1. Therapeutic response of patients with adult Still’s disease to biologic agents: multicenter results in Japan
- Author
-
Sachiko Soejima, Hisako Inoue, Akihide Ohta, Seiji Minota, Shuji Takei, Takahiko Horiuchi, Yoshiaki Ishigatsubo, Syuichi Koarada, Hiroki Takahashi, Rie Suematsu, Emi Matsuura, Takao Fujii, Toshiyuki Ota, Kohei Nagasawa, and Yoshifumi Tada
- Subjects
Adult ,Male ,musculoskeletal diseases ,medicine.medical_specialty ,Adolescent ,Kaplan-Meier Estimate ,Pharmacology ,Antibodies, Monoclonal, Humanized ,Receptors, Tumor Necrosis Factor ,Etanercept ,Young Adult ,chemistry.chemical_compound ,Tocilizumab ,Refractory ,Rheumatology ,Internal medicine ,Humans ,Medicine ,Young adult ,Child ,skin and connective tissue diseases ,Retrospective Studies ,Adult Still's disease ,Drug Substitution ,business.industry ,Antibodies, Monoclonal ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Infliximab ,C-Reactive Protein ,Treatment Outcome ,chemistry ,Antirheumatic Agents ,Immunoglobulin G ,Ferritins ,Female ,business ,Still's Disease, Adult-Onset ,medicine.drug - Abstract
The efficacy of biologics in treating adult Still’s disease (ASD) is suggested, but the information is still lacking and the validation is insufficient. To determine the efficacy of several biologic agents in refractory ASD in Japan, a multicenter survey was performed. Clinical data on 16 ASD patients who had been treated with at least 1 of the biological agents (total 24 occasions) were collected retrospectively. Infliximab was used in 9 cases, etanercept in 4, and tocilizumab in 11. Half of the patients that had been treated initially with infliximab or etanercept were changed to another biologics. Tocilizumab was effective in cases switched from another 2 drugs. Tocilizumab showed efficacy in treating both systemic and arthritic symptoms and showed apparent steroid-sparing effect and the highest continuation rate. Tocilizumab may be a promising biologic agent in refractory ASD.
- Published
- 2012