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Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1995 May; Vol. 171 (5), pp. 1302-8. - Publication Year :
- 1995
-
Abstract
- Class II major histocompatibility complex (MHC)-deficient (H-2b) mice do not express I-A or I-E molecules and, as a result, do not develop CD4 cells. Thus, they represent the ideal model for examining the importance of CD4 cells and MHC class II molecules in resistance to infection with Leishmania major and the capacity of MHC class I-restricted T cells to mediate resistance to L. major. Class II MHC-deficient mice and control (C57BL/6, normal and nude) mice were infected with L. major. Although MHC class II-deficient mice were able to control infection more effectively than nude mice, cutaneous lesions on the mice eventually progressed, and parasite replication became uncontrolled. These results suggest that CD4 cells and MHC class II molecules are essential for resistance to L. major and that in the absence of these cells and molecules, such mice can transiently control infection with L. major but are unable to resolve such infections.
- Subjects :
- Animals
Genes, MHC Class II genetics
Immunophenotyping
Interferon-gamma biosynthesis
Leishmaniasis, Cutaneous parasitology
Lymph Nodes cytology
Lymph Nodes metabolism
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mutation physiology
Receptors, Antigen, T-Cell, alpha-beta analysis
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Histocompatibility Antigens Class II immunology
Leishmania major growth & development
Leishmaniasis, Cutaneous immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 171
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 7751707
- Full Text :
- https://doi.org/10.1093/infdis/171.5.1302