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Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)

Authors :
Manal M. Hassan
Anthony B. Miller
E. A. Holly
Paolo Boffetta
Parviz Ghadirian
William R. Bamlet
Jerry Polesel
Ersilia Lucenteforte
C. La Vecchia
Michelle Cotterchio
Elizabeth T. H. Fontham
Steve Gallinger
Eric J. Duell
J. Su
Donghui Li
Bu Tian Ji
Debra T. Silverman
Paige M. Bracci
Witold Zatonski
R. Talamini
Eva Negri
Yu-Tang Gao
Patrick Maisonneuve
Cristina Bosetti
H. B. Bueno-de-Mesquita
Gloria M. Petersen
Peter A. Baghurst
Lucenteforte, E.
La Vecchia, C.
Silverman, D.
Petersen, G.M.
Bracci, P.M.
Ji, B.T.
Bosetti, C.
Li, D.
Gallinger, S.
Miller, A.B.
Bueno-de-Mesquita, H.B.
Talamini, R.
Polesel, J.
Ghadirian, P.
Baghurst, P.A.
Zatonski, W.
Fontham, E.
Bamlet, W.R.
Holly, E.A.
Gao, Y.T.
Negri, E.
Hassan, M.
Cotterchio, M.
Su, J.
Maisonneuve, P.
Boffetta, P.
Duell, E.J.
International Prevention Research Institute (IPRI)
The Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai [New York] (MSSM)
Source :
Annals of Oncology, Annals of Oncology, Elsevier, 2012, 23 (2), pp.374-82. ⟨10.1093/annonc/mdr120⟩
Publication Year :
2012
Publisher :
Elsevier BV, 2012.

Abstract

Lucenteforte, E La Vecchia, C Silverman, D Petersen, G M Bracci, P M Ji, B T Bosetti, C Li, D Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Bamlet, W R Holly, E A Gao, Y T Negri, E Hassan, M Cotterchio, M Su, J Maisonneuve, P Boffetta, P Duell, E J eng CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-CP-05225/CP/NCI NIH HHS/ N01-CP-05227/CP/NCI NIH HHS/ N01-CP-31022/CP/NCI NIH HHS/ N01-CP-51089/CP/NCI NIH HHS/ N01-CP-51090/CP/NCI NIH HHS/ N01-CP-51092/CP/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ Meta-Analysis Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't England 2011/05/04 06:00 Ann Oncol. 2012 Feb;23(2):374-82. doi: 10.1093/annonc/mdr120. Epub 2011 May 2.; International audience; BACKGROUND: Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved. METHODS: To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11,827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models. RESULTS: Compared with abstainers and occasional drinkers (< 1 drink per day), we observed no association for light-to-moderate alcohol consumption (/= 9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area. CONCLUSION: This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.

Details

ISSN :
09237534 and 15698041
Volume :
23
Database :
OpenAIRE
Journal :
Annals of Oncology
Accession number :
edsair.doi.dedup.....12c0da28de86164c7ddc5e0ae62c22ff