1. Infection with Leishmania major stimulates haematopoiesis in susceptible BALB/c mice and suppresses haematopoiesis in resistant CBA mice.
- Author
-
Guilpin VO, Nosbisch L, Titus RG, and Swardson-Olver CJ
- Subjects
- Animals, Bone Marrow Cells cytology, Bone Marrow Cells physiology, Female, Interleukin-4 physiology, Leishmaniasis parasitology, Mice, Mice, Inbred BALB C, Mice, Inbred CBA, Tumor Necrosis Factor-alpha physiology, Disease Susceptibility, Hematopoiesis, Leishmania major physiology, Leishmaniasis physiopathology
- Abstract
Cytokine responses to Leishmania infection begin very early in infection, and differ between susceptible and resistant mice. Susceptibility to chronic Leishmania infection has been associated with increased haematopoiesis. To analyse the effect that acute infection with L. major has on bone-marrow haematopoiesis in susceptible (BALB/c) and resistant (CBA) mice, we enumerated erythroid progenitors and granulocyte-monocyte progenitors 3 days after infection. We found that haematopoiesis was stimulated in BALB/c mice infected with L. major, while haematopoiesis was inhibited in CBA mice. We found that this effect could be partially explained by cytokine production: interleukin-4 was involved in stimulation of BALB/c haematopoiesis and tumour necrosis factor-alpha was involved in inhibition of CBA haematopoiesis. Our conclusions are that haematopoietic changes occur shortly after L. major infection, and may be related to disease outcome.
- Published
- 2003
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