Back to Search
Start Over
The effect of p-Chlorophenylalanine on the pethidine- or methadone-induced decrease in locomotor activity of rats
- Source :
- European Journal of Pharmacology. 37:393-395
- Publication Year :
- 1976
- Publisher :
- Elsevier BV, 1976.
-
Abstract
- Either pethidine HCl (50 mg/kg s.c.) or methadone HCl (8 mg/kg s.c.) produced a prominent decrease in locomotor activity of rats. Pretreatment of rats with p-chlorophenylalanine (p-CPA, 320 mg/kg i.p.) 48 h before the narcotic injection significantly antagonized the activity-decreasing effects of narcotics. When rats pretreated with p-CPA were given 5-hydroxytryptophan (75 mg/kg s.c.) 30 min before narcotic administration, the activity-decreasing response to narcotics was restored. Thus, a decrease in locomotor activity induced in rats by either pethidine or methadone is probably mediated by serotonergic mechanisms.
Details
- ISSN :
- 00142999
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....1b2aecf3a360ecb6f5dc901366cd69be