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1. Lung Cancer Among Firefighters: Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies

Author

Bigert, C, Gustavsson, P, Straif, K, Taeger, D, Pesch, B, Kendzia, B, Schuz, J, Stucker, I, Guida, F, Bruske, I, Wichmann, H E, Pesatori, A C, Landi, M T, Caporaso, N, Tse, L A, Yu, I T, Siemiatycki, J, Lavoue, J, Richiardi, L, Mirabelli, D, Simonato, L, Jockel, K H, Ahrens, W, Pohlabeln, H, Tardon, A, Zaridze, D, Field, J K, t Mannetje, A, Pearce, N, McLaughlin, J, Demers, P, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Stanescu Dumitru, R, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Peters, S, Vermeulen, R, Kromhout, H, Bruning, T, Olsson, A C, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Bigert, C., Gustavsson, P., Straif, K., Taeger, D., Pesch, B., Kendzia, B., Schüz, J., Stücker, I., Guida, F., Brüske, I., Wichmann, H.-E., Pesatori, A.C., Landi, M.T., Caporaso, N., Tse, L.A., Yu, I.T.-S., Siemiatycki, J., Lavoué, J., Richiardi, L., Mirabelli, D., Simonato, L., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Tardón, A., Zaridze, D., Field, J.K., Mannetje, A., Pearce, N., McLaughlin, J., Demers, P., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Peters, S., Vermeulen, R., Kromhout, H., Brüning, T., and Olsson, A.C.

Subjects
Gerontology, Canada, China, Lung Neoplasms, Medizin, Logistic regression, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Occupational Exposure, Odds Ratio, Medicine, Humans, 030212 general & internal medicine, Lung cancer, Cell specific, business.industry, Environmental and Occupational Health, Smoking, Public Health, Environmental and Occupational Health, Absolute risk reduction, Case-control study, Odds ratio, medicine.disease, 030210 environmental & occupational health, Europe, Occupational Diseases, Pooled analysis, Case-Control Studies, Firefighters, Lung cancer - firefighters, Public Health, Occupational exposure, business, Demography, New Zealand
Abstract

Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter. Copyright © 2016 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited.

Published
2016

2. Incidence of malignancy in patients treated for antineutrophil cytoplasm antibody-associated vasculitis: follow-up data from European Vasculitis Study Group clinical trials

Author

Heijl, C., Harper, L., Flossmann, O., Stucker, I., Scott, D.G.I., Watts, R.A., Hoglund, P., Westman, K., Mahr, A., European Vasculitis Study Grp EUVA, and Faculteit Medische Wetenschappen/UMCG

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Skin Neoplasms, Cyclophosphamide, Immunology, Population, BLADDER-CANCER, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, THERAPY, General Biochemistry, Genetics and Molecular Biology, WEGENERS-GRANULOMATOSIS, Rheumatology, Neoplasms, Internal medicine, Azathioprine, CYCLOPHOSPHAMIDE, medicine, Humans, Multicenter Studies as Topic, Immunology and Allergy, COHORT, POLYANGIITIS, education, METAANALYSIS, Aged, Randomized Controlled Trials as Topic, RISK, education.field_of_study, Bladder cancer, business.industry, Cancer, Middle Aged, medicine.disease, RANDOMIZED-TRIAL, METHOTREXATE, Europe, Female, Skin cancer, Epidemiologic Methods, Microscopic polyangiitis, Vasculitis, Granulomatosis with polyangiitis, business, Immunosuppressive Agents, medicine.drug
Abstract

Objectives Because standard immunosuppressive treatment for antineutrophil cytoplasm antibody-associated vasculitis (AAV) (granulomatosis with polyangiitis (Wegener's) (GPA) and microscopic polyangiitis (MPA)) has been associated with a significant risk of developing cancer, the cancer incidence of treated AAV patients was assessed.Methods This analysis concerned 535 patients with newly diagnosed AAV from 15 countries who had been enrolled between 1995 and 2002 in four European clinical trials. Over the period 2004-7, study participants' follow-up events were updated, including cancers diagnosed. Age, sex and area-standardised incidence ratios (SIR) and their 95% CI were calculated by linkage to five national cancer databases.Results During the 2650 person-years' observation period, 50 cancers were diagnosed in 46 patients. SIR (95% CI) were 1.58 (1.17 to 2.08) for cancers at all sites, 1.30 (0.90 to 1.80) for cancers at all sites excluding non-melanoma skin cancer (NMSC), 2.41 (0.66 to 6.17) for bladder cancer, 3.23 (0.39 to 11.65) for leukaemia, 1.11 (0.03 to 6.19) for lymphoma and 2.78 (1.56 to 4.59) for NMSC. Subgroup SIR for cancers at all sites were 1.92 (1.31 to 2.71) for GPA and 1.20 (0.71 to 1.89) for MPA.Conclusions Cancer rates for AAV patients treated with conventional immunosuppressive therapy exceeded those expected for the general population. This cancer excess was largely driven by an increased incidence of NMSC. The smaller cancer risk magnitude in this cohort, compared with previous studies, might reflect less extensive use of cyclophosphamide in current treatment protocols. Longer follow-up data are warranted to appraise the risk of developing cancers later during the course of AAV.

Published
2011

3. Occupational exposure to organic dust increases lung cancer risk in the general population

Author

Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.E., Bruske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jockel, K.H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J, Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stucker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Bruning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.-E., Brüske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J., Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stücker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Brüning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Canada, Lung Neoplasms, case-control study, Population, Medizin, Cumulative Exposure, Logistic regression, Article, Toxicology, Occupational Exposure, Environmental health, Humans, Medicine, Lung cancer, education, Aged, Asthma, education.field_of_study, business.industry, Smoking, Case-control study, Public Health, Environmental and Occupational Health, Dust, Middle Aged, medicine.disease, Occupational exposure to organic du, respiratory tract diseases, Europe, Occupational Diseases, lung cancer, Quartile, Case-Control Studies, Meta-analysis, Female, business
Abstract

Background: Organic dust is a complex mixture of particulate matter from microbial, plant or animal origin. Occupations with exposure to animal products have been associated with an increased lung cancer risk, while exposure to microbial components (eg, endotoxin) has been associated with a decreased risk. To date there has not been a comprehensive evaluation of the possible association between occupational organic dust exposure (and its specific constituents) and lung cancer risk in the general population. Methods: The SYNERGY project has pooled information on lifetime working and smoking from 13 300 lung cancer cases and 16 273 controls from 11 case - control studies conducted in Europe and Canada. A newly developed general population job-exposure matrix (assigning no, low or high exposure to organic dust, endotoxin, and contact with animals or fresh animal products) was applied to determine level of exposure. ORs for lung cancer were estimated by logistic regression, adjusted for age, sex, study, cigarette pack-years, time since quitting smoking, and ever employment in occupations with established lung cancer risk. Results: Occupational organic dust exposure was associated with increased lung cancer risk. The second to the fourth quartile of cumulative exposure showed significant risk estimates ranging from 1.12 to 1.24 in a dose-dependent manner (p

Published
2012

4. Polycyclic aromatic hydrocarbons and fatal ischemic heart disease

Author

Burstyn, I., Kromhout, H., Partanen, T.J., Svane, O., Langard, S., Ahrens, W., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Boffetta, P., Faculteit Diergeneeskunde, Secretariat, U754, Unit of Environment Cancer Epidemiology, IARC, Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Department of Public Health Sciences, University of Alberta, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Central American Institute for Studies on Toxic Substances, Universidad National, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Bremen Institute for Prevention Research and Social Medicine, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Institute of Cancer Epidemiology, Danish Cancer Society, Burstyn, I., Kromhout, H., Partanen, T., Svane, O., Langård, S., Ahrens, W., Kauppinen, T., Stücker, I., Shaham, J., Heederik, D., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B.G., Boffetta, P., and Faculteit Diergeneeskunde

Subjects
Male, Epidemiology, Denmark, Myocardial Ischemia, MESH: Occupational Exposure, MESH: Cause of Death, chemistry.chemical_compound, Risk Factors, MESH: Risk Factors, Cause of Death, Germany, Determinants in Health and Disease [EBP 1], Israel, Polycyclic Aromatic Hydrocarbons, Finland, MESH: Finland, Confounding, Smoking, Absolute risk reduction, MESH: Israel, Confounding Factors, Epidemiologic, Occupational Diseases, Cohort, Benzopyrene, MESH: Myocardial Ischemia, France, MESH: Occupational Diseases, medicine.medical_specialty, MESH: Smoking, Ischemic heart disease, Coronacrisis-Taverne, Occupational medicine, MESH: Polycyclic Hydrocarbons, Aromatic, Interventional oncology [UMCN 1.5], Environmental health, Occupational Exposure, medicine, Humans, cardiovascular diseases, Risk factor, MESH: Germany, MESH: Denmark, MESH: Humans, business.industry, MESH: Confounding Factors (Epidemiology), MESH: Male, MESH: France, chemistry, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Relative risk, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

Background: Several toxicologic and epidemiologic studies have produced evidence that occupational exposure to polycyclic aromatic hydrocarbons (PAH) is a risk factor for ischemic heart disease (IHD). However, a clear exposure-response relation has not been demonstrated. Methods: We studied a relation between exposure to PAH and mortality from IHD (418 cases) in a cohort of 12,367 male asphalt workers from Denmark, Finland, France, Germany, Israel, The Netherlands and Norway. The earliest follow up (country-specific) started in 1953 and the latest ended in 2000, averaging 17 years. Exposures to benzo(a)pyrene were assessed quantitatively using measurement-driven exposure models. Exposure to coal tar was assessed in a semiquantitative manner on the basis of information supplied by company representatives. We carried out sensitivity analyses to assess potential confounding by tobacco smoking. Results: Both cumulative and average exposure indices for benzo(a)pyrene were positively associated with mortality from IHD. The highest relative risk for fatal IHD was observed for average benzo(a)pyrene exposures of 273 ng/m 3 or higher, for which the relative risk was 1.64 (95% confidence interval = 1.13-2.38). Similar results were obtained for coal tar exposure. Sensitivity analysis indicated that even in a realistic scenario of confounding by smoking, we would observe approximately 20% to 40% excess risk in IHD in the highest PAH-exposure categories. Conclusions: Our results lend support to the hypothesis that occupational PAH exposure causes fatal IHD and demonstrate a consistent exposure-response relation for this association. Copyright © 2005 by Lippincott Williams & Wilkins.

Published
2005

5. Mortality from obstructive lung diseases and exposure to polycyclic aromatic hydrocarbons among asphalt workers

Author

Burstyn, I., Boffetta, P., Heederik, D.J.J., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Ahrens, W., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, Faculteit Diergeneeskunde, Secretariat, U754, Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Unit of Environment Cancer Epidemiology, IARC, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Bremen Institute for Prevention Research and Social Medicine, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Institute of Cancer Epidemiology, Danish Cancer Society, Universiteit Utrecht, and Faculteit Diergeneeskunde

Subjects
Male, Chronic bronchitis, Pathology, Epidemiology, Abbreviations: ICD-9, MESH: Risk Assessment, MESH: Occupational Exposure, Cohort Studies, Ninth Revision, chemistry.chemical_compound, Road Construction Workers’ Exposure Matrix, Determinants in Health and Disease [EBP 1], Israel, Polycyclic Aromatic Hydrocarbons, MESH: Cohort Studies, Coal Tar, Inhalation Exposure, MESH: Time, Respiratory disease, MESH: Israel, MESH: Follow-Up Studies, Polycyclic aromatic hydrocarbon, Causality, Europe, Occupational Diseases, Benzo(a)pyrene, Bronchitis, MESH: Inhalation Exposure, ICD-9, medicine.drug, MESH: Occupational Diseases, medicine.medical_specialty, Coronacrisis-Taverne, MESH: Coal Tar, MESH: Causality, Risk Assessment, ICD-9 [Abbreviations], Time, Occupational medicine, MESH: Polycyclic Hydrocarbons, Aromatic, International Classification of Diseases, Interventional oncology [UMCN 1.5], Occupational Exposure, Environmental health, polycyclic aromatic hydrocarbon, MESH: Hydrocarbons, MESH: Lung Diseases, Obstructive, medicine, Humans, Lung Diseases, Obstructive, Coal tar, Asthma, MESH: Humans, business.industry, PAH, medicine.disease, Hydrocarbons, MESH: Male, respiratory tract diseases, ROCEM, chemistry, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, Aromatic, Follow-Up Studies
Abstract

Item does not contain fulltext Work in the asphalt industry has been associated with nonmalignant respiratory morbidity and mortality, but the evidence is not consistent. A historical cohort of asphalt workers included 58,862 men (911,209 person-years) first employed between 1913 and 1999 in companies applying and mixing asphalt in Denmark, Finland, France, Germany, Israel, the Netherlands, and Norway. The relations between mortality from nonmalignant respiratory diseases (including the obstructive lung diseases: chronic bronchitis, emphysema, and asthma) and specific chemical agents and mixtures were evaluated using a study-specific exposure matrix. Mortality from obstructive lung diseases was associated with the estimated cumulative and average exposures to polycyclic aromatic hydrocarbons and coal tar (p values of the test for linear trend = 0.06 and 0.01, respectively). The positive association between bitumen fume exposure and mortality from obstructive lung diseases was weak and not statistically significant; confounding by simultaneous exposure to coal tar could not be excluded. The authors lacked data on smoking and full occupational histories. In conclusion, exposures to polycyclic aromatic hydrocarbons, originating from coal tar and possibly from bitumen fume, may have contributed to mortality from obstructive lung diseases among asphalt workers, but confounding and bias cannot be ruled out as an explanation for the observed associations.

Published
2003

6. Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer

Author

Gao, C., Patel, C. J., Michailidou, K., Peters, U., Gong, J., Schildkraut, J., Schumacher, F. R., Zheng, W., Boffetta, P., Stucker, I., Willett, W., Gruber, S., Easton, D. F., Hunter, D. J., Sellers, T. A., Haiman, C., Henderson, B. E., Hung, R. J., Amos, C., Pierce, B. L., Lindström, S., Kraft, P., Hunter, D., Henderson, B., Sellers, T., Hopper, J. L., Southey, M. C., Makalic, E., Schmidt, D. F., Fletcher, O., Peto, J., Gibson, L., Silva, I. S., Waisfisz, Q., Meijers-Heijboer, H., Adank, M., van der Luijt, R. B., Uitterlinden, A. G., Hofman, A., Meindl, A., Schmutzler, R. K., Müller-Myhsok, B., Lichtner, P., Nevanlinna, H., Muranen, T. A., Aittomäki, K., Blomqvist, C., Chang-Claude, J., Hein, R., Dahmen, N., Beckman, L., Hall, P., Czene, K., Irwanto, A., Liu, J., Turnbull, C., Rahman, N., Cramer, D., Terry, K., Sutphen, R., Narod, S., Phelan, C., Risch, H., Pharoah, P., Gayther, S., Menon, U., Wentzensen, N., Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, CCA - Oncogenesis, CCA - Quality of life, and Gao, C. and Patel, C.J. and Michailidou, K. and Peters, U. and Gong, J. and Schildkraut, J. and Schumacher, F.R. and Zheng, W. and Boffetta, P. and Stucker, I. and Willett, W. and Gruber, S. and Easton, D.F. and Hunter, D.J. and Sellers, T.A. and Haiman, C. and Henderson, B.E. and Hung, R.J. and Amos, C. and Pierce, B.L. and Lindström, S. and Kraft, P. and Hunter, D. and Henderson, B. and Sellers, T. and Amos, C. and Hopper, J.L. and Southey, M.C. and Makalic, E. and Schmidt, D.F. and Fletcher, O. and Peto, J. and Gibson, L. and Silva, I.S. and Waisfisz, Q. and Meijers-Heijboer, H. and Adank, M. and van der Luijt, R.B. and Uitterlinden, A.G. and Hofman, A. and Meindl, A. and Schmutzler, R.K. and Müller-Myhsok, B. and Lichtner, P. and Nevanlinna, H. and Muranen, T.A. and Aittomäki, K. and Blomqvist, C. and Chang-Claude, J. and Hein, R. and Dahmen, N. and Beckman, L. and Hall, P. and Czene, K. and Irwanto, A. and Liu, J. and Turnbull, C. and Rahman, N. and Cramer, D. and Terry, K. and Sutphen, R. and Narod, S. and Phelan, C. and Risch, H. and Pharoah, P. and Gayther, S. and Menon, U. and Wentzensen, N.

Subjects
Male, Oncology, obesity, Epidemiology, smoking, adcy3 gene, health statu, Colorectal Neoplasm, cancer risk, genetic risk, lung tumor, Body Mass Index, genetic heterogeneity, 0302 clinical medicine, single nucleotide polymorphism, Epidemiology of cancer, Odds Ratio, tnn13k gene, 030212 general & internal medicine, sec16b gene, 2. Zero hunger, prostate tumor, breast tumor, adult, public health, allele, ovary cancer, General Medicine, prostate cancer, 3. Good health, gnpda2 gene, waist hip ratio, female, Phenotype, risk factor, priority journal, ovary tumor, 030220 oncology & carcinogenesis, child health, gnat2 gene, childhood obesity, Breast Neoplasm, cancer epidemiology, Human, single nucleotide polymorphism, Adiposity, medicine.medical_specialty, gpr61 gene, colorectal cancer, Polymorphism, Single Nucleotide, Article, olfm4 gene, Regression Analysi, 03 medical and health sciences, mc4r gene, Breast cancer, SDG 3 - Good Health and Well-being, tmem18 gene, Internal medicine, pleiotropy, Mendelian randomization, medicine, cancer, controlled study, Mendelian Randomization Analysi, Risk factor, gene, Lung cancer, Post-GWAS study, health risk, genome-wide association study, fto gene, Waist-Hip Ratio, business.industry, Ovarian Neoplasm, Waist-to-hip ratio, birth weight, Cancer, Odds ratio, medicine.disease, major clinical study, Lung Neoplasm, lung cancer, confidence interval, genetic variation, Prostatic Neoplasm, Neoplasm, genetic, business, Body mass index, body ma, colorectal tumor
Abstract

Background: Adiposity traits have been associated with risk of many cancers in observational studies, but whether these associations are causal is unclear. Mendelian randomization (MR) uses genetic predictors of risk factors as instrumental variables to eliminate reverse causation and reduce confounding bias. We performed MR analyses to assess the possible causal relationship of birthweight, childhood and adult body mass index (BMI), and waist-hip ratio (WHR) on the risks of breast, ovarian, prostate, colorectal and lung cancers. Methods: We tested the association between genetic risk scores and each trait using summary statistics from published genome-wide association studies (GWAS) and from 51 537 cancer cases and 61 600 controls in the Genetic Associations and Mechanisms in Oncology (GAME-ON) Consortium. Results: We found an inverse association between the genetic score for childhood BMI and risk of breast cancer [odds ratio (OR)=0.71 per standard deviation (s.d.) increase in childhood BMI; 95% confidence interval (CI): 0.60, 0.80; P=6.5×10-5). We also found the genetic score for adult BMI to be inversely associated with breast cancer risk (OR=0.66 per s.d. increase in BMI; 95% CI: 0.57, 0.77; P=2.5×10-7), and positively associated with ovarian cancer (OR=1.35; 95% CI: 1.05, 1.72; P=0.017), lung cancer (OR=1.27; 95% CI: 1.09, 1.49; P=2.9×10-3) and colorectal cancer (OR=1.39; 95% CI: 1.06, 1.82, P=0.016). The inverse association between genetically predicted adult BMI and breast cancer risk remained even after adjusting for directional pleiotropy via MR-Egger regression. Conclusions: Findings from this study provide additional understandings of the complex relationship between adiposity and cancer risks. Our results for breast and lung cancer are particularly interesting, given previous reports of effect heterogeneity by menopausal status and smoking status. © The Author 2016; Published by Oxford University Press on behalf of the International Epidemiological Association All rights reserved.

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7. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author

Philip Lazarus, Claire M. Healy, Richard B. Hayes, Rolando Herrero, Elaine M. Smith, Stefania Boccia, Leonardo F. Boaventura Rios, Paolo Boffetta, Dana Mates, Jerry Polesel, Marta Vilensky, Jose P. Zevallos, Diego Serraino, Gypsyamber D'Souza, Joshua E. Muscat, Kirsten B. Moysich, Yuan Chin Amy Lee, Mark P. Purdue, Carlo La Vecchia, Heribert Ramroth, Thomas L. Vaughan, Peter Thomson, Karl T. Kelsey, Nicola Torelli, Wolfgang Ahrens, Hermann Brenner, Lorenzo Richiardi, Victor Wünsch-Filho, Kristina Kjærheim, Beata Swiatkowska, Keitaro Matsuo, Fabio Levi, Erich M. Sturgis, Eva Negri, Lorenzo Simonato, Danièle Luce, Guo Pei Yu, Chu Chen, Pagona Lagiou, Silvia Franceschi, Andrew F. Olshan, Alexander W. Daudt, Antonio Agudo, Maria Paula Curado, Peter Rudnai, Tatiana V. Macfarlane, Zuo-Feng Zhang, Mia Hashibe, Paul Brennan, Tatiana Natasha Toporcov, Stimson P. Schantz, Maura L. Gillison, Isabelle Stücker, Tongzhang Zheng, Shu Chun Chuang, Oxana Shangina, Eleonora Fabianova, Hal Morgenstern, David I. Conway, Valeria Edefonti, Cristina Bosetti, Ariana Znaor, Leticia Fernandez, Michael D. McClean, Luigino Dal Maso, Neil D. Gross, Stephen M. Schwartz, Ivana Holcatova, Guojun Li, Ana M. B. Menezes, Francesco Pauli, Gioia Di Credico, Deborah M. Winn, Rosalina Jorge Koifman, Gwenn Menvielle, Gabriella Cadoni, Werner Garavello, Jolanda Lissowska, Università degli Studi di Milano [Milano] (UNIMI), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Glasgow, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), TW001500, National Institutes of Health, P30ES010126, National Institute of Environmental Health Sciences, Italian Ministry of Education, Università degli Studi di Milano, Jonsson Comprehensive Cancer Center, International Union Against Cancer, Fondo para la Investigacion Cientifica y Tecnologica Argentina, Institut Hospital del Mar d’Investigacions Mediquès (IMIM), Fundação de Amparo à Pesquisa no Estado de São Paulo, Spanish Government, European Community, Ministry of Science, Research and Arts Baden-Wurttemberg, German Ministry of Education and Research, Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan, Labor and Welfare of Japan, Italian Foundation for Cancer Research, Di Credico G., Edefonti V., Polesel J., Pauli F., Torelli N., Serraino D., Negri E., Luce D., Stucker I., Matsuo K., Brennan P., Vilensky M., Fernandez L., Curado M.P., Menezes A., Daudt A.W., Koifman R., Wunsch-Filho V., Holcatova I., Ahrens W., Lagiou P., Simonato L., Richiardi L., Healy C., Kjaerheim K., Conway D.I., Macfarlane T.V., Thomson P., Agudo A., Znaor A., Boaventura Rios L.F., Toporcov T.N., Franceschi S., Herrero R., Muscat J., Olshan A.F., Zevallos J.P., La Vecchia C., Winn D.M., Sturgis E.M., Li G., Fabianova E., Lissowska J., Mates D., Rudnai P., Shangina O., Swiatkowska B., Moysich K., Zhang Z.-F., Morgenstern H., Levi F., Smith E., Lazarus P., Bosetti C., Garavello W., Kelsey K., McClean M., Ramroth H., Chen C., Schwartz S.M., Vaughan T.L., Zheng T., Menvielle G., Boccia S., Cadoni G., Hayes R.B., Purdue M., Gillison M., Schantz S., Yu G.-P., Brenner H., D'Souza G., Gross N.D., Chuang S.-C., Boffetta P., Hashibe M., Lee Y.-C.A., Dal Maso L., Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, T, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, L, Toporcov, T, Franceschi, S, Herrero, R, Muscat, J, Olshan, A, Zevallos, J, La Vecchia, C, Winn, D, Sturgis, E, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, Mcclean, M, Ramroth, H, Chen, C, Schwartz, S, Vaughan, T, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Brenner, H, D'Souza, G, Gross, N, Chuang, S, Boffetta, P, Hashibe, M, Lee, Y, Dal Maso, L, Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W., Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I., Macfarlane, Tatiana V., Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Boaventura Rios, Leonardo F., Toporcov, Tatiana N., Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F., Zevallos, Jose P., La Vecchia, Carlo, Winn, Deborah M., Sturgis, Erich M., Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, Mcclean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M., Vaughan, Thomas L., Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B., Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D., Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Dal Maso, Luigino, Università degli Studi di Milano = University of Milan (UNIMI), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)

Subjects
Male, Oral cavity and pharyngeal cancers, Cancer Research, Bivariate spline model, medicine.medical_treatment, Logistic regression, Substance Misuse, 0302 clinical medicine, Risk Factors, Laryngeal cancer, 80 and over, 2.2 Factors relating to the physical environment, Aetiology, 030223 otorhinolaryngology, Head and neck cancer, Cancer, Aged, 80 and over, Confounding, Middle Aged, 3. Good health, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Bivariate spline models, Cigarette smoking duration, Cigarette smoking intensity, Public Health and Health Services, Female, Oral Surgery, Adult, INHANCE, Oncology and Carcinogenesis, [SDV.CAN]Life Sciences [q-bio]/Cancer, Bivariate analysis, Cigarette Smoking, 03 medical and health sciences, Rare Diseases, Clinical Research, Tobacco, medicine, Humans, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Aged, Settore MED/06 - ONCOLOGIA MEDICA, Tobacco Smoke and Health, business.industry, Prevention, Case-control study, Odds ratio, medicine.disease, Former Smoker, Good Health and Well Being, Case-Control Studies, Dentistry, Smoking cessation, business, Demography
Abstract

Objectives: \ud This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.\ud \ud Materials and Methods: \ud We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.\ud \ud Results: \ud For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.\ud \ud Conclusion: \ud Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

Published
2019

8. Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE Consortium

Author

Alexander W. Daudt, Kristina Kjærheim, Paolo Boffetta, Antonio Agudo, Leticia Fernandez, Peter Thomson, Cristina Canova, Alastair Ross, Isabelle Stücker, Diego Serraino, David I. Conway, Marta Vilensky, Rosalina Jorge Koifman, Paul Brennan, Lorenzo Richiardi, Gary J. Macfarlane, Mia Hashibe, Thomas Behrens, Pagona Lagiou, Simone Benhamou, Claire M. Healy, Amy Lee Yuan-Chin, Maria Paula Curado, Victor Wünsch-Filho, Wolfgang Ahrens, Alex D. McMahon, Gwenn Menvielle, Ariana Znaor, Ivana Holcatova, Heribert Ramroth, Jan Hovanec, Danièle Luce, Ana M. B. Menezes, University of Glasgow, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, First Faculty of Medicine Charles University [Prague], University of Athens Medical School [Athens], Universita degli Studi di Padova, University of Turin, Trinity College Dublin, Cancer Registry of Norway, University of Aberdeen, The University of Hong Kong (HKU), L’Hospitalet de Llobregat [Barcelona, Spain], Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), University of Heidelberg, Medical Faculty, Mount Sinai School of Medicine, Department of Psychiatry-Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Bologna, University of Buenos Aires [Argentina], Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Hospital de Clínicas de Porto Alegre (HCPA), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), University of São Paulo (USP), University of Utah School of Medicine [Salt Lake City], National Cancer Institute, NCI: R03CA113157, National Institute of Dental and Craniofacial Research, NIDCR: R03DE016611, European Commission, EC: IC18-CT97-0222, Agence Nationale de la Recherche, ANR, Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP: 01/01768-2, Bundesministerium für Bildung und Forschung, BMBF: 01GB9702/3, Fondation pour la Recherche Médicale, FRM, Fondation ARC pour la Recherche sur le Cancer, ARC, Fondation de France, Ministère des Affaires Sociales et de la Santé, Fifth Framework Programme, FP5: FOR381.88, KFS1069-09-2000, QLK1-CT-2001-00182, Institut National Du Cancer, INCa, Fondo para la Investigación Científica y Tecnológica, FonCyT, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, ANSES, Institut Gustave-Roussy: 88D28, Institut de Veille Sanitaire, InVS, Swiss Cancer Research Foundation: AKT 617, Conway D.I., Hovanec J., Ahrens W., Ross A., Holcatova I., Lagiou P., Serraino D., Canova C., Richiardi L., Healy C., Kjaerheim K., Macfarlane G.J., Thomson P., Agudo A., Znaor A., Brennan P., Luce D., Menvielle G., Stucker I., Benhamou S., Ramroth H., Boffetta P., Vilensky M., Fernandez L., Curado M.P., Menezes A., Daudt A., Koifman R., Wunsch-Filho V., Yuan-Chin A.L., Hashibe M., Behrens T., McMahon A.D., Università degli Studi di Padova = University of Padua (Unipd), Università degli studi di Torino = University of Turin (UNITO), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), University of Bologna/Università di Bologna, Universitad de Buenos Aires = University of Buenos Aires [Argentina], Universidade de São Paulo = University of São Paulo (USP), HAL UR1, Admin, and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)

Subjects
Data Analysis, medicine.medical_specialty, Epidemiology, Risk factors in diseases, Occupational prestige, [SDV]Life Sciences [q-bio], Socioeconomic Factor, Head cancer, socioeconomic, Cancer, Cancer Epidemiology, Occupational, Socioeconomic, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology of cancer, medicine, Humans, 030212 general & internal medicine, Socioeconomic status, Càncer de cap, Original Research, business.industry, Factors de risc en les malalties, Prestige, Risk Factor, Head and neck cancer, Public Health, Environmental and Occupational Health, Case-control study, South America, medicine.disease, Neck cancer, Càncer de coll, [SDV] Life Sciences [q-bio], Europe, Data Analysi, Socioeconomic Factors, cancer: occupational, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Case-Control Studies, cancer epidemiology, business, Case-Control Studie, Psychosocial, Demography, Human
Abstract

BackgroundThe association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures.MethodsPooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige—Treiman’s Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position—International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs.ResultsFor the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94).ConclusionsThese findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work.

Published
2020

9. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

Author

Kai Uwe Saum, Hal Morgenstern, Yun-Chul Hong, Gad Rennert, Nancy Diao, Hidemi Ito, Loic Le Marchand, Ann Olsson, Isabelle Stücker, Walid Saliba, David C. Christiani, Travis J. Meyers, Irene Orlow, Jack Siemiatycki, Anita Koushik, Gord Fehringer, Dario Consonni, Curtis C. Harris, Ann G. Schwartz, Paolo Vineis, Zuo-Feng Zhang, Adonina Tardón, Maria Teresa Landi, Alberto Ruano Raviña, Keitaro Matsuo, John R. McLaughlin, Philip Lazarus, Darren R. Brenner, Eric J. Duell, Paolo Boffetta, Yuan-Chin Amy Lee, Rayjean J. Hung, Kurt Straif, Guillermo Fernández-Tardón, Paul Brennan, Michele L. Cote, Hermann Brenner, Juan Miguel Barros Dios, Angeline S. Andrew, and Brenner, D.R. and Fehringer, G. and Zhang, Z.-F. and Lee, Y.-C.A. and Meyers, T. and Matsuo, K. and Ito, H. and Vineis, P. and Stucker, I. and Boffetta, P. and Brennan, P. and Christiani, D.C. and Diao, N. and Hong, Y.-C. and Landi, M.T. and Morgenstern, H. and Schwartz, A.G. and Rennert, G. and Saliba, W. and McLaughlin, J.R. and Harris, C.C. and Orlow, I. and Barros Dios, J.M. and Ruano Raviña, A. and Siemiatycki, J. and Koushik, A. and Cote, M. and Lazarus, P. and Fernandez-Tardon, G. and Tardon, A. and Le Marchand, L. and Brenner, H. and Saum, K.-U. and Duell, E.J. and Andrew, A.S. and Consonni, D. and Olsson, A. and Hung, R.J. and Straif, K.

Subjects
Male, squamous cell carcinoma, Oncology, Cancer Research, Lung Neoplasms, Epidemiology, cancer risk, Cohort Studies, alcohol, adenocarcinoma, Substance Misuse, Alcohol Use and Health, tobacco consumption, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, middle aged, Odds Ratio, 2.2 Factors relating to the physical environment, 030212 general & internal medicine, Aetiology, Lung, Cancer, Alcoholic Beverages, adult, Hazard ratio, Confounding, drinking behavior, Middle Aged, Stroke, aged, Alcoholism, female, Pooled analysis, priority journal, 030220 oncology & carcinogenesis, Alcoholisme, Public Health and Health Services, Carcinoma, Squamous Cell, Female, beer, Lung cancer, Alcohol, alcoholic beverage, Cohort study, Inverse Association, medicine.medical_specialty, Alcohol Drinking, alcohol consumption, Oncology and Carcinogenesis, cohort analysi, Adenocarcinoma, Article, smoking, 03 medical and health sciences, male, Internal medicine, medicine, Humans, controlled study, Oncology & Carcinogenesis, human, Aged, business.industry, Prevention, questionnaire, Carcinoma, Odds ratio, case control study, medicine.disease, Confidence interval, lung cancer, Good Health and Well Being, Squamous Cell, Case-Control Studies, Càncer de pulmó, business
Abstract

Background There is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders. Methods Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type. Results We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10–19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12–15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90). Conclusions Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.

Published
2019

10. Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Author

Kristina Kjærheim, Dana Hashim, Gwenn Menvielle, Hermann Brenner, Peter Thomson, Prerna Khetan, Diego Serraino, Pagona Lagiou, Carlo La Vecchia, Maria Paula Curado, Mia Hashibe, Lorenzo Richiardi, Yuan Chin Amy Lee, Danièle Luce, Wolfgang Ahrens, Joshua E. Muscat, Thomas L. Vaughan, Dana Mates, Isabelle Stücker, Heribert Ramroth, Paolo Boffetta, Victor Wünsch-Filho, David I. Conway, Ana M. B. Menezes, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, International Prevention Research Institute (IPRI), Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Universidade de São Paulo (USP), Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, National and Kapodistrian University of Athens (NKUA), University of Turin, Cancer Registry of Norway, University of Glasgow, The University of Hong Kong (HKU), Penn State College of Medicine, Penn State System-Pennsylvania Commonwealth System of Higher Education (PCSHE), National Institute of Public Health [Romania] (INSP), Heidelberg University Hospital [Heidelberg], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universität Heidelberg [Heidelberg], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), University of Utah School of Medicine [Salt Lake City], Università degli Studi di Milano [Milano] (UNIMI), International Agency for Cancer Research (IACR), The INHANCE Consortium was supported by NIH grants NCI R03CA113157 and NIDCR R03DE016611. Studies participating in the pooled analysis were supported by: Latin America study: Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina, IMIM (Barcelona), Fundaco de Amparo a` Pesquisa no Estado de Sao Paulo (FAPESP) [No 01/01768–2], and European Commission [IC18-CT97–0222]. Sao Paulo: Sao Paulo Research Foundation (FAPESP) (GENCAPO 04/12054–9, 10/51168–0). Western Europe multicenter (ARCAGE): European Community (5th Framework Programme) grant no QLK1-CT-2001-00182. New York multicenter: NY multicenter study: NIH [P01CA068384 K07CA104231]. Central Europe multicenter (INCO): Central Europe study: World Cancer Research Fund and the European Commission INCO-COPERNICUS Program [Contract No. IC15- CT98–0332]. Tampa study: NIH [P01CA068384, K07CA104231, R01DE013158] Germany-Heidelberg: Germany-Heidelberg study: grant No. 01GB9702/3 from the German Ministry of Education and Research. Seattle-Leo: Seattle-LEO study: NIH[R01CA030022]. MSKCC: MSKCC study: NIH [R01CA051845]. Germany-Saarland: Saarland study: Ministry of Science, Research and Arts Baden-Wurttemberg.. France multicenter (ICARE): French National Research Agency (ANR), French National Cancer Institute (INCA), French Agency for Food, Environmental and Occupational Health and Safety (ANSES), French Association for Research on Cancer (ARC), Fondation pour la Recherche Médicale (FRM), French Institute for Public Health Surveillance (InVS), Fondation de France, Ministry of Labour, Ministry of Health, LUCE, Danièle, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Universidade de São Paulo = University of São Paulo (USP), Università degli studi di Torino = University of Turin (UNITO), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Università degli Studi di Milano = University of Milan (UNIMI), Khetan P., Boffetta P., Luce D., Stucker I., Curado M.P., Menezes A., Wunsch-Filho V., Ahrens W., Lagiou P., Serraino D., Richiardi L., Kjaerheim K., Conway D., Thomson P., Muscat J., Mates D., Ramroth H., Menvielle G., Vaughan T.L., Brenner H., Lee Y.-C.A., La Vecchia C., Hashibe M., Hashim D., and Universität Heidelberg [Heidelberg] = Heidelberg University

Subjects
medicine.medical_specialty, Databases, Factual, Population, Logistic regression, Article, Pooled, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology, medicine, Humans, education, Cancer, education.field_of_study, Occupation, business.industry, Head and neck cancer, Public Health, Environmental and Occupational Health, Odds ratio, medicine.disease, 030210 environmental & occupational health, Confidence interval, Europe, Occupational Diseases, Latin America, Logistic Models, Head and Neck Neoplasms, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Head, Larynx, Neck, Attributable risk, North America, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Demography
Abstract

Objective: To investigate the associations between head and neck cancer\ud (HNC) risk and occupations. Methods: We harmonized data on occupations\ud in a pooled analysis of 8839 HNC cases and 13,730 controls in International\ud Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic\ud regression was used to estimate odds ratios (ORs) for associations of\ud occupations and HNC risk. Population attributable fraction (PAF)\ud for occupations was calculated using the formula PEC (OR 1)/OR.1\ud Results: Trend of increasing HNC risk was found with increasing duration\ud of employment for many occupations, including cooks (OR ¼ 1.36; 95%\ud confidence interval [CI] 1.09 to 1.68), cleaners (OR ¼ 1.38; 95% CI 1.13 to\ud 1.69), painters (OR ¼ 1.82; 95% CI 1.42 to 2.35). The PAF for a priori\ud occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC. Conclusions: We\ud found associations between certain occupations and HNC risks, including for\ud subsites, with a duration– response relationship.

Published
2019

11. The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer

Author

Neonila Szeszenia-Dabrowska, Dana Mates, Danièle Luce, Lorenzo Simonato, José Eluf-Neto, Michael Pawlita, Elaine M. Smith, Kim De Ruyck, Gwenn Menvielle, Cristina Bosetti, Deborah M. Winn, David Zaridze, Gabriella Cadoni, Keitaro Matsuo, Diego Serraino, Isabelle Stücker, Richard B. Hayes, Mia Hashibe, Andrew F. Olshan, Robert I. Haddad, David I. Conway, Guo-Pei Yu, Tatiana V. Macfarlane, Simone Benhamou, Chu Chen, Brenda Diergaarde, Maura L. Gillison, Paul Brennan, Michael D. McClean, Kristina Kjærheim, Vladimir Bencko, Peter Rudnai, Guojun Li, Eleonora Fabianova, Pagona Lagiou, Thomas L. Vaughan, Witold Zatonski, Silvia Franceschi, Gypsyamber D'Souza, Rayjean J. Hung, Victor Wünsch-Filho, Antonio Agudo, Yuan Chin Amy Lee, Martin Lacko, Erich M. Sturgis, Xavier Castellsagué, Fabio Levi, Luigino Dal Maso, Jolanta Lissowska, Carlo La Vecchia, Franco Merletti, Steve Schwartz, Oxana Shangina, Ariana Znaor, Gregory T. Wolf, Jonathan N. Hofmann, Ivana Holcatova, Wolfgang Ahrens, Rolando Herrero, Alexander W. Daudt, Kirsten B. Moysich, Heribert Ramroth, Karl T. Kelsey, Maria Paula Curado, Zuo-Feng Zhang, Ana M. B. Menezes, Philip Lazarus, Laura S. Rozek, Tongzhang Zheng, Paolo Boffetta, Jose P. Zevallos, Peter Thomson, Claire M. Healy, Stefania Boccia, Wilbert H.M. Peters, Stimson P. Schantz, Marta Vilensky, Joshua E. Muscat, Hermann Brenner, Sergio Koifman, Geoffrey Liu, Manoj B. Mahimkar, Leticia Fernandez, Winn, D.M., Lee, Y.-C., Hashibe, M., Boffetta, P., Agudo, A., Ahrens, W., Bencko, V., Benhamou, S., Boccia, S., Bosetti, C., Brennan, P., Brenner, H., Cadoni, G., Castellsague, X., Chen, C., Conway, D., Curado, M.P., D'Souza, G., Maso, L.D., Daudt, A.W., Ruyck, K.D., Diergaarde, B., Eluf-Neto, J., Fabianova, E., Fernandez, L., Franceschi, S., Gillison, M., Haddad, R.I., Hayes, R., Healy, C., Herrero, R., Hofmann, J., Holcátová, I., Hung, R., Kelsey, K., Kjaerheim, K., Koifman, S., Vecchia, C.L., Lacko, M., Lagiou, P., Lazarus, P., Levi, F., Li, G., Lissowska, J., Liu, G., Luce, D., Macfarlane, T., Mahimkar, M., Mates, D., Matsuo, K., McClean, M., Menezes, A., Menvielle, G., Merletti, F., Moysich, K., Muscat, J., Olshan, A., Pawlita, M., Peters, W.H.M., Ramroth, H., Rozek, L., Rudnai, P., Schantz, S., Schwartz, S., Serraino, D., Shangina, O., Simonato, L., Smith, E., Stucker, I., Sturgis, E.M., Szeszenia-Dabrowska, Neonila and Thomson, P., Vaughan, T., Vilensky, M., Wolf, G., Wünsch-Filho, V., Yu, G., Zaridze, D., Zatonski, W., Zevallos, J.P., Zhang, Z.-F., Zheng, T.-Z., and Znaor, A.

Subjects
Larynx, Data Pooling, Oncology, medicine.medical_specialty, Research groups, Alcohol Drinking, Scientific productivity, Risk Factors, Internal medicine, Epidemiology, Humans, Medicine, Cooperative Behavior, Family history, Settore MED/42 - IGIENE GENERALE E APPLICATA, General Dentistry, business.industry, Smoking, Head and neck cancer, Confounding, medicine.disease, Diet, Surgery, medicine.anatomical_structure, Socioeconomic Factors, Otorhinolaryngology, Head and Neck Neoplasms, epidemiology, head and neck cancer, Settore MED/31 - OTORINOLARINGOIATRIA, business
Abstract

The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects. © 2015 John Wiley & Sons A/S.

Published
2015

12. International Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways

Author

Vladimir Bencko, Kazuo Tajima, Keitaro Matsuo, Giuseppe Matullo, John K. Field, Lenka Foretova, Rayjean Hung, Leah E. Mechanic, Gary E. Goodman, John K. Wiencke, David C. Christiani, Yun Chul Hong, Neonila Szeszenia-Dabrowska, David Zaridze, Chu Chen, Benhnaz Pezeshki, John R. McLaughlin, Paul Brennan, Aage Haugen, Qing Lan, Ann G. Schwartz, Eric J. Duell, Simone Benhamou, Ping Yang, Paolo Vineis, Adeline Seow, Eleonora Fabianova, Daniel P.K. Ng, Shan Zienolddiny, Loic LeMarchand, Zuo-Feng Zhang, Philip Lazarus, Angeline S. Andrew, Paolo Boffetta, Dana Mates, Peter Rudnai, Michael J. Thun, Curtis C. Harris, Odilia Popanda, Vladimir Janout, Neil E. Caporaso, Maria Teresa Landi, Isabelle Stücker, Christine Bouchardy, Joshua E. Muscat, Margaret R. Spitz, Jolanta Lissowska, Stéphanie Monnier, Richard S. Houlston, Chikako Kiyohara, Hongbing Shen, Angela Risch, H.-Erich Wichmann, Hung, R.J., Christiani, D.C., Risch, A., Popanda, O., Haugen, A., Zienolddiny, S., Benhamou, S., Bouchardy, C., Lan, Q., Spitz, M.R., Wichmann, H.-E., LeMarchand, L., Vineis, P., Matullo, G., Kiyohara, C., Zhang, Z.-F., Pezeshki, B., Harris, C., Mechanic, L., Seow, A., Ng, D.P.K., Szeszenia-Dabrowska, N., Zaridze, D., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Caporaso, N., Chen, C., Duell, E.J., Goodman, G., Field, J.K., Houlston, R.S., Hong, Y.-C., Landi, M.T., Lazarus, P., Muscat, J., McLaughlin, J., Schwartz, A.G., Shen, H., Stucker, I., Tajima, K., Matsuo, K., Thun, M., Yang, P., Wiencke, J., Andrew, A.S., Monnier, S., Boffetta, P., Brennan, P., Benhamou, Simone, and Bouchardy Magnin, Christine

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Lung Neoplasms/genetics, Lung Neoplasms, DNA Repair, Epidemiology, Cell Cycle Proteins, Genome-wide association study, Biology, Bioinformatics, Article, XRCC1, DNA Repair/genetics, XRCC3, Cell cycle polymorphisms, Internal medicine, medicine, Humans, Lung cancer, ddc:613, Aged, Cell Cycle Proteins/genetics, Aged, 80 and over, Genetic Variation, Cancer, DNA repair polymorphisms, Lung Cancer, Heterozygote advantage, DNA, Middle Aged, medicine.disease, Lung cancer susceptibility, DNA-Binding Proteins, lung cancer, Pooled analysi, Female, ERCC1, DNA-Binding Proteins/genetics, Genome-Wide Association Study
Abstract

Background: The International Lung Cancer Consortium was established in 2004. To clarify the role of DNA repair genes in lung cancer susceptibility, we conducted a pooled analysis of genetic variants in DNA repair pathways, whose associations have been investigated by at least 3 individual studies. Methods: Data from 14 studies were pooled for 18 sequence variants in 12 DNA repair genes, including APEX1, OGG1, XRCC1, XRCC2, XRCC3, ERCC1, XPD, XPF, XPG, XPA, MGMT, and TP53. The total number of subjects included in the analysis for each variant ranged from 2,073 to 13,955 subjects. Results: Four of the variants were found to be weakly associated with lung cancer risk with borderline significance: these were XRCC3 T241M [heterozygote odds ratio (OR), 0.89; 95% confidence interval (95% CI), 0.79-0.99 and homozygote OR, 0.84; 95% CI, 0.71-1.00] based on 3,467 cases and 5,021 controls from 8 studies, XPD K751Q (heterozygote OR, 0.99; 95% CI, 0.89-1.10 and homozygote OR, 1.19; 95% CI, 1.02-1.39) based on 6,463 cases and 6,603 controls from 9 studies, and TP53 R72P (heterozygote OR, 1.14; 95% CI, 1.00-1.29 and homozygote OR, 1.20; 95% CI, 1.02-1.42) based on 3,610 cases and 5,293 controls from 6 studies. OGG1 S326C homozygote was suggested to be associated with lung cancer risk in Caucasians (homozygote OR, 1.34; 95% CI, 1.01-1.79) based on 2,569 cases and 4,178 controls from 4 studies but not in Asians. The other 14 variants did not exhibit main effects on lung cancer risk. Discussion: In addition to data pooling, future priorities of International Lung Cancer Consortium include coordinated genotyping and multistage validation for ongoing genome-wide association studies. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3081–9)

Published
2008

13. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author

Chu Chen, Renato Talamini, Andrew F. Olshan, Dario Arzani, Tatiana V. Macfarlane, Claire M. Healy, Guo-Pei Yu, Hal Morgenstern, Jolanta Lissowska, Kristina Kjærheim, Leticia Fernandez, Walter Ricciardi, Yuan-Chin Lee, Rolando Herrero, Mark P. Purdue, Lorenzo Richiardi, Silvia Franceschi, Stefania Boccia, Emanuele Leoncini, Peter Thomson, Neonila Szeszenia-Dabrowska, Xavier Castellsagué, Thomas L. Vaughan, Alexander W. Daudt, Mia Hashibe, Isabelle Stücker, Sergio Koifman, David I. Conway, Jaroslav Betka, Pagona Lagiou, Antonio Agudo, Stephen M. Schwartz, Lorenzo Simonato, Shu Chun Chuang, Philip Lazarus, Wolfgang Ahrens, Livia Petrelli, Elena Matos, Zuo-Feng Zhang, Paul Brennan, Michael D. McClean, Stimson P. Schantz, Hermann Brenner, Peter Rudnai, Ana A. Menezes, Carlo La Vecchia, Dana Mates, Ariana Znaor, Joshua E. Muscat, Keitaro Matsuo, Luigino Dal Maso, Oxana Shangina, Richard B. Hayes, Paolo Boffetta, Eleonora Fabianova, Fabio Levi, Karl T. Kelsey, Gaetano Paludetti, Deborah M. Winn, Danièle Luce, Gabriella Cadoni, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Leoncini, E., Ricciardi, W., Cadoni, G., Arzani, D., Petrelli, L., Paludetti, G., Brennan, P., Luce, D., Stucker, I., Matsuo, K., Talamini, R., La Vecchia, C., Olshan, A.F., Winn, D.M., Herrero, R., Franceschi, S., Castellsague, X., Muscat, J., Morgenstern, H., Zhang, Z.-F., Levi, F., Dal Maso, L., Kelsey, K., McClean, M., Vaughan, T.L., Lazarus, P., Purdue, M.P., Hayes, R.B., Chen, C., Schwartz, S.M., Shangina, O., Koifman, S., Ahrens, W., Matos, E., Lagiou, P., Lissowska, J., Szeszenia-Dabrowska, N., Fernandez, L., Menezes, A., Agudo, A., Daudt, A.W., Richiardi, L., Kjaerheim, K., Mates, D., Betka, J., Yu, G.-P., Schantz, S., Simonato, L., Brenner, H., Conway, D.I., Macfarlane, T.V., Thomson, P., Fabianova, E., Znaor, A., Rudnai, P., Healy, C., Boffetta, P., Chuang, S.-C., Lee, Y.-C.A., Hashibe, M., and Boccia, S.

Subjects
Adult, Male, Gerontology, Inverse Association, medicine.medical_specialty, Alcohol Drinking, Epidemiology, Overweight, Head and neck neoplasms, Article, Interviews as Topic, head and neck, Risk Factors, Odds Ratio, Humans, Medicine, Càncer, Settore MED/42 - IGIENE GENERALE E APPLICATA, Aged, Cancer, Height, business.industry, Incidence, Incidence (epidemiology), Smoking, Head and neck cancer, Case-control study, Odds ratio, Middle Aged, Alcohol Drinking/adverse effects, Alcohol Drinking/epidemiology, Body Height, Case-Control Studies, Educational Status, Female, Head and Neck Neoplasms/diagnosis, Head and Neck Neoplasms/epidemiology, Logistic Models, Overweight/epidemiology, Smoking/adverse effects, Smoking/epidemiology, medicine.disease, Confidence interval, 3. Good health, health-care system, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Settore MED/31 - OTORINOLARINGOIATRIA, pooled analysis, medicine.symptom, business, Consortium, Demography
Abstract

Leoncini, Emanuele Ricciardi, Walter Cadoni, Gabriella Arzani, Dario Petrelli, Livia Paludetti, Gaetano Brennan, Paul Luce, Daniele Stucker, Isabelle Matsuo, Keitaro Talamini, Renato La Vecchia, Carlo Olshan, Andrew F Winn, Deborah M Herrero, Rolando Franceschi, Silvia Castellsague, Xavier Muscat, Joshua Morgenstern, Hal Zhang, Zuo-Feng Levi, Fabio Dal Maso, Luigino Kelsey, Karl McClean, Michael Vaughan, Thomas L Lazarus, Philip Purdue, Mark P Hayes, Richard B Chen, Chu Schwartz, Stephen M Shangina, Oxana Koifman, Sergio Ahrens, Wolfgang Matos, Elena Lagiou, Pagona Lissowska, Jolanta Szeszenia-Dabrowska, Neonila Fernandez, Leticia Menezes, Ana Agudo, Antonio Daudt, Alexander W Richiardi, Lorenzo Kjaerheim, Kristina Mates, Dana Betka, Jaroslav Yu, Guo-Pei Schantz, Stimson Simonato, Lorenzo Brenner, Hermann Conway, David I Macfarlane, Tatiana V Thomson, Peter Fabianova, Eleonora Znaor, Ariana Rudnai, Peter Healy, Claire Boffetta, Paolo Chuang, Shu-Chun Lee, Yuan-Chin Amy Hashibe, Mia Boccia, Stefania eng Netherlands 2013/11/26 06:00 Eur J Epidemiol. 2014 Jan;29(1):35-48. doi: 10.1007/s10654-013-9863-2. Epub 2013 Nov 24.; International audience; Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Published
2014

14. Exposure assessment for a nested case-control study of lung cancer among European asphalt workers

Author

Kristina Kjærheim, Gilles Ferro, Hans Kromhout, Christoffer Johansen, Pirjo Heikkilä, Sverre Langård, Johnni Hansen, Frank de Vocht, Christina Funch Lassen, Wolfgang Ahrens, Michela Agostini, Thomas Behrens, Judith Shaham, Marja Liisa Lindbohm, Ann Olsson, Lützen Portengen, Isabelle Stücker, Igor Burstyn, Dick Heederik, Paolo Boffetta, Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Agostini, M., Ferro, G., Olsson, A., Burstyn, I., De Vocht, F., Hansen, J., Funch Lassen, C., Johansen, C., Kjaerheim, K., Langard, S., Stucker, I., Ahrens, W., Behrens, T., Lindbohm, M.-L., Heikkilä, P., Heederik, D., Portengen, L., Shaham, J., Boffetta, P., and Kromhout, H.

Subjects
Male, Lung Neoplasms, Time Factors, exposure assessment, assessment, asphalt industry, Cohort Studies, nested case-control study, Personal hygiene, Surveys and Questionnaires, Prevalence, Imputation (statistics), Polycyclic Aromatic Hydrocarbons, bitumen, Skin, Inhalation exposure, General Medicine, Skin Care, Europe, Occupational Diseases, dermal exposure, inhalation exposure, Cohort, epidemiology, Algorithms, Cohort study, medicine.medical_specialty, Coronacrisis-Taverne, Air Pollutants, Occupational, European, Exposure, Occupational medicine, Environmental health, Occupational Exposure, medicine, Humans, Occupations, Exposure assessment, Aged, business.industry, Protective Devices, Construction Industry, Public Health, Environmental and Occupational Health, case–control study, Hydrocarbons, Surgery, asphalt, lung cancer, Case-Control Studies, workers, Nested case-control study, Carcinogens, business
Abstract

Objective: Development of a method for retrospective assessment of exposure to bitumen fume, bitumen condensate, organic vapour, polycyclic aromatic hydrocarbons, and co-exposures to known or suspected lung carcinogens for a nested case-control study of lung cancer mortality among European asphalt workers.Methods: Company questionnaires and structured questionnaires used in interviews and industry-specific job-exposure matrices (JEMs) were elaborated and applied. Three sources of information were eventually used for exposure assessment and assignment: (i) data obtained in cohort phase, (ii) data from living subjects, next-of-kin, and fellow-workers questionnaires, and (iii) JEMs for bitumen exposure by inhalation and via skin and co-exposures to known or suspected lung carcinogens within and outside cohort companies. Inhalation and dermal exposure estimates for bitumen were adjusted for time trends, time spent in a job, and other determinants of exposure (e.g. oil gravel paving). Clothing patterns, personal protective devices, and personal hygiene were taken into consideration while estimating dermal exposure.Results: Occupational exposures could be assessed for 433 cases and 1253 controls for relevant time periods. Only 43% of work histories were spent inside original asphalt and construction companies. A total of 95.8% of job periods in cohort companies could be coded at a more detailed level. Imputation of work time and 'hygienic behaviour' multipliers was needed for 0.7) among bitumen-related agents, while correlations between coal tar, bitumen-related agents, and established lung carcinogens were weaker (r < 0.4).Conclusions: A systematic and detailed approach was developed to estimate inhalation and dermal exposure for a nested case-control study among asphalt workers. © The Author 2010.

Published
2010

15. Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium

Author

Keitaro Matsuo, Yun Chul Hong, Lambertus A. Kiemeney, Lenka Foretova, Bernard J. Park, Stefano Bonassi, Rayjean J. Hung, Monica Neri, Chikako Kiyohara, Carol J. Etzel, Dana Mates, Curtis C. Harris, Erich Wichmann, John K. Field, Gad Rennert, Loic Le Marchand, Philip Lazarus, Isabelle Stücker, Eric J. Duell, Paolo Boffetta, Jose I. Mayordomo, David C. Christiani, Ping Yang, Anne Tjønnelan, Mei Liu, David Zaridze, Zuo-Feng Zhang, Hal Morgenstern, Ann G. Schwartz, Jolanta Lissowska, John K. Wiencke, John R. McLaughlin, Katja K.H. Aben, Olaide Y. Raji, Ivana Holcatova, Vladimir Bencko, Neonila Szeszenia-Dabrowska, Michele L. Cote, Irene Orlow, Vladimir Janout, Donatella Ugolini, Angeline S. Andrew, Paul Brennan, Qing Lan, Adeline Seow, Eleonora Fabianova, Margaret R. Spitz, Hermann Brenner, Penella J. Woll, Henricus F. M. van der Heijden, Heiko Mueller, Dolores Isla, Mila Pinchev, Heike Bickeböller, Joshua E. Muscat, M. Dawn Teare, Hedy S. Rennert, Peter Rudnai, Søren Friis, Coté, M.L., Liu, M., Bonassi, S., Neri, M., Schwartz, A.G., Christiani, D.C., Spitz, M.R., Muscat, J.E., Rennert, G., Aben, K.K., Andrew, A.S., Bencko, V., Bickeböller, H., Boffetta, P., Brennan, P., Brenner, H., Duell, E.J., Fabianova, E., Field, J.K., Foretova, L., Friis, S., Harris, C.C., Holcatova, I., Hong, Y.-C., Isla, D., Janout, V., Kiemeney, L.A., Kiyohara, C., Lan, Q., Lazarus, P., Lissowska, J., Le Marchand, L., Mates, D., Matsuo, K., Mayordomo, J.I., McLaughlin, J.R., Morgenstern, H., Müeller, H., Orlow, I., Park, B.J., Pinchev, M., Raji, O.Y., Rennert, H.S., Rudnai, P., Seow, A., Stucker, I., Szeszenia-Dabrowska, N., Dawn Teare, M., Tjønnelan, A., Ugolini, D., Van Der Heijden, H.F.M., Wichmann, E., Wiencke, J.K., Woll, P.J., Yang, P., Zaridze, D., Zhang, Z.-F., Etzel, C.J., and Hung, R.J.

Subjects
Male, Familial aggregation, Cancer Research, History, Lung Neoplasms, Aetiology, screening and detection [ONCOL 5], Disease, 0302 clinical medicine, Risk Factors, Ethnicity, Odds Ratio, Family history, Aged, 80 and over, 0303 health sciences, Confounding, Smoking, Age Factors, Family aggregation, Middle Aged, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Female, Lung cancer, Case-Control Studie, Social Adjustment, Adult, medicine.medical_specialty, Sibling, Histology, Logistic Model, Article, 03 medical and health sciences, Interviews, Translational research [ONCOL 3], Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Age Of Onset, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], Aged, 030304 developmental biology, Family Health, business.industry, Lung neoplasm, Meta-analysis, Siblings, Case-control study, Odds ratio, medicine.disease, Surgery, Lung Neoplasm, Case-Control Studies, Càncer de pulmó, Age of onset, business, Confidence Interval
Abstract

Item does not contain fulltext BACKGROUND AND METHODS: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. RESULTS: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR)=1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR=1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR=1.44, 95% CI: 1.07, 1.93), after adjustment. CONCLUSIONS: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group. 01 september 2012

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