineis, P., Tumino, R., Mattiello, A., Peeters, P.H.M., Parr, C.L., Gram, I.T., Skeie, G., Sánchez, M.-J., Larrañaga, N., Ardanaz, E., Navarro, C., Rodríguez, L., Ulmert, D., Ehrnström, R., Hallmans, G., Ljungberg, B., Roddam, A.W., Bingham, S.A., Khaw, K.-T., Slimani, N., Boffetta, P.A., Jenab, M., Mouw, T., Michaud, D.S., and Riboli, E.
Subjects: medicine.medical_specialty, Meat, Nitrosamines, Epidemiology, Aetiology, screening and detection [ONCOL 5], Heme, Gastroenterology, Molecular epidemiology [NCEBP 1], dietary nitrosamine, chemistry.chemical_compound, Risk Factors, Internal medicine, Medicine, Humans, Prospective Studies, Risk factor, Prospective cohort study, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], Bladder cancer, business.industry, red meat, heme iron risk, Cancer, medicine.disease, Surgery, European Prospective Investigation into Cancer and Nutrition, Diet, Europe, Oncology, chemistry, Urinary Bladder Neoplasms, Red Meat Consumption, Nitrosamine, Red meat, bladder cancer, business, Iron, Dietary
Abstract: Background: Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines [NDMA: N-nitrosodimethylamine, and ENOC (endogenous nitroso compounds)], and the risk of bladder cancer. We investigated the association between red meat consumption, dietary nitrosamines, and heme iron and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Data on food consumption and complete follow-up for cancer occurrence were available for a total of 481,419 participants, recruited in 10 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, gender, and study center and adjusted for total energy intake, smoking status, lifetime intensity of smoking, duration of smoking, educational level, and BMI. Results: After a mean follow-up of 8.7 years, 1,001 participants were diagnosed with bladder cancer. We found no overall association between intake of red meat (log2 HR: 1.06; 95% CI: 0.99–1.13), nitrosamines (log2 HR: 1.09; 95% CI: 0.92–1.30 and HR: 0.98; 95% CI: 0.92–1.05 for ENOC and NDMA, respectively) or heme iron (log2 HR: 1.05; 95 CI: 0.99–1.12) and bladder cancer risk. The associations did not vary by sex, high- versus low-risk bladder cancers, smoking status, or occupation (high vs. low risk). Conclusions: Our findings do not support an effect of red meat intake, nitrosamines (endogenous or exogenous), or heme iron intake on bladder cancer risk. Cancer Epidemiol Biomarkers Prev; 20(3); 555–9. ©2011 AACR.
Published: 2011

30. Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author: Witold Zatonski, Eva Negri, Elizabeth T. H. Fontham, Debra T. Silverman, Donghui Li, Eric J. Duell, Sara H. Olson, Michelle Cotterchio, H. B. Bueno-de-Mesquita, Steve Gallinger, Paige M. Bracci, Herbert Yu, Paolo Boffetta, E. A. Holly, Harvey A. Risch, Paola Bertuccio, William R. Bamlet, J. Su, C. La Vecchia, Jerry Polesel, Ersilia Lucenteforte, Gloria M. Petersen, Robert C. Kurtz, Peter A. Baghurst, Patrick Maisonneuve, Cristina Bosetti, Parviz Ghadirian, Manal M. Hassan, Anthony B. Miller, R. Talamini, Bertuccio, P., La Vecchia, C., Silverman, D.T., Petersen, G.M., Bracci, P.M., Negri, E., Li, D., Risch, H.A., Olson, S.H., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E.T., Bamlet, W.R., Holly, E.A., Lucenteforte, E., Hassan, M., Yu, H., Kurtz, R.C., Cotterchio, M., Su, J., Maisonneuve, P., Duell, E.J., Bosetti, C., and Boffetta, P.
Subjects: Oncology, Adult, Male, Risk, medicine.medical_specialty, Cigar Smoking, Pancreatic disease, Tobacco, Smokeless, pancreatic cancer, tobacco, smoking, cigar, pancreatic cancer, pooled analysis, smokeless tobacco, tobacco, pipe, Pancreatic cancer, Internal medicine, Epidemiology, medicine, Humans, cancer, education, Aged, Aged, 80 and over, Smoking pipe, education.field_of_study, business.industry, Cigar, technology, industry, and agriculture, Cancer, Hematology, Tobacco Use Disorder, Original Articles, smokeless tobacco, Middle Aged, medicine.disease, Surgery, Pancreatic Neoplasms, stomatognathic diseases, pipe, Smokeless tobacco, Case-Control Studies, pancreatic, Female, Biostatistics, pooled analysis, business
Abstract: Background: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. Materials and methods: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11 338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates. Results: Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95% CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95% CI 1.4-1.6). The OR was 1.1 (95% CI 0.69-1.6) for pipeonly smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for = 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95% CI 0.75-1.3). Conclusion: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Published: 2011

31. Anthropometry, physical activity and hip fractures in the elderly

Author: Valeria Pala, Yvonne T. van der Schouw, Graziella Frasca, Petra H.M. Peeters, H. Bas Bueno-de-Mesquita, Ioannis S. Benetos, Jone M. Altzibar, Vassiliki Benetou, Alberto Evangelista, Heiner Boeing, Maria Concetta Giurdanella, Ulrika Pettersson, Paolo Boffetta, Bethany Van Guelpen, Sabine Rohrmann, Jakob Linseisen, Cornelia Weikert, Philippos Orfanos, Antonia Trichopoulou, Benetou, V., Orfanos, P., Benetos, I.S., Pala, V., Evangelista, A., Frasca, G., Giurdanella, M.C., Peeters, P.H.M., Van Der Schouw, Y.T., Rohrmann, S., Linseisen, J., Boeing, H., Weikert, C., Pettersson, U., Van Guelpen, B., Bueno-De-Mesquita, H.B., Altzibar, J., Boffetta, P., and Trichopoulou, A.
Subjects: Male, musculoskeletal diseases, medicine.medical_specialty, Poison control, Motor Activity, Hip fracture, Waist–hip ratio, Elderly, Bone Density, Risk Factors, Surveys and Questionnaires, Humans, Medicine, Prospective Studies, Body mass index, Aged, General Environmental Science, Anthropometry, Hip Fractures, Waist-Hip Ratio, business.industry, Physical activity, Incidence, Public health, Waist-to-hip ratio, Human factors and ergonomics, Middle Aged, medicine.disease, Diet, Europe, EPIC study, Body height, Orthopedic surgery, Physical therapy, General Earth and Planetary Sciences, Female, business
Abstract: Introduction: Hip fractures constitute a major and growing public health problem amongst the elderly worldwide. We examined the association of anthropometry and physical activity with hip fracture incidence in a cohort of elderly Europeans, participants in the European Prospective Investigation into Cancer and nutrition (EPIC) study. Materials and methods: The study population consisted of 27 982 volunteers (10 553 men and 17 429 women) aged 60 years and above from five European countries. Information on anthropometry, physical activity, medical history and other characteristics was collected at baseline. During a median follow-up of 8 years, 261 incident hip fractures (203 women and 58 men) were recorded. Data were analysed through Cox proportional hazard regression with adjustment for potential confounders. Results: A higher body mass index (BMI) was associated with lower hip fracture risk (hazard ratio (HR) per increasing sex-specific-quintile: 0.85, 95% confidence interval (95% CI): 0.77-0.94). Body height was associated with increased hip fracture risk (HR per 5 cm: 1.13, 95% CI: 1.01-1.25). Waist-to-hip ratio was not related to hip fracture risk. Increasing levels of leisure-time physical activity were related to lower risk (HR per increasing tertile: 0.84, 95% CI: 0.70-0.99, p for trend: 0.039). Conclusions: In a prospective cohort study of elderly Europeans, we found evidence that high body stature increased and high BMI decreased the incidence of hip fractures. After adjustment for BMI, waist-to-hip ratio was not associated with hip fracture risk. Leisure-time physical activity appears to play a beneficial role in the prevention of hip fractures. © 2010 Elsevier Ltd. All rights reserved.
Published: 2011

32. Diet and hip fractures among elderly Europeans in the EPIC cohort

Author: Ingegerd Johansson, Antonia Trichopoulou, Dimosthenis Zylis, Paolo Boffetta, H. Boeing, Cornelia Weikert, Maria Concetta Giurdanella, J. Linseisen, Philippos Orfanos, Alexandra Nieters, H. B. Bueno-De-Mesquita, R. Tumino, Miren Dorronsoro, P. H. M. Peeters, Paolo Contiero, Ulrika Pettersson, Sabina Sieri, Vassiliki Benetou, Benetou, V., Orfanos, P., Zylis, D., Sieri, S., Contiero, P., Tumino, R., Giurdanella, M.C., Peeters, P.H.M., Linseisen, J., Nieters, A., Boeing, H., Weikert, C., Pettersson, U., Johansson, I., Bueno-De-Mesquita, H.B., Dorronsoro, M., Boffetta, P., and Trichopoulou, A.
Subjects: Male, medicine.medical_specialty, hip, Medicine (miscellaneous), European, elderly, Risk Factors, Surveys and Questionnaires, Vegetables, medicine, Vitamin D and neurology, Humans, hip fractures, diet, nutrients, risk factors, ddc:610, Prospective Studies, Risk factor, Prospective cohort study, Aged, Proportional Hazards Models, Geriatrics, Aged, 80 and over, Hip fracture, Nutrition and Dietetics, business.industry, Hip Fractures, Incidence (epidemiology), Incidence, cohort, Feeding Behavior, Middle Aged, medicine.disease, Surgery, Diet, Europe, Nutrition Assessment, fracture, Cohort, Fatty Acids, Unsaturated, Female, EPIC, business, Demography, Cohort study
Abstract: Background/Objectives:Evidence on the role of diet during adulthood and beyond on fracture occurrence is limited. We investigated diet and hip fracture incidence in a population of elderly Europeans, participants in the European Prospective Investigation into Cancer and nutrition study.Subjects/Methods:29 122 volunteers (10 538 men, 18 584 women) aged 60 years and above (mean age: 64.3) from five countries were followed up for a median of 8 years and 275 incident hip fractures (222 women and 53 men) were recorded. Diet was assessed at baseline through validated dietary questionnaires. Data were analyzed through Cox proportional-hazards regression with adjustment for potential confounders.Results:No food group or nutrient was significantly associated with hip fracture occurrence. There were suggestive inverse associations, however, with vegetable consumption (hazard ratio (HR) per increasing sex-specific quintile: 0.93, 95% confidence interval (CI): 0.85-1.01), fish consumption (HR per increasing sex-specific quintile: 0.93, 95% CI: 0.85-1.02) and polyunsaturated lipid intake (HR per increasing sex-specific quintile: 0.92, 95% CI: 0.82-1.02), whereas saturated lipid intake was positively associated with hip fracture risk (HR per increasing sex-specific quintile: 1.13, 95% CI: 0.99-1.29). Consumption of dairy products did not appear to influence the risk (HR per increasing sex-specific quintile: 1.02, 95% CI: 0.93-1.12).Conclusions: In a prospective study of the elderly, diet, including consumption of dairy products, alcohol and vitamin D, did not appear to play a major role in hip fracture incidence. There is however, weak and statistically non-significant evidence that vegetable and fish consumption and intake of polyunsaturated lipids may have a beneficial, whereas saturated lipid intake a detrimental effect. © 2011 Macmillan Publishers Limited All rights reserved.
Published: 2010

33. Occupation and risk of lymphoma: a multicentre prospective cohort study (EPIC)

Author: Beatrice Malmer, Jonas Manjer, Anne Tjønneland, Paolo Vineis, Laudina Rodríguez Suárez, Carlos A. González, Roel Vermeulen, Rosario Tumino, H. Bas Bueno-de-Mesquita, Amalia Mattiello, Paolo Crosignani, Kim Overvad, Aurelio Barricarte, Franco Berrino, Pietro Ferrari, Jakob Linseisen, Ole Raaschou-Nielsen, Elio Riboli, Sheila Bingham, Göran Berglund, Timothy J. Key, Giovanna Masala, Antonia Trichopoulou, Manuela M. Bergmann, Stefano Rosso, Sophia Zackrisson, Heiner Boeing, Kay-Tee Khaw, Göran Hallmans, Nadia Slimani, David Neasham, Kaspar René Nielsen, Ruth C. Travis, Paolo Boffetta, Ahlem Sifi, Carmen Navarro, Rudolf Kaaks, Eiliv Lund, Neasham, D., Sifi, A., Nielsen, K.R., Overvad, K., Raaschou-Nielsen, O., Tjønneland, A., Barricarte, A., González, C.A., Navarro, C., Suarez, L.R., Travis, R.C., Key, T., Linseisen, J., Kaaks, R., Crosignani, P., Berrino, F., Rosso, S., Mattiello, A., Vermeulen, R.C.H., Bueno-de-Mesquita, H.B., Berglund, G., Manjer, J., Zackrisson, S., Hallmans, G., Malmer, B., Bingham, S., Khaw, K.T., Bergmann, M.M., Boeing, H., Trichopoulou, A., Masala, G., Tumino, R., Lund, E., Slimani, N., Ferrari, P., Boffetta, P., Vineis, P., and Riboli, E.
Subjects: Adult, Male, medicine.medical_specialty, Lymphoma, 03 medical and health sciences, 0302 clinical medicine, Age Distribution, immune system diseases, Internal medicine, hemic and lymphatic diseases, Occupational Exposure, Epidemiology, medicine, Humans, multicentre prospective cohort study, ddc:610, Risk factor, Occupations, Prospective cohort study, Multiple myeloma, 030304 developmental biology, risk, Aged, 0303 health sciences, Occupation, business.industry, Lymphoma, Non-Hodgkin, Public Health, Environmental and Occupational Health, Middle Aged, medicine.disease, 3. Good health, Surgery, European Prospective Investigation into Cancer and Nutrition, Europe, Occupational Diseases, 030220 oncology & carcinogenesis, Plasmacytoma, Female, business, EPIC, Epidemiologic Methods, Cohort study
Abstract: ObjectivesEvidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study.MethodsWe investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma.ResultsThe following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95% CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95% CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95% CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95% CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95% CI 1.08 to 19.6).ConclusionThe findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.
Published: 2010

34. Consumption of meat and dairy and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition

Author: Kay-Tee Khaw, Petra H.M. Peeters, Aurelio Barricarte, Esther Molina, Nikolaus Becker, Androniki Naska, Miren Dorronsoro, Vassiliki Benetou, Jonas Manjer, Nadia Slimani, Valeria Pala, Guri Skeie, Ulrika Ericson, Ruth C. Travis, Magritt Brustad, Kim Overvad, Rosario Tumino, Nicholas J. Wareham, Ole Raaschou-Nielsen, Beatrice Melin, Jakob Linseisen, Aneire E. Khan, Paolo Vineis, Giovanna Masala, Paolo Boffetta, Eiliv Lund, H. Bas Bueno-de-Mesquita, Antonia Trichopoulou, Teresa Norat, Heiner Boeing, Anne-Claire Vergnaud, Roel Vermeulen, Sabina Rinaldi, Rudolf Kaaks, Paula Jakszyn, Amalia Mattiello, Marianne Uhre Jakobsen, Marie-Christine Boutron-Ruault, Anne Tjønneland, María José Tormo, Timothy J. Key, Manuela M. Bergmann, Sabine Rohrmann, Marcial Argüelles, University of Zurich, Rohrmann, S, Rohrmann, S., Linseisen, J., Jakobsen, M.U., Overvad, K., Raaschou-Nielsen, O., Tjonneland, A., Boutron-Ruault, M.C., Kaaks, R., Becker, N., Bergmann, M., Boeing, H., Khaw, K.-T., Wareham, N.J., Key, T.J., Travis, R., Benetou, V., Naska, A., Trichopoulou, A., Pala, V., Tumino, R., Masala, G., Mattiello, A., Brustad, M., Lund, E., Skeie, G., Bueno-De-Mesquita, H.B., Peeters, P.H.M., Vermeulen, R.C.H., Jakszyn, P., Dorronsoro, M., Barricarte, A., Tormo, M.-J., Molina, E., Argüelles, M., Melin, B., Ericson, U., Manjer, J., Rinaldi, S., Slimani, N., Boffetta, P., Vergnaud, A.-C., Khan, A., Norat, T., and Vineis, P.
Subjects: Male, Oncology, medicine.medical_specialty, Cancer Research, Lymphoma, B-Cell, Consumption, lymphoma, 610 Medicine & health, Lymphoma, T-Cell, Risk Assessment, Cohort Studies, Food group, meat, Cheese, immune system diseases, Internal medicine, hemic and lymphatic diseases, lymhomas, meat consumption, dairy consumption, cohort study, Humans, Medicine, 1306 Cancer Research, ddc:610, Risk factor, risk, business.industry, Lymphoma, Non-Hodgkin, Cancer, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), European Prospective Investigation into Cancer and Nutrition, Yogurt, medicine.disease, Lymphoma, Europe, Relative risk, Immunology, dairy, Female, 2730 Oncology, Dairy Products, Waldenstrom Macroglobulinemia, business, Risk assessment, Cohort study
Abstract: The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition. During a median follow-up of 8.5 years, 1,334 lymphomas (1,267 non-Hodgkin lymphoma (NHL) and 67 Hodgkin lymphomas) were identified. Consumption of red and processed meat, poultry, milk and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, the consumption of foods of animal origin was not associated with an increased risk of NHLS or HL, but the associations with specific subgroups of NHL entities were noted. A high intake of processed meat was associated with an increased risk of B-cell chronic lymphocytic leukemia (BCLL) [relative risk (RR) per 50 g intake = 1.31, 95% confidence interval (CI) 1.06-1.63], but a decreased risk of follicular lymphomas (FL) (RR = 0.58; CI 0.38-0.89). A high intake of poultry was related to an increased risk of B-cell lymphomas (RR = 1.22; CI 1.05-1.42 per 10 g intake), FL (RR = 1.65; CI 1.18-2.32) and BCLL (RR = 1.54; CI 1.18-2.01) in the continuous models. In conclusion, no consistent associations between red and processed meat consumption and lymphoma risk were observed, but we found that the consumption of poultry was related to an increased risk of B-cell lymphomas. Chance is a plausible explanation of the observed associations, which need to be confirmed in further studies. Copyright © 2010 UICC.
Published: 2010

35. Plasma vitamins B2, B6, B12, and related genetic variants as predictors of colorectal cancer risk

Author: Simone J. P. M. Eussen, Øivind Midttun, Kim Overvad, Elio Riboli, Tobias Pischon, Ole Thorlacius-Ussing, Paolo Vineis, Rudolf Kaaks, Laudina Rodríguez, Domenico Palli, Bethany VanGuelpen, Mazda Jenab, Per Magne Ueland, Ulrika Ericson, Cornelia Weikert, Åse Fredriksen, Anne Tjønneland, Carmen Enid Martínez, Petra H.M. Peeters, Paolo Boffetta, Klaus Meyer, Carmen Navarro, H. Bas Bueno-de-Mesquita, Jonas Manjer, Valeria Pala, Françoise Clavel-Chapelon, Teresa Norat, Sophie Morois, Fränzel J.B. Van Duijnhoven, Anja Olsen, Rosario Tumino, Kay-Tee Khaw, Steinar Hustad, Jakob Linseisen, Michael Katsoulis, Richard Palmqvist, Stein Emil Vollset, Sheila Bingham, Antonia Trichopoulou, Guri Skeie, Miren Dorronsoro, Demosthenes Zilis, Nadia Slimani, Eva Ardanaz, Salvatore Panico, Xavier Muñoz, Marie-Christine Boutron-Ruault, Eussen, Sj, Vollset, Se, Hustad, S, Midttun, Ø, Meyer, K, Fredriksen, A, Ueland, Pm, Jenab, M, Slimani, N, Boffetta, P, Overvad, K, Thorlacius Ussing, O, Tjønneland, A, Olsen, A, Clavel Chapelon, F, Boutron Ruault, Mc, Morois, S, Weikert, C, Pischon, T, Linseisen, J, Kaaks, R, Trichopoulou, A, Zilis, D, Katsoulis, M, Palli, D, Pala, V, Vineis, P, Tumino, R, Panico, Salvatore, Peeters, Ph, Bueno de Mesquita, Hb, van Duijnhoven, Fj, Skeie, G, Muñoz, X, Martínez, C, Dorronsoro, M, Ardanaz, E, Navarro, C, Rodríguez, L, Vanguelpen, B, Palmqvist, R, Manjer, J, Ericson, U, Bingham, S, Khaw, Kt, Norat, T, Riboli, E., Eussen, S.J.P.M., Vollset, S.E., Hustad, S., Midttun, Ø., Meyer, K., Fredriksen, Å., Ueland, P.M., Jenab, M., Slimani, N., Boffetta, P., Overvad, K., Thorlacius-Ussing, O., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Morois, S., Weikert, C., Pischon, T., Linseisen, J., Kaaks, R., Trichopoulou, A., Zilis, D., Katsoulis, M., Palli, D., Pala, V., Vineis, P., Tumino, R., Panico, S., Peeters, P.H.M., Bueno-de-Mesquita, H.B., Van Duijnhoven, F.J.B., Skeie, G., Muñoz, X., Martínez, C., Dorronsoro, M., Ardanaz, E., Navarro, C., Rodríguez, L., VanGuelpen, B., Palmqvist, R., Manjer, J., Ericson, U., Bingham, S., Khaw, K.-T., and Norat, T.
Subjects: Oncology, Male, medicine.medical_specialty, Epidemiology, Colorectal cancer, Riboflavin, Polymorphism, Single Nucleotide, Article, Cohort Studies, Folic Acid, Risk Factors, Internal medicine, Genotype, medicine, Humans, Vitamin B12, ONE-CARBON METABOLISM, METHIONINE SYNTHASE GENE, METHYLENETETRAHYDROFOLATE REDUCTASE, FOLATE METABOLISM, MASS-SPECTROMETRY, HOMOCYSTEINE METABOLISM, DNA METHYLATION, DIETARY-INTAKE, RAT-LIVER, POLYMORPHISMS, B12, biology, colorectal cancer risk, business.industry, Case-control study, Cancer, Middle Aged, medicine.disease, Vitamin B 6, B vitamins, Vitamin B 12, Endocrinology, Methylenetetrahydrofolate reductase, Case-Control Studies, biology.protein, B6, Female, B2, business, Colorectal Neoplasms, Cohort study
Abstract: Background: B-vitamins are essential for one-carbon metabolism and have been linked to colorectal cancer. Although associations with folate have frequently been studied, studies on other plasma vitamins B2, B6, and B12 and colorectal cancer are scarce or inconclusive. Methods: We carried out a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, including 1,365 incident colorectal cancer cases and 2,319 controls matched for study center, age, and sex. We measured the sum of B2 species riboflavin and flavin mononucleotide, and the sum of B6 species pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples collected at baseline. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for colorectal cancer were estimated using conditional logistic regression, adjusted for smoking, education, physical activity, body mass index, alcohol consumption, and intakes of fiber and red and processed meat. Results: The relative risks comparing highest to lowest quintile were 0.71 [95% confidence interval (95% CI), 0.56-0.91; Ptrend = 0.02] for vitamin B2, 0.68 (95% CI, 0.53-0.87; Ptrend Conclusions: Higher plasma concentrations of vitamins B2 and B6 are associated with a lower colorectal cancer risk. Impact: This European population-based study is the first to indicate that vitamin B2 is inversely associated with colorectal cancer, and is in agreement with previously suggested inverse associations of vitamin B6 with colorectal cancer. Cancer Epidemiol Biomarkers Prev; 19(10); 2549–61. ©2010 AACR.
Published: 2010

36. Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Françoise Clavel-Chapelon, Sophie Morois, Carla H. van Gils, Miren Dorronsoro, Nadia Slimani, Paolo Boffetta, Rudolf Kaaks, Aurelio Barricarte, Magritt Brustad, Laudina Rodríguez, Frederike L. Büchner, Sabina Sieri, Naomi E. Allen, Dagrun Engeset, Elio Riboli, Kim Overvad, Sheila Bingham, Göran Hallmans, Carlos González, Heiner Boeing, Eiliv Lund, Antonia Trichopoulou, Dimitrios Trichopoulos, Emily Sonestedt, Ingegerd Johansson, Janine Wichmann, Pagona Lagiou, Mazda Jenab, José María Huerta, Anne Tjønneland, H. Bas Bueno-de-Mesquita, Traci Mouw, Jakob Linseisen, Teresa Norat, Jonas Manjer, Michael Nielsen, Petra H.M. Peeters, Vassiliki Benetou, Fränzel J.B. Van Duijnhoven, Anja Olsen, Elisabeth Couto, Pietro Ferrari, Timothy J. Key, Domenico Palli, Marie-Christine Boutron-Ruault, Salvatore Panico, Ute Nöthlings, Kay-Tee Khaw, Androniki Naska, Paolo Vineis, María José Sánchez, Sabine Rohrmann, 33: Boffetta, P, Couto, E, Wichmann, J, Ferrari, P, Trichopoulos, D, Bueno de Mesquita, Hb, van Duijnhoven, Fj, Büchner, Fl, Key, T, Boeing, H, Nöthlings, U, Linseisen, J, Gonzalez, Ca, Overvad, K, Nielsen, Mr, Tjønneland, A, Olsen, A, Clavel Chapelon, F, Boutron Ruault, Mc, Morois, S, Lagiou, P, Naska, A, Benetou, V, Kaaks, R, Rohrmann, S, Panico, Salvatore, Sieri, S, Vineis, P, Palli, D, van Gils, Ch, Peeters, Ph, Lund, E, Brustad, M, Engeset, D, Huerta, Jm, Rodríguez, L, Sánchez, Mj, Dorronsoro, M, Barricarte, A, Hallmans, G, Ohansson, I, Manjer, J, Sonestedt, E, Allen, Ne, Bingham, S, Khaw, Kt, Slimani, N, Jenab, M, Mouw, T, Norat, T, Riboli, E, Trichopoulou, A., Boffetta, P., Couto, E., Wichmann, J., Ferrari, P., Trichopoulos, D., Bueno-De-Mesquita, H.B., Van Duijnhoven, F.J.B., Büchner, F.L., Key, T., Boeing, H., Nöthlings, U., Linseisen, J., Gonzalez, C.A., Overvad, K., Nielsen, M.R.S., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Morois, S., Lagiou, P., Naska, A., Benetou, V., Kaaks, R., Rohrmann, S., Panico, S., Sieri, S., Vineis, P., Palli, D., Van Gils, C.H., Peeters, P.H., Lund, E., Brustad, M., Engeset, D., Huerta, J.M., Rodríguez, L., Sánchez, M.-J., Dorronsoro, M., Barricarte, A., Hallmans, G., Johansson, I., Manjer, J., Sonestedt, E., Allen, N.E., Bingham, S., Khaw, K.-T., Slimani, N., Jenab, M., Mouw, T., Norat, T., and Riboli, E.
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Alcohol Drinking, tobacco, Risk Assessment, smoking, Molecular epidemiology [NCEBP 1], nutrition in cancer, Risk Factors, Neoplasms, Surveys and Questionnaires, Environmental health, Vegetables, Epidemiology, follow-up, Odds Ratio, cancer, vegetable, Humans, Medicine, Prospective Studies, Registries, Food science, ddc:610, Prospective cohort study, Life Style, risk, Aged, Observer Variation, Proportional hazards model, business.industry, Incidence, Hazard ratio, Feeding Behavior, Odds ratio, Middle Aged, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Research Design, Fruit, Cohort, Female, diet, Risk assessment, business
Abstract: Contains fulltext : 88546.pdf (Publisher’s version ) (Closed access) BACKGROUND: It is widely believed that cancer can be prevented by high intake of fruits and vegetables. However, inconsistent results from many studies have not been able to conclusively establish an inverse association between fruit and vegetable intake and overall cancer risk. METHODS: We conducted a prospective analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to assess relationships between intake of total fruits, total vegetables, and total fruits and vegetables combined and cancer risk during 1992-2000. Detailed information on the dietary habit and lifestyle variables of the cohort was obtained. Cancer incidence and mortality data were ascertained, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox regression models. Analyses were also conducted for cancers associated with tobacco and alcohol after stratification for tobacco smoking and alcohol drinking. RESULTS: Of the initial 142 605 men and 335 873 women included in the study, 9604 men and 21 000 women were identified with cancer after a median follow-up of 8.7 years. The crude cancer incidence rates were 7.9 per 1000 person-years in men and 7.1 per 1000 person-years in women. Associations between reduced cancer risk and increased intake of total fruits and vegetables combined and total vegetables for the entire cohort were similar (200 g/d increased intake of fruits and vegetables combined, HR = 0.97, 95% CI = 0.96 to 0.99; 100 g/d increased intake of total vegetables, HR = 0.98, 95% CI = 0.97 to 0.99); intake of fruits showed a weaker inverse association (100 g/d increased intake of total fruits, HR = 0.99, 95% CI = 0.98 to 1.00). The reduced risk of cancer associated with high vegetable intake was restricted to women (HR = 0.98, 95% CI = 0.97 to 0.99). Stratification by alcohol intake suggested a stronger reduction in risk in heavy drinkers and was confined to cancers caused by smoking and alcohol. CONCLUSIONS: A very small inverse association between intake of total fruits and vegetables and cancer risk was observed in this study. Given the small magnitude of the observed associations, caution should be applied in their interpretation.
Published: 2010

37. Plasma folate, related genetic variants, and colorectal cancer risk in EPIC

Author: Elio Riboli, Klaus Meyer, Rudolf Kaaks, Eiliv Lund, Salvatore Panico, Françoise Clavel-Chapelon, Åse Fredriksen, Laudina Rodríguez, H. Bas Bueno-de-Mesquita, Sophie Morois, Richard Palmqvist, Guri Skeie, Teresa Norat, Carmen Navarro, Inger T. Gram, Kim Overvad, Jakob Linseisen, Stein Emil Vollset, Jannicke Igland, Miren Dorronsoro, Demosthenes Zilis, Nadia Slimani, Mazda Jenab, Bethany Van Guelpen, Paolo Vineis, Paolo Boffetta, Ulrika Ericson, Carlos A. González, Petra H.M. Peeters, Marie-Christine Boutron-Ruault, Franco Berrino, Eva Ardanaz, Fränzel J.B. Van Duijnhoven, Sheila Bingham, Anja Olsen, Antonia Trichopoulou, Rosario Tumino, Jonas Manjer, Kay-Tee Khaw, Cornelia Weikert, Carmen Enid Martínez, Simone J. P. M. Eussen, Tobias Pischon, Domenico Palli, Per Magne Ueland, Michael Katsoulis, Anne Tjønneland, Eussen, Sj, Vollset, Se, Igland, J, Meyer, K, Fredriksen, A, Ueland, Pm, Jenab, M, Slimani, N, Boffetta, P, Overvad, K, Tjønneland, A, Olsen, A, Clavel Chapelon, F, Boutron Ruault, Mc, Morois, S, Weikert, C, Pischon, T, Linseisen, J, Kaaks, R, Trichopoulou, A, Zilis, D, Katsoulis, M, Palli, D, Berrino, F, Vineis, P, Tumino, R, Panico, Salvatore, Peeters, Ph, Bueno de Mesquita, Hb, van Duijnhoven, Fj, Gram, It, Skeie, G, Lund, E, González, Ca, Martínez, C, Dorronsoro, M, Ardanaz, E, Navarro, C, Rodríguez, L, Van Guelpen, B, Palmqvist, R, Manjer, J, Ericson, U, Bingham, S, Khaw, Kt, Norat, T, Riboli, E., Eussen, S.J.P.M., Vollset, S.E., Igland, J., Meyer, K., Fredriksen, Å., Ueland, P.M., Jenab, M., Slimani, N., Boffetta, P., Overvad, K., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Morois, S., Weikert, C., Pischon, T., Linseisen, J., Kaaks, R., Trichopoulou, A., Zilis, D., Katsoulis, M., Palli, D., Berrino, F., Vineis, P., Tumino, R., Panico, S., Peeters, P.H.M., Bueno-de-Mesquita, H.B., Van Duijnhoven, F.J.B., Gram, I.T., Skeie, G., Lund, E., González, C.A., Martínez, C., Dorronsoro, M., Ardanaz, E., Navarro, C., Rodríguez, L., Van Guelpen, B., Palmqvist, R., Manjer, J., Ericson, U., Bingham, S., Khaw, K.-T., and Norat, T.
Subjects: Adult, Male, Oncology, medicine.medical_specialty, Epidemiology, Colorectal cancer, colorectal cancer, Biology, medicine.disease_cause, Polymorphism, Single Nucleotide, Article, Methylenetetrahydrofolate reductase polymorphism, Nested case-control, Human methionine synthase, Carbon metabolic pathway, C677T MTHFR polymorphism, Colon-cancer, Folic-acid, Mass-spectrometry, Dietary patterns, Common mutation, Folic Acid, Risk Factors, Molecular genetics, Internal medicine, Genetic variation, medicine, Humans, Genetic Predisposition to Disease, Prospective Studies, Prospective cohort study, Methylenetetrahydrofolate Reductase (NADPH2), Aged, Aged, 80 and over, Genetics, Plasma folate, Case-control study, Middle Aged, Prognosis, medicine.disease, digestive system diseases, Survival Rate, Case-Control Studies, Methylenetetrahydrofolate reductase, Nested case-control study, biology.protein, Female, EPIC, Colorectal Neoplasms, Carcinogenesis
Abstract: Background: A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort.Methods: In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 controls for study center, age, and sex. Risk ratios (RR) were estimated with conditional logistic regression and adjusted for smoking, education, physical activity, and intake of alcohol and fiber.Results: Overall analyses did not reveal associations of plasma folate with CRC. The RR (95% confidence interval; Ptrend) for the fifth versus the first quintile of folate status was 0.94 (0.74-1.20; 0.44). The polymorphisms MTHFR677C→T, MTHFR1298A→C, MTR2756A→G, MTRR66A→G, and MTHFD11958G→A were not associated with CRC risk. However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically nonsignificant increased CRC risk [RR (95% CI; Ptrend) TT versus CC = 1.39 (0.87-2.21); 0.12], whereas those with the highest folate concentrations showed a nonsignificant decreased CRC risk [RR TT versus CC = 0.74 (0.39-1.37); 0.34]. The SLC19A180G→A showed a positive association with CRC risk [RR AA versus GG 1.30 (1.06-1.59); Conclusions: This large European prospective multicenter study did not show an association of CRC risk with plasma folate status nor with MTHFR polymorphisms.Impact: Findings of the present study tend to weaken the evidence that folate plays an important role in CRC carcinogenesis. However, larger sample sizes are needed to adequately address potential gene-environment interactions. Cancer Epidemiol Biomarkers Prev; 19(5); 1328–40. ©2010 AACR.
Published: 2010

38. A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Author: Petra H.M. Peeters, Aurelio Barricarte, Domenico Palli, Naomi E. Allen, Laudina Rodríguez, Sheila Bingham, María Dolores Chirlaque, Antonia Trichopoulou, Sabina Sieri, H. Bas Bueno-de-Mesquita, Kim Overvad, Kay-Tee Khaw, Traci Mouw, María José Sánchez, Teresa Norat, Paolo Contiero, Yvoni Koumantaki, Peter Wallström, Sabine Rohrmann, Göran Hallmans, Rosario Tumino, Andrew W. Roddam, Anne Tjønneland, Rudolf Kaaks, Paolo Vineis, Laura Esquius, Börje Ljungberg, Jonas Manjer, Jytte Halkjær, Paolo Boffetta, Amalia Mattiello, Marianne Uhre Jakobsen, Elio Riboli, Miren Dorronsoro, Demosthenes Zilis, Heiner Boeing, Allen, N.E., Roddam, A.W., Sieri, S., Boeing, H., Jakobsen, M.U., Overvad, K., Tjønneland, A., Halkjær, J., Vineis, P., Contiero, P., Palli, D., Tumino, R., Mattiello, A., Kaaks, R., Rohrmann, S., Trichopoulou, A., Zilis, D., Koumantaki, Y., Peeters, P.H., Bueno-de-Mesquita, H.B., Barricarte, A., Rodríguez, L., Dorronsoro, M., Sánchez, M.-J., Chirlaque, M.D., Esquius, L., Manjer, J., Wallström, P., Ljungberg, B., Hallmans, G., Bingham, S., Khaw, K.-T., Boffetta, P., Norat, T., Mouw, T., and Riboli, E.
Subjects: Adult, Male, Questionnaires, Cancer Research, medicine.medical_specialty, renal cell carcinoma, Meat, macronutrient, Physiology, Risk Assessment, Body Mass Index, Cohort Studies, Renal cell carcinoma, Risk Factors, Internal medicine, Surveys and Questionnaires, medicine, Carcinoma, Humans, Prospective Studies, Prospective cohort study, Carcinoma, Renal Cell, Aged, business.industry, Cancer, Confounding Factors, Epidemiologic, Feeding Behavior, prospective, Middle Aged, medicine.disease, Confounding Factors (Epidemiology), Dietary Fats, Kidney Neoplasms, European Prospective Investigation into Cancer and Nutrition, Endocrinology, Oncology, Female, Food Habits, business, diet, EPIC, Kidney cancer, Body mass index, Kidney disease, Follow-Up Studies
Abstract: Udgivelsesdato: 2009-Aug-15 Previous case-control studies have suggested that a high intake of animal foods and its associated nutrients are associated with an increased risk of renal cell carcinoma, although data from prospective studies are limited. We report here on the relationship between macronutrient intake and renal cell carcinoma incidence among 435,293 participants enrolled in the European Prospective Investigation into Cancer and Nutrition. Cox proportional hazard models were used to examine the association of dietary intake of fat, protein, carbohydrate, fiber and cholesterol and risk of renal cell carcinoma adjusted for age, sex, center, height, body mass index, physical activity, education, smoking, menopausal status, alcohol and energy intake. During an average 8.8 years of follow-up, 507 renal cell carcinoma cases occurred. Risk of renal cell carcinoma was not associated with macronutrient intake, including nutrients derived from animal sources. Our results indicate that macronutrient intake is not associated with risk of renal cell carcinoma in this cohort of European men and women.
Published: 2009

39. Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition

Author: Petra H.M. Peeters, Domenico Palli, Carmen Navarro, Carla H. van Gils, Jonas Manjer, Corinne Casagrande, Mazda Jenab, Jakob Linseisen, Ute Nöthlings, Paolo Vineis, Martine M. Ros, Sheila Bingham, Anja Olsen, Miren Dorronsoro, Elio Riboli, Göran Berglund, Pietro Ferrari, Aurelio Barricarte, Nadia Slimani, Antonia Trichopoulou, Marie-Christine Boutron-Ruault, Dagrun Engeset, Salvatore Panico, Marga C. Ocké, Françoise Clavel-Chapelon, Sabina Sieri, Ole Thorlacius-Ussing, Dimitrios Trichopoulos, Sophie Morois, Timothy J. Key, Kim Overvad, Valentina Gallo, Carlos A. González, Rosario Tumino, Paolo Boffetta, Heiner Boeing, H. Bas Bueno-de-Mesquita, Kay-Tee Khaw, Anne Tjønneland, Teresa Norat, Laudina Rodríguez Suárez, Fränzel J. B. van Duijnhoven, Guri Skeie, Naomi E. Allen, Eiliv Lund, Rudolf Kaaks, Richard Palmqvist, Gesthimani Misirli, María José Sánchez, Göran Hallmans, Hendriek C. Boshuizen, Sabina Rinaldi, Van Duijnhoven, F.J.B., Bueno-De-Mesquita, H.B., Ferrari, P., Jenab, M., Boshuizen, H.C., Ros, M.M., Casagrande, C., Tjønneland, A., Olsen, A., Overvad, K., Thorlacius-Ussing, O., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Morois, S., Kaaks, R., Linseisen, J., Boeing, H., Nöthlings, U., Trichopoulou, A., Trichopoulos, D., Misirli, G., Palli, D., Sieri, S., Panico, S., Tumino, R., Vineis, P., Peeters, P.H.M., Van Gils, C.H., Ocké, M.C., Lund, E., Engeset, D., Skeie, G., Suárez, L.R., González, C.A., Sánchez, M.-J., Dorronsoro, M., Navarro, C., Barricarte, A., Berglund, G., Manjer, J., Hallmans, G., Palmqvist, R., Bingham, S.A., Khaw, K.-T., Key, T.J., Allen, N.E., Boffetta, P., Slimani, N., Rinaldi, S., Gallo, V., Norat, T., Riboli, E., van Duijnhoven, Fj, Bueno De Mesquita, Hb, Ferrari, P, Jenab, M, Boshuizen, Hc, Ros, Mm, Casagrande, C, Tjønneland, A, Olsen, A, Overvad, K, Thorlacius Ussing, O, Clavel Chapelon, F, Boutron Ruault, Mc, Morois, S, Kaaks, R, Linseisen, J, Boeing, H, Nöthlings, U, Trichopoulou, A, Trichopoulos, D, Misirli, G, Palli, D, Sieri, S, Panico, Salvatore, Tumino, R, Vineis, P, Peeters, Ph, van Gils, Ch, Ocké, Mc, Lund, E, Engeset, D, Skeie, G, Suárez, Lr, González, Ca, Sánchez, Mj, Dorronsoro, M, Navarro, C, Barricarte, A, Berglund, G, Manjer, J, Hallmans, G, Palmqvist, R, Bingham, Sa, Khaw, Kt, Key, Tj, Allen, Ne, Boffetta, P, Slimani, N, Rinaldi, S, Gallo, V, and Norat, T
Subjects: Questionnaires, Oncology, Male, medicine.medical_specialty, Time Factors, Colorectal cancer, Medicine (miscellaneous), Environment, Gastroenterology, 03 medical and health sciences, Fruit vegetables colorectal cancer risk The European Prospective Investigation Cancer Nutrition, 0302 clinical medicine, Risk Factors, Internal medicine, Surveys and Questionnaires, Vegetables, medicine, Humans, ddc:610, Prospective Studies, Risk factor, Life Style, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Nutrition and Dietetics, Proportional hazards model, business.industry, Incidence (epidemiology), Incidence, Patient Selection, Hazard ratio, Smoking, Cancer, Reproducibility of Results, Colonoscopy, medicine.disease, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Diet, Europe, 030220 oncology & carcinogenesis, Fruit, Cohort, Female, business, Colorectal Neoplasms, Demography, Follow-Up Studies
Abstract: Background: A high consumption of fruit and vegetables is possibly associated with a decreased risk of colorectal cancer (CRC). However, the findings to date are inconsistent. Objective: We examined the relation between self-reported usual consumption of fruit and vegetables and the incidence of CRC. Design: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 452,755 subjects (131,985 men and 320,770 women) completed a dietary questionnaire in 1992-2000 and were followed up for cancer incidence and mortality until 2006. A multivariate Cox proportional hazard model was used to estimate adjusted hazard ratios (HRs) and 95% CIs. Results: After an average follow-up of 8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and vegetables was inversely associated with CRC in a comparison of the highest with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend = 0.04), particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for trend < 0.01). Only after exclusion of the first 2 y of follow-up were these findings corroborated by calibrated continuous analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P = 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The association between fruit and vegetable consumption and CRC risk was inverse in never and former smokers, but positive in current smokers. This modifying effect was found for fruit and vegetables combined and for vegetables alone (P for interaction < 0.01 for both). Conclusions: These findings suggest that a high consumption of fruit and vegetables is associated with a reduced risk of CRC, especially of colon cancer. This effect may depend on smoking status. © 2009 American Society for Nutrition.
Published: 2009

40. Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Christine M. Friedenreich, Elio Riboli, Sabina Rinaldi, Rosario Tumino, Steffen Loft, Gesthimani Misirli, Jane Christensen, Nicholas J. Wareham, Nina Føns Johnsen, Laudina Rodríguez Suárez, Antonia Trichopoulou, Birthe Lykke Thomsen, Valeria Pala, Anne Tjønneland, Jonas Manjer, Naomi E. Allen, Kim Overvad, Timothy J. Key, Aurelio Barricarte Gurrea, Lambertus A. Kiemeney, Dimosthenis Zylis, Kay-Tee Khaw, Elisabet Wirfält, Petra H. Lahmann, Lotte Mejlvig, Heiner Boing, Paolo Boffetta, Sabine Rohrmann, Lars Egevad, María José Sánchez, Rudolf Kaaks, José María Huerta, H. Bas Bueno-de-Mesquita, Carlos González, Johnsen, N.F., Tjønneland, A., Thomsen, B.L.R., Christensen, J., Loft, S., Friedenreich, C., Key, T.J., Allen, N.E., Lahmann, P.H., Mejlvig, L., Overvad, K., Kaaks, R., Rohrmann, S., Boing, H., Misirli, G., Trichopoulou, A., Zylis, D., Tumino, R., Pala, V., Bueno-de-Mesquita, H.B., Kiemeney, L.A., Suárez, L.R., Gonzalez, C.A., Sánchez, M.-J., Huerta, J.M., Gurrea, A.B., Manjer, J., Wirfält, E., Khaw, K.-T., Wareham, N., Boffetta, P., Egevad, L., Rinaldi, S., and Riboli, E.
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Time Factors, Aetiology, screening and detection [ONCOL 5], Walking, Metabolic equivalent, Molecular epidemiology [NCEBP 1], Cohort Studies, Young Adult, 03 medical and health sciences, Prostate cancer, Leisure Activities, 0302 clinical medicine, Translational research [ONCOL 3], Risk Factors, Internal medicine, medicine, Humans, Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, Prospective Studies, 030212 general & internal medicine, Risk factor, Exercise, Aged, Aged, 80 and over, Hereditary cancer and cancer-related syndromes [ONCOL 1], Proportional hazards model, business.industry, Incidence, Prostatic Neoplasms, Cancer, Middle Aged, medicine.disease, 3. Good health, European Prospective Investigation into Cancer and Nutrition, 030220 oncology & carcinogenesis, Cohort, Physical therapy, business, Cohort study
Abstract: Contains fulltext : 81941.pdf (Publisher’s version ) (Closed access) The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a metabolic equivalent (MET) score based on weekly time spent on the 4 activities; and a physical activity index. MET hours per week of leisure time activity, higher score in the physical activity index, participation in any of the 4 leisure time activities, and the number of leisure time activities in which the participants were active were not associated with prostate cancer incidence. However, higher level of occupational physical activity was associated with lower risk of advanced stage prostate cancer (p(trend) = 0.024). In conclusion, our data support the hypothesis of an inverse association between advanced prostate cancer risk and occupational physical activity, but we found no support for an association between prostate cancer risk and leisure time physical activity.
Published: 2009

41. Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations

Author: Petra H.M. Peeters, Anne Tjønneland, Philippe Autier, Heiner Boeing, Rudolf Kaaks, Pierre Engel, Françoise Clavel-Chapelon, Fränzel J.B. Van Duijnhoven, James McKay, Anja Olsen, Paolo Vineis, Jakob Linseisen, Aurelio Barricarte, Núria Sala, Elio Riboli, Alina Vrieling, Eva Fisher, Sheila Bingham, Antonia Trichopoulou, Tobias Pischon, Erifili Oustoglou, María Dolores Chirlaque, Graham Byrnes, Miren Dorronsoro, Esther Molina, Hendrik B. Bueno-de-Mesquita, Teresa Norat, Nadia Slimani, Marie-Christine Boutron-Ruault, Pietro Ferrari, Paolo Boffetta, Rosario Tumino, Kay-Tee Khaw, Kim Overvad, Giovanna Masala, Eiliv Lund, Timothy J. Key, Andrew W. Roddam, Mazda Jenab, Eugene Jansen, Göran Hallmans, Sabina Rinaldi, Richard Palmqvist, Vardis Dilis, Franco Berrino, Carla H. van Gils, Magritt Brustad, Laudina Rodríguez Suárez, Amalia Mattiello, Jenab, M., McKay, J., Bueno-De-Mesquita, H.B., Van Duijnhoven, F.J.B., Ferrari, P., Slimani, N., Jansen, E.H.J.M., Pischon, T., Rinaldi, S., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Engel, P., Kaaks, R., Linseisen, J., Boeing, H., Fisher, E., Trichopoulou, A., Dilis, V., Oustoglou, E., Berrino, F., Vineis, P., Mattiello, A., Masala, G., Tumino, R., Vrieling, A., Van Gils, C.H., Peeters, P.H., Brustad, M., Lund, E., Chirlaque, M.-D., Barricarte, A., Suárez, L.R., Molina, E., Dorronsoro, M., Sala, N., Hallmans, G., Palmqvist, R., Roddam, A., Key, T.J., Khaw, K.-T., Bingham, S., Boffetta, P., Autier, P., Byrnes, G., Norat, T., and Riboli, E.
Subjects: Male, Oncology, medicine.medical_specialty, Genotype, Epidemiology, Colorectal cancer, Population, Single-nucleotide polymorphism, Calcitriol receptor, White People, Internal medicine, medicine, Vitamin D and neurology, Humans, Genetic Predisposition to Disease, Vitamin D, education, Life Style, education.field_of_study, Polymorphism, Genetic, business.industry, Case-control study, Cancer, Middle Aged, medicine.disease, Vitamin D receptor calcium sensing receptor polymorphisms colorectal cancer European populations, European Prospective Investigation into Cancer and Nutrition, Calcium, Dietary, Europe, Endocrinology, Case-Control Studies, Receptors, Calcitriol, Female, Colorectal Neoplasms, business, Receptors, Calcium-Sensing
Abstract: Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake. (Cancer Epidemiol Biomarkers Prev 2009;18(9):2485-91)
Published: 2009

42. Ethanol intake and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Anette Hjartåker, Rudolf Kaaks, Björn Lindkvist, Larraitz Arriola, Albert B. Lowenfels, Guy Fagherazzi, Heiner Boeing, Weimin Ye, Kay-Tee Khaw, H. Bas Bueno-de-Mesquita, Nadia Slimani, Traci Mouw, Françoise Clavel-Chapelon, Salvatore Panico, Eric J. Duell, Paolo Boffetta, Jonas Manjer, Majken K. Jensen, Jakob Linseisen, Aurelio Barricarte Gurrea, Andrew W. Roddam, Petra H.M. Peeters, Antonio Agudo, Alina Vrieling, Dominique S. Michaud, Gesthimani Misirli, Ingegerd Johansson, Naomi E. Allen, Eiliv Lund, Domenico Palli, Marie-Christine Boutron-Ruault, Manuela M. Bergmann, Anja Olsen, Rachael Z. Stolzenberg-Solomon, Sheila Bingham, Antonia Trichopoulou, Sabine Rohrmann, Anne Tjønneland, María José Sánchez, Pagona Lagiou, Rosario Tumino, Paolo Vineis, María José Tormo, Ma Luisa Redondo Cornejo, Kim Overvad, Elio Riboli, Valeria Pala, Mazda Jenab, Rohrmann, S, Linseisen, J, Vrieling, A, Boffetta, P, Stolzenberg Solomon, Rz, Lowenfels, Ab, Jensen, Mk, Overvad, K, Olsen, A, Tjonneland, A, Boutron Ruault, Mc, Clavel Chapelon, F, Fagherazzi, G, Misirli, G, Lagiou, P, Trichopoulou, A, Kaaks, R, Bergmann, Mm, Boeing, H, Bingham, S, Khaw, Kt, Allen, N, Roddam, A, Palli, D, Pala, V, Panico, Salvatore, Tumino, R, Vineis, P, Peeters, Ph, Hjartåker, A, Lund, E, Redondo Cornejo, Ml, Agudo, A, Arriola, L, Sánchez, Mj, Tormo, Mj, Barricarte Gurrea, A, Lindkvist, B, Manjer, J, Johansson, I, Ye, W, Slimani, N, Duell, Ej, Jenab, M, Michaud, D, Mouw, T, Riboli, E, Bueno de Mesquita, Hb, Rohrmann, S., Linseisen, J., Vrieling, A., Boffetta, P., Stolzenberg-Solomon, R.Z., Lowenfels, A.B., Jensen, M.K., Overvad, K., Olsen, A., Tjonneland, A., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Fagherazzi, G., Misirli, G., Lagiou, P., Trichopoulou, A., Kaaks, R., Bergmann, M.M., Boeing, H., Bingham, S., Khaw, K.-T., Allen, N., Roddam, A., Palli, D., Pala, V., Panico, S., Tumino, R., Vineis, P., Peeters, P.H.M., Hjartåker, A., Lund, E., Cornejo, M.L.R., Agudo, A., Arriola, L., Sánchez, M.-J., Tormo, M.-J., Barricarte Gurrea, A., Lindkvist, B., Manjer, J., Johansson, I., Ye, W., Slimani, N., Duell, E.J., Jenab, M., Michaud, D.S., Mouw, T., Riboli, E., and Bueno-De-Mesquita, H.B.
Subjects: Male, Oncology, Cancer Research, medicine.medical_specialty, Alcohol Drinking, EPIC, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Pancreatic cancer, Internal medicine, Epidemiology, medicine, Humans, ddc:610, 030212 general & internal medicine, Proportional Hazards Models, business.industry, Cancer, Middle Aged, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Surgery, Pancreatic Neoplasms, medicine.anatomical_structure, Ethanol, pancreatic cancer, epidemiology, EPIC, 030220 oncology & carcinogenesis, Female, Ethanol intake, Risk assessment, business, Pancreas, Follow-Up Studies
Abstract: Objective: To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes. Results: Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69-1.27 comparing 30+ g/d vs. 0.1-4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65-1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93-2.10 comparing 10+ g/d vs. 0.1-4.9 g/d), but no associations were observed for wine and beer consumption. Conclusion: These results suggest no association of alcohol consumption with the risk of pancreatic cancer. © 2009 Springer Science+Business Media B.V.
Published: 2009

43. The Role of Smoking and Diet in Explaining Educational Inequalities in Lung Cancer Incidence

Author: Elisabet Wirfält, Salvatore Panico, Jonas Manjer, Jakob Linseisen, Kay-Tee Khaw, Sheila Bingham, Rosario Tumino, María José Tormo, Petra H.M. Peeters, H. Bas Bueno-de-Mesquita, Naomi E. Allen, Anne Tjønneland, Torgny Rasmuson, Antonia Trichopoulou, Gwenn Menvielle, Pietro Ferrari, Nadia Slimani, Paolo Boffetta, Valentina Gallo, Ole Raaschou-Nielsen, Domenico Palli, Timothy J. Key, Elio Riboli, Hendriek Boshuizen, Antonio Agudo, Anton E. Kunst, Susanne Oksbjerg Dalton, Eric J. Duell, Paolo Vineis, Tonje Braaten, Silke Hermann, Maria Kosti, Carla H. van Gils, Vardis Dilis, Göran Hallmans, Eva Ardanaz, Manuela M. Bergmann, María José Sánchez, Inger T. Gram, Vittorio Krogh, Eiliv Lund, Laudina Rodríguez, Frederike L. Büchner, Rudolf Kaaks, Kaniewski, Nadine, Department of Public Health, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Institute of Cancer Epidemiology, Danish Cancer Society, University of Torino and CPO-Piemonte, Università degli studi di Torino = University of Turin (UNITO), Department of Epidemiology, German Institute of Human Nutrition, Division of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Unit of Nutrition, Environment, and Cancer, Catalan Institute of Oncology, Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Department of Preventive & Predictive Medicine, Italian National Center Institute, Department of Clinical and Experimental Medicine, Frederico II University, Cancer Registry Azienda, Civile - M.P.Arezzo Hospital, Julius Center for Health Sciences and Primary Care, VU University Medical Center [Amsterdam], Institute of Community Medicine, University of Tromsø (UiT), Public Health Directorate, Unit of Nutrition, Environment and Cancer, Andalusian School of Public Health [Granada], CIBER Epidemiologia y Salud Publica, CIBER de Epidemiología y Salud Pública (CIBERESP), Murcia Health Council, Public Health Institute of Navarra, Department of surgery, Lund University [Lund]-Malmö University Hospital, Department of Clinical Sciences, Nutrition Epidemiology, Lund University [Lund], Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Department of Radiation Sciences, Oncology, MRC Centrer for Nutritional Epidemiology and Cancer Prevention and Survival, University of Cambridge [UK] (CAM), Cancer Epidemiology Unit, University of Oxford, Departement of Epidemiolgy and Public Health, Imperial College London, Menvielle, G, Boshuizen, H, Kunst, Ae, Dalton, So, Vineis, P, Bergmann, Mm, Hermann, S, Ferrari, P, Raaschou Nielsen, O, Tjønneland, A, Kaaks, R, Linseisen, J, Kosti, M, Trichopoulou, A, Dilis, V, Palli, D, Krogh, V, Panico, Salvatore, Tumino, R, Büchner, Fl, van Gils, Ch, Peeters, Ph, Braaten, T, Gram, It, Lund, E, Rodriguez, L, Agudo, A, Sánchez, Mj, Tormo, Mj, Ardanaz, E, Manjer, J, Wirfält, E, Hallmans, G, Rasmuson, T, Bingham, S, Khaw, Kt, Allen, N, Key, T, Boffetta, P, Duell, Ej, Slimani, N, Gallo, V, Riboli, E, Bueno de Mesquita, Hb, Public and occupational health, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Università degli studi di Torino (UNITO), University of Oxford [Oxford], Malmö University Hospital-Lund University [Lund], Public Health, Cell biology, Menvielle, G., Boshuizen, H., Kunst, A.E., Dalton, S.O., Vineis, P., Bergmann, M.M., Hermann, S., Ferrari, P., Raaschou-Nielsen, O., Tjønneland, A., Kaaks, R., Linseisen, J., Kosti, M., Trichopoulou, A., Dilis, V., Palli, D., Krogh, V., Panico, S., Tumino, R., Büchner, F.L., Van Gils, C.H., Peeters, P.H.M., Braaten, T., Gram, I.T., Lund, E., Rodriguez, L., Agudo, A., Sánchez, M.-J., Tormo, M.-J., Ardanaz, E., Manjer, J., Wirfält, E., Hallmans, G., Rasmuson, T., Bingham, S., Khaw, K.-T., Allen, N., Key, T., Boffetta, P., Duell, E.J., Slimani, N., Gallo, V., Riboli, E., and Bueno-De-Mesquita, H.B.
Subjects: Male, Cancer Research, Lung Neoplasms, Aetiology, screening and detection [ONCOL 5], 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Vegetables, Odds Ratio, Prospective Studies, 030212 general & internal medicine, 10. No inequality, Prospective cohort study, education, Mediterranean Region, Incidence, Incidence (epidemiology), 1. No poverty, Confounding Factors, Epidemiologic, Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Research Design, 030220 oncology & carcinogenesis, Cohort, Educational Status, lung cancer incidence, Female, women, Cohort study, Adult, medicine.medical_specialty, men, Risk Assessment, Article, smoking, Molecular epidemiology [NCEBP 1], 03 medical and health sciences, Sex Factors, SDG 3 - Good Health and Well-being, medicine, cohort study, Humans, ddc:610, Sex Distribution, Risk factor, Lung cancer, Socioeconomic status, Aged, Proportional Hazards Models, business.industry, Feeding Behavior, medicine.disease, Social Mobility, Surgery, Social Class, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Fruit, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, EPIC, diet, Demography
Abstract: Background: Studies in many countries have reported higher lung cancer incidence and mortality in individuals with lower socioeconomic status. Methods: To investigate the role of smoking in these inequalities, we used data from 391 251 participants in the European Prospective Investigation into Cancer and Nutrition study, a cohort of individuals in 10 European countries. We collected information on smoking (history and quantity), fruit and vegetable consumption, and education through questionnaires at study entry and gathered data on lung cancer incidence for a mean of 8.4 years. Socioeconomic status was defined as the highest attained level of education, and participants were grouped by sex and region of residence (Northern Europe, Germany, or Southern Europe). Relative indices of inequality (RIIs) of lung cancer risk unadjusted and adjusted for smoking were estimated using Cox regression models. Additional analyses were performed by histological type. Results: During the study period, 939 men and 692 women developed lung cancer. Inequalities in lung cancer risk (RII men = 3.62, 95% confidence interval [CI] = 2.77 to 4.73, 117 vs 52 per 100 000 person-years for lowest vs highest education level; RII women = 2.39, 95% CI = 1.77 to 3.21, 46 vs 25 per 100 000 person-years) decreased after adjustment for smoking but remained statistically significant (RIImen = 2.29, 95% CI = 1.75 to 3.01; RII women = 1.59, 95% CI = 1.18 to 2.13). Large RIIs were observed among men and women in Northern European countries and among men in Germany, but inequalities in lung cancer risk were reverse (RIIs < 1) among women in Southern European countries. Inequalities differed by histological type. Adjustment for smoking reduced inequalities similarly for all histological types and among men and women in all regions. In all analysis, further adjustment for fruit and vegetable consumption did not change the estimates. Conclusion: Self-reported smoking consistently explains approximately 50% of the inequalities in lung cancer risk due to differences in education. © The Author 2009. Published by Oxford University Press. All rights reserved.
Published: 2009

44. Menstrual and reproductive factors and pancreatic cancer in the search program of the IARC

Author: Witold Zatonski, Parviz Ghadirian, H. Bas Bueno-de-Mesquita, Eric J. Duell, Anthony B. Miller, Paolo Boffetta, Peter Boyle, Alina Vrieling, Peter A. Baghurst, Patrick Maisonneuve, Duell, E.J., Maisonneuve, P., Baghurst, P.A., Bueno-De-Mesquita, H.B., Ghadirian, P., Miller, A.B., Zatonski, W., Vrieling, A., Boffetta, P., and Boyle, P.
Subjects: Adult, Cancer Research, medicine.medical_specialty, Adolescent, media_common.quotation_subject, Population, Young Adult, Risk Factors, Pancreatic cancer, Epidemiology, medicine, Humans, Child, education, Prospective cohort study, Reproductive History, Menstrual Cycle, Menstrual cycle, media_common, Menarche, Gynecology, education.field_of_study, Obstetrics, business.industry, Menstrual reproductive factors pancreatic cancer search program IARC, Middle Aged, medicine.disease, Pancreatic Neoplasms, medicine.anatomical_structure, Oncology, Case-Control Studies, Female, Menopause, Pancreas, business, Risk assessment, Carcinoma, Pancreatic Ductal
Abstract: We conducted a population-based case-control study on the relation of menstrual and reproductive factors and hormone use with pancreatic cancer risk among female participants of the SEARCH program study. We evaluated 367 cases of ductal adenocarcinoma and 821 controls for associations between pancreatic cancer and age at menarche, age at menopause, number of pregnancies, exogenous hormone use, and history of gynaecologic surgery. Among directly interviewed and proxy participants, we found a statistically significant association for having age of menarche at 11 years or younger compared with menarche at ages 12-13 years (OR = 1.8, 95% CI = 1.1-3.1). This result was consistent, but not statistically significant, among three of the four studies analyzed, and when the data were analyzed separately by response status (direct vs. proxy interviews). No other menstrual or reproductive factors were associated with pancreatic cancer risk in this study. In conclusion, earlier age at menarche may be weakly associated with pancreatic cancer, but it seems unlikely that menstrual and reproductive factors play more than only a minor role in pancreatic cancer. Additional analyses in large prospective study populations and in pooled studies may help to clarify remaining inconsistencies.
Published: 2009

45. Plasma selenium concentration and prostate cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Steffen Weikert, Nina Føns Johnsen, Domenico Palli, Elio Riboli, Aurelio Barricarte, Rosario Tumino, Sheila Bingham, Rudolf Kaaks, Nadia Slimani, Kim Overvad, Timothy J. Key, Andrew W. Roddam, Antonia Trichopoulou, Laudina Rodríguez, Carlotta Sacerdote, Gesthimani Misirli, Antonio Agudo, Paul N. Appleby, Dimitrios Trichopoulos, Kay-Tee Khaw, María José Tormo, Lambertus A. Kiemeney, Paolo Boffetta, Pär Stattin, H. Bas Bueno-de-Mesquita, María José Sánchez, H. Boeing, Anne Tjønneland, Göran Hallmans, Naomi E. Allen, Sabina Rinaldi, Nerea Larrañaga, Sara Grioni, Jakob Linseisen, Allen, N.E., Appleby, P.N., Roddam, A.W., Tjønneland, A., Johnsen, N.F., Overvad, K., Boeing, H., Weikert, S., Kaaks, R., Linseisen, J., Trichopoulou, A., Misirli, G., Trichopoulos, D., Sacerdote, C., Grioni, S., Palli, D., Tumino, R., Bueno-de-Mesquita, H.B., Kiemeney, L.A., Barricarte, A., Larrañaga, N., Sánchez, M.-J., Agudo, A., Tormo, M.-J., Rodriguez, L., Stattin, P., Hallmans, G., Bingham, S., Khaw, K.-T., Slimani, N., Rinaldi, S., Boffetta, P., Riboli, E., and Key, T.J.
Subjects: Male, Oncology, medicine.medical_specialty, alpha-Tocopherol, Medicine (miscellaneous), chemistry.chemical_element, Aetiology, screening and detection [ONCOL 5], Antioxidants, Molecular epidemiology [NCEBP 1], Cohort Studies, Selenium, Prostate cancer, Translational research [ONCOL 3], Risk Factors, Internal medicine, Determinants in Health and Disease [EBP 1], medicine, Humans, ddc:610, Risk factor, selenium, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], Aged, Neoplasm Staging, Gynecology, gamma-Tocopherol, Nutrition and Dietetics, Hereditary cancer and cancer-related syndromes [ONCOL 1], business.industry, Smoking, Case-control study, Prostatic Neoplasms, Cancer, food and beverages, Middle Aged, medicine.disease, prostate cancer, European Prospective Investigation into Cancer and Nutrition, Europe, chemistry, Case-Control Studies, Relative risk, Multivariate Analysis, business, Cohort study
Abstract: Contains fulltext : 71468.pdf (Publisher’s version ) (Closed access) BACKGROUND: Some evidence indicates that a low selenium intake may be associated with an increased risk of prostate cancer. OBJECTIVE: The aim of this study was to investigate the association of plasma selenium concentration with subsequent prostate cancer risk and to examine this association by stage and grade of disease and other factors. DESIGN: A nested case-control study was performed among men in the European Prospective Investigation into Cancer and Nutrition (EPIC). The association between plasma selenium concentration and prostate cancer risk was assessed in 959 men with incident prostate cancer and 1059 matched controls. RESULTS: Overall, plasma selenium concentration was not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of selenium concentration compared with the lowest fifth was 0.96 (95% CI: 0.70, 1.31; P for trend = 0.25). There were no significant differences in the association of plasma selenium with risk when analyzed by stage or grade of disease. Similarly, the association of selenium with risk did not differ by smoking status or by plasma alpha- or gamma-tocopherol concentration. CONCLUSION: Plasma selenium concentration was not associated with prostate cancer risk in this large cohort of European men.
Published: 2008

46. CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Author: Françoise Clavel-Chapelon, Majken K. Jensen, Heiner Boeing, María José Sánchez, Carine Biessy, Roger Stenling, Elio Riboli, Carlos A. González, James D. McKay, Miren Dorronsoro, Nadia Slimani, Petra H.M. Peeters, Paolo Vineis, Núria Sala, Salvador Pena, Pietro Ferrari, Domenico Palli, Manuela M. Bergmann, Anja Olsen, Timothy J. Key, Göran Hallmans, Mazda Jenab, Amalia Mattiello, Kim Overvad, Eva Ardanaz, Jakob Linseisen, José Ramón Quirós, Mattijs E. Numans, Sabina Rinaldi, Marie-Christine Boutron-Ruault, Sheila Bingham, Jonas Manjer, J. B.A. Crusius, Antonia Trichopoulou, Fátima Carneiro, Anne Tjønneland, Gabriel Maria Capella Munar, Theodora Psaltopoulou, Sara Regnér, Rosario Tumino, Stewart Laing, Paolo Boffetta, Christina Georgila, H. Bas Bueno-de-Mesquita, Valeria Pala, Kay-Tee Khaw, Eiliv Lund, Rudolf Kaaks, Carmen Navarro Sánchez, Jenab, M., McKay, J.D., Ferrari, P., Biessy, C., Laing, S., Capella Munar, G.M., Sala, N., Peña, S., Crusius, J.B.A., Overvad, K., Jensen, M.K., Olsen, A., Tjonneland, A., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Kaaks, R., Linseisen, J., Boeing, H., Bergmann, M.M., Trichopoulou, A., Georgila, C., Psaltopoulou, T., Mattiello, A., Vineis, P., Pala, V., Palli, D., Tumino, R., Numans, M.E., Peeters, P.H.M., Bueno-de-Mesquita, H.B., Lund, E., Ardanaz, E., Sánchez, M.-J., Dorronsoro, M., Navarro Sanchez, C., Quirós, J.R., Hallmans, G., Stenling, R., Manjer, J., Régner, S., Key, T., Bingham, S., Khaw, K.-t., Slimani, N., Rinaldi, S., Boffetta, P., Carneiro, F., Riboli, E., Gonzalez, C., General practice, CCA - Disease profiling, and Pathology
Subjects: Male, Cancer Research, medicine.medical_specialty, Genotype, Spirillaceae, Gastroenterology, CDH1, Helicobacter Infections, Antigens, CD, Stomach Neoplasms, Internal medicine, medicine, Humans, E-Cadherin CDH1 Gastric cancer EPIC Smoking Helicobacter pylori Gastric adenocarcinoma, Stomach cancer, Gene, Polymorphism, Genetic, biology, Helicobacter pylori, Smoking, Cancer, Middle Aged, biology.organism_classification, medicine.disease, Cadherins, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Immunology, biology.protein, Female, Epidemiologic Methods
Abstract: Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. E-Cadherin is an adhesion molecule that is thought to be involved in GC. Germline mutations in the E-Cadherin gene (CDH1) have been identified in hereditary diffuse GC. Also, a promoter polymorphism at position -160 C/A has been suggested to lead to transcriptional down regulation and has been shown to affect GC risk in some studies. However, very little information exists on the GC risk association of other CDH1 polymorphisms and it is unclear whether any associations may be different by GC anatomical sites or histological types. Thus, a case-control study (cases = 245/controls = 950) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort was conducted to assess the GC risk association of eight CDH1 gene polymorphisms. None of the CDH1 polymorphisms or haplotypes analysed were associated with GC risk and no differences of effect were observed by Helicobacter pylori infection status. However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers. These findings should be confirmed in larger independent studies. © 2008 Elsevier Ltd. All rights reserved.
Published: 2008

47. Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition (EPIC)

Author: Salvatore Panico, Marga C. Ocké, H. Bas Bueno-de-Mesquita, Carla H. van Gils, Teresa Norat, Antonio Agudo, Pilar Amiano, Göran Berglund, Mazda Jenab, Eva Ardanaz, Rudolf Kaaks, Jonas Manjer, Pietro Ferrari, Dolores C. López, Jakob Linseisen, Elio Riboli, Françoise Clavel-Chapelon, Sophie Morois, María José Sánchez, Mathieu Mazuir, Heiner Boeing, Rosario Tumino, Majken K. Jensen, Christina Kassapa, Marie-Christine Boutron-Ruault, Petra H.M. Peeters, Eiliv Lund, Paolo Vineis, Kim Overvad, Anja Olsen, Timothy J. Key, Paolo Boffetta, Giovanna Masala, Manuela M. Bergmann, Sabine Rohrmann, Vittorio Krogh, Nadia Slimani, Guri Skeie, Naomi E. Allen, Aurelie Moskal, José Ramón Quirós, Bethany Van Guelpen, Richard Palmqvist, Dimitra Kontopoulou, Anne Tjønneland, Sheila Bingham, Antonia Trichopoulou, Ferrari, P, Jenab, M, Norat, T, Moskal, A, Slimani, N, Olsen, A, Tjonneland, A, Overvad, K, Jensen, Mk, BOUTRON RUAULT, Mc, CLAVEL CHAPELON, F, Morois, S, Rohrmann, S, Linseisen, J, Boeing, H, Bergmann, M, Kontopoulou, D, Trichopoulou, A, Kassapa, C, Masala, G, Krogh, V, Vineis, P, Panico, Salvatore, Tumino, R, Gils, Ch, Peeters, P, BUENO DE MESQUITA, Hb, Ocke, Mc, Skeie, G, Lund, E, Agudo, A, Ardanaz, E, Lopez, Dc, Sanchez, Mj, Quiros, Jr, Amiano, P, Berglund, G, Manjer, J, Palmqvist, R, Guelpen, Bv, Allen, N, Key, T, Bingham, S, Mazuir, M, Boffetta, P, Kaaks, R, Riboli, E., Ferrari, P., Jenab, M., Norat, T., Moskal, A., Slimani, N., Olsen, A., Tjønneland, A., Overvad, K., Jensen, M.K., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Morois, S., Rohrmann, S., Linseisen, J., Boeing, H., Bergmann, M., Kontopoulou, D., Trichopoulou, A., Kassapa, C., Masala, G., Krogh, V., Vineis, P., Panico, S., Tumino, R., Van Gils, C.H., Peeters, P., Bueno-de-Mesquita, H.B., Ocké, M.C., Skeie, G., Lund, E., Agudo, A., Ardanaz, E., López, D.C., Sanchez, M.-J., Quirós, J.R., Amiano, P., Berglund, G., Manjer, J., Palmqvist, R., Van Guelpen, B., Allen, N., Key, T., Bingham, S., Mazuir, M., Boffetta, P., and Kaaks, R.
Subjects: Oncology, Male, Cancer Research, medicine.medical_specialty, Time Factors, Alcohol intake and risk of colon and rectal cancers, Alcohol Drinking, Colorectal cancer, alcohol, lifetime exposure, colorectal cancer, prospective study, EPIC, Gastroenterology, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, ddc:610, Risk factor, Prospective cohort study, Colonic disease, Sex Characteristics, business.industry, Rectal Neoplasms, Middle Aged, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Europe, Nutrition Assessment, Colonic Neoplasms, Alcohol intake, Female, business
Abstract: Alcohol consumption may be associated with risk of colorectal cancer (CRC), but the epidemiological evidence for an association with specific anatomical subsites, types of alcoholic beverages and current vs. lifetime alcohol intake is inconsistent. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 478,732 study subjects free of cancer at enrolment between 1992 and 2000 were followed up for an average of 6.2 years, during which 1,833 CRC cases were observed. Detailed information on consumption of alcoholic beverages at baseline (all cases) and during lifetime (1,447 CRC cases, 69% of the cohort) was collected from questionnaires. Cox proportional hazard models were used to examine the alcohol-CRC association. After adjustment for potential confounding factors, lifetime alcohol intake was significantly positively associated to CRC risk (hazard ratio, HR = 1.08, 95%CI = 1.04-1.12 for 15 g/day increase), with higher cancer risks observed in the rectum (HR = 1.12, 95%CI = 1.06-1.18) than distal colon (HR = 1.08, 95%CI = 1.01-1.16), and proximal colon (HR = 1.02, 95%CI = 0.92-1.12). Similar results were observed for baseline alcohol intake. When assessed by alcoholic beverages at baseline, the CRC risk for beer (HR = 1.38, 95%CI = 1.08-1.77 for 20-39.9 vs. 0.1-2.9 g/day) was higher than wine (HR = 1.21, 95%CI = 1.02-1.44), although the two risk estimates were not significantly different from each other. Higher HRs for baseline alcohol were observed for low levels of folate intake (1.13, 95%CI = 1.06-1.20 for 15 g/day increase) compared to high folate intake (1.03, 95%CI = 0.98-1.09). In this large European cohort, both lifetime and baseline alcohol consumption increase colon and rectum cancer risk, with more apparent risk increases for alcohol intakes greater than 30 g/day. © 2007 Wiley-Liss, Inc.
Published: 2007

48. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Pietro Ferrari, Paolo Vineis, John C. Whittaker, Anne Tjønneland, Rosario Tumino, Torgny Rasmuson, Frederike L. Büchner, Hendriek C. Boshuizen, Timothy J. Key, María Dolores Chirlaque, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Domenico Palli, Salvatore Panico, Manuela M. Bergmann, Eva Ardanaz, Majken K. Jensen, H. Bas Bueno-de-Mesquita, Jakob Linseisen, Inger T. Gram, Sabine Rohrmann, Göran Berglund, Petra H.M. Peeters, Elio Riboli, Eiliv Lund, Teresa Norat, Kim Overvad, Stavroula Soukara, María José Sánchez Pérez, Sabina Sieri, Lars Weinehall, Anja Olsen, Antonio Agudo, Naomi E. Allen, Mazda Jenab, Georgia Kyriazi, Sheila Bingham, Antonia Trichopoulou, Lars Janzon, José Ramón Quirós, Paolo Boffetta, Miren Dorronsoro, Kay-Tee Khaw, Heiner Boeing, Rohrmann, S, Linseisen, J, Boshuizen, Hc, Whittaker, J, Agudo, A, Vineis, P, Boffetta, P, Jensen, Mk, Olsen, A, Overvad, K, Tjonneland, A, BOUTRON RUAULT, Mc, CLAVEL CHAPELON, F, Bergmann, Mm, Boeing, H, Allen, N, Key, T, Bingham, S, Khaw, Kt, Kyriazi, G, Soukara, S, Trichopoulou, A, Panico, Salvatore, Palli, D, Sieri, S, Tumino, R, Peeters, Ph, BUENO DE MESQUITA, Hb, Buchner, Fl, Gram, It, Lund, E, Ardanaz, E, Chirlaque, Md, Dorronsoro, M, Perez, Mj, Quiros, Jr, Berglund, G, Janzon, L, Rasmuson, T, Weinehall, L, Ferrari, P, Jenab, M, Norat, T, Riboli, E., Rohrmann, S., Linseisen, J., Boshuizen, H.C., Whittaker, J., Agudo, A., Vineis, P., Boffetta, P., Jensen, M.K., Olsen, A., Overvad, K., Tjønneland, A., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Bergmann, M.M., Boeing, H., Allen, N., Key, T., Bingham, S., Khaw, K.-T., Kyriazi, G., Soukara, S., Trichopoulou, A., Panico, S., Palli, D., Sieri, S., Tumino, R., Peeters, P.H.M., Bueno-De-Mesquita, H.B., Büchner, F.L., Gram, I.T., Lund, E., Ardanaz, E., Chirlaque, M.-D., Dorronsoro, M., Pérez, M.-J.S., Quirós, J.R., Berglund, G., Janzon, L., Rasmuson, T., Weinehall, L., Ferrari, P., Jenab, M., and Norat, T.
Subjects: Adult, Male, medicine.medical_specialty, Epidemiology, lung neoplasms, Lower risk, Risk Assessment, cohort studies, Risk Factors, Interventional oncology [UMCN 1.5], Surveys and Questionnaires, Internal medicine, Determinants in Health and Disease [EBP 1], Humans, Medicine, Prospective Studies, ddc:610, Risk factor, Lung cancer, alcohol drinking, ethanol, Proportional Hazards Models, Ethanol intake and risk of lung cancer, business.industry, Incidence, Hazard ratio, Middle Aged, Anthropometry, medicine.disease, Confidence interval, European Prospective Investigation into Cancer and Nutrition, Surgery, Europe, Female, business, Follow-Up Studies, Cohort study
Abstract: Contains fulltext : 49956.pdf (Publisher’s version ) (Closed access) Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (> or =60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.
Published: 2006

49. Dietary patterns among older Europeans: the EPIC-Elderly study

Author: Domenico Palli, Kay-Tee Khaw, Françoise Clavel-Chapelon, Göran Hallmans, Göran Berglund, Vittorio Krogh, Sheila Bingham, Emmanuelle Kesse, Petra H.M. Peeters, Christina Bamia, Miren Dorronsoro, Nadia Slimani, Carlotta Sacerdote, Caroline T M van Rossum, Anja Olsen, Gabriele Nagel, H. B. Bueno-De-Mesquita, Aurelio Barricarte, Theodora Psaltopoulou, Heidi H. Hundborg, Heiner Boeing, María José Sánchez, Kim Overvad, Marga C. Ocké, Elio Riboli, Carmen Navarro, Philippos Orfanos, Pietro Ferrari, Rosario Tumino, Andrew W. Roddam, Paolo Boffetta, Kurt Hoffmann, Antonia Trichopoulou, Elisabet Wirfält, Salvatore Panico, Nikos Baibas, Marie-Christine Boutron-Ruault, J. R. Quirós, Ingegerd Johansson, Anne Tjønneland, Dimitrios Trichopoulos, Teresa Norat, Elizabeth A Spencer, Bamia, C., Orfanos, P., Ferrari, P., Overvad, K., Hundborg, H.H., Tjøonneland, A., Olsen, A., Kesse, E., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Nagel, G., Boffetta, P., Boeing, H., Hoffmann, K., Trichopoulos, D., Baibas, N., Psaltopoulou, T., Norat, T., Slimani, N., Palli, D., Krogh, V., Panico, S., Tumino, R., Sacerdote, C., Bueno-de-Mesquita, H.B., Ocké, M.C., Peeters, P.H., van Rossum, C.T., Quirós, J.-R., Sánchez, M.-J., Navarro, C., Barricarte, A., Dorronsoro, M., Berglund, G., Wirfält, E., Hallmans, G., Johansson, I., Bingham, S., Khaw, K.-T., Spencer, E.A., Roddam, A.W., Riboli, E., Trichopoulou, A., Bamia, C, Orfanos, P, Ferrari, P, Overvad, K, Hundborg, Hh, Tjonneland, A, Olsen, A, Kesse, E, BOUTRON RUAULT, Mc, CLAVEL CHAPELON, F, Nagel, G, Boffetta, P, Boeing, H, Hoffmann, K, Trichopoulos, D, Baibas, N, Psaltopoulou, T, Norat, T, Slimani, N, Palli, D, Krogh, V, Panico, Salvatore, Tumino, R, Sacerdote, C, BUENO DE MESQUITA, Hb, Ocke, Mc, Peeters, Ph, VAN ROSSUM, Ct, Quiros, Jr, Sanchez, Mj, Navarro, C, Barricarte, A, Dorronsoro, M, Berglund, G, Wirfalt, E, Hallmans, G, Johansson, I, Bingham, S, Khaw, Kt, Spencer, Ea, Roddam, Aw, and Riboli, E
Subjects: Gerontology, Male, medicine.medical_specialty, endocrine system, Waist, Medicine (miscellaneous), Disease cluster, Body Mass Index, Age Distribution, Epidemiology, Vegetables, Medicine, Cluster Analysis, Humans, Prospective Studies, Dietary patterns, Sex Distribution, Prospective cohort study, Exercise, Aged, Principal Component Analysis, Nutrition and Dietetics, business.industry, Smoking, food and beverages, Feeding Behavior, Middle Aged, Dietary Fats, European Prospective Investigation into Cancer and Nutrition, Europe, Food, Cohort, Educational Status, Regression Analysis, Female, business, Energy Intake, Body mass index, Demography, Cohort study
Abstract: Overall dietary patterns have been associated with health and longevity. We used principal component (PC) and cluster analyses to identify the prevailing dietary patterns of 99 744 participants, aged 60 years or older, living in nine European countries and participating in the European Prospective Investigation into Cancer and Nutrition (EPIC-Elderly cohort) and to examine their socio-demographic and lifestyle correlates. Two PC were identified: PC1 reflects a 'vegetable-based' diet with an emphasis on foods of plant origin, rice, pasta and other grain rather than on margarine, potatoes and non-alcoholic beverages. PC2 indicates a 'sweet- and fat-dominated' diet with a preference for sweets, added fat and dairy products but not meat, alcohol, bread and eggs. PC1 was associated with a younger age, a higher level of education, physical activity, a higher BMI, a lower waist:hip ratio and never and past smoking. PC2 was associated with older age, less education, never having smoked, a lower BMI and waist:hip ratio and lower levels of physical activity. Elderly individuals in southern Europe scored positively on PC1 and about zero on PC2, whereas the elderly in northern Europe scored negatively on PC1 and variably on PC2. The results of cluster analysis were compatible with the indicated dietary patterns. 'Vegetable-based' and a 'sweet- and fat-dominated' diets are prevalent among the elderly across Europe, and there is a north - south gradient regarding their dietary choices. Our study contributes to the identification of groups of elderly who are likely to have different prospects for long-term disease occurrence and survival. © The Authors 2005.
Published: 2005

50. Amount of DNA in plasma and cancer risk: A prospective study

Author: Göran Hallmans, Kim Overvad, H. Bas Bueno-de-Mesquita, Carmen Martinez, Teresa Norat, Eiliv Lund, Paolo Boffetta, Emmanuelle Gormally, Paolo Vineis, Miren Dorronsoro, Salvatore Panico, Françoise Clavel-Chapelon, Rudolf Kaaks, Antonia Trichopoulou, Domenico Palli, M. José Tormo, Christian Malaveille, Nicholas E. Day, Marco Peluso, Alison M. Dunning, Rosario Tumino, Elio Riboli, Pierre Hainaut, J. Ramón Quirós, Giuseppe Matullo, Heiner Boeing, Anne Tjønneland, Seymour Garte, Elodie Caboux, Rodolfo Saracci, Vittorio Krogh, Herman Autrup, Petra H.M. Peeters, Timothy J. Key, Luisa Airoldi, Aurelio Barricarte, Carlos A. González, Göran Berglund, Fabrizio Veglia, Gormally, E, Hainaut, P, Caboux, E, Airoldi, L, Autrup, H, Malaveille, C, Dunning, A, Garte, S, Matullo, G, Overvad, K, Tjonneland, A, CLAVEL CHAPELON, F, Boffetta, P, Boeing, H, Trichopoulou, A, Palli, D, Krogh, V, Tumino, R, Panico, Salvatore, BUENO DE MESQUITA, Hb, Peeters, Ph, Lund, E, Gonzalez, Ca, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, Mj, Quiros, Jr, Berglund, G, Hallmans, G, Day, Ne, Key, Tj, Veglia, F, Peluso, M, Norat, T, Saracci, R, Kaaks, R, Riboli, E, Vineis, P., Gormally, E., Hainaut, P., Caboux, E., Airoldi, L., Autrup, H., Malaveille, C., Dunning, A., Garte, S., Matullo, G., Overvad, K., Tjonneland, A., Clavel-Chapelon, F., Boffetta, P., Boeing, H., Trichopoulou, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H.B., Peeters, P.H., Lund, E., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Tormo, M.J., Quiros, J.R., Berglund, G., Hallmans, G., Day, N.E., Key, T.J., Veglia, F., Peluso, M., Norat, T., Saracci, R., Kaaks, R., and Riboli, E.
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Population, Gastroenterology, Pulmonary Disease, Chronic Obstructive, Risk Factors, Neoplasms, Internal medicine, Odds Ratio, medicine, Humans, cancer, plasmatic DNA, prospective studies, molecular repidemiology, Risk factor, Prospective cohort study, education, Aged, COPD, education.field_of_study, Leukemia, business.industry, Cancer, DNA, Odds ratio, Middle Aged, Prognosis, medicine.disease, European Prospective Investigation into Cancer and Nutrition, Oncology, Case-Control Studies, Amount of DNA in plasma and cancer risk, Immunology, Female, business, Blood drawing
Abstract: Levels of plasma DNA concentrations in cancer patients have been shown to be higher than the plasma DNA concentrations found in healthy subjects. The value of plasma DNA levels for development of neoplastic or pulmonary disease was evaluated in a large prospective study. Plasma samples (n = I,184) were analyzed from 776 controls, 359 cases of cancer (lung, bladder, oral cavity, pharynx, larynx, leukemia) and 49 deaths from chronic obstructive pulmonary disease (COPD), including never smokers and ex-smokers, from 9 countries across Europe. The amount of plasma DNA was variable across the European Prospective Investigation into Cancer and Nutrition (EPIC) centers. High DNA concentrations in some centers might be due to the type of population recruited and/or the treatment of the samples. An elevated and statistically significant odds ratio (OR) was found for COPD deaths (OR = 2.53; 95% CI = 1.06-6.02), while nonsignificant increased ORs were present for oral cancers, cancers of the pharynx and larynx and leukemia. When the analyses were stratified by time since recruitment (below or above 36 months), the increased ORs were limited to the more recent period of recruitment, i.e., a time elapsed between blood drawing and disease onset lower than 36 months. This was particularly true for COPD deaths (OR = 12.7; 95% CI = 1.57-103) and leukemia (OR = 2.37; 95% CI = 1.20-4.67). © 2004 Wiley-Liss, Inc.
Published: 2004

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