1. Effect of anticonvulsants on pentylenetetrazol-induced power spectrum changes in electroencephalograms in rats
- Author
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Atsushi Ishige, Eiichi Sugaya, Yutaka Matsuzaki, Susumu Iizuka, Eikichi Hosoya, Kyoji Sekiguchi, Masaki Aburada, and Kenji Sakamoto
- Subjects
Male ,medicine.medical_treatment ,Electroencephalography ,Pharmacology ,Seizures ,Convulsion ,Cyclic AMP ,medicine ,Animals ,Pentylenetetrazol ,Cerebral Cortex ,medicine.diagnostic_test ,Chemistry ,Valproic Acid ,Spectral density ,Rats, Inbred Strains ,Rats ,Electrophysiology ,Anticonvulsant ,Ethosuximide ,Neurology ,Phenobarbital ,Anesthesia ,Pentylenetetrazole ,Anticonvulsants ,Neurology (clinical) ,medicine.symptom ,medicine.drug - Abstract
The effect of anticonvulsants on pentylenetetrazol (PTZ)-induced EEG power spectrum changes was examined. When the minimum dose of PTZ (15 mg/kg) was administered intravenously twice, with an interval of 80 min, a clear EEG power spectrum change was observed after the second PTZ administration, irrespective of whether or not the first PTZ administration evoked marked EEG changes. We defined the values F/N, S/N and S/F. The value F/N, obtained by dividing the power spectrum area after the first PTZ administration by the normal power spectrum area, was 1.06 +/- 0.05 (mean +/- S.E.). The value S/N, obtained by dividing the power spectrum area after the second PTZ administration by the normal power spectrum area, was 2.00 +/- 0.21. The value S/F, obtained by dividing S/N by F/N, was 1.86 +/- 0.16. The S/F value was almost constant regardless of whether or not the first PTZ administration could evoke marked EEG changes. The effect of anticonvulsants was examined by S/F value changes, and 100 mg/kg of PHT completely inhibited the double PTZ effect. Phenobarbital, ethosuximide and sodium valproate also inhibited the double PTZ effect. Using the S/F value of the EEG power spectrum with minimum dose double PTZ administration, quantitative evaluation is possible for anticonvulsant drugs.
- Published
- 1987