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7 results on '"UCL - (MGD) Dermatologie"'

1. Localized bullous pemphigoid: Four clinical cases and a literature review

Author

Olivier Vanhooteghem, Ivan Theate, Chloe Algoet, Sabine Mostinckx, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Dermatologie

Subjects
medicine.medical_specialty, Pemphigoid, pemphigoid, lcsh:Medicine, Case Report, autoimmune disease, Case Reports, 030204 cardiovascular system & hematology, comorbidities, 03 medical and health sciences, 0302 clinical medicine, localized bullous pemphigoid, Medicine, skin and connective tissue diseases, Autoimmune disease, lcsh:R5-920, integumentary system, medicine.diagnostic_test, business.industry, lcsh:R, General Medicine, medicine.disease, Dermatology, eye diseases, nervous system diseases, 030220 oncology & carcinogenesis, Skin biopsy, sense organs, Bullous pemphigoid, lcsh:Medicine (General), business, Bullous rash
Abstract

Localized bullous pemphigoid (LBP) rarely evolves into the generalized form, and the prognosis is better. In our opinion, the occurrence of LBP is underestimated because of incorrect diagnoses. It is therefore important to perform a skin biopsy each time a bullous rash is concerned in order to make a definite diagnosis.

Published
2020

2. Increased CD8+CD28- circulating T cells and high blood interferon score characterize the systemic inflammation of amyopathic dermatomyositis

Author

R. Amode, François Chasset, Maxime Battistella, Armand Bensussan, Martine Bagot, Jean-David Bouaziz, Marie Jachiet, Charles Cassius, Claude Bachmeyer, Adèle de Masson, Clémence Lepelletier, Laure Frumholtz, Djaouida Bengoufa, Florence Cordoliani, Mylene Branchtein, Hélène Le Buanec, Jean-Benoît Monfort, Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de dermatologie [Paris], Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Catholique de Louvain = Catholic University of Louvain (UCL), Université libre de Bruxelles (ULB), Service d'anatomo-pathologie [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Service de Médecine Interne [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hématologie -Immunologie -Cibles thérapeutiques, Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut Mondor de recherche biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de Dermatologie [AP-HP Hôpital Saint-Louis], Hopital Saint-Louis [AP-HP] (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), CHU UCL Namur, Service de pathologie [Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Médecine Interne = Hôpital de jour de médecine [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Le Buanec, Hélène, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Dermatologie

Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology, dermatomyositis, CD28- lymphocytes, Dermatology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Cd8 cd28, Systemic inflammation, Peripheral blood mononuclear cell, 03 medical and health sciences, 0302 clinical medicine, Interferon, adaptive immune system, Healthy control, Medicine, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, business.industry, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, Dermatomyositis, [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology, Acquired immune system, medicine.disease, 3. Good health, amyopathic dermatomyositis, Amyopathic dermatomyositis, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, 030220 oncology & carcinogenesis, [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology, Immunology, flowcytometry, type I interferon, [SDV.IMM]Life Sciences [q-bio]/Immunology, medicine.symptom, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, business, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, medicine.drug
Abstract

Amyopathic dermatomyositis (ADM) is a subtype of DM defined by the presence of cutaneous signs of DM with no evidence of muscle weakness or abnormal muscle enzymes for ≥ 6 months.1 Classical DM (CDM) is characterized by modification of circulating lymphocytes 4, type I interferon (IFN) signature 2, elevation of serum pro-inflammatory cytokines 3. Pathophysiology of ADM is less studied. We analysed circulating T cells by flowcytometry (using specific monoclonal antibodies), peripheral blood mononuclear cells type I IFN signature by PCR and serum cytokine levels by ELISA in a series of 17 ADM and 15 CDM patients. [...]

Published
2021

3. A rapid unfavorable penile calciphylaxis case followed by total penectomy

Author

Ivan Theate, Michele Lejeune, Charlotte Roquet-Gravy, Olivier Vanhooteghem, UCL - (MGD) Dermatologie, and UCL - SSS/IREC/MONT - Pôle Mont Godinne

Subjects
medicine.medical_specialty, Medicine (General), medicine.medical_treatment, renal insufficient, Case Report, Case Reports, penile, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, R5-920, amputation, medicine, Calciphylaxis, hemodialysis, Penectomy, Medical treatment, treatment, business.industry, calciphylaxis, General Medicine, medicine.disease, Surgery, Amputation, 030220 oncology & carcinogenesis, Medicine, Hemodialysis, business
Abstract

When the diagnosis of penile calciphylaxis is suggested, the evolution of the disease is rapidly unfavorable; in this case, a rapid medical treatment must be established to obtain an improvement of the disease to avoid penectomy.

Published
2021

4. Halo Nevi Are Not Trivial: About 2 Young Patients of Regressed Primary Melanoma That Simulates Halo Nevi

Author

S De Schrijver, O Vanhooteghem, I Theate, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Dermatologie

Subjects
medicine.medical_specialty, business.industry, Melanoma, Case Report, Vitiligo, Dermatology, medicine.disease, Malignancy, Atypical nevus, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, RL1-803, Familial history, medicine, Halo, Young adult, business, skin and connective tissue diseases, Halo nevus
Abstract

Background. Halo nevi are often considered benign, and the possibility of malignancy is not always clear to practitioners. We present two case reports suggesting that a halo nevus appearance can be seen in melanoma, even in young adults. A literature search for halo nevi revealing melanoma shows that this is a very rare condition. Case presentation. This report of two young patients indicates the importance of obtaining a detailed history to detect warning signs such as itching, pain, spontaneous bleeding, and previous alterations according to the patient, including a previously totally black colour in an already fully regressed melanoma. Conclusions. The risk of a halo nevus being malignant is higher if there is only one unique halo nevus and no personal or familial history of vitiligo. We postulate that a regressing atypical nevus or a regressing melanoma may be induced by an immunologic reaction as halo nevus type of clinical picture.

Published
2021

5. MDA5+ Dermatomyositis Is Associated with Stronger Skin Type I Interferon Transcriptomic Signature with Upregulation of IFN-κ Transcript

Author

Marie Jachiet, Florence Cordoliani, Antonio José Alberdi, D. Boccara, R. Amode, Hélène Le Buanec, Marc Delord, Jacqueline Lehmann-Che, Clémence Lepelletier, Jennifer Wong, Alexandre How-Kit, Laure Frumholtz, Charles Cassius, Adèle de Masson, Sylvie Dubanchet, Maxime Battistella, Jean-David Bouaziz, Justine Poirot, Martine Bagot, Marine Merandet, Armand Bensussan, Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), CHU UCL Namur, Université Catholique de Louvain = Catholic University of Louvain (UCL), Groupe d'Etude des Maladies Systémiques En Dermatologie (EMSED - Paris), Société Française de Dermatologie et de Pathologie Sexuellement Transmissible (SFDPST - Paris), Service de Dermatologie [AP-HP Hôpital Saint-Louis], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Direction à la recherche clinique et à l'innovation [CH de Versailles André Mignot] (DRCI), Centre Hospitalier de Versailles André Mignot (CHV), Laboratoire de pathologie [AP-HP Hôpital Saint-Louis], Fondation Jean Dausset CEPH, Service de chirurgie plastique et reconstructive [Hôpital Saint Louis], Service d'Hémato-oncologie [CHU Saint-Louis], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Université de Paris (UP), Le Buanec, Hélène, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Cité (UPCité), UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Dermatologie

Subjects
Adult, Male, Interferon-Induced Helicase, IFIH1, Skin type, Dermatology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biochemistry, Dermatomyositis, Transcriptome, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Interferon, medicine, Humans, Molecular Biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS, Aged, Autoantibodies, Oligonucleotide Array Sequence Analysis, Skin, 030304 developmental biology, Aged, 80 and over, 030203 arthritis & rheumatology, 0303 health sciences, business.industry, Gene Expression Profiling, MDA5, Cell Biology, Middle Aged, medicine.disease, Fold change, Up-Regulation, 3. Good health, Gene Expression Regulation, Case-Control Studies, Interferon Type I, Cancer research, Female, business, medicine.drug
Abstract

TO THE EDITOR, Dermatomyositis (DM) is a chronic inflammatory and autoimmune disorder belonging to the idiopathic inflammatory myopathies affecting primarily skin and muscle with variable extent. Disease mechanism comprehension is growing, with a pivotal role of both the innate and adaptive immune system and involvement of both cellular and humoral actors (Nagaraju and Lundberg, 2011). [...]

Published
2020

6. Seborrheic keratosis evolution into squamous cell carcinoma: A truly modified sun-related tumor? A case report and review of the literature

Author

Ioana Cimpean, Olivier Vanhooteghem, Ivan Theate, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Dermatologie

Subjects
Seborrheic keratosis, medicine.medical_specialty, Erythema, Case Report, Dermatology, Histopathological examination, Malignant transformation, Lesion, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Squamous cell carcinoma, medicine, lcsh:Dermatology, Basal cell, integumentary system, business.industry, Incidence (epidemiology), Sun, lcsh:RL1-803, medicine.disease, Increased risk, 030220 oncology & carcinogenesis, medicine.symptom, business
Abstract

The incidence of seborrheic keratosis (SK) generally increases with age and are mostly localized on the trunk, face and neck, especially on sun-exposed areas. The association between SK and skin malignancies appears to be accidental, but in situ transformation occurs more frequently in sun-exposed areas. Histopathological examination of all SK cases should be considered, especially when SK lesions exhibit atypical clinical manifestations, such as ulceration and cresting, as they may herald malignant transformation. In addition, other features associated with malignant transformation include excoriations or hemorrhages identified on the lesion, modification and evolution of the macroscopic characteristics, and the presence of local erythema or pruritus. Immunocompromised patients exhibit an increased risk of malignant transformation, even when radiation is involved.

Published
2019

7. Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome

Author

R. Amode, Charles Cassius, J.-D. Bouaziz, Hélène Le Buanec, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Dermatologie, Le Buanec, Hélène, Service de Dermatologie [AP-HP Hôpital Saint-Louis], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Université Sorbonne Paris Cité (USPC), Université Catholique de Louvain = Catholic University of Louvain (UCL), Service de Dermatologie [Hôpital Bichat – Claude-Bernard - APHP], and AP-HP - Hôpital Bichat - Claude Bernard [Paris]

Subjects
0301 basic medicine, lcsh:Immunologic diseases. Allergy, Adult, medicine.medical_specialty, [SDV.IMM] Life Sciences [q-bio]/Immunology, Article Subject, Immunology, Review Article, Dermatomyositis, Disease activity, 03 medical and health sciences, 0302 clinical medicine, Daily practice, Neoplasms, Immunology and Allergy, Medicine, Humans, Intensive care medicine, Skin, 030203 arthritis & rheumatology, business.industry, General Medicine, [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology, medicine.disease, Medical research, Prognosis, Adult dermatomyositis, 3. Good health, Clinical trial, 030104 developmental biology, Neoplasms diagnosis, Potential biomarkers, [SDV.IMM]Life Sciences [q-bio]/Immunology, business, lcsh:RC581-607, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, Biomarkers
Abstract

International audience; Dermatomyositis pathophysiology is complex. In recent years, medical research has identified molecules associated with disease activity. Besides providing insights into the driving mechanisms of dermatomyositis, these findings could provide potential biomarkers. Activity markers can be used to monitor disease activity in clinical trials and may also be useful in daily practice. This article reviews molecules that could be used as biomarkers for diagnosis and monitoring dermatomyositis disease activity.

Published
2019

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