1. Pretreatment levels of serum soluble interleukin-2 receptor are useful in selecting the treatment regimen for newly diagnosed advanced-stage follicular lymphoma with low tumor burden
- Author
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Tetsuhisa Kitamura, Masashi Nakagawa, Jun Ishikawa, Ryoto Sakaniwa, Yasuhiro Moriyama, Hirohiko Shibayama, Yasuhiko Azenishi, Tsuyoshi Kamae, Satoru Kosugi, Kenji Nozaki, Takahiro Karasuno, Hiroyuki Sugahara, Manabu Kawakami, Shuji Ueda, and Masato Iida
- Subjects
Adult ,Male ,Interleukin 2 ,medicine.medical_specialty ,medicine.medical_treatment ,Clinical Decision-Making ,Follicular lymphoma ,Gastroenterology ,hemic and lymphatic diseases ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,Biomarkers, Tumor ,medicine ,Humans ,Receptor ,Lymphoma, Follicular ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Chemotherapy ,Hematology ,business.industry ,Advanced stage ,Disease Management ,Receptors, Interleukin-2 ,Middle Aged ,Prognosis ,medicine.disease ,Tumor Burden ,Regimen ,Female ,Rituximab ,business ,medicine.drug - Abstract
High pre-treatment serum soluble interleukin-2 receptor (sIL-2R) levels are associated with poor overall survival (OS) of patients with newly diagnosed follicular lymphoma (FL). We evaluated the usefulness of pre-treatment sIL-2R levels in selecting a treatment regimen for advanced-stage FL with low tumor burden (FL-LTB). This retrospective, multicenter observational study enrolled consecutive patients who received a rituximab-containing regimen for newly diagnosed advanced stage FL-LTB (grade 1-3a) between 2008 and 2018. We applied a previously reported cut-off value of 1800 IU/mL for sIL-2R. A total of 211 patients were eligible for the analysis. Among patients with high sIL-2R (47 patients, 22.3%), the OS rates for patients treated by rituximab monotherapy (R-mono) (11 patients) were significantly lower than those treated by rituximab-combination chemotherapy (R-chemo) (36 patients): 5-year OS rates were 66.7% and 94.4%, respectively (P = 0.007). Among patients with low sIL-2R (164 patients, 77.7%), OS rates were comparably good between the R-mono group (34 patients) and the R-chemo group (130 patients): 5-year OS rates were 100% and 98.3%, respectively (P = 0.38). Our results suggest that R-chemo may yield better OS than R-mono for patients with newly diagnosed advanced-stage FL-LTB and high pre-treatment serum sIL-2R levels.
- Published
- 2021