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Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma
- Source :
- Cancer Science. 95:583-587
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- The expression of the Wilms' tumor gene WT1 was examined by immunohistochemistry in 40 cases of pancreatic ductal adenocarcinoma. WT1 protein was expressed in 30 (75%) of the 40 pancreatic ductal adenocarcinomas, but not in the remaining 10 (25%). In normal pancreatic ductal cells, WT1 protein was undetectable. No correlations between WT1 expression and clinicopathological parameters such as age, sex, T or N stage, tumor location, and tumor differentiation were observed. Treatment with WT1 antisense oligomers significantly inhibited the growth of five human pancreatic cancer cell lines, PSN1, MiaPaCa2, ASPC1, BxPC3, and PCI6, expressing the WT1 gene. These results indicate an important role of the WT1 gene in the tumorigenesis of pancreatic ductal adenocarcinoma expressing WT1 and provide a rationale for new treatment strategies to treat pancreatic ductal adenocarcinoma by targeting the WT1 gene and its product.
- Subjects :
- Male
congenital, hereditary, and neonatal diseases and abnormalities
Cancer Research
Adenocarcinoma
Biology
urologic and male genital diseases
medicine.disease_cause
medicine
Carcinoma
Humans
WT1 Proteins
Gene
Aged
Aged, 80 and over
urogenital system
fungi
Wilms' tumor
General Medicine
Middle Aged
Oligonucleotides, Antisense
medicine.disease
Immunohistochemistry
female genital diseases and pregnancy complications
Up-Regulation
Pancreatic Neoplasms
Cell Transformation, Neoplastic
medicine.anatomical_structure
Oncology
Cancer research
Female
CA19-9
Carcinogenesis
Pancreas
Carcinoma, Pancreatic Ductal
Subjects
Details
- ISSN :
- 13497006 and 13479032
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Cancer Science
- Accession number :
- edsair.doi.dedup.....352c6d4f729730040e2529a9985a371a