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Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium
- Source :
- Eur J Epidemiol, Eur J Epidemiol, 2014, 29 (1), pp.35-48. ⟨10.1007/s10654-013-9863-2⟩, Dipòsit Digital de la UB, Universidad de Barcelona, Recercat. Dipósit de la Recerca de Catalunya, instname, European Journal of Epidemiology, vol. 29, no. 1, pp. 35-48
- Publication Year :
- 2014
- Publisher :
- Springer Science+Business Media B.V., 2014.
-
Abstract
- Leoncini, Emanuele Ricciardi, Walter Cadoni, Gabriella Arzani, Dario Petrelli, Livia Paludetti, Gaetano Brennan, Paul Luce, Daniele Stucker, Isabelle Matsuo, Keitaro Talamini, Renato La Vecchia, Carlo Olshan, Andrew F Winn, Deborah M Herrero, Rolando Franceschi, Silvia Castellsague, Xavier Muscat, Joshua Morgenstern, Hal Zhang, Zuo-Feng Levi, Fabio Dal Maso, Luigino Kelsey, Karl McClean, Michael Vaughan, Thomas L Lazarus, Philip Purdue, Mark P Hayes, Richard B Chen, Chu Schwartz, Stephen M Shangina, Oxana Koifman, Sergio Ahrens, Wolfgang Matos, Elena Lagiou, Pagona Lissowska, Jolanta Szeszenia-Dabrowska, Neonila Fernandez, Leticia Menezes, Ana Agudo, Antonio Daudt, Alexander W Richiardi, Lorenzo Kjaerheim, Kristina Mates, Dana Betka, Jaroslav Yu, Guo-Pei Schantz, Stimson Simonato, Lorenzo Brenner, Hermann Conway, David I Macfarlane, Tatiana V Thomson, Peter Fabianova, Eleonora Znaor, Ariana Rudnai, Peter Healy, Claire Boffetta, Paolo Chuang, Shu-Chun Lee, Yuan-Chin Amy Hashibe, Mia Boccia, Stefania eng Netherlands 2013/11/26 06:00 Eur J Epidemiol. 2014 Jan;29(1):35-48. doi: 10.1007/s10654-013-9863-2. Epub 2013 Nov 24.; International audience; Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.
- Subjects :
- Adult
Male
Gerontology
Inverse Association
medicine.medical_specialty
Alcohol Drinking
Epidemiology
Overweight
Head and neck neoplasms
Article
Interviews as Topic
head and neck
Risk Factors
Odds Ratio
Humans
Medicine
Càncer
Settore MED/42 - IGIENE GENERALE E APPLICATA
Aged
Cancer
Height
business.industry
Incidence
Incidence (epidemiology)
Smoking
Head and neck cancer
Case-control study
Odds ratio
Middle Aged
Alcohol Drinking/adverse effects
Alcohol Drinking/epidemiology
Body Height
Case-Control Studies
Educational Status
Female
Head and Neck Neoplasms/diagnosis
Head and Neck Neoplasms/epidemiology
Logistic Models
Overweight/epidemiology
Smoking/adverse effects
Smoking/epidemiology
medicine.disease
Confidence interval
3. Good health
health-care system
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Settore MED/31 - OTORINOLARINGOIATRIA
pooled analysis
medicine.symptom
business
Consortium
Demography
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Eur J Epidemiol, Eur J Epidemiol, 2014, 29 (1), pp.35-48. ⟨10.1007/s10654-013-9863-2⟩, Dipòsit Digital de la UB, Universidad de Barcelona, Recercat. Dipósit de la Recerca de Catalunya, instname, European Journal of Epidemiology, vol. 29, no. 1, pp. 35-48
- Accession number :
- edsair.doi.dedup.....f2c7456f893d2ff8cf75d31af581219b