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MDA5+ Dermatomyositis Is Associated with Stronger Skin Type I Interferon Transcriptomic Signature with Upregulation of IFN-κ Transcript
- Source :
- Journal of Investigative Dermatology, Journal of Investigative Dermatology, Nature Publishing Group, 2020, 140 (6), pp.1276-1279.e7. ⟨10.1016/j.jid.2019.10.020⟩, The Journal of investigative dermatology, Vol. 140, no. 6, p. 1276-1279.e7 (2020)
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- TO THE EDITOR, Dermatomyositis (DM) is a chronic inflammatory and autoimmune disorder belonging to the idiopathic inflammatory myopathies affecting primarily skin and muscle with variable extent. Disease mechanism comprehension is growing, with a pivotal role of both the innate and adaptive immune system and involvement of both cellular and humoral actors (Nagaraju and Lundberg, 2011). [...]
- Subjects :
- Adult
Male
Interferon-Induced Helicase, IFIH1
Skin type
Dermatology
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biochemistry
Dermatomyositis
Transcriptome
Young Adult
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Interferon
medicine
Humans
Molecular Biology
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
ComputingMilieux_MISCELLANEOUS
Aged
Autoantibodies
Oligonucleotide Array Sequence Analysis
Skin
030304 developmental biology
Aged, 80 and over
030203 arthritis & rheumatology
0303 health sciences
business.industry
Gene Expression Profiling
MDA5
Cell Biology
Middle Aged
medicine.disease
Fold change
Up-Regulation
3. Good health
Gene Expression Regulation
Case-Control Studies
Interferon Type I
Cancer research
Female
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 0022202X and 15231747
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology, Journal of Investigative Dermatology, Nature Publishing Group, 2020, 140 (6), pp.1276-1279.e7. ⟨10.1016/j.jid.2019.10.020⟩, The Journal of investigative dermatology, Vol. 140, no. 6, p. 1276-1279.e7 (2020)
- Accession number :
- edsair.doi.dedup.....90d814fafd4a6f6982d31ee521f27e4d
- Full Text :
- https://doi.org/10.1016/j.jid.2019.10.020⟩