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Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus
- Source :
- Annals of the Rheumatic Diseases. 49:387-390
- Publication Year :
- 1990
- Publisher :
- BMJ, 1990.
-
Abstract
- The clinical importance of IgG anticardiolipin antibodies was investigated in systemic lupus erythematosus (SLE). IgG anticardiolipin antibodies were found in 69 of 155 (44.5%) patients with SLE. Serial measurements of IgG anticardiolipin antibodies allowed the patients to be classified into two groups: group A, persistently positive for IgG anticardiolipin antibodies; group B, positive only in active phases. The IgG anticardiolipin antibody titre in group A was significantly higher than in group B. The incidence of thromboses, spontaneous abortions, and lupus anticoagulant in group A was significantly higher than in group B (p less than 0.05). By contrast, the incidence of renal diseases and anti-dsDNA antibodies in group B was significantly higher than in group A (p less than 0.05). This study showed that group A formed a separate subgroup of patients with SLE who had a high risk of thromboses and spontaneous abortions despite having milder disease activity.
- Subjects :
- Adult
Male
Systemic disease
Adolescent
Cardiolipins
Immunology
Enzyme-Linked Immunosorbent Assay
Group A
General Biochemistry, Genetics and Molecular Biology
Immunoglobulin G
Group B
Rheumatology
Pregnancy
immune system diseases
medicine
Humans
Lupus Erythematosus, Systemic
Immunology and Allergy
Longitudinal Studies
skin and connective tissue diseases
Lupus anticoagulant
Lupus erythematosus
biology
business.industry
Thrombosis
Middle Aged
medicine.disease
Abortion, Spontaneous
Titer
biology.protein
Female
Antibody
business
Research Article
Subjects
Details
- ISSN :
- 00034967
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....317cbb23a3c977e978ba5b67d31762bd