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Inhibitory effect of TJ-960 (SK) on pentylenetetrazol-induced EEG power spectrum changes
- Source :
- Epilepsy research. 2(1)
- Publication Year :
- 1988
-
Abstract
- Effects of the Japanese Kampo medicine ‘Shosaiko-to-go-keishika-shyakuyaku-to’ (TJ-960), which is a mixture of 9 herbal drugs and is practically equivalent to ‘Saiko-keishi-to’ (SK), on the pentylenetetrazol (PTZ)-induced EEG power spectrum changes were examined. The EEG power spectrum change with 2 PTZ administrations at an 80 min interval was clearly inhibited by oral administration of 1.0 mg/kg of TJ-960. By separate single administrations of the main component herbal drugs, Bupleuri radix, Cinnamomi cortex, Paeoniae radix and Zingiberis rhizoma, only Paeoniae radix showed statistically significant inhibition of PTZ-induced EEG power spectrum changes at a proportional dose of 1.0 mg/kg of TJ-960. The other main component herbal drugs showed no statistically significant inhibitory effect although they had a tendency to inhibit. These findings suggest that the Japanese Kampo medicine, TJ-960 (SK), has an inhibitory effect on PTZ-induced power spectrum changes and one of the component herbal drugs, Paeoniae radix, is the important component drug.
- Subjects :
- Drug
Male
media_common.quotation_subject
medicine.medical_treatment
Kampo
Administration, Oral
Electroencephalography
Pharmacology
Oral administration
Seizures
Convulsion
Medicine
Animals
Pentylenetetrazol
Inhibitory effect
media_common
medicine.diagnostic_test
Traditional medicine
business.industry
Rats, Inbred Strains
Rats
Anticonvulsant
Neurology
Pentylenetetrazole
Neurology (clinical)
medicine.symptom
business
medicine.drug
Drugs, Chinese Herbal
Phytotherapy
Subjects
Details
- ISSN :
- 09201211
- Volume :
- 2
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Epilepsy research
- Accession number :
- edsair.doi.dedup.....29b4bc48ea081917af00445ed3d1f942