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WT1 Gene Transcript Assay for Relapse in Acute Leukemia after Transplantation
- Source :
- Leukemia & Lymphoma. 45:1747-1753
- Publication Year :
- 2004
- Publisher :
- Informa UK Limited, 2004.
-
Abstract
- The WT1 gene is highly expressed in various types of leukemia, particularly in acute type leukemia. The extent of minimal residual disease (MRD) of leukemia can be evaluated by measuring the WT1 gene expression level using a quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method. The WT1 transcript assay can be applied to almost all patients with leukemia regardless of the presence or absence of chimeric DNA markers. Furthermore, because of the fact that WT1 expression levels increase significantly at relapse compared with those at the time of diagnosis, and because of the decrease in background levels of WT1 expression in bone marrow following allogeneic SCT, the WT1 transcript assay possesses a high degree of sensitivity following allogeneic SCT. Frequent monitoring of the WT1 gene expression level predicts the risk of relapse following allogeneic SCT, and furthermore, the kinetics of WT1 transcripts predict the efficacy of immunomodulation therapy such as donor leukocyte infusion.
- Subjects :
- Cancer Research
Transcription, Genetic
Biology
urologic and male genital diseases
Recurrence
Transcription (biology)
hemic and lymphatic diseases
medicine
Animals
Humans
WT1 Proteins
Transplantation
Acute leukemia
Leukemia
urogenital system
fungi
Hematology
medicine.disease
Minimal residual disease
female genital diseases and pregnancy complications
medicine.anatomical_structure
Oncology
Genetic marker
Acute Disease
Immunology
Cancer research
Immunomodulation Therapy
Bone marrow
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....328af2bccdc26f8efdfb3a175d5152ae