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Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)
- Source :
- Annals of Oncology, Annals of Oncology, Elsevier, 2012, 23 (2), pp.374-82. ⟨10.1093/annonc/mdr120⟩
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Lucenteforte, E La Vecchia, C Silverman, D Petersen, G M Bracci, P M Ji, B T Bosetti, C Li, D Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Bamlet, W R Holly, E A Gao, Y T Negri, E Hassan, M Cotterchio, M Su, J Maisonneuve, P Boffetta, P Duell, E J eng CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-CP-05225/CP/NCI NIH HHS/ N01-CP-05227/CP/NCI NIH HHS/ N01-CP-31022/CP/NCI NIH HHS/ N01-CP-51089/CP/NCI NIH HHS/ N01-CP-51090/CP/NCI NIH HHS/ N01-CP-51092/CP/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ Meta-Analysis Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't England 2011/05/04 06:00 Ann Oncol. 2012 Feb;23(2):374-82. doi: 10.1093/annonc/mdr120. Epub 2011 May 2.; International audience; BACKGROUND: Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved. METHODS: To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11,827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models. RESULTS: Compared with abstainers and occasional drinkers (< 1 drink per day), we observed no association for light-to-moderate alcohol consumption (/= 9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area. CONCLUSION: This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Pathology
alcohol drinking
case–control
studies
ethanol
pancreatic cancer
pooled analysis
risk factors
Alcohol
chemistry.chemical_compound
Internal medicine
Pancreatic cancer
Odds Ratio
medicine
Adult Aged Alcohol Drinking/*adverse effects Case-Control Studies Confounding Factors (Epidemiology) Female Humans Logistic Models Male Middle Aged Odds Ratio Pancreatic Neoplasms/*epidemiology/etiology Pancreatitis/complications Risk Factors Smoking/adverse effects
Humans
risk of pancreatic cancer
Aged
business.industry
Smoking
Confounding Factors, Epidemiologic
Original Articles
Hematology
Middle Aged
medicine.disease
Pancreatic Neoplasms
Logistic Models
Pooled analysis
Pancreatitis
chemistry
Case-Control Studies
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Female
business
Alcohol consumption
heavy alcohol consumptio
Subjects
Details
- ISSN :
- 09237534 and 15698041
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Annals of Oncology
- Accession number :
- edsair.doi.dedup.....12c0da28de86164c7ddc5e0ae62c22ff