Search

Your search keyword '"Ai, Min"' showing total 597 results
Start Over Author "Ai, Min" Topic humans
597 results on '"Ai, Min"'

1. Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China.

Author

Liu, Xing, Baecker, Aileen, Wu, Ming, Zhou, Jin-Yi, Yang, Jie, Han, Ren-Qiang, Wang, Pei-Hua, Liu, Ai-Min, Gu, Xiaoping, Zhang, Xiao-Feng, Wang, Xu-Shan, Su, Ming, Hu, Xu, Sun, Zheng, Li, Gang, Jin, Zi-Yi, Jung, Su Yon, Mu, Lina, He, Na, Lu, Qing-Yi, Li, Liming, Zhao, Jin-Kou, and Zhang, Zuo-Feng

Subjects
Humans, Garlic, Liver Neoplasms, Diet, Odds Ratio, Risk Factors, Case-Control Studies, Adult, Aged, Middle Aged, China, Female, Male, Raw Foods, Chinese population, garlic, hepatitis B virus, interaction, liver cancer, Chronic Liver Disease and Cirrhosis, Alcoholism, Alcohol Use and Health, Digestive Diseases, Substance Abuse, Liver Disease, Emerging Infectious Diseases, Nutrition, Infectious Diseases, Cancer, Clinical Research, Hepatitis, Oral and gastrointestinal, Food Sciences, Nutrition and Dietetics
Abstract

Although the major risk factors for liver cancer have been established, preventive factors for liver cancer have not been fully explored. We evaluated the association between raw garlic consumption and liver cancer in a large population-based case-control study in Eastern China. The study was conducted in Jiangsu, China, from 2003 to 2010. A total of 2011 incident liver cancer cases and 7933 randomly selected population-controls were interviewed. Epidemiological data including raw garlic intake and other exposures were collected, and serum markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were assayed. Overall, eating raw garlic twice or more per week was inversely associated with liver cancer, with an adjusted odds ratio (aOR) of 0.77 (95% confidence interval (CI): 0.62-0.96) compared to those ingesting no raw garlic or less than twice per week. In stratified analyses, high intake of raw garlic was inversely associated with liver cancer among Hepatitis B surface antigen (HBsAg) negative individuals, frequent alcohol drinkers, those having history of eating mold-contaminated food or drinking raw water, and those without family history of liver cancer. Marginal interactions on an additive scale were observed between low raw garlic intake and HBsAg positivity (attributable proportion due to interaction (AP) = 0.31, 95% CI: -0.01-0.62) and heavy alcohol drinking (AP = 0.28, 95% CI: 0.00-0.57). Raw garlic consumption is inversely associated with liver cancer. Such an association shed some light on the potential etiologic role of garlic intake on liver cancer, which in turn might provide a possible dietary intervention to reduce liver cancer in Chinese population.

Published
2019

2. Family history of liver cancer may modify the association between HBV infection and liver cancer in a Chinese population

Author

Liu, Xing, Baecker, Aileen, Wu, Ming, Zhou, Jin‐Yi, Yang, Jie, Han, Ren‐Qiang, Wang, Pei‐Hua, Jin, Zi‐Yi, Liu, Ai‐Min, Gu, Xiaoping, Zhang, Xiao‐Feng, Wang, Xu‐Shan, Su, Ming, Hu, Xu, Sun, Zheng, Li, Gang, Fu, Alan, Jung, Su Yon, Mu, Lina, He, Na, Li, Liming, Zhao, Jin‐Kou, and Zhang, Zuo‐Feng

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Hepatitis, Cancer, HIV/AIDS, Hepatitis - B, Liver Disease, Chronic Liver Disease and Cirrhosis, Infectious Diseases, Digestive Diseases, Clinical Research, Good Health and Well Being, Aged, Aged, 80 and over, Case-Control Studies, China, Female, Hepatitis B, Humans, Liver Neoplasms, Male, Middle Aged, family history, hepatitis B Virus, hepatocellular carcinoma, interaction, serological marker, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsThe potential interaction between family history of liver cancer and HBV infection on liver cancer has not been fully examined.MethodsWe conducted a population-based case-control study composed of 2011 liver cancer cases and 7933 controls in Jiangsu province, China from 2003 to 2010. Data on major risk or protective factors were collected and HBV/HCV sero-markers were assayed using blood samples. Semi-Bayes (SB) adjustments were applied to provide posterior estimates.ResultsBoth family history of liver cancer (adjusted odds ratios [OR]: 4.32, 95% confidence intervals [CI]: 3.25-5.73) and hepatitis B surface antigen (HBsAg) positivity (adjusted OR: 9.94, 95% CI: 8.33-11.87) were strongly associated with liver cancer development. For individuals with different combinations of serological markers, the adjusted ORs were 8.45 (95% CI: 5.16-13.82) for HBsAg- and HBcAb-positive; 7.57 (95% CI: 4.87-11.77) for HBsAg-, HBeAg- and HBcAb-positive; and 3.62 (95% CI: 2.47-5.31) for HBsAg-, HBeAb- and HBcAb-positive, compared to all negatives in HBV serological markers. One log increase in HBV DNA level was associated with 17% increased risk (adjusted OR: 1.17, 95% CI: 1.03-1.32). The SB-adjusted OR of HBV-positive individuals with family history of liver cancer was 41.34 (95% posterior interval [PI]: 23.69-72.12) compared with those HBV-negative without family history. Relative excess risk due to additive interaction, the attributable proportion and synergy index were 73.13, 0.87 and 8.04 respectively. Adjusted ratio of OR for multiplicative interaction was 2.84 (95% CI: 1.41-5.75).ConclusionsSuper-additive and super-multiplicative interactions may exist between family history of liver cancer and HBV infection on the development of liver cancer.

Published
2019

3. Consumption of garlic and its interactions with tobacco smoking and alcohol drinking on esophageal cancer in a Chinese population

Author

Jin, Zi-Yi, Wallar, Gina, Zhou, Jin-Yi, Yang, Jie, Han, Ren-Qiang, Wang, Pei-Hua, Liu, Ai-Min, Gu, Xiao-Ping, Zhang, Xiao-Feng, Wang, Xu-Shan, Su, Ming, Hu, Xu, Sun, Zheng, Li, Gang, Mu, Li-Na, Lu, Qing-Yi, Liu, Xing, Li, Li-Ming, He, Na, Wu, Ming, Zhao, Jin-Kou, and Zhang, Zuo-Feng

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Public Health, Health Sciences, Nutrition, Cancer, Tobacco Smoke and Health, Substance Misuse, Prevention, Clinical Research, Alcoholism, Alcohol Use and Health, Tobacco, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, Stroke, Oral and gastrointestinal, Cardiovascular, Good Health and Well Being, Aged, Alcohol Drinking, Case-Control Studies, China, Diet Surveys, Esophageal Neoplasms, Feeding Behavior, Female, Garlic, Humans, Male, Middle Aged, Risk Factors, Tobacco Smoking, alcohol drinking, esophageal cancer, garlic, interaction, smoking, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health
Abstract

Garlic consumption has been associated inversely with esophageal cancer (EC); however, its interactions with tobacco smoking and alcohol consumption have never been evaluated in an epidemiological study. We evaluated the potential interactions between garlic intake and tobacco smoking as well as alcohol consumption in a population-based case-control study with 2969 incident EC cases and 8019 healthy controls. Epidemiologic data were collected by face-to-face interviews using a questionnaire. The adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated and additive and multiplicative interactions were evaluated using unconditional logistic regression models, adjusting for potential confounding factors. Semi-Bayes (SB) adjustments were used to reduce potential false-positive findings. EC was associated inversely with raw garlic intake [SB-adjusted OR for more than once a week=0.68, 95% CI: 0.57-0.80], with a strong dose-response pattern in the overall analysis and in the stratified analyses by smoking and drinking. EC was associated positively with smoking and alcohol drinking, with SB-adjusted OR of 1.73 (95% CI: 1.62-1.85) and 1.37 (95% CI: 1.28-1.46) in dose-response effects of increased intensity and longer duration of smoking/drinking. Moreover, garlic intake interacts with smoking [synergy index (S)=0.83, 95% CI: 0.67-1.02; ratio of OR=0.88, 95% CI: 0.80-0.98] and alcohol drinking (S=0.73, 95% CI: 0.57-0.93; ratio of OR=0.86, 95% CI: 0.77-0.95) both multiplicatively and additively. Our findings suggested that high intake of raw garlic may reduce EC risk and may interact with tobacco smoking and alcohol consumption, which might shed a light on the development of EC as well as a potential dietary intervention among high-risk smokers and drinkers for EC prevention in the Chinese population.

Published
2019

4. Interaction between tobacco smoking and hepatitis B virus infection on the risk of liver cancer in a Chinese population

Author

Liu, Xing, Baecker, Aileen, Wu, Ming, Zhou, Jin‐Yi, Yang, Jie, Han, Ren‐Qiang, Wang, Pei‐Hua, Jin, Zi‐Yi, Liu, Ai‐Min, Gu, Xiaoping, Zhang, Xiao‐Feng, Wang, Xu‐Shan, Su, Ming, Hu, Xu, Sun, Zheng, Li, Gang, Mu, Lina, He, Na, Li, Liming, Zhao, Jin‐Kou, and Zhang, Zuo‐Feng

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Chronic Liver Disease and Cirrhosis, Hepatitis, Hepatitis - B, Digestive Diseases, Tobacco Smoke and Health, Infectious Diseases, Clinical Research, HIV/AIDS, Cancer, Emerging Infectious Diseases, Tobacco, Liver Disease, Infection, Good Health and Well Being, Asian People, Bayes Theorem, Case-Control Studies, Female, Hepatitis B, Hepatitis B Surface Antigens, Hepatitis B virus, Humans, Liver Neoplasms, Male, Middle Aged, Odds Ratio, Risk Factors, Smoking, Tobacco Smoking, liver cancer, tobacco smoking, population attributable risk, interaction, Chinese population, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Although tobacco smoking has been reported as a risk factor for liver cancer, few studies have specifically explored the association among Chinese females and the potential interaction between smoking and other risk factors. A population-based case-control study was conducted and 2,011 liver cancer cases and 7,933 healthy controls were enrolled in Jiangsu, China from 2003 to 2010. Epidemiological data were collected, and serum hepatitis B surface antigen (HBsAg) and anti-HCV antibody were measured. Unconditional logistic regression was used to examine association and potential interaction, while semi-Bayes (SB) method was employed to make estimates more conservative. The prevalence of serum HBsAg positivity was 43.2% among cases and 6.5% among controls. The adjusted odds ratios (OR) for ever smoking were 1.62 (95% confidence interval [CI]: 1.33-1.96) among male and 0.82 (95% CI: 0.53-1.26) among female. Age at first cigarette, duration of smoking and pack-years of smoking were all significantly associated with liver cancer among men. Compared to HBsAg-negative never smokers, the adjusted ORs were 1.25 (95% CI: 1.03-1.52) for HBsAg-negative ever smokers, 7.66 (95% CI: 6.05-9.71) for HBsAg-positive never smokers, and 15.68 (95% CI: 12.06-20.39) for HBsAg-positive ever smokers. These different odds ratios indicated super-additive (RERI: 7.77, 95% CI: 3.81-11.73) and super-multiplicative interactions (ROR: 1.64, 95% CI: 1.17-2.30) between hepatitis B virus (HBV) infection and tobacco smoking. Most associations and interactions detected remained statistically significant after SB adjustments. Tobacco smoking and HBV infection positively interact in the development of liver cancer.

Published
2018

5. A pharmacokinetics and safety phase 1/1b study of oral ixazomib in patients with multiple myeloma and severe renal impairment or end-stage renal disease requiring haemodialysis.

Author

Gupta, Neeraj, Hanley, Michael, Harvey, R, Badros, Ashraf, Lipe, Brea, Kukreti, Vishal, Berdeja, Jesus, Yang, Huyuan, Hui, Ai-Min, Qian, Mark, Zhang, Xiaoquan, Venkatakrishnan, Karthik, and Chari, Ajai

Subjects
dialysis, ixazomib, multiple myeloma, pharmacokinetics, renal impairment, Administration, Oral, Adult, Aged, Aged, 80 and over, Anemia, Blood Proteins, Boron Compounds, Drug Dosage Calculations, Female, Glycine, Humans, Kidney Failure, Chronic, Male, Middle Aged, Multiple Myeloma, Protease Inhibitors, Renal Dialysis, Renal Insufficiency
Abstract

Renal impairment (RI) is a major complication of multiple myeloma (MM). This study aimed to characterize the single-dose pharmacokinetics (PK) of the oral proteasome inhibitor, ixazomib, in cancer patients with normal renal function [creatinine clearance (CrCl) ≥90 ml/min; n = 20), severe RI (CrCl

Published
2016

6. A first-in-human, phase 1a dose-escalation study of the selective MEK1/2 inhibitor FCN-159 in patients with advanced NRAS-mutant melanoma

Author

Lili Mao, Jun Guo, Lingjun Zhu, Yu Jiang, Wangjun Yan, Jian Zhang, Ai-Min Hui, Yuchen Yang, Lei Diao, Yan Tan, Han Zhao, Yiqian Jiang, Zhuli Wu, and Lu Si

Subjects
Cancer Research, Dose-Response Relationship, Drug, Maximum Tolerated Dose, Oncology, Neoplasms, Humans, Membrane Proteins, Antineoplastic Agents, Melanoma, Protein Kinase Inhibitors, Progression-Free Survival, GTP Phosphohydrolases
Abstract

A phase 1a first-in-human study evaluated the safety/tolerability, preliminary antitumour activity and pharmacokinetics of the oral MEK1/2 inhibitor FCN-159 in Chinese patients with advanced, NRAS-mutant melanoma.Patients received a single FCN-159 dose at assigned levels, proceeding to continuous dosing (once daily [QD] for 28-day cycles) if no dose-limiting toxicities (DLTs) occurred within the next 3 days. Dose escalation was initiated after review of data for the previous dose level. The primary end-point was incidence of DLTs after the first dose.Thirty-three patients were enrolled across nine FCN-159 dose groups (0.2-15 mg QD). One DLT occurred: grade 3 folliculitis in the 15-mg group. There was one gradegt;3 treatment-emergent adverse event (TEAE), death of unknown aetiology (not FCN-159 related). The most common FCN-159-related TEAE was rash (36.4%), and the incidence of grade ≥3 FCN-159-related TEAEs was 15.2%. Antitumour activity at QD doseslt;6 mg was limited; therefore, efficacy data are presented only for doses ≥6 mg (n = 21). The objective response and clinical benefit rates were 19.0% (four partial responses) and 52.4%, respectively. Median (95% confidence interval) duration of response and progression-free survival were 4.8 months (2.8-not reached) and 3.8 months (1.8-5.6), respectively. FCN-159 exposure increased dose-proportionately; geometric mean terminal half-life was 29.9-56.9 h.FCN-159 was well tolerated and demonstrated promising antitumour activity at doses ≥6 mg QD in patients with advanced, NRAS-mutant melanoma. The recommended phase 2 dose was 12 mg QD.NCT03932253. https://clinicaltrials.gov/ct2/show/NCT03932253.

Published
2022

7. A phase I study of FCN-411, a pan-HER inhibitor, in EGFR-mutated advanced NSCLC after progression on EGFR tyrosine kinase inhibitors

Author

Lin, Lin, Hongming, Pan, Xingya, Li, Chengling, Zhao, Jiangtao, Sun, Xingsheng, Hu, Yiping, Zhang, Mengzhao, Wang, Xiubao, Ren, Xiaoyong, Luo, Guoyong, Shan, Ai-Min, Hui, Zhuli, Wu, Huilong, Liu, Ling, Tian, and Yuankai, Shi

Subjects
Adult, ErbB Receptors, Pulmonary and Respiratory Medicine, Cancer Research, Lung Neoplasms, Oncology, Carcinoma, Non-Small-Cell Lung, Mutation, Humans, Protein Kinase Inhibitors
Abstract

There are no approved epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for EGFR-mutated non-small cell lung cancer (NSCLC) without EGFR T790M mutation after progression on first- or second-generation EGFR-TKIs.We conducted this phase I, open-label, multicenter, dose-escalation/dose-expansion study to evaluate the safety, tolerability, antitumor activity, and pharmacokinetics of FCN-411, a TKI targeting EGFR, HER2, and HER4, in patients with EGFR-mutated advanced NSCLC whose disease had progressed during treatment of EGFR-TKIs. Adult patients with stage IIIB-IV NSCLC harboring EGFR mutations (exon 18/19/20/21) who had progressed on prior EGFR-TKIs were enrolled. In the dose-escalation phase, patients received 4 mg, 8 mg, 12 mg, and 16 mg FCN-411 once daily until the maximum tolerated dose (MTD). In the dose-expansion phase, patients received FCN-411 at the recommended phase II dose (RP2D) continuously in 21-day cycles. The primary endpoints were safety, tolerability, MTD, and RP2D.From July 23, 2018 to September 29, 2020, 77 patients were enrolled, including 30 with EGFR T790M mutation in tumor tissues. The cut-off date was February 1, 2021. No dose-limiting toxicities were observed. The most common grade ≥ 3 treatment-emergent adverse events among all patients were diarrhea (8; 10.4%) and dermatitis acneiform (7; 9.1%). Ten of 67 evaluable patients achieved confirmed partial response, with an objective response rate (ORR) of 14.9% (95% confidence interval [CI], 8.3-24.0); the ORR was 33.3%, 14.0%, 0, and 25.0% at 4 mg, 8 mg, 12 mg, and 16 mg, respectively. Besides, the ORR in patients without and with EGFR T790M mutation was 20.5% and 7.4%, respectively. Moreover, 39 patients achieved stable disease across all doses, and the disease control rate was 73.1% (95% CI, 60.9-83.2). Median progression-free survival was 4.1 (95% CI, 2.9-5.3) months. Median duration of response and overall survival have not been reached.FCN-411 was well tolerated and demonstrated preliminary antitumor activity in patients with EGFR-mutated NSCLC after progression on EGFR-TKIs, especially in those without EGFR T790M mutation. The RP2D was defined as 8 mg once daily. Future studies are warranted.ClinicalTrials.gov, NCT03420079.

Published
2022

8. Neurophysiological mechanisms of cancer-induced bone pain

Author

Jin-Feng Huang, Ai-Min Wu, Xuan-Qi Zheng, and Yu-hao Wu

Subjects
medicine.medical_specialty, Medicine (General), Central sensitization, Science (General), Bone Neoplasms, Acidic environment, Cancer-induced bone pain, Bone and Bones, P2X Family, Q1-390, Quality of life (healthcare), R5-920, Neuroinflammation, medicine, Humans, Intensive care medicine, Bone pain, ComputingMethodologies_COMPUTERGRAPHICS, Multidisciplinary, business.industry, Mechanism (biology), Cancer, Cancer Pain, Neurophysiology, medicine.disease, TRPV, Neuroinflammatory Diseases, Neuropathic pain, Quality of Life, Medicine, medicine.symptom, business, Cell activation
Abstract

Graphical abstract, Highlights • The development of scientific research in CIBP was elaborated in a complete and clear perspective. • The possible mechanisms, including the new achievements in central sensitization, glial cell activation, acid environment, of CIBP were reviewed. • Several key molecules and treatments as well as the potential targets and promising therapies were also briefly reviewed. • The challenges we faced and the future directions are also summarized and elaborated., Background Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditions and the complexity of neuropathic pain, related mechanisms have been continuously supplemented but have not been perfected. Aim of Review Therefore, the current review highlights the latest progress in basic research on the field and proposes potential therapeutic targets, representative drugs and upcoming therapies. Key Scientific Concepts of Review Notably, factors such as central sensitization, neuroinflammation, glial cell activation and an acidic environment are considered to be related to neuropathic pain in CIBP. Nonetheless, further research is needed to ascertain the mechanism of CIBP in order to develop highly effective drugs. Moreover, more attention needs to be paid to the care of patients with advanced cancer.

Published
2022

9. Right and left ventricular function and flow quantification in pediatric patients with repaired tetralogy of Fallot using four-dimensional flow magnetic resonance imaging

Author

Yao Xiaofen, Yumin Zhong, Rongzhen Ouyang, Ai-Min Sun, Yafeng Peng, Wei-Hui Xie, Liwei Hu, Qian Wang, and Fei Feng

Subjects
Male, Cardiac magnetic resonance, Intraclass correlation, Heart Ventricles, Cardiac-Gated Imaging Techniques, 4D flow, Magnetic Resonance Imaging, Cine, Ventricular Function, Left, medicine.artery, Ascending aorta, Image Interpretation, Computer-Assisted, Repaired tetralogy of Fallot, medicine, Medical technology, Humans, Radiology, Nuclear Medicine and imaging, R855-855.5, Child, Tetralogy of Fallot, Retrospective Studies, Reproducibility, medicine.diagnostic_test, Ventricular function, business.industry, Research, Reproducibility of Results, Magnetic resonance imaging, medicine.disease, Flow (mathematics), Flow quantification, Ventricular Function, Right, cardiovascular system, Female, Nuclear medicine, business, Blood Flow Velocity
Abstract

Background To assess the accuracy and reproducibility of right ventricular (RV) and left ventricular (LV) function and flow measurements in children with repaired tetralogy of Fallot (rTOF) using four-dimensional (4D) flow, compared with conventional two-dimensional (2D) magnetic resonance imaging (MRI) sequences. Methods Thirty pediatric patients with rTOF were retrospectively enrolled to undergo 2D balanced steady-state free precession cine (2D b-SSFP cine), 2D phase contrast (PC), and 4D flow cardiac MRI. LV and RV volumes and flow in the ascending aorta (AAO) and main pulmonary artery (MPA) were quantified. Pearson’s or Spearman’s correlation tests, paired t-tests, the Wilcoxon signed-rank test, Bland–Altman analysis, and intraclass correlation coefficients (ICC) were performed. Results The 4D flow scan time was shorter compared with 2D sequences (P 0.05), and showed strong correlations (r > 0.90, P 0.60, P 0.85). Conclusions RV and LV function and flow quantification in pediatric patients with rTOF using 4D flow MRI can be measured accurately and reproducibly compared to those with conventional 2D sequences.

Published
2021

10. Global, regional, and national burden of bone fractures in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019

Author

Gdiom Gebreheat Abady, Hadis Pourchamani, Ali Bijani, Hai Quang Pham, Mehdi Naderi, Jagadish Rao Padubidri, Navid Rabiee, Rosa A. S. Couto, Marina Pinheiro, Luis Camera, Marcos Roberto Tovani-Palone, David Laith Rawaf, Irina Filip, Ratilal Lalloo, Spencer L. James, Suzanne Polinder, Rohollah Kalhor, Tanuj Kanchan, Ali Manafi, Eman Abu-Gharbieh, Bach Xuan Tran, Mohammad Hifz Ur Rahman, Navid Manafi, Saeed Shahabi, Tiffany K. Gill, Vijay Krishnamoorthy, Samer Hamidi, Zhi-Jiang Zhang, Ejaz Ahmad Khan, Cuong Tat Nguyen, Diana Zuleika Velazquez, Simon I. Hay, Ravensara S. Travillian, Michael T. Chung, Narinder Kumar, Daniel Y. Cho, David C. Schwebel, Milena Ilic, Tommi Vasankari, Jeevan Pereira, Ai-Min Wu, Zichen Liu, Rafael Tabarés-Seisdedos, Jalal Arabloo, Stanislav S. Otstavnov, Bhawna Gupta, Giang Thu Vu, G Anil Kumar, Atalel Fentahun Awedew, Ali H. Mokdad, Narayanaswamy Venketasubramanian, Amir Radfar, Rakhi Dandona, Bartosz Miazgowski, Irena Ilic, Mukhammad David Naimzada, Amin Soheili, Malke Asaad, Catherine Bisignano, Masood Ali Shaikh, Lalit Dandona, Lidia Sanchez Riera, Rajan Nikbakhsh, Maciej Banach, Xiaochen Dai, Ritesh G. Menezes, Abdollah Mohammadian-Hafshejani, Vinod C Nayak, Arvin Haj-Mirzaian, Mikk Jürisson, Florian Fischer, Salman Rawaf, Aidin Abedi, Andrew T Olagunju, Nikita Otstavnov, Rovshan Khalilov, Ted R. Miller, Rebecca Ivers, Savita Lasrado, Vahid Alipour, Srinivasa Rao Bolla, Stephen S Lim, Srikanta Banerjee, A. A. Fomenkov, Jung-Chen Chang, Mohammad Reza Saeb, Theo Vos, Taras Kavetskyy, Tuomo J. Meretoja, Yousef Mohammad, Farshad Farzadfar, Tesega Tesega Mengistu Birhanu, Robert Kaba Alhassan, Wondwossen Niguse Asmare, Pascual R. Valdez, Abdallah M. Samy, Christopher J L Murray, Juanita A. Haagsma, Maseer Khan, Cameron J. Kneib, HUS Comprehensive Cancer Center, and University of Helsinki

Subjects
Burden of disease, EXCESS MORTALITY, medicine.medical_specialty, Health (social science), Population, Osteoporosis, UNITED-STATES, OSTEOPOROSIS, Global Burden of Disease, 03 medical and health sciences, Fractures, Bone, 0302 clinical medicine, Age groups, Epidemiology, INJURY, medicine, Prevalence, EPIDEMIOLOGY, Humans, Disabled Persons, education, Aged, 030222 orthopedics, education.field_of_study, Hip fracture, business.industry, Public health, Incidence (epidemiology), Incidence, HIP FRACTURE, Articles, medicine.disease, NONUNION, 3. Good health, LIFE, Psychiatry and Mental health, 3121 General medicine, internal medicine and other clinical medicine, 030220 oncology & carcinogenesis, Geriatrics and Gerontology, Family Practice, business, COSTS, Osteoporotic Fractures, Demography
Abstract

Background Bone fractures are a global public health issue; however, to date, no comprehensive study of their incidence and burden has been done. We aimed to measure the global, regional, and national incidence, prevalence, and years lived with disability (YLDs) of fractures from 1990 to 2019. Methods Using the framework of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we compared numbers and age-standardised rates of global incidence, prevalence, and YLDs of fractures across the 21 GBD regions and 204 countries and territories, by age, sex, and year, from 1990 to 2019. We report estimates with 95% uncertainty intervals (UIs). Findings Globally, in 2019, there were 178 million (95% UI 162-196) new fractures (an increase of 33.4% [30.1-37.0] since 1990), 455 million (428-484) prevalent cases of acute or long-term symptoms of a fracture (an increase of 70.1% [67.5-72.5] since 1990), and 25.8 million (17.8-35.8) YLDs (an increase of 65.3% [62.4-68.0] since 1990). The age-standardised rates of fractures in 2019 were 2296.2 incident cases (2091.1-2529.5) per 100 000 population (a decrease of 9.6% [8.1-11.1] since 1990), 5614.3 prevalent cases (5286.1-5977.5) per 100 000 population (a decrease of 6.7% [5.7-7.6] since 1990), and 319.0 YLDs (220.1-442.5) per 100 000 population (a decrease of 8.4% [7.2-9.5] since 1990). Lower leg fractures of the patella, tibia or fibula, or ankle were the most common and burdensome fracture in 2019, with an age-standardised incidence rate of 419.9 cases (345.8-512.0) per 100 000 population and an age-standardised rate of YLDs of 190.4 (125.0-276.9) per 100 000 population. In 2019, age-specific rates of fracture incidence were highest in the oldest age groups, with, for instance, 15 381.5 incident cases (11 245.3-20 651.9) per 100 000 population in those aged 95 years and older. Interpretation The global age-standardised rates of incidence, prevalence, and YLDs for fractures decreased slightly from 1990 to 2019, but the absolute counts increased substantially. Older people have a particularly high risk of fractures, and more widespread injury-prevention efforts and access to screening and treatment of osteoporosis for older individuals should help to reduce the overall burden. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.

Published
2021

11. Targeting the RNA G-Quadruplex and Protein Interactome for Antiviral Therapy

Author

Li-Yan Zhai, Jing-Fan Liu, Jian-Jin Zhao, Ai-Min Su, Xu-Guang Xi, and Xi-Miao Hou

Subjects
G-Quadruplexes, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Drug Discovery, Molecular Medicine, Humans, RNA, Ligands, Antiviral Agents
Abstract

In recent years, G-quadruplexes (G4s), types of noncanonical four-stranded nucleic acid structures, have been identified in many viruses that threaten human health, such as HIV and Epstein-Barr virus. In this context, G4 ligands were designed to target the G4 structures, among which some have shown promising antiviral effects. In this Perspective, we first summarize the diversified roles of RNA G4s in different viruses. Next, we introduce small-molecule ligands developed as G4 modulators and highlight their applications in antiviral studies. In addition to G4s, we comprehensively review the medical intervention of G4-interacting proteins from both the virus (N protein, viral-encoded helicases, severe acute respiratory syndrome-unique domain, and Epstein-Barr nuclear antigen 1) and the host (heterogeneous nuclear ribonucleoproteins, RNA helicases, zinc-finger cellular nucelic acid-binding protein, and nucleolin) by inhibitors as an alternative way to disturb the normal functions of G4s. Finally, we discuss the challenges and opportunities in G4-based antiviral therapy.

Published
2022

12. Distinct proteomic profiles in prefrontal subareas of elderly major depressive disorder and bipolar disorder patients

Author

Yang-Jian Qi, Yun-Rong Lu, Li-Gen Shi, Jeroen A. A. Demmers, Karel Bezstarosti, Erikjan Rijkers, Rawien Balesar, Dick Swaab, Ai-Min Bao, Netherlands Institute for Neuroscience (NIN), and Biochemistry

Subjects
Proteomics, Depressive Disorder, Depressive Disorder, Major, Bipolar Disorder, Major, Profilins/metabolism, Magnetic Resonance Imaging, Gyrus Cinguli, Magnetic Resonance Imaging/methods, Profilins, Cellular and Molecular Neuroscience, Psychiatry and Mental health, SDG 3 - Good Health and Well-being, Humans, Biological Psychiatry, Aged
Abstract

We investigated for the first time the proteomic profiles both in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) of major depressive disorder (MDD) and bipolar disorder (BD) patients. Cryostat sections of DLPFC and ACC of MDD and BD patients with their respective well-matched controls were used for study. Proteins were quantified by tandem mass tag and high-performance liquid chromatography-mass spectrometry system. Gene Ontology terms and functional cluster alteration were analyzed through bioinformatic analysis. Over 3000 proteins were accurately quantified, with more than 100 protein expressions identified as significantly changed in these two brain areas of MDD and BD patients as compared to their respective controls. These include OGDH, SDHA and COX5B in the DLPFC in MDD patients; PFN1, HSP90AA1 and PDCD6IP in the ACC of MDD patients; DBN1, DBNL and MYH9 in the DLPFC in BD patients. Impressively, depending on brain area and distinct diseases, the most notable change we found in the DLPFC of MDD was ‘suppressed energy metabolism’; in the ACC of MDD it was ‘suppressed tissue remodeling and suppressed immune response’; and in the DLPFC of BD it was differentiated ‘suppressed tissue remodeling and suppressed neuronal projection’. In summary, there are distinct proteomic changes in different brain areas of the same mood disorder, and in the same brain area between MDD and BD patients, which strengthens the distinct pathogeneses and thus treatment targets.

Published
2022

13. Sex differences in the neuropathological hallmarks of Alzheimer’s disease: focus on cognitively intact elderly individuals

Author

Hugo McGurran, Jackson Boonstra, Ai-Min Bao, Dick F. Swaab, Rawien Balesar, Arja A. Sluiter, Jochem Stormmesand, Yu-Ting Hu, Ronald W.H. Verwer, and Netherlands Institute for Neuroscience (NIN)

Subjects
Male, 0301 basic medicine, Aging, Histology, Amyloid, Physiology, tau Proteins, Disease, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, β amyloid, Physiology (medical), mental disorders, Entorhinal Cortex, Humans, Medicine, Aged, Aged, 80 and over, Sex Characteristics, Amyloid beta-Peptides, business.industry, Brain, Neurofibrillary Tangles, Entorhinal cortex, 030104 developmental biology, Neurology, Female, Brain bank, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

AIMS Women are more vulnerable to Alzheimer's disease (AD) than men. We investigated (i) whether and at what age the AD hallmarks, that is, β-amyloid (Aβ) and hyperphosphorylated Tau (p-Tau) show sex differences; and (ii) whether such sex differences may occur in cognitively intact elderly individuals. METHODS We first analysed the entire post-mortem brain collection of all non-demented 'controls' and AD donors from our Brain Bank (245 men and 403 women), for the presence of sex differences in AD hallmarks. Second, we quantitatively studied possible sex differences in Aβ, Aβ42 and p-Tau in the entorhinal cortex of well-matched female (n = 31) and male (n = 21) clinically cognitively intact elderly individuals. RESULTS Women had significantly higher Braak stages for tangles and amyloid scores than men, after 80 years. In the cognitively intact elderly, women showed higher levels of p-Tau, but not Aβ or Aβ42, in the entorhinal cortex than men, and a significant interaction of sex with age was found only for p-Tau but not Aβ or Aβ42. CONCLUSIONS Enhanced p-Tau in the entorhinal cortex may play a major role in the vulnerability to AD in women.

Published
2021

14. Enhanced anti-melanoma efficacy through a combination of the armed oncolytic adenovirus ZD55-IL-24 and immune checkpoint blockade in B16-bearing immunocompetent mouse model

Author

Xiu Liang, Jing Xiao, Jinfa Gu, Ai-Min Ni, Hai-Jun Hu, Hai-Lang Li, Lanying Sun, Jin-Qing Hu, Xinyuan Liu, and Huai-Yuan Wang

Subjects
Oncolytic adenovirus, Cancer Research, Oncolytic virus, Combination therapy, Tumor immune recognition, medicine.medical_treatment, Immunology, PD-1 blockade, Adenoviridae, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Animals, Humans, Immunology and Allergy, Melanoma, Immune Checkpoint Inhibitors, 030304 developmental biology, Oncolytic Virotherapy, 0303 health sciences, business.industry, Interleukins, Therapeutic effect, Genetic Therapy, Immunotherapy, medicine.disease, Combined Modality Therapy, Immune checkpoint, Blockade, Mice, Inbred C57BL, Disease Models, Animal, Oncolytic Viruses, HEK293 Cells, Oncology, 030220 oncology & carcinogenesis, Cancer research, Original Article, Female, business, Tumor immune infiltration
Abstract

Although the recent treatment in melanoma through the use of anti-PD-1 immunotherapy is successful, the efficacy of this approach remains to be improved. Here, we explore the feasibility of combination strategy with the armed oncolytic adenovirus ZD55-IL-24 and PD-1 blockade. We find that combination therapy with localized ZD55-IL-24 and systemic PD-1 blockade leads to synergistic inhibition of both local and distant established tumors in B16-bearing immunocompetent mouse model. Our further mechanism investigation reveals that synergistic therapeutic effect is associated with marked promotion of tumor immune infiltration and recognition in both local and distant tumors as well as spleens. PD-1 blockade has no obvious effect on promotion of tumor immune infiltration and recognition. Localized therapy with ZD55-IL-24, however, can help PD-1 blockade to overcome the limitation of relatively low tumor immune infiltration and recognition. This study provides a rationale for investigation of such combination therapy in the clinic. Supplementary information The online version contains supplementary material available at 10.1007/s00262-021-02946-z.

Published
2021

15. The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women

Author

Ai Min Yao, Liang Yu Xia, Peng Ju Liu, Yanping Liu, Lihong Liu, Zhuoling An, Ting Hu, and Liangkun Ma

Subjects
Adult, 0301 basic medicine, China, Taurine, Science, Physiology, 030209 endocrinology & metabolism, Early pregnancy factor, Article, 03 medical and health sciences, chemistry.chemical_compound, Endocrinology, 0302 clinical medicine, Asian People, Pregnancy, Risk Factors, Insulin-Secreting Cells, medicine, Humans, Glucose homeostasis, Multidisciplinary, biology, business.industry, Confounding, Health care, medicine.disease, Gestational diabetes, Diabetes, Gestational, Parity, 030104 developmental biology, chemistry, Plasma taurine level, biology.protein, Gestation, Medicine, Female, Pregnant Women, business, Biomarkers
Abstract

Taurine is a sulfur-containing amino acid that plays an important role in glucose homeostasis. However, it remains unknown whether the plasma concentration of taurine affects the risk of later gestational diabetes mellitus (GDM) development. We recruited 398 singleton-pregnancy women and followed up them during the course of pregnancy. We measured the plasma concentrations of taurine based on blood samples collected at nine-week gestation on average and obtained the data regarding both mothers and their infants from medical records. There was a significant increment in the mean value of HOMA-β across the tertiles of plasma taurine in multiparous women rather than in primiparous women. After adjustment for confounders, an increase of plasma taurine was nominally and significantly associated with a decrease risk of GDM; moreover, women with plasma taurine concentrations in the lowest tertile and in the second tertile had a higher risk of GDM than did those with plasma taurine in the top tertile in multiparous women other than primiparous women. Plasma taurine level seems to be associated with insulin secretion in early pregnancy and be more closely associated with β-cell function and the risk of GDM development in multiparas in comparison to primiparas.

Published
2021

16. Progestin-Primed Ovarian Stimulation Protocol for Patients With Endometrioma

Author

Ai-Min Yang, Teng-Fei Feng, Yan Han, Zhi-Ming Zhao, Wei Wang, Yi-Zhuo Wang, Xiao-Qi Zuo, Xiuhua Xu, Bao-Jun Shi, Lipeng Li, Gui-Min Hao, and Na Cui

Subjects
Observational Studies as Topic, Hormone Antagonists, Ovulation Induction, Pregnancy, Endocrinology, Diabetes and Metabolism, Endometriosis, Humans, Female, Fertilization in Vitro, Progestins, Retrospective Studies
Abstract

ObjectiveTo evaluate the pregnancy outcomes of progestin-primed ovarian stimulation (PPOS) protocol for patients with endometrioma underwent in vitro fertilization/intra-cytoplasmic sperm injection embryo transfer (IVF/ICSI-ET).DesignObservational retrospective cohort study.SettingUniversity affiliated reproductive center.Study Participants605 infertile patients with endometrioma underwent IVF/ICSI-ET from January 2016 to March 2021 were included in this study.MethodsMultivariable logistic regression analyses were conducted to determine the independent effect of controlled ovarian stimulation (COS) protocols on reproductive outcomes of first embryo transfer (ET) cycles. The live birth was primary outcome, the implantation rate, biochemical pregnancy, clinical pregnancy and ongoing pregnancy were secondary outcomes.ResultsCompared to PPOS protocol, the probability of implantation showed no significant difference with ultra-long gonadotrophin-releasing hormone agonist (GnRHa) protocol and gonadotrophin-releasing hormone antagonist (GnRHant) protocol (OR 1.7, 95% CI 0.9-3.1, OR 1.2, 95% CI 0.7-2.1, respectively). The PPOS protocol was correlated with a significantly lower biochemical pregnancy and clinical pregnancy than ultra-long GnRHa protocol in the multivariable logistic regression analysis (OR 2.3, 95% CI 1.1-4.9, OR 2.4, 95% CI 1.1-5.3, respectively). However, there was no significant difference in terms of biochemical pregnancy, clinical pregnancy and ongoing pregnancy between PPOS and GnRHant protocol (OR 1.4, 95% CI 0.7-2.7, OR 1.3, 95% CI 0.7-2.4, OR 1.1, 95% CI 0.6-2.3, respectively). In addition, compared to PPOS protocol, ultra-long GnRHa protocol and GnRHant protocol demonstrated no statistical difference in ongoing pregnancy (OR 2.0, 95% CI 0.9-4.5, OR 2.1, 95% CI 0.6-2.3, respectively). Notably, the ultra-long GnRHa protocol was associated with a significant higher probability of live birth than PPOS protocol both in crude analysis and multivariable logistic regression analysis (OR 2.6, 95% CI 1.3-5.1, OR 2.5, 95% CI 1.1-5.7, respectively). Nevertheless, no statistical difference was found in live birth between PPOS and GnRHant protocol either in crude analysis and multivariable logistic regression analysis (OR1.2, 95% CI 0.6-2.3, OR 1.2, 95% CI 0.6-2.5, respectively).ConclusionsBased on the reproductive outcomes of the first ET cycles in patients with endometrioma, PPOS protocol may associated with inferior reproductive outcomes in terms of biochemical pregnancy, clinical pregnancy and live birth than ultra-long GnRHa protocol. However, there was no significant difference in implantation rate, clinical pregnancy, ongoing pregnancy and live birth between PPOS and GnRHant protocol.

Published
2022

17. Optimizing estradiol level for gonadotrophin-releasing hormone antagonist initiation among patients with simple tubal factor infertility

Author

Yizhuo Wang, Xiuhua Xu, Ai-min Yang, Jie Zhang, Zhuo-ye Luo, Yan Han, Na Cui, Qian Li, Baojun Shi, Zhi-ming Zhao, and Gui-min Hao

Subjects
Gonadotropin-Releasing Hormone, Hormone Antagonists, Estradiol, Pregnancy, Endocrinology, Diabetes and Metabolism, Infertility, Humans, Female, Fertilization in Vitro, Retrospective Studies
Abstract

ObjectiveThe aim of this study is to investigate the optimal estradiol (E2) level on the day of gonadotropin-releasing hormone antagonist (GnRH-ant) initiation to maximize the clinical pregnancy rate (CPR) after fresh embryo transfer among patients with simple tubal factor infertility.MethodsA retrospective cohort study was conducted in the Reproductive Medicine Center, the Second Hospital of Hebei Medical University. A total of 1,493 IVF-ET cycles of patients diagnosed with single tubal factor infertility from August 2016 to August 2021 were included and equally allocated into five distinct groups according to the quintile serum E2 levels on the day of GnRH-ant initiation. The five groups had similar baseline data except for antral follicle count.Result(s)The serum E 2 level on GnRH-ant initiation day was determined as an independent predictor of clinical pregnancy after adjusting for confounding factors such as age, infertility duration, body mass index, cycle number, antral follicle count, and the number of transferred embryos. Through smooth curve fitting, we found that, with the increase of serum E2 levels on the day of GnRH-ant initiation, CPR showed a trend of slight increase and then slight decrease. The maximal CPR was achieved when the serum E2 level on GnRH-ant initiation day was 498 pg/ml. When E2 was less than 498 pg/ml, the odds ratio (OR) of clinical pregnancy was 1.05 (95% CI: 1.00, 1.11, P = 0.0583). When E2 was greater than 498 pg/ml, the OR of clinical pregnancy was 0.97 (95% CI: 0.95, 0.98, P = 0.0003). Furthermore, CPR remained high when E2 was 436.8–658.6 pg/ml but declined significantly by more than 40% when E2 was ≥ 894.4 pg/ml (P < 0.05).Conclusion(s)The serum E2 level should be considered as an adjuvant parameter for GnRH-ant initiation. The best E2 value was 498 pg/ml, and GnRH-ant administration could be recommended to initiate when serum E2 was 436.8–658.6 pg/ml. If GnRH-ant was initiated when serum E2 was above 894.4 pg/ml, then the CPR after fresh embryo transfer may decline dramatically, and thus, cancellation of fresh embryo transfer and earlier initiation of GnRH-ant in future cycles should be considered.

Published
2022

18. Immune Persistence and Safety After SARS-CoV-2 BNT162b1 mRNA Vaccination in Chinese Adults: A Randomized, Placebo-Controlled, Double-Blind Phase 1 Trial

Author

Jingxin Li, Ai-Min Hui, Xiang Zhang, Lei Ge, Yuanzheng Qiu, Rong Tang, Huayue Ye, Xiyuan Wang, Mei Lin, Zhongkui Zhu, Jianfei Zheng, Jingjun Qiu, Eleni Lagkadinou, Svetlana Shpyro, Orkun Ozhelvaci, Özlem Türeci, Zakaria Khondker, Wanrong Yin, Yoana Shishkova, Siyue Jia, Hongxing Pan, Fuzhong Peng, Zhilong Ma, Zhenggang Wu, Xiling Guo, Yunfeng Shi, Alexander Muik, Uğur Şahin, Li Zhu, and Fengcai Zhu

Subjects
Adult, China, Vaccines, COVID-19 Vaccines, SARS-CoV-2, Vaccination, COVID-19, General Medicine, Antibodies, Neutralizing, Double-Blind Method, Liposomes, Humans, Nanoparticles, Pharmacology (medical), RNA, Messenger, BNT162 Vaccine, Aged
Abstract

BNT162b1 is a lipid nanoparticle-formulated, nucleoside-modified mRNA SARS-CoV-2 vaccine. Here, we report safety and immune persistence data following a primary two-dose vaccination schedule administered 21 days apart.Immune persistence was determined at month 3 in 72 younger participants (aged 18-55 years) and at month 6 in 70 younger and 69 older participants (aged 65-85 years).In younger participants, neutralizing antibody (nAb) geometric mean titers (GMTs) for the 10 and 30 µg dose levels declined from 233 and 254 (21 days after dose 2) to 55 and 87 at month 3, respectively, and to 16 and 27 at month 6, respectively. In older participants, nAb GMTs declined from 80 and 160 (21 days after dose 2) to 10 and 21 at month 6. Overall, higher antibody titers were observed in younger participants, and the 30 µg dose induced higher levels of nAb, which declined more slowly by month 6. No serious adverse events were reported in the vaccine group.This study showed BNT162b1 maintains a favorable safety profile in younger and older participants in the 6 months after vaccination. This study further extends our understanding of immune persistence and the safety of the BNT162b1 vaccine as a candidate vaccine in the BioNTech pipeline.NCT04523571, registered August 21, 2020.

Published
2022

19. Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis

Author

Haibo Liang, Yaosen Wu, Xin Wang, Yifeng Shi, Ai-Min Wu, Ben Wang, Guoling Zeng, Boda Chen, Chenglong Xie, Chongan Huang, Xiaolei Zhang, Weiyang Gao, Yifei Zhou, Zhenxuan Shao, Naifeng Tian, and H. Zhang

Subjects
0301 basic medicine, Senescence, Small interfering RNA, Nucleus Pulposus, Cell Survival, NF-E2-Related Factor 2, Blotting, Western, Biomedical Engineering, Intervertebral Disc Degeneration, Punctures, In Vitro Techniques, Antioxidants, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Rheumatology, Western blot, Senotherapeutics, In vivo, medicine, Animals, Humans, Orthopedics and Sports Medicine, Intervertebral Disc, Senolytic, Cellular Senescence, 030203 arthritis & rheumatology, medicine.diagnostic_test, Chemistry, NF-kappa B, NF-κB, Phenotype, In vitro, Rats, Cell biology, Disease Models, Animal, 030104 developmental biology, Gene Knockdown Techniques, Quercetin, Senescence-Associated Secretory Phenotype
Abstract

Summary Objective Intervertebral disc degeneration (IDD) represents major cause of low back pain. Quercetin (QUE) is one of the approved senolytic agents. In this study, we evaluated the protective effects of QUE on IDD development and its underlying mechanism. Methods Effects of senolytic agent QUE on the viability of nucleus pulposus cells (NPCs) were measured by CCK-8 assays and EdU staining. The senescence associated secreted phenotype (SASP) factors expressions were measured by qPCR, western blot, and ELISA; and NF-κB pathway was detected by immunofluorescence and western blot. Molecular docking was applied to predict the interacting protein of QUE; while Nrf2 was knocked down by siRNAs to confirm its role in QUE regulated senescence phenotype. X-ray, MRI, Hematoxylin-Eosin and Safranin O-Fast green staining were performed to evaluate the therapeutic effects of QUE on IDD in the puncture-induced rat model. Results In in vitro experiments, QUE inhibited SASP factors expression and senescence phenotype in IL-1β-treated NPCs. Mechanistically, QUE suppressed IL-1β induced activation of the NF-κB pathway cascades; it was also demonstrated in molecular docking and knock down studies that QUE might bind to Keap1-Nrf2 complex to suppress NF-κB pathway. In vivo, QUE ameliorated the IDD process in the puncture-induced rat model. Conclusions Together the present work suggests that QUE inhibits SASP factors expression and senescence phenotype in NPCs and ameliorates the progression of IDD via the Nrf2/NF-κB axis, which supports senolytic agent QUE as a potential therapeutic agent for the treatment of IDD.

Published
2021

20. Tumor Mutation Burden, Immune Cell Infiltration, and Construction of Immune-Related Genes Prognostic Model in Head and Neck Cancer

Author

Tao Tian, Ai-Min Jiang, Xiao Fu, Zhiping Ruan, Na Liu, Yu Yao, Meng-Di Ren, Xuan Liang, Jingjing Wang, Xiaoqiang Zheng, and Huan Gao

Subjects
CD4-Positive T-Lymphocytes, DNA Mutational Analysis, Datasets as Topic, Kaplan-Meier Estimate, Tumor mutation burden (TMB), CD8-Positive T-Lymphocytes, Malignancy, Polymorphism, Single Nucleotide, Risk Assessment, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Immune system, Tumor-Associated Macrophages, Biomarkers, Tumor, Tumor Microenvironment, Humans, Medicine, Missense mutation, Prospective Studies, IRGs, Models, Genetic, Immune-related genes (IRGs), Squamous Cell Carcinoma of Head and Neck, business.industry, Gene Expression Profiling, Head and neck cancer, Models, Immunological, Head and neck squamous cell carcinoma (HNSCC), General Medicine, TCGA, Prognosis, medicine.disease, Head and neck squamous-cell carcinoma, Gene Expression Regulation, Neoplastic, Immune cell infiltration, Head and Neck Neoplasms, Mutation, Cancer research, 030211 gastroenterology & hepatology, business, CD8, Research Paper, FAT1
Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, and the prognosis of HNSCC remains bleak. Numerous studies revealed that the tumor mutation burden (TMB) could predict the survival outcomes of a variety of tumors. Objectives: This study aimed to investigate the TMB and immune cell infiltration in these patients and construct an immune-related genes (IRGs) prognostic model. Methods: The expression data of 546 HNSCC patients were obtained from The Cancer Genome Atlas (TCGA) database. All patients were divided into high- and low- TMB groups, and the relationship between TMB and clinical relevance was further analyzed. The differentially expressed genes (DEGs) were identified using the R software package, limma. Functional enrichment analyses were conducted to identify the significantly enriched pathways between two groups. CIBERSORT algorithm was adopted to calculate the abundance of 22 leukocyte subtypes. The IRGs prognostic model was constructed via the multivariate Cox regression analysis. Results: Missense mutation and single nucleotide variants (SNV) were the most predominant mutation types in HNSCC. TP53, TTN, and FAT1 were the most frequently mutated genes. Patients with high TMB were observed with worse survival outcomes. The functional analysis of TMB associated DEGs showed that the identified DEGs mainly involved in spliceosome, RNA degradation, proteasome, and RNA polymerase pathways. We observed that macrophages, T cells CD8, and T cells CD4 memory were the most commonly infiltrated subtypes of immune cells in HNSCC. Finally, an IRGs prognostic model was constructed, and the AUC of the ROC curve was 0.635. Conclusions: Our results suggest that high TMB is associated with poor prognosis in HNSCC patients. The constructed model has potential prognostic value for the prognosis of these individuals, and it needs to be further validated in large-scale and prospective studies.

Published
2021

21. Differences of TNF-α, IL-6 and Gal-3 in lobar pneumonia and bronchial pneumonia caused by mycoplasma pneumoniae

Author

Shuang Li, Yu Jiang, Li-Ping Chen, Gang Yuan, Fang Tian, and Ai-Min Zhang

Subjects
medicine.medical_specialty, Mycoplasma pneumoniae, Galectin 3, Biomedical Engineering, Biophysics, Health Informatics, Bioengineering, Bronchopneumonia, 030204 cardiovascular system & hematology, medicine.disease_cause, Gastroenterology, Biomaterials, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Interleukin 6, biology, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, respiratory system, medicine.disease, respiratory tract diseases, Pneumonia, Lobar pneumonia, Mycoplasma pneumonia, biology.protein, Tumor necrosis factor alpha, business, Information Systems
Abstract

OBJECTIVE: To investigate the differences of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and galectin-3 concentrations in lobar pneumonia and bronchopneumonia induced by mycoplasma pneumoniae (MP) in children and to explore these related factors predicting the severity of MP. METHODS: A total of 148 children with mycoplasma pneumoniae pneumonia (MPP) and 32 healthy controls were analyzed from March 2017 to August 2018 in our province. Clinical information was collected from the hospitalized MP patients. The 148 patients with MPP were divided into two groups: lobar pneumonia group and bronchial pneumonia group. The 32 healthy children were considered the control group. The concentrations of TNF-α, IL-6 and Gal-3 were examined in the serum of 148 children patients with MPP and 32 healthy children by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). RESULTS: The TNF-α, IL-6 and Gal-3 levels were obviously higher in both the lobar pneumonia and bronchial pneumonia groups, compared to those in the control group. Furthermore, these levels were significantly higher in the lobar pneumonia group, compared to the bronchial pneumonia group. After treatment, the levels of TNF-α, IL-6 and Gal-3 totally descended during the recovery period. CONCLUSION: There are differences in serum TNF-α, IL-6 and Gal-3 concentrations in lobar pneumonia and bronchial pneumonia caused by MP in children. In general, the TNF-α, IL-6 and Gal-3 levels were significantly higher in the lobar pneumonia group, when compared to the bronchial pneumonia group. This was because most lobar pneumonia cases are much more serious than bronchial pneumonia. Moreover, it has been proven that TNF-α, IL-6 and Gal-3 may play an important role in the pathogenesis development of MPP. At the same time, these are important issues in diagnosing MPP.

Published
2020

22. Hydrogen sulfide protects against IL‐1β‐induced inflammation and mitochondrial dysfunction‐related apoptosis in chondrocytes and ameliorates osteoarthritis

Author

Daoliang Xu, Ben Wang, Jiaoxiang Chen, Xiaoyun Pan, Mingbao Gu, Libin Ni, Yingzhao Yan, Zhenxuan Shao, Haiming Jin, Yifeng Shi, and Ai-Min Wu

Subjects
Male, 0301 basic medicine, MAPK/ERK pathway, Physiology, Interleukin-1beta, Clinical Biochemistry, Apoptosis, Inflammation, Sodium hydrosulfide, Sulfides, Chondrocyte, Proinflammatory cytokine, 03 medical and health sciences, chemistry.chemical_compound, Chondrocytes, 0302 clinical medicine, Osteoarthritis, medicine, Animals, Humans, Hydrogen Sulfide, Phosphorylation, Protein kinase B, Cells, Cultured, PI3K/AKT/mTOR pathway, Aged, NF-kappa B, Cell Biology, Middle Aged, Mitochondria, Cell biology, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, chemistry, Antirheumatic Agents, Case-Control Studies, 030220 oncology & carcinogenesis, Female, Joints, Inflammation Mediators, Mitogen-Activated Protein Kinases, Phosphatidylinositol 3-Kinase, medicine.symptom, Proto-Oncogene Proteins c-akt, Signal Transduction
Abstract

The inflammatory environment and excessive chondrocyte apoptosis have been demonstrated to play crucial roles in the onset of osteoarthritis (OA). Hydrogen sulfide (H2 S), a gaseous signalling molecule, exerts an inhibitory effect on inflammation and apoptosis in several degenerative diseases. However, the protective effect of H2 S against OA has not been fully clarified, and its underlying mechanism should be examined further. In the current study, the role of endogenous H2 S in the pathogenesis of OA and its protective effects on interleukin (IL)-1β-induced chondrocytes were identified. Our data revealed decreased H2 S expression in both human degenerative OA cartilage tissue and IL-1β-induced chondrocytes. Pretreatment with the H2 S donor sodium hydrosulfide (NaHS) dramatically attenuated IL-1β-induced overproduction of inflammatory cytokines and improved the balance between anabolic and catabolic chondrocyte capacities, and these effects were dependent on PI3K/AKT pathway-mediated inhibition of nuclear factor kappa B (NF-κB). Moreover, mitochondrial dysfunction-related apoptosis was significantly reversed by NaHS in IL-1β-stimulated chondrocytes. Mechanistically, NaHS partially suppressed IL-1β-induced phosphorylation of the mitogen-activated protein kinase (MAPK) cascades. Furthermore, in the destabilization of the medial meniscus mouse model, OA progression was ameliorated by NaHS administration. Taken together, these results suggest that H2 S may antagonize IL-1β-induced inflammation and mitochondrial dysfunction-related apoptosis via selective suppression of the PI3K/Akt/NF-κB and MAPK signalling pathways, respectively, in chondrocytes and may be a potential therapeutic agent for the treatment of OA.

Published
2020

23. Prognostic Nomograms to Predict Overall Survival and Cancer-specific Survival in Sacrum/Pelvic Chondrosarcoma (SC) Patients

Author

Dong Chen, Ai-Min Wu, Jin-Feng Huang, Xuan-Qi Zheng, and Jia-Liang Lin

Subjects
Sacrum, medicine.medical_specialty, medicine.medical_treatment, Concordance, Chondrosarcoma, Malignancy, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Humans, Orthopedics and Sports Medicine, Longitudinal Studies, Propensity Score, 030222 orthopedics, business.industry, Nomogram, Prognosis, medicine.disease, Radiation therapy, Nomograms, Propensity score matching, Surgery, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery, SEER Program
Abstract

Study design A longitudinal cohort study. Objective The objective of this study was to evaluate the prognostic factors and determine the difference between different surgery scopes. Nomograms were constructed and validated to predict overall survival (OS) and cancer-specific survival (CSS) of sacrum/pelvic chondrosarcoma (SC) patients. Summary of background data Chondrosarcoma is a bone malignancy which is reported to be resistant to both chemotherapy and radiotherapy. Therefore, surgery is the most preferred treatment method. However, this remains a great challenge due to the complex anatomy of the area. Materials and methods Data from the Surveillance, Epidemiology, and End Results (SEER) database of patients with conventional SC between 1998 and 2016 was retrieved for analysis. Cox analysis was used to estimate the mortality hazards ratios among patients. Propensity score matching was used to compare different surgery scope. Nomograms were constructed to predict the OS and CSS of patients with SC. Results A total of 377 patients were included in this study. The cutoff value for tumor size was considered to be 118 mm. The concordance indices (C-index) value for nomogram predictions of CSS were 0.871. Following propensity score matching, 158 patients were selected for the second time and its result showed no significant difference between the scope of surgery. Conclusions Tumor size was considered to be closely related to the outcome of SC. There is no significant difference in the scope of surgery and limb salvage can be considered. The nomograms can precisely predict OS and CSS in patients with SC. These could help clinicians to perform survival assessments and identify patients at high risk. Level of evidence Level IV.

Published
2020

24. Lysine (K)-specific demethylase 5C regulates the incidence of severe preeclampsia by adjusting the expression of bone morphogenetic protein-7

Author

Xu-Feng Shi, Zhan Zhang, Hai-Ying Wu, Yu Wang, Ai-Min Chang, Jun-Jun Gao, Kan Liu, Wan-Yu Song, Li Wang, and Huan-Ping Wang

Subjects
Histone Demethylases, Bone Morphogenetic Protein 7, Incidence, Lysine, Placenta, Endothelial Cells, Bioengineering, General Medicine, Bone Morphogenetic Protein Receptors, Type II, Applied Microbiology and Biotechnology, Pre-Eclampsia, Pregnancy, Humans, Female, RNA, Messenger, Biotechnology
Abstract

This study aimed to investigate the roles of the lysine (K)-specific demethylase 5C (KDM5C)-bone morphogenetic protein-7 (BMP-7) signaling pathway in the pathogenesis of severe preeclampsia (sPE). A total of 180 pregnant patients were enrolled in the study and classified into three groups: an early-onset sPE group (EOsPE) (

Published
2022

25. Pharmacokinetics and Safety of Ferric Pyrophosphate Citrate in Chinese Subjects with and without Hemodialysis-Dependent Stage 5 Chronic Kidney Disease

Author

Liangying Gan, Panpan Xie, Yan Tan, Gang Wei, Xiaojuan Yuan, Zhifei Lu, Raymond Pratt, Yongchun Zhou, Ai-Min Hui, Kexin Li, Yi Fang, and Li Zuo

Subjects
Pharmacology, Adult, China, Iron, Middle Aged, Diphosphates, Young Adult, Renal Dialysis, Area Under Curve, Hematinics, Humans, Citrates, Renal Insufficiency, Chronic, Aged
Abstract

Anemia caused by iron depletion is common in patients with hemodialysis-dependent stage 5 chronic kidney disease (CKD-5HD) patients. To maintain the iron levels, external administration of iron is essential. Ferric pyrophosphate citrate (FPC) is a novel, water-soluble complex iron salt. The present study was conducted to evaluate the pharmacokinetic (PK) parameters and safety of FPC in adult healthy Chinese subjects and patients with CKD-5HD.Two open-label, single-center studies were conducted in healthy subjects and patients with CKD-5HD. Healthy subjects received a single intravenous dose of 6.5 mg FPC solution, while CKD-5HD patients were randomized to two different sequences of FPC administration at two sequential hemodialysis (HD) treatments (dose 1 and dose 2). Patients received 27.2 mg of FPC at a dialysate concentration of 95 μg/L for 4 h or a single 6.5 mg dose of FPC administered intravenously via the pre-dialyzer blood circuit. The primary objective was to determine the PK parameters of total serum iron (FeA total of 14 healthy subjects with a mean age of 30.8 ± 5.92 years and 12 HD patients with a mean age of 54.3 ± 16.47 years were included. In healthy subjects, the peak serum concentration was reached at the end of infusion of FPC, with an adjusted mean maximum concentration (CFPC showed a good PK and safety profile and hence can be used as maintenance therapy for patients with CKD-5HD by choosing a better method of administration based on clinical feasibility and requirement.CTR20181113 and CTR20181119.

Published
2022

26. Novel recombinant human thyroid-stimulating hormone in aiding postoperative assessment of patients with differentiated thyroid cancer-phase I/II study

Author

Yan-Song Lin, Hui Yang, Xiao-Yi Li, Li-Qing Wu, Jin-Guo Xu, Ai-Min Yang, Zai-Rong Gao, Yong Ding, Ying-Qiang Zhang, Kai Chen, Zhuan-Zhuan Mu, Jian-Min Jia, Na Niu, Di Sun, Xin Zhang, Shao-Qiang Zhang, Qian-Qian Geng, Ya-Jing Zhang, Fang-Ni Chen, and Bao-Xia He

Subjects
Iodine Radioisotopes, Thyroid Hormones, Thyroxine, Quality of Life, Humans, Thyrotropin, Radiology, Nuclear Medicine and imaging, General Medicine, Thyroid Neoplasms, Adenocarcinoma, Tomography, X-Ray Computed, Thyrotropin Alfa
Abstract

Purpose Thyroid hormone withdrawal (THW) inevitably induced hypothyroidism in patients with differentiated thyroid cancer (DTC), we aimed to evaluate the safety and efficacy of a novel recombinant human thyroid-stimulating hormone (rhTSH, ZGrhTSH) as an alternative of THW in China.Methods Totally, 64 DTC patients were enrolled with 24 in the dose-escalation cohort equally grouped into 0.9 mg×1d, 0.9 mg×2d, 1.8 mg×1d and 1.8 mg×2d dosage, and 40 further enrolled into 0.9 mg×2d dose-expansion cohort. All patients underwent both ZGrhTSH phase and levothyroxine (L-T4) withdrawal phase for self-comparison in terms of TSH levels, the radioactive iodine (RAI) uptake, stimulated thyroglobulin level, and the quality of life (QoL).Results In ZGrhTSH phase, no major serious adverse events was observed, mild symptom of headache was observed in 6.3%, lethargy in 4.7%, asthenia in 3.1% of the patients, and mostly resolved spontaneously within 2 days. Concordant RAI uptake was noticed in 89.1% (57/64) of the patients between ZGrhTSH and L-T4 withdrawal phases. The concordant thyroglobulin level with a cut-off of 1 mg/L was noticed in 84.7% (50/59) of the patients without the interference of anti-thyroglobulin antibody. The QoL was far better during ZGrhTSH phase than L-T4 withdrawal phase, with lower Billewicz (-51.30±4.70 vs. -39.10±16.61, P4 withdrawal phase, a median of 23 days after L-T4 withdrawal was needed, with the mean TSH level of 82.20±31.37 mU/L. The half-life for ZGrhTSH clearance was about 20h.Conclusion The ZGrhTSH held the promise to be a safe and effective modality in facilitating RAI uptake and serum thyroglobulin stimulation, with better QoL of patients with DTC compared with L-T4 withdrawal.

Published
2022

28. Chinese guideline for the application of rectal cancer staging recognition systems based on artificial intelligence platforms (2021 edition)

Author

Yuan Gao, Yun Lu, Shuai Li, Yong Dai, Bo Feng, Fang-Hai Han, Jia-Gang Han, Jing-Jing He, Xin-Xiang Li, Guo-Le Lin, Qian Liu, Gui-Ying Wang, Quan Wang, Zhen-Ning Wang, Zheng Wang, Ai-Wen Wu, Bin Wu, Ying-Chi Yang, Hong-Wei Yao, Wei Zhang, Jian-Ping Zhou, Ai-Min Hao, Zhong-Tao Zhang, Yuan-Yuan Ji, Colorectal Surgery Group of the Surgery Branch in the Chinese Medical Association, and Beihang University State Key Laboratory of Virtual Reality Technology and Systems

Subjects
medicine.medical_specialty, China, business.industry, Colorectal cancer, Rectal Neoplasms, Consensus Statements, General Medicine, Guideline, medicine.disease, Prognosis, Artificial Intelligence, Medicine, Humans, Medical physics, Neural Networks, Computer, business, Neoplasm Staging
Published
2021

29. 4D-Printed Dynamic Materials in Biomedical Applications: Chemistry, Challenges, and Their Future Perspectives in the Clinical Sector

Author

Xiaoyan Wang, Wenxian Zhou, Min-Min Shao, Pooyan Makvandi, Xiao-Lei Sun, Xuan-Qi Zheng, Ai-Min Wu, Hui Wang, Xiaolei Zhang, Yan Michael Li, Dong Chen, Jianfeng Huang, Ehsan Nazarzadeh Zare, Lei Yang, Shan Fang, Zhi-Guang Qiao, and Jing Zheng

Subjects
0303 health sciences, 3D bioprinting, Future perspective, Tissue Engineering, Chemistry, Biomedical Technology, Bioprinting, Biocompatible Materials, 01 natural sciences, Field (computer science), 0104 chemical sciences, law.invention, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, law, Printing, Three-Dimensional, Drug Discovery, Systems engineering, Animals, Humans, Molecular Medicine, 4d printing, Forecasting, 030304 developmental biology
Abstract

Most of the biomedical materials printed using 3D bioprinting are static and are unable to alter/transform with dynamic changes in the internal environment of the body. The emergence of four-dimensional (4D) printing addresses this problem. By preprogramming dynamic polymer materials and their nanocomposites, 4D printing is able to produce the desired shapes or transform functions under specific conditions or stimuli to better adapt to the surrounding environment. In this review, the current and potential applications of 4D-printed materials are introduced in different aspects of the biomedical field, e.g., tissue engineering, drug delivery, and sensors. In addition, the existing limitations and possible solutions are discussed. Finally, the current limitations of 4D-printed materials along with their future perspective are presented to provide a basis for future research.

Published
2020

30. Clinical impact of cardiovascular disease on patients with bronchiectasis

Author

Zhang Tao, Shanshan Chen, Hai-Lin Zhang, and Ai-Min Qiu

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, China, Microbiological culture, Exacerbation, Disease, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Medicine, Humans, Pseudomonas Infections, 030212 general & internal medicine, Lung, Aged, Retrospective Studies, Clinical impact, lcsh:RC705-779, Bronchiectasis, business.industry, Sputum, Odds ratio, lcsh:Diseases of the respiratory system, Middle Aged, Brain natriuretic peptide, medicine.disease, Cardiovascular disease, Confidence interval, Logistic Models, 030228 respiratory system, Cardiovascular Diseases, Cohort, Pseudomonas aeruginosa, Disease Progression, Female, business, Research Article
Abstract

Background Patients with bronchiectasis have a higher cardiovascular risk than their matched controls. However, the effect of cardiovascular (CV) disease on bronchiectasis remains unclear. Thus, we aimed to investigate the clinical impacts of cardiovascular disease on adult patients with bronchiectasis. Methods The study cohort comprised 603 consecutive inpatients diagnosed with bronchiectasis in the Affiliated Yancheng Hospital of Southeast University Medical College (Jiangsu, China) from January 2014 to December 2017. Symptoms, bacterial cultures, blood biochemical indicator levels, and chest high-resolution computed tomography scans were assessed during their initial hospitalization for bronchiectasis. Three hundred and thirty five subjects finished 1 year follow-up after their hospital discharge. Results Three hundred thirty five patients had at least one bronchiectasis exacerbation during the 1-year follow-up period. Patients with CV comorbidities were more likely to present with symptoms of wheezing (65.3%) and had a higher levels of brain natriuretic peptide (P P = 0.006), the isolation of Pseudomonas aeruginosa (OR 2.076, 95% CI 1.100–3.919; P = 0.024), and extension to more than two lobes (OR 2.485, 95% CI 1.195–5.168; P = 0.015). Conclusion The existence of cardiovascular disease was independently associated with increased bronchiectasis exacerbation.

Published
2020

31. Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots

Author

Sheng-Nan Ni, Wu Ying-Zheng Guo, Yuan-Yuan Fang, Ai-Min Yan, Wen-Chao Yang, Yao Sun, Rong-Rong Li, Guang-Fu Yang, Qing-Jian Dong, and Shiyu Liu

Subjects
Lung Diseases, General Physics and Astronomy, Nanoprobe, 02 engineering and technology, Sulfides, Lung injury, 010402 general chemistry, 01 natural sciences, In vivo, Quantum Dots, Cadmium Compounds, Fluorescence Resonance Energy Transfer, medicine, Humans, General Materials Science, Selenium Compounds, Fluorescent Dyes, Lung, Chemistry, Elastase, General Engineering, 021001 nanoscience & nanotechnology, In vitro, 0104 chemical sciences, Förster resonance energy transfer, medicine.anatomical_structure, Zinc Compounds, Biophysics, Leukocyte Elastase, 0210 nano-technology, Preclinical imaging
Abstract

There is an increasing demand for effective noninvasive diagnosis against common pulmonary diseases, which are rising sharply due to the serious air pollution. Human neutrophil elastase (HNE), a typical protease highly involved in pulmonary inflammatory diseases and lung cancer, is a potential predictor for disease progression. Currently, few of the HNE-targeting probes are applicable in vivo due to the limitation in sensitivity and biocompatibility. Herein, we reported the achievement of in vitro detection and in vivo imaging of HNE by incorporating the HNE-specific peptide substrate, quantum dots (QDs), and organic dyes into the fluorescence resonance energy transfer (FRET) system. The refined nanoprobe, termed QDP, could specifically measure the HNE with excellent sensitivity of 7.15 pM in aqueous solution and successfully image the endogenous and exogenous HNE in living cells. In addition, this nanoprobe enabled HNE imaging in mouse models of lung cancer and acute lung injury, and the HNE activity at high temporal and spatial resolution was continuously monitored. Most importantly, QDP successfully discriminated the serums of patients with lung diseases from those of the healthy controls based on the HNE activity determination. Overall, this study demonstrates the advantages of a FRET-system-based nanoprobe in imaging performance and provides an applicable tool for in vivo HNE detection and pulmonary disease diagnosis.

Published
2020

32. Estimating global injuries morbidity and mortality

Author

Zohreh Arefi, Rasmus Havmoeller, Pietro Ferrara, Vijay Kumar Chattu, Payman Salamati, Agegnehu Bante Getenet, Seyedeh Zahra Masoumi, Alexander C. Tsai, Andrew T Olagunju, Carl Abelardo T. Antonio, Morteza Abdullatif Khafaie, Tim Driscoll, Reza Rawassizadeh, Vishnu Renjith, Taras Kavetskyy, Ejaz Ahmad Khan, Gebreamlak Gebremedhn Gebremeskel, Richard C. Franklin, Naznin Hossain, Bhaskaran Unnikrishnan, Fariborz Mansour-Ghanaei, Arash Tehrani-Banihashemi, Morteza Naserbakht, Sangram Kishor Patel, Vera Marisa Costa, Suzanne Polinder, Ziad El-Khatib, Ashish Pathak, Mika Shigematsu, Bryan L. Sykes, David M. Pigott, Zeleke Aschalew Melketsedik, Hadi Hassankhani, Nuworza Kugbey, Lal B. Rawal, Masoud Foroutan, Dejana Braithwaite, Muluken Bekele Sorrie, Grant M. A. Wyper, Joht Singh Chandan, Akbar Barzegar, Hamid Safarpour, Kate E. LeGrand, Giulio Castelpietra, Dina Nur Anggraini Ningrum, Seth Christopher Yaw Appiah, Amin Soheili, Azeem Majeed, Akshaya Srikanth Bhagavathula, Nikolay Ivanovich Briko, Vahid Yazdi-Feyzabadi, Walter Mendoza, Ghulam Mustafa, Cuong Tat Nguyen, Pengpeng Ye, Mahesh P A, Carlos Miguel Rios González, Ahmad Daryani, Ibrahim Abdollahpour, Masoud Moradi, Haileab Fekadu Wolde, Mohammad Rabiee, Jaya Prasad Tripathy, Jack T Fox, Diep Ngoc Nguyen, Pallab K. Maulik, Ai-Min Wu, Félix Carvalho, Yun Jin Kim, Fatemeh Rajati, Nathaniel J Henry, David C. Schwebel, Ali H. Mokdad, Akine Eshete Abosetugn, Leonardo Roever, Ketema Bizuwork Gebremedhin, Khalid A Altirkawi, Hayimro Edemealem Merie, Farhad Ghamari, Ramesh Holla, Arash Sarveazad, Devasahayam J. Christopher, Kedir Hussein Abegaz, Suresh Jungari, Rohan Borschmann, Irfan Ullah, Nitin Joseph, Catalina Liliana Andrei, Abdallah M. Samy, Roman Topor-Madry, Michal Grivna, Ivo Rakovac, Mohammad Zamani, Antonio Maria Borzì, Atif Amin Baig, Mohsen Bayati, Mohammad Ali Mansournia, Fatemeh Heydarpour, Juanita A. Haagsma, Segun Emmanuel Ibitoye, Mehdi Sayyah, Teshome Abegaz Kamil, Fakher Rahim, Dillon O Sylte, Feng Sha, Palash Chandra Banik, Mohan Bairwa, Mariya Vladimirovna Titova, Yong Yu, Delia Hendrie, Spencer L. James, Anusha Ganapati Bhat, Seok Jun Yoon, Siavash Rahimi, Jost B. Jonas, Michael R. Phillips, Diana Silva, Amir Hossein Goudarzian, Samath D Dharmaratne, Roba Khundkar, Jemal Abdu Mohammed, Joemer C. Maravilla, Eleonora Dubljanin, Arun Balachandran, Arman Latifi, Randah R. Hamadeh, G. K. Mini, Alessandra C. Goulart, Andreea Mirica, Fatemeh Zarei, Habte Belete, Telma Zahirian Moghadam, Maseer Khan, Morenike Oluwatoyin Folayan, Atte Meretoja, Jasvinder A. Singh, Guilherme Borges, Yasir Waheed, Fahad Alanezi, Masoud Moghadaszadeh, Guoqing Hu, Archith Boloor, Luca Ronfani, Olayinka Stephen Ilesanmi, Vahid Rashedi, Mehran Shams-Beyranvand, Trang Huyen Nguyen, Yonatal Mesfin Tefera, Yousef Khader, Adnan Kisa, Simon I. Hay, Takeshi Fukumoto, Shahrzad Bazargan-Hejazi, Yuichiro Yano, Carlos A Castañeda-Orjuela, Suzanne Barker-Collo, Ghasem Azarian, Sezer Kisa, Basema Saddik, Leake Gebremeskel, Yetunde O. John-Akinola, Jennifer Rickard, Ilais Moreno Velásquez, Priya Rathi, Ali Bijani, Smita Pakhale, Francesco Saverio Violante, Neeraj Bedi, Efat Mohamadi, Deborah Carvalho Malta, Marek Majdan, Feleke Mekonnen Demeke, Chukwudi A Nnaji, Richard Ofori-Asenso, Prateek Rastogi, Xuefeng Liu, Monika Sawhney, Ayman Grada, Prasanna Mithra, Shanshan Li, Masood Ali Shaikh, Erin B Hamilton, Hung Chak Ho, Zichen Liu, Irini Chatziralli, Paulo A. Lotufo, Yuming Guo, Daniel N. Kiirithio, Hamidreza Komaki, Aristidis Tsatsakis, Brijesh Sathian, Daniel Kim, Yoosik Youm, Kebreab Paulos, Saqib Ali, Beriwan Abdulqadir Ali, M. Mofizul Islam, Ahad Bakhtiari, Karen M. Tabb, Davood Anvari, Tomislav Mestrovic, Yunquan Zhang, Muhammad Aziz Rahman, Naohiro Yonemoto, Rupak Desai, Peter Njenga Keiyoro, Rajan Nikbakhsh, Zahra Sadat Dibaji Forooshani, Carlo La Vecchia, Amrit Banstola, Niguse Meles Alema, Shivakumar K.M. Kondlahalli, Soraya Seedat, Filippo Ariani, Chi Linh Hoang, Maziar Moradi-Lakeh, Erika Ota, Dimas Ria Angga Pribadi, Van C. Lansingh, Mohammed Madadin, Mostafa Dianati Nasab, Biniyam Sahiledengle Geberemariyam, Amanda J. Mason-Jones, Marcela Agudelo-Botero, Dinh-Toi Chu, Bach Xuan Tran, Till Bärnighausen, Mehdi Mirzaei-Alavijeh, Mohammad Ali Jahani, Bereket Duko Adema, In-Hwan Oh, Paul S. F. Yip, Ionut Negoi, Eduarda Fernandes, Reza Ghanei Gheshlagh, Kelly Jones, Mahdi Safdarian, Josep Maria Haro, Zahiruddin Quazi Syed, Diego De Leo, Khanh Bao Tran, Syed Mohamed Aljunid, Yasser S. Amer, Tommi Vasankari, Vasily Vlassov, Jose C. Adsuar, Zoubida Zaidi, Asadollah Gholamian, Theo Vos, Nauman Khalid, Malke Asaad, André Faro, Rushdia Ahmed, Tuomo J. Meretoja, Ireneous N. Soyiri, Ana Isabel Ribeiro, Hoa Thi Do, Temesgen Gebeyehu Wondmeneh, Vladimir Andreevich Korshunov, Manasi Kumar, Josip Car, Shoaib Hassan, Mukhammad David Naimzada, Gurudatta Naik, Ali Rajabpour-Sanati, Mustafa Z. Younis, Farid Najafi, Ester Cerin, Lorenzo Monasta, Amit Arora, Rizwan Suliankatchi Abdulkader, Huong Lan Thi Nguyen, Javad Nazari, Joel M. Francis, Martin Amogre Ayanore, Farahnaz Joukar, Babak Moazen, Kebede Deribe, Nithin Kumar, Seyed-Mohammad Fereshtehnejad, Getinet Ayano, Serge Resnikoff, Mark A. Stokes, Alaa Badawi, Narinder Kumar, Habibolah Khazaie, Sojib Bin Zaman, Faris Lami, Jens R. Chapman, Onome Bright Oghenetega, Dhirendra N Sinha, Engida Yisma, Aso Mohammad Darwesh, Demelash Abewa Elemineh, Junaid Khan, Shane D. Morrison, Mansour Ghafourifard, Ata Rafiee, Hadush Gebremariam, Oghenowede Eyawo, Amir Hasanzadeh, Ana Laura Manda, Muhammed Magdy Abd El Razek, Morteza Arab-Zozani, Narayana Manjunatha, Navid Manafi, Ritesh G. Menezes, Ferrán Catalá-López, Hossein Poustchi, Ghobad Moradi, Suliman Alghnam, Tinuke O Olagunju, Mohiuddin Ahsanul Kabir Chowdhury, Man Mohan Mehndiratta, Sorin Hostiuc, Jalal Arabloo, Shaun Wen Huey Lee, Chris D Castle, Joan B. Soriano, Syed Amir Gilani, Mariam Molokhia, Gaurav Gupta, Inga Dora Sigfusdottir, Isabela M. Benseñor, Desalegn Getnet Demsie, Atalay Goshu Muluneh, Young Eun Kim, Olatunde Aremu, Leeberk Raja Inbaraj, Jae Il Shin, Berhe Etsay Tesfay, Neha Chaudhary, Juan Sanabria, Soosanna Kumary Chattu, Sanni Yaya, Rekha Thapar, Biruk Wogayehu Taddele, Maciej Banach, Salman Rawaf, Nicholas L S Roberts, Jagadish Rao Padubidri, Manoochehr Karami, Derrick A Bennett, Duduzile Ndwandwe, Soheil Hassanipour, Ashish Badiye, Krittika Bhattacharyya, Obinna Onwujekwe, Kewal Krishan, João Coelho, Ahmed Abdelalim, Kerrie E. Doyle, Tomasz Miazgowski, Rahman Shiri, Demelash Woldeyohannes Handiso, Navid Rabiee, Nikita Otstavnov, Brian J. Hall, Olalekan A. Uthman, Rohollah Kalhor, Swayam Prakash, Beatriz Paulina Ayala Quintanilla, Gebre Teklemariam Demoz, Ted R. Miller, Rebecca Ivers, Chuanhua Yu, Pascual R. Valdez, Martha Híjar, Taweewat Wiangkham, Maysaa El Sayed Zaki, Rafael Tabarés-Seisdedos, Melkamu Merid Mengesha, Seyedmojtaba Seyedmousavi, Ravi Prakash Jha, Songhomitra Panda-Jonas, Aidin Abedi, Savita Lasrado, Veincent Christian Filipino Pepito, Amir Almasi-Hashiani, Burcu Kucuk Bicer, Hagazi Gebremedhin Kassaye, Yousef Veisani, Ayenew Kassie Tesema, Amir Radfar, Pawan Faris, Oladimeji Adebayo, Fares Alahdab, Heather Orpana, Narayan Bahadur Mahotra, Tripti Khanna, Girikumar Kumaresh, Alireza Rafiei, João Mauricio Castaldelli-Maia, Subramanian Senthilkumaran, Cyrus Alinia, Era Upadhyay, Stanislav S. Otstavnov, Ahmed Omar Bali, Farshad Farzadfar, Vivek Kumar, Sanghamitra Pati, Gholamreza Roshandel, Daiane Borges Machado, Yuan-Pang Wang, Rafael Alves Guimarães, Aziz Sheikh, Jeevan Pereira, Ahamarshan Jayaraman Nagarajan, Soraya Siabani, Kamarul Imran Musa, Farshad Pourmalek, Janet L Leasher, Shafiu Mohammed, Shyam Sundar Budhathoki, Mehdi Naderi, Mehdi Hosseinzadeh, Eun-Kee Park, Marwa Rashad Salem, Alireza Ansari-Moghaddam, Achala Upendra Jayatilleke, Paolo Lauriola, Amir Kasaeian, Adam Belay Wondmieneh, Tilahun Belete Mossie, Rovshan Khalilov, Milena M Santric Milicevic, Ai Koyanagi, Shailesh Advani, Felix Akpojene Ogbo, Nihad A. Almasri, Abdur Razzaque Sarker, Salman Khazaei, Narayanaswamy Venketasubramanian, Josephine W. Ngunjiri, Mihajlo Jakovljevic, Matthew Cunningham, Shaimaa I. El-Jaafary, Hosni Salem, Sharareh Eskandarieh, Muktar Beshir Ahmed, Amy E. Peden, Rajaram Yadav, Srikanta Banerjee, Kenean Getaneh Tlaye, Ronan A Lyons, Farzad Jalilian, Jacek Jerzy Jozwiak, Soufiane Boufous, Leila R Kalankesh, Abdelrahman Ibrahim Abushouk, Mikk Jürisson, Hamid Reza Tohidinik, Flavia M. Cicuttini, Zachary V Dingels, Florian Fischer, Saad M.A. Dahlawi, Rahmatollah Moradzadeh, Getnet Gedefaw, Tauseef Ahmad, Faramarz Shaahmadi, Hamed Zandian, Bruno Ramos Nascimento, Gregory J. Bertolacci, Hamid Yimam Hassen, Christian Lycke Ellingsen, Zulfiqar A Bhutta, Pankaj Bhardwaj, Dawit Habte Woldeyes, Robert C. Reiner, Rakhi Dandona, Akram Pourshams, Lorainne Tudor Car, Inbal Salz, Reza Mohammadpourhodki, Farnam Mohebi, A. A. Fomenkov, Abraham Getachew Kelbore, Benjamin B. Massenburg, Yousef Mohammad, Arash Ziapour, Zabihollah Yousefi, Biresaw Wassihun Alemu, Neeti Kapoor, Seyed Sina Naghibi Irvani, Vinod C. Nayak, Yoshan Moodley, Venkatesh Maled, Zhi-Jiang Zhang, Arielle Wilder Eagan, Saif Ullah, Anwar Rafay, Ali Koolivand, Ibrahim A Khalil, Parul Puri, Lidia Sanchez Riera, Vinay Nangia, Tanuj Kanchan, Mu'awiyyah Babale Sufiyan, Lidia Morawska, Saeed Shahabi, Tiffany K. Gill, Traolach S. Brugha, Michael K. Hole, Vahid Alipour, Sowmya J. Rao, Pankaj Singh, Rosario Cárdenas, Abdollah Mohammadian-Hafshejani, Sanjay Zodpey, Birhanu Geta, Amaha Kahsay, Moritz U. G. Kraemer, Claudio Alberto Dávila-Cervantes, Samer Hamidi, Gbenga A. Kayode, Miloud Taki Eddine Aichour, Peter Memiah, Erkin M. Mirrakhimov, Sheikh Mohammed Shariful Islam, Sadia Bibi, Bartosz Miazgowski, Daniel Y. Cho, Keyvan Pakshir, Aziz Rezapour, R V Polibin, Sudha Jayaraman, S. Mohammad Sajadi, Amir Manafi, Berhe Gebremichael, Ali Yadollahpour, Barthelemy Kuate Defo, Alan D. Lopez, Masoud Behzadifar, Mohammad A. Mohseni Bandpei, Ali Kabir, Jee-Young Jasmine Choi, Gebretsadkan Hintsa Tekulu, Kidanemaryam Berhe, Bill & Melinda Gates Foundation, Sanofi, HUS Comprehensive Cancer Center, Clinicum, University of Helsinki, Helsinki University Hospital Area, HUS Neurocenter, James, S. L., Castle, C. D., Dingels, Z. V., Fox, J. T., Hamilton, E. B., Liu, Z., Roberts, N. L. S., Sylte, D. O., Bertolacci, G. J., Cunningham, M., Henry, N. J., Legrand, K. E., Abdelalim, A., Abdollahpour, I., Abdulkader, R. S., Abedi, A., Abegaz, K. H., Abosetugn, A. E., Abushouk, A. I., Adebayo, O. M., Adsuar, J. C., Advani, S. M., Agudelo-Botero, M., Ahmad, T., Ahmed, M. B., Ahmed, R., Aichour, M. T. E., Alahdab, F., Alanezi, F. M., Alema, N. M., Alemu, B. W., Alghnam, S. A., Ali, B. A., Ali, S., Alinia, C., Alipour, V., Aljunid, S. M., Almasi-Hashiani, A., Almasri, N. A., Altirkawi, K., Amer, Y. S. A., Andrei, C. L., Ansari-Moghaddam, A., Antonio, C. A. T., Anvari, D., Appiah, S. C. Y., Arabloo, J., Arab-Zozani, M., Arefi, Z., Aremu, O., Ariani, F., Arora, A., Asaad, M., Quintanilla, B. P. A., Ayano, G., Ayanore, M. A., Azarian, G., Badawi, A., Badiye, A. D., Baig, A. A., Bairwa, M., Bakhtiari, A., Balachandran, A., Banach, M., Banerjee, S. K., Banik, P. C., Banstola, A., Barker-Collo, S. L., Barnighausen, T. W., Barzegar, A., Bayati, M., Bazargan-Hejazi, S., Bedi, N., Behzadifar, M., Belete, H., Bennett, D. A., Bensenor, I. M., Berhe, K., Bhagavathula, A. S., Bhardwaj, P., Bhat, A. G., Bhattacharyya, K., Bhutta, Z. A., Bibi, S., Bijani, A., Boloor, A., Borges, G., Borschmann, R., Borzi, A. M., Boufous, S., Braithwaite, D., Briko, N. I., Brugha, T., Budhathoki, S. S., Car, J., Cardenas, R., Carvalho, F., Castaldelli-Maia, J. M., Castaneda-Orjuela, C. A., Castelpietra, G., Catala-Lopez, F., Cerin, E., Chandan, J. S., Chapman, J. R., Chattu, V. K., Chattu, S. K., Chatziralli, I., Chaudhary, N., Cho, D. Y., Choi, J. -Y. J., Chowdhury, M. A. K., Christopher, D. J., Chu, D. -T., Cicuttini, F. M., Coelho, J. M., Costa, V. M., Dahlawi, S. M. A., Daryani, A., Davila-Cervantes, C. A., De Leo, D., Demeke, F. M., Demoz, G. T., Demsie, D. G., Deribe, K., Desai, R., Nasab, M. D., Da Silva, D. D., Forooshani, Z. S. D., Do, H. T., Doyle, K. E., Driscoll, T. R., Dubljanin, E., Adema, B. D., Eagan, A. W., Elemineh, D. A., El-Jaafary, S. I., El-Khatib, Z., Ellingsen, C. L., El Sayedzaki, M., Eskandarieh, S., Eyawo, O., Faris, P. S., Faro, A., Farzadfar, F., Fereshtehnejad, S. -M., Fernandes, E., Ferrara, P., Fischer, F., Folayan, M. O., Fomenkov, A. A., Foroutan, M., Francis, J. M., Franklin, R. C., Fukumoto, T., Geberemariyam, B. S., Gebremariam, H., Gebremedhin, K. B., Gebremeskel, L. G., Gebremeskel, G. G., Gebremichael, B., Gedefaw, G. A., Geta, B., Getenet, A. B., Ghafourifard, M., Ghamari, F., Gheshlagh, R. G., Gholamian, A., Gilani, S. A., Gill, T. K., Goudarzian, A. H., Goulart, A. C., Grada, A., Grivna, M., Guimaraes, R. A., Guo, Y., Gupta, G., Haagsma, J. A., Hall, B. J., Hamadeh, R. R., Hamidi, S., Handiso, D. W., Haro, J. M., Hasanzadeh, A., Hassan, S., Hassanipour, S., Hassankhani, H., Hassen, H. Y., Havmoeller, R., Hendrie, D., Heydarpour, F., Hijar, M., Ho, H. C., Hoang, C. L., Hole, M. K., Holla, R., Hossain, N., Hosseinzadeh, M., Hostiuc, S., Hu, G., Ibitoye, S. E., Ilesanmi, O. S., Inbaraj, L. R., Irvani, S. S. N., Islam, M. M., Islam, S. M. S., Ivers, R. Q., Jahani, M. A., Jakovljevic, M., Jalilian, F., Jayaraman, S., Jayatilleke, A. U., Jha, R. P., John-Akinola, Y. O., Jonas, J. B., Jones, K. M., Joseph, N., Joukar, F., Jozwiak, J. J., Jungari, S. B., Jurisson, M., Kabir, A., Kahsay, A., Kalankesh, L. R., Kalhor, R., Kamil, T. A., Kanchan, T., Kapoor, N., Karami, M., Kasaeian, A., Kassaye, H. G., Kavetskyy, T., Kayode, G. A., Keiyoro, P. N., Kelbore, A. G., Khader, Y. S., Khafaie, M. A., Khalid, N., Khalil, I. A., Khalilov, R., Khan, M., Khan, E. A., Khan, J., Khanna, T., Khazaei, S., Khazaie, H., Khundkar, R., Kiirithio, D. N., Kim, Y. -E., Kim, Y. J., Kim, D., Kisa, S., Kisa, A., Komaki, H., Kondlahalli, S. K. M., Koolivand, A., Korshunov, V. A., Koyanagi, A., Kraemer, M. U. G., Krishan, K., Defo, B. K., Bicer, B. K., Kugbey, N., Kumar, N., Kumar, M., Kumar, V., Kumaresh, G., Lami, F. H., Lansingh, V. C., Lasrado, S., Latifi, A., Lauriola, P., Vecchia, C. L., Leasher, J. L., Lee, S. W. H., Li, S., Liu, X., Lopez, A. D., Lotufo, P. A., Lyons, R. A., Machado, D. B., Madadin, M., Abd El Razek, M. M., Mahotra, N. B., Majdan, M., Majeed, A., Maled, V., Malta, D. C., Manafi, N., Manafi, A., Manda, A. -L., Manjunatha, N., Mansour-Ghanaei, F., Mansournia, M. A., Maravilla, J. C., Mason-Jones, A. J., Masoumi, S. Z., Massenburg, B. B., Maulik, P. K., Mehndiratta, M. M., Melketsedik, Z. A., Memiah, P. T. N., Mendoza, W., Menezes, R. G., Mengesha, M. M., Meretoja, T. J., Meretoja, A., Merie, H. E., Mestrovic, T., Miazgowski, B., Miazgowski, T., Miller, T. R., Mini, G. K., Mirica, A., Mirrakhimov, E. M., Mirzaei-Alavijeh, M., Mithra, P., Moazen, B., Moghadaszadeh, M., Mohamadi, E., Mohammad, Y., Darwesh, A. M., Mohammadian-Hafshejani, A., Mohammadpourhodki, R., Mohammed, S., Mohammed, J. A., Mohebi, F., Bandpei, M. A. M., Molokhia, M., Monasta, L., Moodley, Y., Moradi, M., Moradi, G., Moradi-Lakeh, M., Moradzadeh, R., Morawska, L., Velasquez, I. M., Morrison, S. D., Mossie, T. B., Muluneh, A. G., Musa, K. I., Mustafa, G., Naderi, M., Nagarajan, A. J., Naik, G., Naimzada, M. D., Najaf, F., Nangia, V., Nascimento, B. R., Naserbakht, M., Nayak, V., Nazari, J., Ndwandwe, D. E., Negoi, I., Ngunjiri, J. W., Nguyen, T. H., Nguyen, C. T., Nguyen, D. N., Nguyen, H. L. T., Nikbakhsh, R., Ningrum, D. N. A., Nnaji, C. A., Ofori-Asenso, R., Ogbo, F. A., Oghenetega, O. B., Oh, I. -H., Olagunju, A. T., Olagunju, T. O., Bali, A. O., Onwujekwe, O. E., Orpana, H. M., Ota, E., Otstavnov, N., Otstavnov, S. S., Mahesh, A. P., Padubidri, J. R., Pakhale, S., Pakshir, K., Panda-Jonas, S., Park, E. -K., Patel, S. K., Pathak, A., Pati, S., Paulos, K., Peden, A. E., Pepito, V. C. F., Pereira, J., Phillips, M. R., Polibin, R. V., Polinder, S., Pourmalek, F., Pourshams, A., Poustchi, H., Prakash, S., Pribadi, D. R. A., Puri, P., Syed, Z. Q., Rabiee, N., Rabiee, M., Radfar, A., Rafay, A., Rafee, A., Rafei, A., Rahim, F., Rahimi, S., Rahman, M. A., Rajabpour-Sanati, A., Rajati, F., Rakovac, I., Rao, S. J., Rashedi, V., Rastogi, P., Rathi, P., Rawaf, S., Rawal, L., Rawassizadeh, R., Renjith, V., Resnikoff, S., Rezapour, A., Ribeiro, A. I., Rickard, J., Gonzalez, C. M. R., Roever, L., Ronfani, L., Roshandel, G., Saddik, B., Safarpour, H., Safdarian, M., Sajadi, S. M., Salamati, P., Salem, M. R. R., Salem, H., Salz, I., Samy, A. M., Sanabria, J., Riera, L. S., Milicevic, M. M. S., Sarker, A. R., Sarveazad, A., Sathian, B., Sawhney, M., Sayyah, M., Schwebel, D. C., Seedat, S., Senthilkumaran, S., Seyedmousavi, S., Sha, F., Shaahmadi, F., Shahabi, S., Shaikh, M. A., Shams-Beyranvand, M., Sheikh, A., Shigematsu, M., Shin, J. I., Shiri, R., Siabani, S., Sigfusdottir, I. D., Singh, J. A., Singh, P. K., Sinha, D. N., Soheili, A., Soriano, J. B., Sorrie, M. B., Soyiri, I. N., Stokes, M. A., Sufiyan, M. B., Sykes, B. L., Tabares-Seisdedos, R., Tabb, K. M., Taddele, B. W., Tefera, Y. M., Tehrani-Banihashemi, A., Tekulu, G. H., Tesema, A. K. T., Tesfay, B. E., Thapar, R., Titova, M. V., Tlaye, K. G., Tohidinik, H. R., Topor-Madry, R., Tran, K. B., Tran, B. X., Tripathy, J. P., Tsai, A. C., Tsatsakis, A., Car, L. T., Ullah, I., Ullah, S., Unnikrishnan, B., Upadhyay, E., Uthman, O. A., Valdez, P. R., Vasankari, T. J., Veisani, Y., Venketasubramanian, N., Violante, F. S., Vlassov, V., Waheed, Y., Wang, Y. -P., Wiangkham, T., Wolde, H. F., Woldeyes, D. H., Wondmeneh, T. G., Wondmieneh, A. B., Wu, A. -M., Wyper, G. M. A., Yadav, R., Yadollahpour, A., Yano, Y., Yaya, S., Yazdi-Feyzabadi, V., Ye, P., Yip, P., Yisma, E., Yonemoto, N., Yoon, S. -J., Youm, Y., Younis, M. Z., Yousef, Z., Yu, C., Yu, Y., Moghadam, T. Z., Zaidi, Z., Zaman, S. B., Zamani, M., Zandian, H., Zarei, F., Zhang, Z. -J., Zhang, Y., Ziapour, A., Zodpey, S., Dandona, R., Dharmaratne, S. D., Hay, S. I., Mokdad, A. H., Pigott, D. M., Reiner, R. C., Vos, T., James, S, Castle, C, Dingels, Z, Fox, J, Hamilton, E, Liu, Z, Roberts, N, Sylte, D, Bertolacci, G, Cunningham, M, Henry, N, Legrand, K, Abdelalim, A, Abdollahpour, I, Abdulkader, R, Abedi, A, Abegaz, K, Abosetugn, A, Abushouk, A, Adebayo, O, Adsuar, J, Advani, S, Agudelo-Botero, M, Ahmad, T, Ahmed, M, Ahmed, R, Eddine Aichour, M, Alahdab, F, Alanezi, F, Alema, N, Alemu, B, Alghnam, S, Ali, B, Ali, S, Alinia, C, Alipour, V, Aljunid, S, Almasi-Hashiani, A, Almasri, N, Altirkawi, K, Abdeldayem Amer, Y, Andrei, C, Ansari-Moghaddam, A, T Antonio, C, Anvari, D, Yaw Appiah, S, Arabloo, J, Arab-Zozani, M, Arefi, Z, Aremu, O, Ariani, F, Arora, A, Asaad, M, Ayala Quintanilla, B, Ayano, G, Ayanore, M, Azarian, G, Badawi, A, Badiye, A, Baig, A, Bairwa, M, Bakhtiari, A, Balachandran, A, Banach, M, Banerjee, S, Banik, P, Banstola, A, Barker-Collo, S, Bärnighausen, T, Barzegar, A, Bayati, M, Bazargan-Hejazi, S, Bedi, N, Behzadifar, M, Belete, H, Bennett, D, Bensenor, I, Berhe, K, Bhagavathula, A, Bhardwaj, P, Bhat, A, Bhattacharyya, K, Bhutta, Z, Bibi, S, Bijani, A, Boloor, A, Borges, G, Borschmann, R, Borzì, A, Boufous, S, Braithwaite, D, Briko, N, Brugha, T, Budhathoki, S, Car, J, Cárdenas, R, Carvalho, F, Castaldelli-Maia, J, Castañeda-Orjuela, C, Castelpietra, G, Catalá-López, F, Cerin, E, Chandan, J, Chapman, J, Chattu, V, Chattu, S, Chatziralli, I, Chaudhary, N, Cho, D, Choi, J, Kabir Chowdhury, M, Christopher, D, Chu, D, Cicuttini, F, Coelho, J, Costa, V, Dahlawi, S, Daryani, A, Dávila-Cervantes, C, Leo, D, Demeke, F, Demoz, G, Demsie, D, Deribe, K, Desai, R, Nasab, M, Silva, D, Dibaji Forooshani, Z, Do, H, Doyle, K, Driscoll, T, Dubljanin, E, Adema, B, Eagan, A, Elemineh, D, El-Jaafary, S, El-Khatib, Z, Ellingsen, C, Zaki, M, Eskandarieh, S, Eyawo, O, Faris, P, Faro, A, Farzadfar, F, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Fischer, F, Folayan, M, Fomenkov, A, Foroutan, M, Francis, J, Franklin, R, Fukumoto, T, Geberemariyam, B, Gebremariam, H, Gebremedhin, K, Gebremeskel, L, Gebremeskel, G, Gebremichael, B, Gedefaw, G, Geta, B, Getenet, A, Ghafourifard, M, Ghamari, F, Gheshlagh, R, Gholamian, A, Gilani, S, Gill, T, Goudarzian, A, Goulart, A, Grada, A, Grivna, M, Guimarães, R, Guo, Y, Gupta, G, Haagsma, J, Hall, B, Hamadeh, R, Hamidi, S, Handiso, D, Haro, J, Hasanzadeh, A, Hassan, S, Hassanipour, S, Hassankhani, H, Hassen, H, Havmoeller, R, Hendrie, D, Heydarpour, F, Híjar, M, Ho, H, Hoang, C, Hole, M, Holla, R, Hossain, N, Hosseinzadeh, M, Hostiuc, S, Hu, G, Ibitoye, S, Ilesanmi, O, Inbaraj, L, Naghibi Irvani, S, Mofizul Islam, M, Shariful Islam, S, Ivers, R, Jahani, M, Jakovljevic, M, Jalilian, F, Jayaraman, S, Jayatilleke, A, Jha, R, John-Akinola, Y, Jonas, J, Jones, K, Joseph, N, Joukar, F, Jozwiak, J, Jungari, S, Jürisson, M, Kabir, A, Kahsay, A, Kalankesh, L, Kalhor, R, Kamil, T, Kanchan, T, Kapoor, N, Karami, M, Kasaeian, A, Kassaye, H, Kavetskyy, T, Kayode, G, Keiyoro, P, Kelbore, A, Khader, Y, Khafaie, M, Khalid, N, Khalil, I, Khalilov, R, Khan, M, Khan, E, Khan, J, Khanna, T, Khazaei, S, Khazaie, H, Khundkar, R, Kiirithio, D, Kim, Y, Kim, D, Kisa, S, Kisa, A, Komaki, H, Kondlahalli, S, Koolivand, A, Korshunov, V, Koyanagi, A, Kraemer, M, Krishan, K, Defo, B, Bicer, B, Kugbey, N, Kumar, N, Kumar, M, Kumar, V, Kumaresh, G, Lami, F, Lansingh, V, Lasrado, S, Latifi, A, Lauriola, P, Vecchia, C, Leasher, J, Huey Lee, S, Li, S, Liu, X, Lopez, A, Lotufo, P, Lyons, R, Machado, D, Madadin, M, Abd El Razek, M, Mahotra, N, Majdan, M, Majeed, A, Maled, V, Malta, D, Manafi, N, Manafi, A, Manda, A, Manjunatha, N, Mansour-Ghanaei, F, Mansournia, M, Maravilla, J, Mason-Jones, A, Masoumi, S, Massenburg, B, Maulik, P, Mehndiratta, M, Melketsedik, Z, Memiah, P, Mendoza, W, Menezes, R, Mengesha, M, Meretoja, T, Meretoja, A, Merie, H, Mestrovic, T, Miazgowski, B, Miazgowski, T, Miller, T, Mini, G, Mirica, A, Mirrakhimov, E, Mirzaei-Alavijeh, M, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Mohammad, Y, Darwesh, A, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, S, Mohammed, J, Mohebi, F, Mohseni Bandpei, M, Molokhia, M, Monasta, L, Moodley, Y, Moradi, M, Moradi, G, Moradi-Lakeh, M, Moradzadeh, R, Morawska, L, Velásquez, I, Morrison, S, Mossie, T, Muluneh, A, Musa, K, Mustafa, G, Naderi, M, Nagarajan, A, Naik, G, Naimzada, M, Najafi, F, Nangia, V, Nascimento, B, Naserbakht, M, Nayak, V, Nazari, J, Ndwandwe, D, Negoi, I, Ngunjiri, J, Nguyen, T, Nguyen, C, Nguyen, D, Thi Nguyen, H, Nikbakhsh, R, Anggraini Ningrum, D, Nnaji, C, Ofori-Asenso, R, Ogbo, F, Oghenetega, O, Oh, I, Olagunju, A, Olagunju, T, Bali, A, Onwujekwe, O, Orpana, H, Ota, E, Otstavnov, N, Otstavnov, S, P A, M, Padubidri, J, Pakhale, S, Pakshir, K, Panda-Jonas, S, Park, E, Patel, S, Pathak, A, Pati, S, Paulos, K, Peden, A, Filipino Pepito, V, Pereira, J, Phillips, M, Polibin, R, Polinder, S, Pourmalek, F, Pourshams, A, Poustchi, H, Prakash, S, Angga Pribadi, D, Puri, P, Syed, Z, Rabiee, N, Rabiee, M, Radfar, A, Rafay, A, Rafiee, A, Rafiei, A, Rahim, F, Rahimi, S, Rahman, M, Rajabpour-Sanati, A, Rajati, F, Rakovac, I, Rao, S, Rashedi, V, Rastogi, P, Rathi, P, Rawaf, S, Rawal, L, Rawassizadeh, R, Renjith, V, Resnikoff, S, Rezapour, A, Ribeiro, A, Rickard, J, Rios González, C, Roever, L, Ronfani, L, Roshandel, G, Saddik, B, Safarpour, H, Safdarian, M, Mohammad Sajadi, S, Salamati, P, Rashad Salem, M, Salem, H, Salz, I, Samy, A, Sanabria, J, Riera, L, Santric Milicevic, M, Sarker, A, Sarveazad, A, Sathian, B, Sawhney, M, Sayyah, M, Schwebel, D, Seedat, S, Senthilkumaran, S, Seyedmousavi, S, Sha, F, Shaahmadi, F, Shahabi, S, Shaikh, M, Shams-Beyranvand, M, Sheikh, A, Shigematsu, M, Shin, J, Shiri, R, Siabani, S, Sigfusdottir, I, Singh, J, Singh, P, Sinha, D, Soheili, A, Soriano, J, Sorrie, M, Soyiri, I, Stokes, M, Sufiyan, M, Sykes, B, Tabarés-Seisdedos, R, Tabb, K, Taddele, B, Tefera, Y, Tehrani-Banihashemi, A, Tekulu, G, Tesema Tesema, A, Tesfay, B, Thapar, R, Titova, M, Tlaye, K, Tohidinik, H, Topor-Madry, R, Tran, K, Tran, B, Tripathy, J, Tsai, A, Tsatsakis, A, Car, L, Ullah, I, Ullah, S, Unnikrishnan, B, Upadhyay, E, Uthman, O, Valdez, P, Vasankari, T, Veisani, Y, Venketasubramanian, N, Violante, F, Vlassov, V, Waheed, Y, Wang, Y, Wiangkham, T, Wolde, H, Woldeyes, D, Wondmeneh, T, Wondmieneh, A, Wu, A, Wyper, G, Yadav, R, Yadollahpour, A, Yano, Y, Yaya, S, Yazdi-Feyzabadi, V, Ye, P, Yip, P, Yisma, E, Yonemoto, N, Yoon, S, Youm, Y, Younis, M, Yousefi, Z, Yu, C, Yu, Y, Moghadam, T, Zaidi, Z, Zaman, S, Zamani, M, Zandian, H, Zarei, F, Zhang, Z, Zhang, Y, Ziapour, A, Zodpey, S, Dandona, R, Dharmaratne, S, Hay, S, Mokdad, A, Pigott, D, Reiner, R, Vos, T, James, S.L., Castle, C.D., Dingels, Z.V., Fox, J.T., Hamilton, E.B., Liu, Z., Roberts, N.L.S., Sylte, D.O., Bertolacci, G.J., Cunningham, M., Henry, N.J., Legrand, K.E., Abdelalim, A., Abdollahpour, I., Abdulkader, R.S., Abedi, A., Abegaz, K.H., Abosetugn, A.E., Abushouk, A.I., Adebayo, O.M., Adsuar, J.C., Advani, S.M., Agudelo-Botero, M., Ahmad, T., Ahmed, M.B., Ahmed, R., Aichour, M.T.E., Alahdab, F., Alanezi, F.M., Alema, N.M., Alemu, B.W., Alghnam, S.A., Ali, B.A., Ali, S., Alinia, C., Alipour, V., Aljunid, S.M., Almasi-Hashiani, A., Almasri, N.A., Altirkawi, K., Amer, Y.S.A., Andrei, C.L., Ansari-Moghaddam, A., Antonio, C.A.T., Anvari, D., Appiah, S.C.Y., Arabloo, J., Arab-Zozani, M., Arefi, Z., Aremu, O., Ariani, F., Arora, A., Asaad, M., Quintanilla, B.P.A., Ayano, G., Ayanore, M.A., Azarian, G., Badawi, A., Badiye, A.D., Baig, A.A., Bairwa, M., Bakhtiari, A., Balachandran, A., Banach, M., Banerjee, S.K., Banik, P.C., Banstola, A., Barker-Collo, S.L., Bärnighausen, T.W., Barzegar, A., Bayati, M., Bazargan-Hejazi, S., Bedi, N., Behzadifar, M., Belete, H., Bennett, D.A., Bensenor, I.M., Berhe, K., Bhagavathula, A.S., Bhardwaj, P., Bhat, A.G., Bhattacharyya, K., Bhutta, Z.A., Bibi, S., Bijani, A., Boloor, A., Borges, G., Borschmann, R., Borzì, A.M., Boufous, S., Braithwaite, D., Briko, N.I., Brugha, T., Budhathoki, S.S., Car, J., Cárdenas, R., Carvalho, F., Castaldelli-Maia, J.M., Castañeda-Orjuela, C.A., Castelpietra, G., Catalá-López, F., Cerin, E., Chandan, J.S., Chapman, J.R., Chattu, V.K., Chattu, S.K., Chatziralli, I., Chaudhary, N., Cho, D.Y., Choi, J.-Y.J., Chowdhury, M.A.K., Christopher, D.J., Chu, D.-T., Cicuttini, F.M., Coelho, J.M., Costa, V.M., Dahlawi, S.M.A., Daryani, A., Dávila-Cervantes, C.A., De Leo, D., Demeke, F.M., Demoz, G.T., Demsie, D.G., Deribe, K., Desai, R., Nasab, M.D., Da Silva, D.D., Forooshani, Z.S.D., Do, H.T., Doyle, K.E., Driscoll, T.R., Dubljanin, E., Adema, B.D., Eagan, A.W., Elemineh, D.A., El-Jaafary, S.I., El-Khatib, Z., Ellingsen, C.L., El Sayedzaki, M., Eskandarieh, S., Eyawo, O., Faris, P.S., Faro, A., Farzadfar, F., Fereshtehnejad, S.-M., Fernandes, E., Ferrara, P., Fischer, F., Folayan, M.O., Fomenkov, A.A., Foroutan, M., Francis, J.M., Franklin, R.C., Fukumoto, T., Geberemariyam, B.S., Gebremariam, H., Gebremedhin, K.B., Gebremeskel, L.G., Gebremeskel, G.G., Gebremichael, B., Gedefaw, G.A., Geta, B., Getenet, A.B., Ghafourifard, M., Ghamari, F., Gheshlagh, R.G., Gholamian, A., Gilani, S.A., Gill, T.K., Goudarzian, A.H., Goulart, A.C., Grada, A., Grivna, M., Guimarães, R.A., Guo, Y., Gupta, G., Haagsma, J.A., Hall, B.J., Hamadeh, R.R., Hamidi, S., Handiso, D.W., Haro, J.M., Hasanzadeh, A., Hassan, S., Hassanipour, S., Hassankhani, H., Hassen, H.Y., Havmoeller, R., Hendrie, D., Heydarpour, F., Híjar, M., Ho, H.C., Hoang, C.L., Hole, M.K., Holla, R., Hossain, N., Hosseinzadeh, M., Hostiuc, S., Hu, G., Ibitoye, S.E., Ilesanmi, O.S., Inbaraj, L.R., Irvani, S.S.N., Islam, M.M., Islam, S.M.S., Ivers, R.Q., Jahani, M.A., Jakovljevic, M., Jalilian, F., Jayaraman, S., Jayatilleke, A.U., Jha, R.P., John-Akinola, Y.O., Jonas, J.B., Jones, K.M., Joseph, N., Joukar, F., Jozwiak, J.J., Jungari, S.B., Jürisson, M., Kabir, A., Kahsay, A., Kalankesh, L.R., Kalhor, R., Kamil, T.A., Kanchan, T., Kapoor, N., Karami, M., Kasaeian, A., Kassaye, H.G., Kavetskyy, T., Kayode, G.A., Keiyoro, P.N., Kelbore, A.G., Khader, Y.S., Khafaie, M.A., Khalid, N., Khalil, I.A., Khalilov, R., Khan, M., Khan, E.A., Khan, J., Khanna, T., Khazaei, S., Khazaie, H., Khundkar, R., Kiirithio, D.N., Kim, Y.-E., Kim, Y.J., Kim, D., Kisa, S., Kisa, A., Komaki, H., Kondlahalli, S.K.M., Koolivand, A., Korshunov, V.A., Koyanagi, A., Kraemer, M.U.G., Krishan, K., Defo, B.K., Bicer, B.K., Kugbey, N., Kumar, N., Kumar, M., Kumar, V., Kumar, N., Kumaresh, G., Lami, F.H., Lansingh, V.C., Lasrado, S., Latifi, A., Lauriola, P., Vecchia, C.L., Leasher, J.L., Lee, S.W.H., Li, S., Liu, X., Lopez, A.D., Lotufo, P.A., Lyons, R.A., Machado, D.B., Madadin, M., Abd El Razek, M.M., Mahotra, N.B., Majdan, M., Majeed, A., Maled, V., Malta, D.C., Manafi, N., Manafi, A., Manda, A.-L., Manjunatha, N., Mansour-Ghanaei, F., Mansournia, M.A., Maravilla, J.C., Mason-Jones, A.J., Masoumi, S.Z., Massenburg, B.B., Maulik, P.K., Mehndiratta, M.M., Melketsedik, Z.A., Memiah, P.T.N., Mendoza, W., Menezes, R.G., Mengesha, M.M., Meretoja, T.J., Meretoja, A., Merie, H.E., Mestrovic, T., Miazgowski, B., Miazgowski, T., Miller, T.R., Mini, G.K., Mirica, A., Mirrakhimov, E.M., Mirzaei-Alavijeh, M., Mithra, P., Moazen, B., Moghadaszadeh, M., Mohamadi, E., Mohammad, Y., Darwesh, A.M., Mohammadian-Hafshejani, A., Mohammadpourhodki, R., Mohammed, S., Mohammed, J.A., Mohebi, F., Bandpei, M.A.M., Molokhia, M., Monasta, L., Moodley, Y., Moradi, M., Moradi, G., Moradi-Lakeh, M., Moradzadeh, R., Morawska, L., Velásquez, I.M., Morrison, S.D., Mossie, T.B., Muluneh, A.G., Musa, K.I., Mustafa, G., Naderi, M., Nagarajan, A.J., Naik, G., Naimzada, M.D., Najaf, F., Nangia, V., Nascimento, B.R., Naserbakht, M., Nayak, V., Nazari, J., Ndwandwe, D.E., Negoi, I., Ngunjiri, J.W., Nguyen, T.H., Nguyen, C.T., Nguyen, D.N., Nguyen, H.L.T., Nikbakhsh, R., Ningrum, D.N.A., Nnaji, C.A., Ofori-Asenso, R., Ogbo, F.A., Oghenetega, O.B., Oh, I.-H., Olagunju, A.T., Olagunju, T.O., Bali, A.O., Onwujekwe, O.E., Orpana, H.M., Ota, E., Otstavnov, N., Otstavnov, S.S., Mahesh, A.P., Padubidri, J.R., Pakhale, S., Pakshir, K., Panda-Jonas, S., Park, E.-K., Patel, S.K., Pathak, A., Pati, S., Paulos, K., Peden, A.E., Pepito, V.C.F., Pereira, J., Phillips, M.R., Polibin, R.V., Polinder, S., Pourmalek, F., Pourshams, A., Poustchi, H., Prakash, S., Pribadi, D.R.A., Puri, P., Syed, Z.Q., Rabiee, N., Rabiee, M., Radfar, A., Rafay, A., Rafee, A., Rafei, A., Rahim, F., Rahimi, S., Rahman, M.A., Rajabpour-Sanati, A., Rajati, F., Rakovac, I., Rao, S.J., Rashedi, V., Rastogi, P., Rathi, P., Rawaf, S., Rawal, L., Rawassizadeh, R., Renjith, V., Resnikoff, S., Rezapour, A., Ribeiro, A.I., Rickard, J., González, C.M.R., Roever, L., Ronfani, L., Roshandel, G., Saddik, B., Safarpour, H., Safdarian, M., Sajadi, S.M., Salamati, P., Salem, M.R.R., Salem, H., Salz, I., Samy, A.M., Sanabria, J., Riera, L.S., Milicevic, M.M.S., Sarker, A.R., Sarveazad, A., Sathian, B., Sawhney, M., Sayyah, M., Schwebel, D.C., Seedat, S., Senthilkumaran, S., Seyedmousavi, S., Sha, F., Shaahmadi, F., Shahabi, S., Shaikh, M.A., Shams-Beyranvand, M., Sheikh, A., Shigematsu, M., Shin, J.I., Shiri, R., Siabani, S., Sigfusdottir, I.D., Singh, J.A., Singh, P.K., Sinha, D.N., Soheili, A., Soriano, J.B., Sorrie, M.B., Soyiri, I.N., Stokes, M.A., Sufiyan, M.B., Sykes, B.L., Tabarés-Seisdedos, R., Tabb, K.M., Taddele, B.W., Tefera, Y.M., Tehrani-Banihashemi, A., Tekulu, G.H., Tesema, A.K.T., Tesfay, B.E., Thapar, R., Titova, M.V., Tlaye, K.G., Tohidinik, H.R., Topor-Madry, R., Tran, K.B., Tran, B.X., Tripathy, J.P., Tsai, A.C., Tsatsakis, A., Car, L.T., Ullah, I., Ullah, S., Unnikrishnan, B., Upadhyay, E., Uthman, O.A., Valdez, P.R., Vasankari, T.J., Veisani, Y., Venketasubramanian, N., Violante, F.S., Vlassov, V., Waheed, Y., Wang, Y.-P., Wiangkham, T., Wolde, H.F., Woldeyes, D.H., Wondmeneh, T.G., Wondmieneh, A.B., Wu, A.-M., Wyper, G.M.A., Yadav, R., Yadollahpour, A., Yano, Y., Yaya, S., Yazdi-Feyzabadi, V., Ye, P., Yip, P., Yisma, E., Yonemoto, N., Yoon, S.-J., Youm, Y., Younis, M.Z., Yousef, Z., Yu, C., Yu, Y., Moghadam, T.Z., Zaidi, Z., Zaman, S.B., Zamani, M., Zandian, H., Zarei, F., Zhang, Z.-J., Zhang, Y., Ziapour, A., Zodpey, S., Dandona, R., Dharmaratne, S.D., Hay, S.I., Mokdad, A.H., Pigott, D.M., Reiner, R.C., Vos, T., Instituto de Saúde Pública da Universidade do Porto, James, Spencer L, Castle, Chris D, Dingels, Zachary V, Fox, Jack T, Adema, Bereket Duko, Yisma, Engida, Vos, Theo, and Public Health

Subjects
Male, Populations/contexts, 1106 Human Movement and Sports Sciences, Global injuries, population, 030204 cardiovascular system & hematology, Global Health, contexts, context, Global Burden of Disease, 0302 clinical medicine, Quality-Adjusted Life Year, Global health, 030212 general & internal medicine, Original Research, Data, populations/contexts, Incidence (epidemiology), Incidence, methodology, 3142 Public health care science, environmental and occupational health, Female, Public Health, TERRITORIES, Quality-Adjusted Life Years, descriptive epidemiology, Human, Disabilities, 195 COUNTRIES, statistical issue, 1117 Public Health and Health Services, 03 medical and health sciences, AGE, Life Expectancy, Environmental health, Injury prevention, SYSTEMATIC ANALYSIS, statistical issues, Humans, Mortality, Estimation, SEX-SPECIFIC MORTALITY, DISABILITY, Public Health, Environmental and Occupational Health, populations, Morbidity, Wounds and Injuries, 1106 Human Movement and Sports Sciences, 1117 Public Health and Health Services, 1701 Psychology, Quality-adjusted life year, Years of potential life lost, 1701 Psychology, Life expectancy, Estimates, Human medicine, populations/context
Abstract

Background. While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods. In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. Results. GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. Conclusions. GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future. Seyed Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. Alaa Badawi acknowledges support by the Public Health Agency of Canada. Till Bärnighausen acknowledges support by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. Traolach Brugha received support from NatCen Social Research (http://natcen.ac.uk/) via NHS Digital and Department of Health and Social Care London, for the Adult Psychiatric Morbidity Survey (APMS) programme. Felix Carvalho received support from UID/MULTI/04378/2019 with funding from FCT/MCTES through national funds. Vera M Costa acknowledges support from grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006. Kebede Deribe is supported by a grant from the Wellcome Trust [grant number 201900] as part of his International Intermediate Fellowship. Tim Driscoll acknowledges that work on occupational risk factors was partially supported by funds from the World Health Organization. Eduarda Fernandes acknowledges support from UID/QUI/50006/2019 with funding from FCT/MCTES through national funds. Yuming Guo acknowledges support from Career Development Fellowships of the Australian National Health and Medical Research Council (numbers APP1107107 and APP1163693). Sheikh Mohammed Shariful Islam is funded by a Fellowship from National Heart Foundation of Australia and Institute for Physical Activity and Nutrition, Deakin University. Mihajlo Jakovljevic acknowledges support by the Ministry of Education Science and Technological Development of the Republic of Serbia through the Grant number OI175014; publication of results was not contingent upon Ministry's censorship or approval. Sudha Jayaraman acknowledges support from: NIH R21: 1R21TW010439-01A1 (PI); Rotary Foundation Global Grant #GG1749568 (PI); NIH P20: 1P20CA210284-01A1 (Co-PI) and DOD grant W81XWH-16-2-0040 (Co-I), during the period of this study. Yun Jin Kim acknowledges support from a grant from the Research Management Centre, Xiamen University Malaysia [grant number: XMUMRF/2018-C2/ITCM/0001]. Kewal Krishan is supported by UGC Centre of Advanced Study (CAS II) awarded to the Department of Anthropology, Panjab University, Chandigarh, India. Mansai Kumar acknowledges support from FIC/ NIH K43 1K43MH114320-01. Amanda Mason-Jones acknowledges support by the University of York. Mariam Molokhia is supported by the National Institute for Health Research Biomedical Research Center at Guy’s and St Thomas’s National Health Service Foundation Trust and King’s College London. Ilais Moreno Velasquez is supported by the Sistema Nacional de Investigación (SNI, Senacyt, Panama). Mukhammad David Naimzada acknowledges support from Government of the Russian Federation (Agreement No – 075-02-2019-967). Duduzile Ndwandwe acknowledges support from Cochrane South Africa, South African Medical Research Council. Stanislav S. Otstavnov acknowledges the support from the Government of the Russian Federation (Agreement No – 075-02-2019-967). Ashish Pathak acknowledges support from Indian Council of Medical Research (ICMR), New Delhi, India (Grant number 2013-1253). Michael R Phillips acknowledges support in part by a grant from the National Natural Science Foundation of China (No.81761128031). Abdallah M. Samy received a fellowship from the Egyptian Fulbright Mission Program. Milena Santric Milicevic acknowledges the support from the Ministry of Education, Science and Technological Development, Republic of Serbia (Contract No. 175087). Seyedmojtaba Seyedmousavi was supported by the Intramural Research Program of the National Institutes of Health, Clinical Center, Department of Laboratory Medicine, Bethesda, MD, USA. Rafael Tabarés-Seisdedos was supported in part by the national grant PI17/00719 from ISCIII-FEDER. Sojib Bin Zaman acknowledges support from an "Australian Government Research Training Program (RTP) Scholarship.

Published
2020

33. Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1

Author

Xuehui Guo, Bo Feng, Ai-Min Ren, Jia Li, Gao Lixin, Wen-Long Wang, Chun Zhang, Yu-Bo Zhou, Xue Yan, and Yitao Sun

Subjects
chemistry.chemical_classification, Fluorescence-lifetime imaging microscopy, biology, Molecular Structure, Chemistry, Protein Tyrosine Phosphatase, Non-Receptor Type 6, General Physics and Astronomy, Quantum yield, Protein tyrosine phosphatase, biology.organism_classification, Fluorescence, HeLa, Enzyme, Thiadiazoles, Biophysics, Molecule, Humans, Physical and Theoretical Chemistry, Enzyme Inhibitors, Density Functional Theory, Proto-oncogene tyrosine-protein kinase Src, HeLa Cells
Abstract

As one member of PTPs, Src homology-2 domain-containing protein tyrosine phosphatase 1 (SHP1) is mainly restricted to hematopoietic and epithelial cells and widely accepted as a convergent node for oncogenic cell-signaling cascades. Developing efficient methods for rapidly tracing and inhibiting the SHP1 activity in complex biological systems is of considerable significance for advancing the integration of diagnosis and treatment of related disease. On this goal, we designed and synthesized five 2-phenyl-1,3,4-thiadiazole derivatives (PT2, PT5, PT8, PT9 and PT10) here basing on the reported SHP1 inhibitors (PT1, PT3, PT4, PT6 and PT7) with planarity structure. The photophysical properties and inhibitory activities of these 2-phenyl-1,3,4-thiadiazole derivatives (PT1 ‒ PT10) for SHP1 were thoroughly studied from theoretical aspect and experimental application. The representative compound PT10 exhibited the larger quantum yield than the other molecules because of smaller geometric relaxation and reorganization energy of the excited state, which was consistent with the results from the fluorescence experiments in organic solvent. In addition, PT10 showed selectively fluorescence response for SHP1 activity and low-cytotoxicity on Hela cells. Lastly, it indicated the potential application in two-photon cell fluorescence imaging in the future according to the calculated excellent two-photon absorption properties. In this contribution, we offered the fluorescent and activated molecule PT10 against SHP1 firstly, which achieved the integration of visualization and inhibitory activity of SHP1 preliminarily in enzyme molecular level.

Published
2021

34. Ethnicity evaluation of ferric pyrophosphate citrate among Asian and Non-Asian populations: a population pharmacokinetics analysis

Author

Lingxiao Zhang, Liangying Gan, Kexin Li, Panpan Xie, Yan Tan, Gang Wei, Xiaojuan Yuan, Raymond Pratt, Yongchun Zhou, Ai-Min Hui, Yi Fang, Li Zuo, and Qingshan Zheng

Subjects
Pharmacology, Diphosphates, Dialysis Solutions, Iron, Ethnicity, Hematinics, Humans, Kidney Failure, Chronic, Reproducibility of Results, Pharmacology (medical), General Medicine, Citrates
Abstract

Purpose To evaluate the potential ethnic differences of ferric pyrophosphate citrate (FPC, Triferic) in healthy subjects and patients with hemodialysis-dependent stage 5 chronic kidney disease (CKD-5HD) and identify covariates that may influence pharmacokinetics (PK) of FPC. Methods Data were collected from 2 Asian and 4 non-Asian clinical studies involving healthy subjects and CKD-5HD patients. Three population PK models were developed: M1 for intravenous (IV) administration of FPC in healthy subjects; M2 for dialysate administration of FPC in CKD-5HD patients; M3 for pre-dialyzer administration of FPC in CKD-5HD patients. All the models were fitted to concentration versus time data of FPC using the nonlinear mixed effect approach with the NONMEM® program. All statistical analyses were performed using SAS version 9.4. Results In total, 26 Asians and 65 non-Asians were included in the final model analysis database. Forty healthy subjects were administered FPC via intravenous (IV) route and 51 patients with CKD-5HD via dialysate (N = 50) and pre-dialyzer blood circuit administration (N = 51). The PK parameters of FPC IV were similar. The population PK model showed good parameter precision and reliability as shown by model evaluation, and no relevant influence of ethnicity on PK parameters was observed. In healthy subjects, the maximum observed plasma concentration (Cmax) and area under the plasma concentration–time curve (AUC) decreased with increase in lean body mass (LBM) and the average serum total iron at 6 h before the baseline period (Feav), whereas, in both patient populations, Cmax and AUC decreased with increase in LBM and decrease in Febaseline. Other factors such as gender, age, Feav, and ethnicity had no influence on PK exposures in patients. The influence of LBM on PK exposures in patients was smaller than that in healthy subjects (ratio of AUC0-24 for the 5th [68 kg] and 95th [45 kg] patient’s LBM was almost 1). The influence of Feav and LBM on PK exposures was Conclusion The population pharmacokinetics model successfully described the PK parameters of FPC in healthy subjects and CKD-5HD patients and were comparable between Asian and non-Asian populations.

Published
2021

35. [Mechanism of Liangfu Dropping Pills in treatment of gastrointestinal diseases based on plasma pharmacochemistry and network pharmacology]

Author

Chang-Li, Fu, Chun-Hua, Liu, Jie, Pan, Yuan, Lu, Jia, Sun, Yong-Jun, Li, and Ai-Min, Wang

Subjects
Molecular Docking Simulation, Gastrointestinal Diseases, Humans, Drugs, Chinese Herbal, Signal Transduction
Abstract

To study the active chemical components and mechanism of Liangfu Dropping Pills in treatment of gastrointestinal diseases. The UHPLC-Q-TOF-MS method was employed to analyze the components of Liangfu Dropping Pills in plasma. The protein targets of the absorbed compounds were predicted in the TCMSP database and the SwissTargetPrediction database. The targets associated with gastrointestinal diseases were collected from OMIM, CTD, GeneCards, and DrugBank. The common target genes between components and diseases were screened out for the building of protein-protein interaction(PPI) network in the STRING database. Metascape was used to carry out gene ontology(GO) and Kyoto encyclopedia of genes and genomes(KEGG) pathway enrichment analysis. Cytoscape was employed to construct the PPI network diagram and absorbed component-target network diagram. The molecular docking between the components absorbed in blood and potential key targets was performed by AutoDock vina 4.2.6 to screen and verify the main active components and targets. Twelve chemcial components were identified in Liangfu Dropping Pills, in which four components were absorbed in blood, including galangin, rhamnocitrin, galangin 3-methyl ether, and α-cyperone. These components acted on 189 common targets which were mainly involved in the cell responses to nitrogen compounds, organic cyclic compounds, and hormones, and enriched in the PI3 K-Akt signaling pathway, Foxo signaling pathway, and IL-17 signaling pathway. Molecular docking results showed that the four components had strong affinity with core targets. The material basis of Liangfu Dropping Pills treating gastrointestinal diseases may be galangin, rhamnocitrin, galangin 3-methyl ether, and α-cyperone. This study provides a theoretical basis for further development and application of Liangfu Dripping Pills.

Published
2021

36. c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression

Author

Wen-die Wang, Yue Shang, Chen Wang, Jun Ni, Ai-min Wang, Gao-jie Li, Ling Su, and Shu-zhen Chen

Subjects
Pharmacology, Lung Neoplasms, Forkhead Box Protein M1, CASP8 and FADD-Like Apoptosis Regulating Protein, Drug Resistance, Forkhead Transcription Factors, General Medicine, Thiostrepton, Gene Expression Regulation, Neoplastic, Mice, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Humans, Animals, Pharmacology (medical), Cell Proliferation
Abstract

The forkhead box M1 (FoxM1) protein, a transcription factor, plays critical roles in regulating tumor growth and drug resistance, while cellular FLICE-inhibitory protein (c-FLIP), an anti-apoptotic regulator, is involved in the ubiquitin-proteasome pathway. In this study, we investigated the effects of c-FLIP on the expression and ubiquitination levels of FoxM1 along with drug susceptibility in non-small-cell lung cancer (NSCLC) cells. We first showed that the expression levels of FoxM1 and c-FLIP were increased and positively correlated (R

Published
2021

37. Theoretical Study of a Two-Photon Fluorescent Probe Based on Nile Red Derivatives with Controllable Fluorescence Wavelength and Water Solubility

Author

Jing-Fu Guo, Li-Ying Yu, Li-Bo Yu, Ai-Min Ren, Wei-bo Cui, Xue-hui Guo, Ze-xing Qu, Xue Wei, Teng-Fei He, and Xue-Li Hao

Subjects
Aqueous solution, General Chemical Engineering, Nile red, Quantum yield, Chemical modification, Water, General Chemistry, Library and Information Sciences, Models, Theoretical, Fluorescence, Computer Science Applications, chemistry.chemical_compound, chemistry, Two-photon excitation microscopy, Solubility, Oxazines, Biophysics, Humans, Absorption (electromagnetic radiation), Fluorescent Dyes
Abstract

Hypochloric acid (HOCl) plays a vital role in the natural defense system, but abnormal levels of it can cause cell damage, accelerated human aging, and various diseases. It is of great significance to develop new probes for detecting HOCl in biosystems nondestructively and noninvasively. The purpose of this work is to explore new chemical modification strategies of two-photon excitation fluorescence (TPEF) probes to improve the poor water solubility and low efficiency in imaging applications. Nil-OH-6 has a two-photon absorption cross-section value as high as 243 GM and attains a good quantum yield of 0.49. In addition, the modification of terminal groups with different azetidine-heterospirocycles or N,N-dialkyl fused amino groups to Nile Red can effectively improve the fluorescence efficiency as well as increase the solubility to some extent. This study provides some strategies to simultaneously improve the fluorescence performance and solubility of these two-photon probes and, hence, reliable guidance and a foundation for the subsequent synthesis of TPEF probes based on Nile Red.

Published
2021

38. Elevated lipoprotein(a) and genetic polymorphisms in the LPA gene may predict cardiovascular events

Author

Jun-Xu Gu, Juan Huang, Shan-Shan Li, Li-Hua Zhou, Ming Yang, Yang Li, Ai-Min Zhang, Yue Yin, Na Zhang, Mei Jia, and Ming Su

Subjects
Multidisciplinary, Risk Factors, Humans, Coronary Disease, Polymorphism, Single Nucleotide, Lipoprotein(a)
Abstract

Elevated lipoprotein(a) [Lp(a)] is a risk factor for coronary heart disease (CHD), but there are few studies on the prediction of future cardiovascular events by Lp(a) and its LPA single nucleotide polymorphisms (SNPs). The aim of this study was to investigate whether elevated Lp(a) and its SNPs can predict cardiovascular events. We evaluated whether Lp(a) and LPA SNPs rs6415084 and rs12194138 were associated with the incidence rate and severity of CHD. All participants were followed up for 5 years. Elevated Lp(a) is an independent risk factor for the risk and severity of CHD (CHD group vs. control group: OR = 1.793, 95% CI: 1.053–2.882, p = 0.043; multiple-vessel disease group vs. single-vessel disease group: OR = 1.941, 95% CI: 1.113–3.242, p = 0.027; high GS group vs. low GS group: OR = 2.641, 95% CI: 1.102–7.436, p = 0.040). Both LPA SNPs were risk factors for CHD, and were positively associated with the severity of CHD (LPA SNPs rs6415084: CHD group vs. control group: OR = 1.577, 95% CI: 1.105–1.989, p = 0.004; multiple-vessel disease group vs. single-vessel disease group: OR = 1.613, 95% CI: 1.076–2.641, p = 0.030; high GS group vs. low GS group: OR = 1.580, 95% CI: 1.088–2.429, p = 0.024; LPA SNPs rs12194138: CHD group vs. control group: OR = 1.475, 95% CI: 1.040–3.002, p = 0.035; multiple-vessel disease group vs. single-vessel disease group: OR = 2.274, 95% CI: 1.060–5.148, p = 0.038; high GS group vs. low GS group: OR = 2.067, 95% CI: 1.101–4.647, p = 0.021). After 5 years of follow-up, elevated Lp(a) and LPA SNPs rs6415084 and rs12194138 can independently predict cardiovascular events. The increase of serum Lp(a) and LPA SNPs rs6415084 and rs12194138 are associated with increased prevalence and severity of CHD, and can independently predict cardiovascular events.

Published
2021

39. Distribution and identification of Mycobacterium tuberculosis lineage in Kashgar prefecture

Author

Su-Jie Zhang, AniKiz Abuduaini, Xiao-Guang Zou, Aihemaitijiang Kaisaier, Ya-Hui Zhen, Li Li, Ai-Min Xu, Zureguli Tuerxun, Jing-Ran Xu, Yin-Zhong Sha, Hong-Mei Peng, Xiang Chen, and Chuan-Jiang He

Subjects
Lineage (genetic), Genotype, Mycobacterium tuberculosis, Biology, Tuberculosis, Lymph Node, biology.organism_classification, Infectious Diseases, Evolutionary biology, Distribution (pharmacology), Humans, Identification (biology), Pakistan, Phylogeny
Abstract

Objectives Kashgar prefecture is an important transportation and trade hub with a high incidence of tuberculosis. The following study analyzed the composition and differences in Mycobacterium tuberculosis (M.tb) lineage and specific tags to distinguish the lineage of the M.tb in Kashgar prefecture, thus providing a basis for the classification and diagnosis of tuberculosis in this area. Methods Whole-genome sequencing (WGS) of 161 M.tb clinical strains was performed. The phylogenetic tree was constructed using Maximum Likelihood (ML) based on single nucleotide polymorphisms (SNPs) and verified through principal component analysis (PCA). The composition structure of M.tb in different regions was analyzed by combining geographic information. Results M.tb clinical strains were composed of lineage 2 (73/161, 45.34%), lineage 3 (52/161, 32.30%) and lineage 4 (36/161, 22.36%). Moreover, the 3 lineages were subdivided into 11 sublineages, among which lineage 2 included lineage 2.2.2/Asia Ancestral 1 (9/73, 12.33%), lineage 2.2.1-Asia Ancestral 2 (9/73, 12.33%), lineage 2.2.1-Asia Ancestral 3 (18/73, 24.66%), and lineage 2.2.1-Modern Beijing (39/73, 53.42%). Lineage 3 included lineage 3.2 (14/52, 26.92%) and lineage 3.3 (38/52, 73.08%), while lineage 4 included lineage 4.1 (3/36, 8.33%), lineage 4.2 (2/36, 5.66%), lineage 4.4.2 (1/36, 2.78%), lineage 4.5 (28/36, 77.78%) and lineage 4.8 (2/36, 5.66%), all of which were consistent with the PCA results. One hundred thirty-six markers were proposed for discriminating known circulating strains. Reconstruction of a phylogenetic tree using the 136 SNPs resulted in a tree with the same number of delineated clades. Based on geographical location analysis, the composition of Lineage 2 in Kashgar prefecture (45.34%) was lower compared to other regions in China (54.35%-90.27%), while the composition of Lineage 3 (32.30%) was much higher than in other regions of China (0.92%-2.01%), but lower compared to the bordering Pakistan (70.40%). Conclusion Three lineages were identified in M.tb clinical strains from Kashgar prefecture, with 136 branch-specific SNP. Kashgar borders with countries that have a high incidence of tuberculosis, such as Pakistan and India, which results in a large difference between the M.tb lineage and sublineage distribution in this region and other provinces of China.

Published
2021

40. [Effect of Mobile Health for Standardized Management on Women with Gestational Diabetes Mellitus]

Author

Fei-Ling, Huang, Hui-Ying, Hu, Su-Han, Zhang, Li, Li, Li, Zhang, Xiao-Xia, Chen, Chu-Ci, Zhang, Hong-Xiu, Zhong, Ai-Min, Yao, Cui-Ying, Liu, Ning-Zhi, Zhang, Xiao-Wen, Xue, and Liang-Kun, Ma

Subjects
Diabetes, Gestational, Cesarean Section, Pregnancy, Infant, Newborn, Pregnancy Outcome, Humans, Premature Birth, Female, Telemedicine, Fetal Macrosomia
Abstract

Objective To explore the performance of mobile health platform for standardized management of pregnant women with gestational diabetes mellitus(GDM). Methods A randomized controlled trial was conducted,in which 295 women with GDM were randomized into two groups(traditional management group and mobile health management group)by a computer-generated sequence.The traditional management group accepted standardized GDM management,and the mobile health management group was supplemented by mobile health management based on the standardized management.The glycemic control rate and the incidences of low birth weight,macrosomia,preterm birth,premature rupture of membranes,postpartum hemorrhage after cesarean section,neonatal asphyxia,malformation,and admission to the neonatal intensive care unit were compared between the two groups. Results The glycemic control rate in mobile health management group was significantly higher than that in the traditional management group [(67.22±22.76)%

Published
2021

41. Changes of hypocretin (orexin) system in schizophrenia

Author

Tingting Mou, Rolf Fronczek, Dick F. Swaab, Kangyu Jin, Jinfeng Duan, Haimei Li, Weijuan Xu, Ai-Min Bao, Jing Lu, Jin-Hui Li, Manli Huang, and Netherlands Institute for Neuroscience (NIN)

Subjects
Adult, Male, medicine.medical_specialty, Prefrontal Cortex, superior frontal gyrus, Neurotransmission, cerebrospinal fluid, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Sex Factors, Orexin Receptors, Internal medicine, mental disorders, medicine, Humans, hypothalamus, Receptor, orexin, hypocretin receptor, plasma, Orexins, hypocretin receptor, business.industry, Middle Aged, medicine.disease, 030227 psychiatry, Orexin, schizophrenia, Psychiatry and Mental health, Endocrinology, Superior frontal gyrus, orexin, nervous system, Schizophrenia, Hypothalamus, Female, Autopsy, hypocretin, business, 030217 neurology & neurosurgery, psychological phenomena and processes, Hypocretin orexin, Regular Articles
Abstract

Hypocretin (also called orexin) regulates various functions, such as sleep-wake rhythms, attention, cognition, and energy balance, which show significant changes in schizophrenia (SCZ). We aimed to identify alterations in the hypocretin system in SCZ patients. We measured plasma hypocretin-1 levels in SCZ patients and healthy controls and found significantly decreased plasma hypocretin-1 levels in SCZ patients, which was mainly due to a significant decrease in female SCZ patients compared with female controls. In addition, we measured postmortem hypothalamic hypocretin-1-immunoreactivity (ir), ventricular cerebrospinal fluid (CSF) hypocretin-1 levels, and hypocretin receptor (Hcrt-R) mRNA expression in the superior frontal gyrus (SFG) in SCZ patients and controls We observed a significant decrease in the amount of hypothalamic hypocretin-1 ir in SCZ patients, which was due to decreased amounts in female but not male patients. Moreover, Hcrt-R2 mRNA in the SFG was decreased in female SCZ patients compared with female controls, while male SCZ patients showed a trend of increased Hcrt-R1 mRNA and Hcrt-R2 mRNA expression compared with male controls. We conclude that central hypocretin neurotransmission is decreased in SCZ patients, especially female patients, and this is reflected in the plasma.

Published
2021

43. Training Benefits and Injury Risks of Standing Yoga Applied in Musculoskeletal Problems: Lower Limb Biomechanical Analysis

Author

Hwai-Ting Lin, Hsiu-Tao Hsu, Jing-Min Liang, Wen-Lan Wu, I-Hua Chu, and Ai-Min Liu

Subjects
medicine.medical_specialty, electromyography, Knee Joint, Vastus medialis, Health, Toxicology and Mutagenesis, medicine.medical_treatment, education, Electromyography, Rectus femoris muscle, Article, biomechanics, Quadriceps Muscle, Physical medicine and rehabilitation, Medicine, Humans, Muscle, Skeletal, joint moments, Balance (ability), yoga asana, Rehabilitation, medicine.diagnostic_test, business.industry, Yoga, Public Health, Environmental and Occupational Health, medicine.anatomical_structure, Lower Extremity, Patella, Ankle, business, human activities, Hamstring
Abstract

Standing yoga poses strengthen a person’s legs and helps to achieve the goal of musculoskeletal rehabilitation, but inadequate exercise planning can cause injuries. This study investigated changes in the electromyogram and joint moments of force (JMOFs) of lower extremities during common standing yoga poses in order to explore the feasibility and possible injury risk in dealing with musculoskeletal problems. Eleven yoga instructors were recruited to execute five yoga poses (Chair, Tree, Warrior 1, 2, and 3). The results revealed significant differences in hip, knee, and ankle JMOFs and varying degrees of muscle activation among the poses. Among these poses, rectus femoris muscle activation during the Chair pose was the highest, Warrior 2 produced the highest muscle activation in the vastus lateralis of the front limb, while Warrior 1 had the highest muscle activation in the vastus medialis of the back limb. Therefore, all three poses can possibly be suggested as a therapeutic intervention for quadriceps strengthening. Warrior 1 was possibly suggested as a therapeutic intervention in order to reduce excessive lateral overload of the patella, but the possible adverse effects of Warrior 2 with the highest knee adductor JMOF in the back limb could raise joint reaction forces across the medial condyles. In single-leg balance postures, Warrior 3 had unique training effects on the hamstring, and is therefore suggested as a part of hamstring rehabilitation exercises. The Tree pose induced low lower-extremity JMOFs and a low level of thigh muscle activations when it was performed by senior instructors with excellent balance control, however, for yoga beginners with insufficient stability, it will be a useful training mode for strengthening the muscles that help to keep one upright. This study quantified the physical demands of yoga poses using biomechanical data and elucidated the structures and principles underlying each yoga movement. This is crucial for yoga practitioners.

Published
2021
Full Text
View/download PDF

44. Sexual differentiation of the human hypothalamus: Relationship to gender identity and sexual orientation

Author

Dick F, Swaab, Samantha E C, Wolff, and Ai-Min, Bao

Subjects
Male, Sex Differentiation, Pregnancy, Sexual Behavior, Hypothalamus, Gender Identity, Humans, Female, Transsexualism
Abstract

Gender identity (an individual's perception of being male or female) and sexual orientation (heterosexuality, homosexuality, or bisexuality) are programmed into our brain during early development. During the intrauterine period in the second half of pregnancy, a testosterone surge masculinizes the fetal male brain. If such a testosterone surge does not occur, this will result in a feminine brain. As sexual differentiation of the brain takes place at a much later stage in development than sexual differentiation of the genitals, these two processes can be influenced independently of each other and can result in gender dysphoria. Nature produces a great variability for all aspects of sexual differentiation of the brain. Mechanisms involved in sexual differentiation of the brain include hormones, genetics, epigenetics, endocrine disruptors, immune response, and self-organization. Furthermore, structural and functional differences in the hypothalamus relating to gender dysphoria and sexual orientation are described in this review. All the genetic, postmortem, and in vivo scanning observations support the neurobiological theory about the origin of gender dysphoria, i.e., it is the sizes of brain structures, the neuron numbers, the molecular composition, functions, and connectivity of brain structures that determine our gender identity or sexual orientation. There is no evidence that one's postnatal social environment plays a crucial role in the development of gender identity or sexual orientation.

Published
2021

45. Matching of the postmortem hypothalamus from patients and controls

Author

Dick F, Swaab and Ai-Min, Bao

Subjects
Male, Postmortem Changes, Hypothalamus, Brain, Gender Identity, Humans, Female, Neuropathology, Aged, Netherlands
Abstract

The quality of postmortem hypothalamus research depends strongly on a thorough clinical investigation and documentation of the patient's disorder and therapies. In addition, a systematic and professional neuropathological investigation of the entire brain of both the cases and the controls is absolutely crucial. In the experience of the Netherlands Brain Bank (NBB), about 20% of the clinical neurological diagnoses, despite being made in first rate clinics, have to be revised or require extra diagnoses after a complete and thorough neuropathologic review by the NBB. The neuropathology examination may reveal for instance that the elderly "controls" already have preclinical neurodegenerative alterations. In postmortem studies, the patient and control groups must be matched for as many as possible of the known confounding factors. This is necessary to make the groups as similar as possible, except for the topic being investigated. Confounding factors are present (i) before, (ii) during, and (iii) after death. They are, respectively: (i) genetic background, systemic diseases, duration and gravity of illness, medicines and addictive compounds used, age, sex, gender identity, sexual orientation, clock- and seasonal time of death, and lateralization; (ii) agonal state, stress of dying; and (iii) postmortem delay, freezing procedures, fixation, and storage time. Agonal state is generally estimated by measuring the pH of the brain. However, there are disorders in which pH is lower as a part of the disease process. Because of the large number of potentially confounding factors that differ according to, for instance, brain area and disease, a brain bank should have a large number of controls at its disposal for appropriate matching. If matching fails for some confounders, the influence of the confounders may be determined by statistical methods, such as analysis of variance or the regression models.

Published
2021

46. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Sorin Hostiuc, Shaun Wen Huey Lee, Jorge R. Ledesma, Carsten Flohr, Masoumeh Sadeghi, João Mauricio Castaldelli-Maia, Behzad Karami Matin, Cyrus Alinia, Mehdi Bohluli, Félix Carvalho, Yun Jin Kim, Catalina Liliana Andrei, Seyyed Meysam Mousavi, Bernhard T. Baune, Ehsan Ahmadpour, Dinh-Toi Chu, Beatrix Haddock, Gianfranco Alicandro, Vasily Vlassov, Mohammad Taghi Khodayari, Gianna Gayle Herrera Amul, Arash Tehrani-Banihashemi, Govinda Prasad Dhungana, Fereshteh Ansari, Michael K. Hole, Azeem Majeed, Iman Halvaei, Saqib Ali, Arianna Maever L. Amit, Tomas Y. Yeheyis, John S. Ji, Martin McKee, Jamileh Shadid, Leonardo Roever, Peng Jia, Ettore Beghi, Pablo M. Lavados, Young Eun Kim, Vahid Alipour, Sowmya J. Rao, Ahmad Daryani, Cathleen Keller, Ibrahim Abdollahpour, Nicole K. DeCleene, Ebrahim Babaee, Saman Esmaeilnejad, Boris Bikbov, William M. Gardner, Lydia M. Haile, Luca Ronfani, Azalea M. Thomson, Irena Ilic, Ruth W. Kimokoti, Yingxi Zhao, Guoqing Hu, Mehran Shams-Beyranvand, Ilais Moreno Velásquez, Nathaniel J. Henry, Brijesh Sathian, Daniel Kim, Peter Memiah, Mohammad Hadi Abbasi, Andrea Farioli, Zahra Kamiab, Bolajoko O. Olusanya, Matthew C. Doxey, Tommi Vasankari, Hamideh Salimzadeh, Luisa Sorio Flor, Priya Rathi, Shanshan Li, Tanvir M. Huda, Dillon O Sylte, Rosario Cárdenas, Agegnehu Bante, Helen Ippolito, Alyssa Acebedo, Jeffrey D. Stanaway, Anwar Faraj, João Pedro Silva, Amin Mousavi Khaneghah, Pushpendra Kumar, Sangram Kishor Patel, Josephine W. Ngunjiri, Holly E. Erskine, Eugene Sobngwi, Filippo Ariani, Shane D. Morrison, Mohammad Aghaali, Meghan D. Mooney, Vera Marisa Costa, Palash Chandra Banik, Rupak Desai, Ken Takahashi, Maigeng Zhou, Morteza Oladnabi, Bogdan Oancea, Daniela Ribeiro, Mohammad Farahmand, Irmina Maria Michalek, Yetunde O. John-Akinola, Khem Narayan Pokhrel, Emilie R Maddison, Syed Mohamed Aljunid, Damian G. Hoy, Hosni Salem, V. Prakash, Shuhei Nomura, Inga Dora Sigfusdottir, Anders Larsson, Sharareh Eskandarieh, Abdollah Mohammadian-Hafshejani, Somayeh Bohlouli, Joana Morgado-da-Costa, Siamak Sabour, Theo Vos, Han Yong Wunrow, Khaled Khatab, Alireza Zangeneh, Ann Kristin Knudsen, Marissa B Reitsma, Hannah J. Henrikson, Randah R. Hamadeh, Tuomo J. Meretoja, Ireneous N. Soyiri, Giuseppe Grosso, Ziyad Al-Aly, Taraneh Yousefinezhadi, Joseph L Ward, Roba Khundkar, Ricardo Santiago Gomez, Reza Malekzadeh, John J. McGrath, Sandra B. Munro, Shahin Soltani, Amy E. Peden, Rufus Akinyemi, Marcel Ausloos, Naohiro Yonemoto, Bogdan Wojtyniak, Ahmad Ghashghaee, Guilherme Borges, Sadia Bibi, Farhad Islami, Hamed Mirzaei, Mohammad Ali Sahraian, M. Ashworth Dirac, Hosna Janjani, Kairat Davletov, Hermann Brenner, Yuichiro Yano, Elissa M. Abrams, Ana Vukovic, Bartosz Miazgowski, Jobert Richie Nansseu, Jennifer O Lam, Mona Pathak, Leeberk Raja Inbaraj, Thirunavukkarasu Sathish, Asadollah Gholamian, Carlos A Castañeda-Orjuela, Babak Eshrati, Edgar Denova-Gutiérrez, Atte Meretoja, Lorenzo Monasta, Ronan A. Lyons, Neda Kianipour, Desalegn Getnet Demsie, Yasir Waheed, Desta Debalkie Atnafu, Davide Sattin, Kevin S Ikuta, Ghobad Moradi, Srinivas Goli, Krittika Bhattacharyya, Mika Kivimäki, Christopher Troeger, Jordi Alonso, Alireza Ahmadi, Navid Manafi, Caroline Stein, Songhomitra Panda-Jonas, Jason Nguyen, Moses K. Muriithi, Aziz Rezapour, Ismael R. Campos-Nonato, Adrian Pana, H. Dean Hosgood, Noore Alam, James L. Fisher, Mariam Molokhia, Susan F. Rumisha, Ernoiz Antriyandarti, Ayman Grada, Emma Nichols, Babak Asghari, André Luiz Sena Guimarães, Ferrán Catalá-López, Aletta E. Schutte, Fiona B. Bennitt, Maciej Banach, Antonio Biondi, Donal Bisanzio, Josip Car, Ronny Westerman, Shafiu Mohammed, Biniyam Sahiledengle Geberemariyam, Kenji Shibuya, Meghdad Pirsaheb, Milena Santric-Milicevic, Karen M. Tabb, Paula Moraga, Soheil Hassanipour, Hasan Yusefzadeh, Avina Vongpradith, Dara K. Mohammad, Ralph Maddison, Babak Moazen, Getachew Mullu Kassa, Rahman Shiri, Fernando Neves Hugo, Hmwe H Kyu, Zachary V Dingels, Florian Fischer, Valentin Yurievich Skryabin, Rafael Tabarés-Seisdedos, Massimo Cirillo, Nikita Otstavnov, Robert C. Reiner, Van C. Lansingh, Rodrigo Sarmiento-Suarez, Ashkan Afshin, Benjamin A Stark, Mohsen Abbasi-Kangevari, Natalie C. Galles, Behnam Heidari, Eun-Kee Park, Mohammad Ali Jahani, Suzanne Polinder, Mahalaqua Nazli Khatib, Farhad Jadidi-Niaragh, Amir Radfar, Mowafa Househ, Derrick A Bennett, Gaorui Guo, Hesam Ghiasvand, Taweewat Wiangkham, Tamás Joó, Cristiana Abbafati, Kathryn Mei Ming Lau, Anita K. Nandi, Miklós Szócska, Manasi Kumar, Eduardo A. Undurraga, Oladimeji M. Adebayo, Simon Yadgir, Victor Aboyans, Justin J. Lang, Catherine O. Johnson, Soewarta Kosen, Carla Sofia e.Sá Farinha, Marcos Roberto Tovani-Palone, Kamarul Imran Musa, Farshad Pourmalek, Kiomars Sharafi, Heather Orpana, Samuel B. Albertson, Mahdi Afshari, Nicholas J K Breitborde, Nelson J. Alvis-Zakzuk, Adrian Oţoiu, Iván Landires, Robert G. Weintraub, Kidanemaryam Berhe, André Faro, Sophia Emmons-Bell, Lauren E. Schaeffer, Alexandre C. Pereira, Mehdi Naderi, Yordanos Gizachew Yeshitila, Mehdi Hosseinzadeh, Arash Etemadi, Oleguer Plana-Ripoll, Theodore Patrick Younker, Joemer C. Maravilla, Alireza Ansari-Moghaddam, Borhan Mansouri, Narayanaswamy Venketasubramanian, Seyed Mohammad Kazem Aghamir, Linda Morales, Amanda Deen, Noushin Mohammadifard, Obinna Onwujekwe, Ai Koyanagi, Michele Nguyen, Chieh Han, Kiana Ramezanzadeh, Mika Shigematsu, Mohammed Shannawaz, Khurshid Alam, Javad Nazari, Bryan L. Sykes, Rajat Das Gupta, Stephen S Lim, Lingkan Barua, Zubair Kabir, Michael Brauer, Afarin Rahimi-Movaghar, Deepa Jahagirdar, Kaja Abbas, Gholamreza Bazmandegan, Mark A. Stokes, Rajaa Al-Raddadi, Kanyin L. Ong, Kate Causey, Ahmed Omar Bali, Matilde Leonardi, Jeffrey V. Lazarus, Wondimeneh Shibabaw Shiferaw, André Karch, Blair R. Bumgarner, Nelson Alvis-Guzman, Jennifer H MacLachlan, Saeed Amini, Parvaiz A Koul, Blessing J. Akombi, Ro Ting Lin, Dabere Nigatu, Alaa Badawi, Flavia M. Cicuttini, Deanna Anderlini, Claudio Alberto Dávila-Cervantes, Rupert R A Bourne, Tanuj Kanchan, Catherine P. Benziger, Tahiya Alam, M. Mofizul Islam, Muktar Omer Omer, Leila Zaki, Mehdi Mirzaei-Alavijeh, Inbal Salz, Katharine J Looker, Shiwei Liu, Fatemeh Amiri, Christopher R. Cederroth, Mitra Abbasifard, Hamidreza Pazoki Toroudi, Gbenga A. Kayode, Antonio Luiz Pinho Ribeiro, Krishna Kumar Aryal, Mu'awiyyah Babale Sufiyan, Mohamed M. Gad, Assefa Desalew, Lidia Morawska, Davood Anvari, Mohammad Reza Salahshoor, Hadi Pourjafar, Abdu A. Adamu, Maryam Adabi, Zulfiqar A. Bhutta, Jessica A. Cruz, Foad Abd-Allah, Amir Hasanzadeh, Jordan Weiss, Maryam Ghadimi, Seyed-Mohammad Fereshtehnejad, Serge Resnikoff, Joanna L Whisnant, Kelly Compton, Priya Parmar, Sanjay Basu, Leila R Kalankesh, Nickolas Reinig, Ana Maria Mantilla Herrera, Fatemeh Rajati, Damian Santomauro, Mojisola Oluwasanu, Sheikh Mohammed Shariful Islam, David M. Pereira, Joht Singh Chandan, Deepak Kumar Pasupula, Aristidis Tsatsakis, Hoa Thi Do, Whitney L. Teagle, Hans W. Hoek, James Leigh, Morteza Arab-Zozani, Yasser Vasseghian, Stephanie R M Zimsen, Charlie Ashbaugh, Fariba Dorostkar, Abdelrahman Ibrahim Abushouk, Mikk Jürisson, Golnaz Heidari, Kala M. Mehta, Saeed Shahabi, Sarah Wulf Hanson, Nizal Sarrafzadegan, Dharmesh Kumar Lal, Hai Quang Pham, Aleksandr Y. Aravkin, Joshua A. Salomon, David C. Schwebel, Milena Ilic, Kareha M Agesa, Jost B. Jonas, Dian Kusuma, Benjamin B. Massenburg, Santosh Varughese, Yousef Mohammad, Beatriz Paulina Ayala Quintanilla, Mihaela Hostiuc, Richard G. Cowden, Morteza Shamsizadeh, Thomas Pilgrim, Alessandra C. Goulart, Leila Doshmangir, Gabriele Nagel, Saravanan Muthupandian, Zahra Sadat Dibaji Forooshani, Maryam Mirzaei, Zabihollah Yousefi, Shadrach Wilson, Iman El Sayed, Juanita A. Haagsma, Segun Emmanuel Ibitoye, Eirini Skiadaresi, Reza Shirkoohi, Tim Driscoll, Morteza Jafarinia, Maha El Tantawi, Telma Zahirian Moghadam, Katarzyna Kissimova-Skarbek, Abdilahi Yousuf Yousuf, Dickson A. Amugsi, Awoke Misganaw, Maseer Khan, Norito Kawakami, Jingkai Wei, Jai K Das, Vishnu Renjith, Tessa M. Pilz, Sameer Vali Gopalani, Roghiyeh Faridnia, Islam Y. Elgendy, Prateek Rastogi, Lauren B. Wilner, Josep Maria Haro, Zahiruddin Quazi Syed, Ben Lacey, Ketema Bizuwork Gebremedhin, Sam Rolfe, Iffat Elbarazi, Yannick Béjot, Raimundas Lunevicius, Sezer Kisa, Harish Chander Gugnani, Basema Saddik, Manu Raj Mathur, Mansour Ghafourifard, Riaz Uddin, Anna Poznańska, Faris Lami, Niguse Meles Alema, Michael T. Chung, Arya Aminorroaya, Arash Sarveazad, Erkin M. Mirrakhimov, Seyed Hossein Yahyazadeh Jabbari, João M. Furtado, Hamid Ahmadieh, Sara Conti, Yunquan Zhang, Manthan D Janodia, Aislyn U. Orji, S. Mohammad Sajadi, Jalal Arabloo, Gabrielle B. Britton, Colm McAlinden, Francisco Rogerlândio Martins-Melo, Simona Cătălina Ştefan, Ester Cerin, Nuno Taveira, Lars Jacob Stovner, Amir Taherkhani, Masoud Foroutan, Tomasz Miazgowski, Amir Manafi, Yeshambel T. Nigatu, Barthelemy Kuate Defo, Mithila Faruque, Alan D. Lopez, Man Mohan Mehndiratta, Graeme J. Hankey, Mojgan Gitimoghaddam, Chantal Huynh, G Anil Kumar, Martin Amogre Ayanore, Abbas Sheikhtaheri, Turki Alanzi, Simon Øverland, David Laith Rawaf, Brian J. Hall, Edward J Mills, Ali Kabir, Ravi Prakash Jha, Akbar Barzegar, Simin Mouodi, Alize J. Ferrari, Chirag P. Doshi, Saleh Salehi Zahabi, Mohsen Naghavi, Mohammad Hassan Emamian, Amir Jalali, Chukwudi A Nnaji, Kebadnew Mulatu Mihretie, Maarten J. Postma, David Edvardsson, Chhabi Lal Ranabhat, Catherine M. Antony, Hannah Han, Ken Lee Chin, Getinet Ayano, Kewal Krishan, Maryam Zamanian, Farshad Farzadfar, Ali A. Asadi-Pooya, Daniel Diaz, Oliver J. Brady, Mohsen Bayati, Christopher M Odell, Jalil Jaafari, Walter Mendoza, Susanna Dunachie, Raffaele Palladino, Raaj Kishore Biswas, Alessandra Lugo, Reshmi Bhageerathy, Paulo A. Lotufo, Maia Kereselidze, Salman Rawaf, Olayinka Stephen Ilesanmi, Mousa Yaminfirooz, Neeraj Bedi, Mahesh P A, Harvey Whiteford, Gina Agarwal, Pallab K. Maulik, Ranjitha S Shetty, Adhanom Gebreegziabher Baraki, Prasanna Mithra, Binyam Minuye Birihane, Mohammad Ali Mansournia, Tomislav Mestrovic, Razique Anwer, Marcello Tonelli, Hanne Christensen, Juan Jesus Carrero, Ali H. Mokdad, Alberto Ortiz, Samad Azari, Ted R. Miller, Rebecca Ivers, Stephen R. Robinson, Saeid Safiri, Masood Ali Shaikh, Rajesh Sagar, Kelly Cercy, Mehran Asadi-Aliabadi, João Vasco Santos, Maziar Moradi-Lakeh, Sarah Lewington, Dimas Ria Angga Pribadi, Savita Lasrado, Abdul Moiz Hafiz, Amir Almasi-Hashiani, Burcu Kucuk Bicer, Praveen Hoogar, Fatemeh Heydarpour, Hala Rashad Elhabashy, Peng Zheng, Senthilkumar Balakrishnan, Paul H. Lee, Cameron J. Kneib, Srinivasa Rao Bolla, Harrison Chase Gottlich, Andrew M. Briggs, Alibek Mereke, Om P Kurmi, Kavumpurathu Raman Thankappan, Nikolay Ivanovich Briko, Shahram Saeidi, Anbissa Muleta Senbeta, Assefa Ayalew Ayalew Ayalew Gebreslassie, Aminu K. Bello, Tomi Akinyemiju, Ambrish Singh, Anamika Pandey, Matthew Cunningham, Endalkachew Worku Mengesha, Christine Linehan, Ata Rafiee, Maria Inês Schmidt, Vincent C. Iannucci, Stanislav S. Otstavnov, Andre M. N. Renzaho, Dinesh Bhandari, Masoud Moghadaszadeh, Atkilt Esaiyas Etisso, Valery L. Feigin, Christopher J L Murray, James D. Harvey, Daniel Cury Ribeiro, Girikumar Kumaresh, Javad Yoosefi Lebni, Elisabetta Pupillo, Shaimaa I. El-Jaafary, Marlena S Bannick, Caitlyn Steiner, Agus Sudaryanto, Eduardo Bernabé, Fereshteh Mehri, Rafael Alves Guimarães, Zemenu Tadesse Tessema, Shaun Roberts, Rajeev Gupta, Jamal A. Yearwood, Nima Rezaei, Muhammad Shahdaat Bin Sayeed, David M. Pigott, Hadi Hassankhani, Samuel M. Ostroff, Gerhard Sulo, Keyghobad Ghadiri, Pankaj Bhardwaj, Suzanne Lyn Barker-Collo, Fiona J Charlson, Norberto Perico, Jonathan M. Kocarnik, Sergio I. Prada, Mohammad Sadegh Rezai, Mustafa Z. Younis, Neeraj Bhala, Mahmoud Yousefifard, Hue Thi Mai, Marwa Rashad Salem, Reza Pourmirza Kalhori, Carl Abelardo T. Antonio, Stefan Lorkowski, Farzad Jalilian, Nicholas J Kassebaum, Haley Lescinsky, Gholamreza Roshandel, Reza Heidari-Soureshjani, Kirsten E. Wiens, Ionut Negoi, Bhaskaran Unnikrishnan, Daniel J. Weiss, Sare Safi, Hamid Reza Tohidinik, Fablina Sharara, François Alla, Mohammad Rabiee, Sivan Yegnanarayana Iyer Saraswathy, Jack T Fox, Amirhossein Sahebkar, Ratilal Lalloo, Panniyammakal Jeemon, Rohollah Kalhor, Firooz Esmaeilzadeh, Brittney S. Sheena, Kyle E. Simpson, Muluken Bekele Sorrie, Vivekanand Jha, Morteza Abdullatif Khafaie, Seyed Mohammad Riahi, Nader Jahanmehr, Yuming Guo, George C. Patton, Rashid Abdi Guled, Tim C.D. Lucas, Alberto Raggi, Peter W. Gething, Mohaimenul Islam, Abdallah M. Samy, Cuong Tat Nguyen, Kaleab Alemayehu Zewdie, Ahamarshan Jayaraman Nagarajan, Roman Topor-Madry, C. E. G. Brayne, Phoebe Anne Rhinehart, Isabela M. Benseñor, Michal Grivna, Taren M. Gorman, Natalie C. Momen, Afsaneh Arzani, Tufa Kolola, Maryam Khayamzadeh, Alexandra S. Boon-Dooley, Ihoghosa Osamuyi Iyamu, Nima Hafezi-Nejad, Hassan Abolhassani, Perminder S. Sachdev, Vivek Kumar, Anton Sokhan, Mahmood Moosazadeh, Davoud Adham, Ahad Bakhtiari, Nataliya A. Foigt, Venkatesh Maled, Henok Biresaw Netsere, Seyedeh Zahra Masoumi, Ashley Marks, Rizwan Kalani, Soraya Siabani, Jiayu Wang, Samath Dhamminda Dharmaratne, Lucas Guimarães Abreu, Vivian Chia-Rong Hsieh, Kris J. Krohn, Falk Schwendicke, Alex R. Chang, Muhammad Ali, Christine Lin, Rose G Bender, Arielle Wilder Eagan, Tissa Wijeratne, Chris D Castle, Saif Ullah, Nikolaos Dervenis, Joan B. Soriano, Syed Amir Gilani, Jianing Ma, Giuseppe Remuzzi, Dana Bryazka, Christian Razo, Manuela L. Ferreira, Ankur Joshi, Alireza Rafiei, Vinay Nangia, Victor Adekanmbi, Frances E. Dean, Chuanhua Yu, Elizabeth A. Cromwell, Pascual R. Valdez, Jennifer Rickard, Daniel Youngwhan Cho, Ashish Pathak, Angel Paternina-Caicedo, Mehdi Ahmadi, Zichen Liu, Achala Upendra Jayatilleke, Diego De Leo, Sarah Charlotte Johnson, Getenet Dessie, Zhi Jiang Zhang, Christopher S. Crowe, Farhad Ghamari, Behshad Naghshtabrizi, Francesco Saverio Violante, Muhammad Aziz Rahman, Ramesh Holla, Kate E. LeGrand, Christian Kieling, Vahid Yazdi-Feyzabadi, Shivanthi Balalla, Molly H Biehl, Mostafa Dianatinasab, Mina Anjomshoa, Abdel Douiri, Laith J. Abu-Raddad, Rade Vukovic, Amiran Gamkrelidze, Michael R. Phillips, Yafeng Wang, Sachin R Atre, Miriam Levi, Zelalem Nigussie Azene, Kevan R. Polkinghorne, Deepak Paudel, Hung Chun Liu, Zainab Samad, Robert P. Dellavalle, Florentino Luciano Caetano dos Santos, Juan Sanabria, Mohammad Fareed, Enrico Rubagotti, Samantha Leigh Larson, Anurag Agrawal, Shai Linn, Saad M.A. Dahlawi, Janni Leung, Shokofeh Maleki, Michael R.M. Abrigo, Michael Kravchenko, Mohd Anisul Karim, Alyssa N. Sbarra, Jacob L. Stubbs, Timothy J. Steiner, Helena Manguerra, Olatunji O. Adetokunboh, Amira Shaheen, Stein Emil Vollset, Yared Asmare Aynalem, Rajan Nikbakhsh, Ilana N. Ackerman, Srinivasa Vittal Katikireddi, Davide Rasella, Hedayat Abbastabar, Floriane Ausloos, Nauman Khalid, Ewerton Cousin, Nermin Ghith, Nebiyu Dereje Dereje, Rakhi Dandona, Mojtaba Bagherzadeh, Ahmed Abdelalim, Benn Sartorius, Giulio Castelpietra, Masih Tajdini, Stefanos Tyrovolas, Akram Pourshams, Ritesh G. Menezes, Eve E. Wool, Mohamed Hsairi, Alberto L. García-Basteiro, Lorainne Tudor Car, Rachelle Buchbinder, Franz Castro, Samiah Alam, Iman Ansari, Ahmed I. Hasaballah, Sanni Yaya, Silvia Schiavolin, Reza Mohammadpourhodki, Khalid A Altirkawi, Marco Vacante, Jacek A. Kopec, Archith Boloor, Simon I. Hay, Mathilde Touvier, Ensiyeh Jenabi, Deborah Carvalho Malta, Scott B. Patten, Arash Ziapour, Carlo La Vecchia, Seyed Sina Naghibi Irvani, Thomas Truelsen, Houman Goudarzi, Ryan Fitzgerald, Di H. Cross, Eduarda Fernandes, Chandrashekhar T Sreeramareddy, Odgerel Chimed-Ochir, Iqbal R. F. Elyazar, Alexandrea Watson, Bo Norrving, Kerem Shuval, Chidozie Declan Iwu, Jasvinder A. Singh, Bárbara Niegia Garcia Goulart, Shirin Djalalinia, Marisa Freitas, Feleke Mekonnen Demeke, Hiroyasu Iso, Hussain Jafari, Lee Ling Lim, Roman V. Polibin, Charles D.A. Wolfe, Ulrich O Mueller, Luis Camera, Fabiana Madotto, Gregory A. Roth, Nevine El Nahas, Paul S. F. Yip, Miguel A Barboza, Anna E. Torre, Ali Rajabpour-Sanati, Hailey Hagins, Tauseef Ahmad, Platon D. Lopukhov, Giovanni Damiani, Mohammad Hossein Bakhshaei, Hirut Teame, Silvano Gallus, Tudorel Andrei, Suzanne H. Keddie, Madgalene K. Walters, Mohammad Abdollahi, Temesgen Yihunie Akalu, Catherine Bisignano, Iyad Sultan, Ira Martopullo, Emma L. Collins, Spencer L. James, Rasmus Havmoeller, Alireza Esteghamati, Seok Jun Yoon, Paramjit Gill, Maryam Hashemian, Klara Dokova, Weijia Fu, Anna Gershberg Hayoon, Kathryn H. Jacobsen, Zohra S Lassi, Morenike Oluwatoyin Folayan, Sanjeev Nair, Phetole Walter Mahasha, Shelly Balassyano, Giulia Carreras, Ruxandra Irina Negoi, Reinhard Busse, Takeshi Fukumoto, Abdullah Al Mamun, Sarika Chaturvedi, Stefania Mondello, Christoph Nowak, Vijay Kumar Chattu, Efat Mohamadi, Mohammad Ebrahimi Kalan, Paul S Briant, M Alijanzadeh, Giuseppe Gorini, Berhane Fseha Teklehaimanot, Jacqueline Elizabeth Alcalde-Rabanal, Katya Anne Shackelford, Mehdi Fazlzadeh, Virginia Núñez-Samudio, Minh Nguyen, Payman Salamati, Itamar S. Santos, Bach Xuan Tran, Lal B. Rawal, Louisa Degenhardt, Dietrich Plass, Jacob Olusegun Olusanya, José Neves, Kazumasa Yamagishi, Mona M. Khater, Alyssa Pennini, Ehsan Sadeghi, Salah Eddin Karimi, Ravensara S. Travillian, Alexander C. Tsai, Emilie E. Agardh, Rahmatollah Moradzadeh, Hamed Zandian, Zahid A Butt, Subramanian Senthilkumaran, Ai-Min Wu, Bing Fang Hwang, Sadaf G. Sepanlou, Jeff T. Zhao, Paolo Cortesi, Giorgia Giussani, Gregory J. Bertolacci, Andrew T Olagunju, Søren Thorgaard Skou, Peter Allebeck, Benjamin C Cowie, Aso Mohammad Darwesh, In-Hwan Oh, Erin B. Hamilton, Puja C Rao, Vinod C Nayak, Carla Fornari, Khezar Hayat, Rannveig Sigurvinsdottir, Emmanuel Peprah, Oommen John, Sonyah Terrason, Mohammed Ibrahim Mohialdeen Gubari, Sojib Bin Zaman, Jean Jacques Noubiap, Emmanuela Gakidou, Abiyu Mekonnen Gebrehiwot, Celine M. Barthelemy, Nicholas L S Roberts, Jagadish Rao Padubidri, Navid Rabiee, Alireza Ghajar, Mark G. Shrime, Hamed Kalani, Mayowa O. Owolabi, Lisa M. Force, Irina Filip, Jacek Jerzy Jozwiak, Gelin Xu, Thomas R. Hird, Kara Estep, Mohammad Zamani, Lalit Dandona, João Massano, Antonio Maria Borzì, Masoud Moradi, Molly R Nixon, Delia Hendrie, Mostafa Amini-Rarani, Mikhail Sergeevich Zastrozhin, Rachel Feldman, Emmanuel Wandera Okunga, Bruce Bartholow Duncan, Nazir Fattahi, Joshua R. Ehrlich, Adnan Kisa, Ghasem Azarian, Naser Mohammad Gholi Mezerji, Reed J D Sorensen, Roderick J. Hay, Johan Ärnlöv, Liliana G Ciobanu, Claudiu Herteliu, Andreea Mirica, Sofia Boston Redford, Wahengbam Bigyananda Meitei, Jae Il Shin, Kanaan Hamagharib Abdullah, Abhijit Pakhare, Santosh Kumar Tadakamadla, Rixing Xu, Jonathan F. Mosser, Meresa Berwo Mengesha, Veincent Christian Filipino Pepito, Andre Rodrigues Duraes, Yuan-Pang Wang, Jaimie D. Adelson, Felix Akpojene Ogbo, Alireza Vakilian, Mihajlo Jakovljevic, Ali S. Shalash, Vos, T, Lim, S, Abbafati, C, Abbas, K, Abbasi, M, Abbasifard, M, Abbasi-Kangevari, M, Abbastabar, H, Abd-Allah, F, Abdelalim, A, Abdollahi, M, Abdollahpour, I, Abolhassani, H, Aboyans, V, Abrams, E, Abreu, L, Abrigo, M, Abu-Raddad, L, Abushouk, A, Acebedo, A, Ackerman, I, Adabi, M, Adamu, A, Adebayo, O, Adekanmbi, V, Adelson, J, Adetokunboh, O, Adham, D, Afshari, M, Afshin, A, Agardh, E, Agarwal, G, Agesa, K, Aghaali, M, Aghamir, S, Agrawal, A, Ahmad, T, Ahmadi, A, Ahmadi, M, Ahmadieh, H, Ahmadpour, E, Akalu, T, Akinyemi, R, Akinyemiju, T, Akombi, B, Al-Aly, Z, Alam, K, Alam, N, Alam, S, Alam, T, Alanzi, T, Albertson, S, Alcalde-Rabanal, J, Alema, N, Ali, M, Ali, S, Alicandro, G, Alijanzadeh, M, Alinia, C, Alipour, V, Aljunid, S, Alla, F, Allebeck, P, Almasi-Hashiani, A, Alonso, J, Al-Raddadi, R, Altirkawi, K, Alvis-Guzman, N, Alvis-Zakzuk, N, Amini, S, Amini-Rarani, M, Aminorroaya, A, Amiri, F, Amit, A, Amugsi, D, Amul, G, Anderlini, D, Andrei, C, Andrei, T, Anjomshoa, M, Ansari, F, Ansari, I, Ansari-Moghaddam, A, Antonio, C, Antony, C, Antriyandarti, E, Anvari, D, Anwer, R, Arabloo, J, Arab-Zozani, M, Aravkin, A, Ariani, F, Arnlov, J, Aryal, K, Arzani, A, Asadi-Aliabadi, M, Asadi-Pooya, A, Asghari, B, Ashbaugh, C, Atnafu, D, Atre, S, Ausloos, F, Ausloos, M, Ayala Quintanilla, B, Ayano, G, Ayanore, M, Aynalem, Y, Azari, S, Azarian, G, Azene, Z, Babaee, E, Badawi, A, Bagherzadeh, M, Bakhshaei, M, Bakhtiari, A, Balakrishnan, S, Balalla, S, Balassyano, S, Banach, M, Banik, P, Bannick, M, Bante, A, Baraki, A, Barboza, M, Barker-Collo, S, Barthelemy, C, Barua, L, Barzegar, A, Basu, S, Baune, B, Bayati, M, Bazmandegan, G, Bedi, N, Beghi, E, Bejot, Y, Bello, A, Bender, R, Bennett, D, Bennitt, F, Bensenor, I, Benziger, C, Berhe, K, Bernabe, E, Bertolacci, G, Bhageerathy, R, Bhala, N, Bhandari, D, Bhardwaj, P, Bhattacharyya, K, Bhutta, Z, Bibi, S, Biehl, M, Bikbov, B, Bin Sayeed, M, Biondi, A, Birihane, B, Bisanzio, D, Bisignano, C, Biswas, R, Bohlouli, S, Bohluli, M, Bolla, S, Boloor, A, Boon-Dooley, A, Borges, G, Borzi, A, Bourne, R, Brady, O, Brauer, M, Brayne, C, Breitborde, N, Brenner, H, Briant, P, Briggs, A, Briko, N, Britton, G, Bryazka, D, Buchbinder, R, Bumgarner, B, Busse, R, Butt, Z, Caetano dos Santos, F, Camera, L, Campos-Nonato, I, Car, J, Cardenas, R, Carreras, G, Carrero, J, Carvalho, F, Castaldelli-Maia, J, Castaneda-Orjuela, C, Castelpietra, G, Castle, C, Castro, F, Catala-Lopez, F, Causey, K, Cederroth, C, Cercy, K, Cerin, E, Chandan, J, Chang, A, Charlson, F, Chattu, V, Chaturvedi, S, Chimed-Ochir, O, Chin, K, Cho, D, Christensen, H, Chu, D, Chung, M, Cicuttini, F, Ciobanu, L, Cirillo, M, Collins, E, Compton, K, Conti, S, Cortesi, P, Costa, V, Cousin, E, Cowden, R, Cowie, B, Cromwell, E, Cross, D, Crowe, C, Cruz, J, Cunningham, M, Dahlawi, S, Damiani, G, Dandona, L, Dandona, R, Darwesh, A, Daryani, A, Das, J, Das Gupta, R, das Neves, J, Davila-Cervantes, C, Davletov, K, De Leo, D, Dean, F, Decleene, N, Deen, A, Degenhardt, L, Dellavalle, R, Demeke, F, Demsie, D, Denova-Gutierrez, E, Dereje, N, Dervenis, N, Desai, R, Desalew, A, Dessie, G, Dharmaratne, S, Dhungana, G, Dianatinasab, M, Diaz, D, Dibaji Forooshani, Z, Dingels, Z, Dirac, M, Djalalinia, S, Do, H, Dokova, K, Dorostkar, F, Doshi, C, Doshmangir, L, Douiri, A, Doxey, M, Driscoll, T, Dunachie, S, Duncan, B, Duraes, A, Eagan, A, Ebrahimi Kalan, M, Edvardsson, D, Ehrlich, J, El Nahas, N, El Sayed, I, El Tantawi, M, Elbarazi, I, Elgendy, I, Elhabashy, H, El-Jaafary, S, Elyazar, I, Emamian, M, Emmons-Bell, S, Erskine, H, Eshrati, B, Eskandarieh, S, Esmaeilnejad, S, Esmaeilzadeh, F, Esteghamati, A, Estep, K, Etemadi, A, Etisso, A, Farahmand, M, Faraj, A, Fareed, M, Faridnia, R, Farinha, C, Farioli, A, Faro, A, Faruque, M, Farzadfar, F, Fattahi, N, Fazlzadeh, M, Feigin, V, Feldman, R, Fereshtehnejad, S, Fernandes, E, Ferrari, A, Ferreira, M, Filip, I, Fischer, F, Fisher, J, Fitzgerald, R, Flohr, C, Flor, L, Foigt, N, Folayan, M, Force, L, Fornari, C, Foroutan, M, Fox, J, Freitas, M, Fu, W, Fukumoto, T, Furtado, J, Gad, M, Gakidou, E, Galles, N, Gallus, S, Gamkrelidze, A, Garcia-Basteiro, A, Gardner, W, Geberemariyam, B, Gebrehiwot, A, Gebremedhin, K, Gebreslassie, A, Gershberg Hayoon, A, Gething, P, Ghadimi, M, Ghadiri, K, Ghafourifard, M, Ghajar, A, Ghamari, F, Ghashghaee, A, Ghiasvand, H, Ghith, N, Gholamian, A, Gilani, S, Gill, P, Gitimoghaddam, M, Giussani, G, Goli, S, Gomez, R, Gopalani, S, Gorini, G, Gorman, T, Gottlich, H, Goudarzi, H, Goulart, A, Goulart, B, Grada, A, Grivna, M, Grosso, G, Gubari, M, Gugnani, H, Guimaraes, A, Guimaraes, R, Guled, R, Guo, G, Guo, Y, Gupta, R, Haagsma, J, Haddock, B, Hafezi-Nejad, N, Hafiz, A, Hagins, H, Haile, L, Hall, B, Halvaei, I, Hamadeh, R, Hamagharib Abdullah, K, Hamilton, E, Han, C, Han, H, Hankey, G, Haro, J, Harvey, J, Hasaballah, A, Hasanzadeh, A, Hashemian, M, Hassanipour, S, Hassankhani, H, Havmoeller, R, Hay, R, Hay, S, Hayat, K, Heidari, B, Heidari, G, Heidari-Soureshjani, R, Hendrie, D, Henrikson, H, Henry, N, Herteliu, C, Heydarpour, F, Hird, T, Hoek, H, Hole, M, Holla, R, Hoogar, P, Hosgood, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hoy, D, Hsairi, M, Hsieh, V, Hu, G, Huda, T, Hugo, F, Huynh, C, Hwang, B, Iannucci, V, Ibitoye, S, Ikuta, K, Ilesanmi, O, Ilic, I, Ilic, M, Inbaraj, L, Ippolito, H, Irvani, S, Islam, M, Islam, S, Islami, F, Iso, H, Ivers, R, Iwu, C, Iyamu, I, Jaafari, J, Jacobsen, K, Jadidi-Niaragh, F, Jafari, H, Jafarinia, M, Jahagirdar, D, Jahani, M, Jahanmehr, N, Jakovljevic, M, Jalali, A, Jalilian, F, James, S, Janjani, H, Janodia, M, Jayatilleke, A, Jeemon, P, Jenabi, E, Jha, R, Jha, V, Ji, J, Jia, P, John, O, John-Akinola, Y, Johnson, C, Johnson, S, Jonas, J, Joo, T, Joshi, A, Jozwiak, J, Jurisson, M, Kabir, A, Kabir, Z, Kalani, H, Kalani, R, Kalankesh, L, Kalhor, R, Kamiab, Z, Kanchan, T, Karami Matin, B, Karch, A, Karim, M, Karimi, S, Kassa, G, Kassebaum, N, Katikireddi, S, Kawakami, N, Kayode, G, Keddie, S, Keller, C, Kereselidze, M, Khafaie, M, Khalid, N, Khan, M, Khatab, K, Khater, M, Khatib, M, Khayamzadeh, M, Khodayari, M, Khundkar, R, Kianipour, N, Kieling, C, Kim, D, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Kissimova-Skarbek, K, Kivimaki, M, Kneib, C, Knudsen, A, Kocarnik, J, Kolola, T, Kopec, J, Kosen, S, Koul, P, Koyanagi, A, Kravchenko, M, Krishan, K, Krohn, K, Kuate Defo, B, Kucuk Bicer, B, Kumar, G, Kumar, M, Kumar, P, Kumar, V, Kumaresh, G, Kurmi, O, Kusuma, D, Kyu, H, La Vecchia, C, Lacey, B, Lal, D, Lalloo, R, Lam, J, Lami, F, Landires, I, Lang, J, Lansingh, V, Larson, S, Larsson, A, Lasrado, S, Lassi, Z, Lau, K, Lavados, P, Lazarus, J, Ledesma, J, Lee, P, Lee, S, Legrand, K, Leigh, J, Leonardi, M, Lescinsky, H, Leung, J, Levi, M, Lewington, S, Li, S, Lim, L, Lin, C, Lin, R, Linehan, C, Linn, S, Liu, H, Liu, S, Liu, Z, Looker, K, Lopez, A, Lopukhov, P, Lorkowski, S, Lotufo, P, Lucas, T, Lugo, A, Lunevicius, R, Lyons, R, Ma, J, Maclachlan, J, Maddison, E, Maddison, R, Madotto, F, Mahasha, P, Mai, H, Majeed, A, Maled, V, Maleki, S, Malekzadeh, R, Malta, D, Mamun, A, Manafi, A, Manafi, N, Manguerra, H, Mansouri, B, Mansournia, M, Mantilla Herrera, A, Maravilla, J, Marks, A, Martins-Melo, F, Martopullo, I, Masoumi, S, Massano, J, Massenburg, B, Mathur, M, Maulik, P, Mcalinden, C, Mcgrath, J, Mckee, M, Mehndiratta, M, Mehri, F, Mehta, K, Meitei, W, Memiah, P, Mendoza, W, Menezes, R, Mengesha, E, Mengesha, M, Mereke, A, Meretoja, A, Meretoja, T, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, I, Mihretie, K, Miller, T, Mills, E, Mirica, A, Mirrakhimov, E, Mirzaei, H, Mirzaei, M, Mirzaei-Alavijeh, M, Misganaw, A, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Mohammad, D, Mohammad, Y, Mohammad Gholi Mezerji, N, Mohammadian-Hafshejani, A, Mohammadifard, N, Mohammadpourhodki, R, Mohammed, S, Mokdad, A, Molokhia, M, Momen, N, Monasta, L, Mondello, S, Mooney, M, Moosazadeh, M, Moradi, G, Moradi, M, Moradi-Lakeh, M, Moradzadeh, R, Moraga, P, Morales, L, Morawska, L, Moreno Velasquez, I, Morgado-da-Costa, J, Morrison, S, Mosser, J, Mouodi, S, Mousavi, S, Mousavi Khaneghah, A, Mueller, U, Munro, S, Muriithi, M, Musa, K, Muthupandian, S, Naderi, M, Nagarajan, A, Nagel, G, Naghshtabrizi, B, Nair, S, Nandi, A, Nangia, V, Nansseu, J, Nayak, V, Nazari, J, Negoi, I, Negoi, R, Netsere, H, Ngunjiri, J, Nguyen, C, Nguyen, J, Nguyen, M, Nichols, E, Nigatu, D, Nigatu, Y, Nikbakhsh, R, Nixon, M, Nnaji, C, Nomura, S, Norrving, B, Noubiap, J, Nowak, C, Nunez-Samudio, V, Otoiu, A, Oancea, B, Odell, C, Ogbo, F, Oh, I, Okunga, E, Oladnabi, M, Olagunju, A, Olusanya, B, Olusanya, J, Oluwasanu, M, Omar Bali, A, Omer, M, Ong, K, Onwujekwe, O, Orji, A, Orpana, H, Ortiz, A, Ostroff, S, Otstavnov, N, Otstavnov, S, Overland, S, Owolabi, M, P A, M, Padubidri, J, Pakhare, A, Palladino, R, Pana, A, Panda-Jonas, S, Pandey, A, Park, E, Parmar, P, Pasupula, D, Patel, S, Paternina-Caicedo, A, Pathak, A, Pathak, M, Patten, S, Patton, G, Paudel, D, Pazoki Toroudi, H, Peden, A, Pennini, A, Pepito, V, Peprah, E, Pereira, A, Pereira, D, Perico, N, Pham, H, Phillips, M, Pigott, D, Pilgrim, T, Pilz, T, Pirsaheb, M, Plana-Ripoll, O, Plass, D, Pokhrel, K, Polibin, R, Polinder, S, Polkinghorne, K, Postma, M, Pourjafar, H, Pourmalek, F, Pourmirza Kalhori, R, Pourshams, A, Poznanska, A, Prada, S, Prakash, V, Pribadi, D, Pupillo, E, Quazi Syed, Z, Rabiee, M, Rabiee, N, Radfar, A, Rafiee, A, Rafiei, A, Raggi, A, Rahimi-Movaghar, A, Rahman, M, Rajabpour-Sanati, A, Rajati, F, Ramezanzadeh, K, Ranabhat, C, Rao, P, Rao, S, Rasella, D, Rastogi, P, Rathi, P, Rawaf, D, Rawaf, S, Rawal, L, Razo, C, Redford, S, Reiner, R, Reinig, N, Reitsma, M, Remuzzi, G, Renjith, V, Renzaho, A, Resnikoff, S, Rezaei, N, Rezai, M, Rezapour, A, Rhinehart, P, Riahi, S, Ribeiro, A, Ribeiro, D, Rickard, J, Roberts, N, Roberts, S, Robinson, S, Roever, L, Rolfe, S, Ronfani, L, Roshandel, G, Roth, G, Rubagotti, E, Rumisha, S, Sabour, S, Sachdev, P, Saddik, B, Sadeghi, E, Sadeghi, M, Saeidi, S, Safi, S, Safiri, S, Sagar, R, Sahebkar, A, Sahraian, M, Sajadi, S, Salahshoor, M, Salamati, P, Salehi Zahabi, S, Salem, H, Salem, M, Salimzadeh, H, Salomon, J, Salz, I, Samad, Z, Samy, A, Sanabria, J, Santomauro, D, Santos, I, Santos, J, Santric-Milicevic, M, Saraswathy, S, Sarmiento-Suarez, R, Sarrafzadegan, N, Sartorius, B, Sarveazad, A, Sathian, B, Sathish, T, Sattin, D, Sbarra, A, Schaeffer, L, Schiavolin, S, Schmidt, M, Schutte, A, Schwebel, D, Schwendicke, F, Senbeta, A, Senthilkumaran, S, Sepanlou, S, Shackelford, K, Shadid, J, Shahabi, S, Shaheen, A, Shaikh, M, Shalash, A, Shams-Beyranvand, M, Shamsizadeh, M, Shannawaz, M, Sharafi, K, Sharara, F, Sheena, B, Sheikhtaheri, A, Shetty, R, Shibuya, K, Shiferaw, W, Shigematsu, M, Shin, J, Shiri, R, Shirkoohi, R, Shrime, M, Shuval, K, Siabani, S, Sigfusdottir, I, Sigurvinsdottir, R, Silva, J, Simpson, K, Singh, A, Singh, J, Skiadaresi, E, Skou, S, Skryabin, V, Sobngwi, E, Sokhan, A, Soltani, S, Sorensen, R, Soriano, J, Sorrie, M, Soyiri, I, Sreeramareddy, C, Stanaway, J, Stark, B, Stefan, S, Stein, C, Steiner, C, Steiner, T, Stokes, M, Stovner, L, Stubbs, J, Sudaryanto, A, Sufiyan, M, Sulo, G, Sultan, I, Sykes, B, Sylte, D, Szocska, M, Tabares-Seisdedos, R, Tabb, K, Tadakamadla, S, Taherkhani, A, Tajdini, M, Takahashi, K, Taveira, N, Teagle, W, Teame, H, Tehrani-Banihashemi, A, Teklehaimanot, B, Terrason, S, Tessema, Z, Thankappan, K, Thomson, A, Tohidinik, H, Tonelli, M, Topor-Madry, R, Torre, A, Touvier, M, Tovani-Palone, M, Tran, B, Travillian, R, Troeger, C, Truelsen, T, Tsai, A, Tsatsakis, A, Tudor Car, L, Tyrovolas, S, Uddin, R, Ullah, S, Undurraga, E, Unnikrishnan, B, Vacante, M, Vakilian, A, Valdez, P, Varughese, S, Vasankari, T, Vasseghian, Y, Venketasubramanian, N, Violante, F, Vlassov, V, Vollset, S, Vongpradith, A, Vukovic, A, Vukovic, R, Waheed, Y, Walters, M, Wang, J, Wang, Y, Ward, J, Watson, A, Wei, J, Weintraub, R, Weiss, D, Weiss, J, Westerman, R, Whisnant, J, Whiteford, H, Wiangkham, T, Wiens, K, Wijeratne, T, Wilner, L, Wilson, S, Wojtyniak, B, Wolfe, C, Wool, E, Wu, A, Wulf Hanson, S, Wunrow, H, Xu, G, Xu, R, Yadgir, S, Yahyazadeh Jabbari, S, Yamagishi, K, Yaminfirooz, M, Yano, Y, Yaya, S, Yazdi-Feyzabadi, V, Yearwood, J, Yeheyis, T, Yeshitila, Y, Yip, P, Yonemoto, N, Yoon, S, Yoosefi Lebni, J, Younis, M, Younker, T, Yousefi, Z, Yousefifard, M, Yousefinezhadi, T, Yousuf, A, Yu, C, Yusefzadeh, H, Zahirian Moghadam, T, Zaki, L, Zaman, S, Zamani, M, Zamanian, M, Zandian, H, Zangeneh, A, Zastrozhin, M, Zewdie, K, Zhang, Y, Zhang, Z, Zhao, J, Zhao, Y, Zheng, P, Zhou, M, Ziapour, A, Zimsen, S, Naghavi, M, Murray, C, Vos, Theo, S Lim, Stephen, Abbafati, Cristiana, M Abbas, Kaja, Abbasi, Mohammad, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abolhassani, Hassan, Aboyans, Victor, M Abrams, Elissa, Guimarães Abreu, Luca, M Abrigo, Michael R, Jamal Abu-Raddad, Laith, I Abushouk, Abdelrahman, Acebedo, Alyssa, N Ackerman, Ilana, Adabi, Maryam, A Adamu, Abdu, M Adebayo, Oladimeji, Adekanmbi, Victor, D Adelson, Jaimie, O Adetokunboh, Olatunji, Adham, Davoud, Afshari, Mahdi, Afshin, Ashkan, E Agardh, Emilie, Agarwal, Gina, M Agesa, Kareha, Aghaali, Mohammad, Mohammad Kazem Aghamir, Seyed, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Alireza, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmadpour, Ehsan, Yihunie Akalu, Temesgen, Olusola Akinyemi, Rufu, Akinyemiju, Tomi, Akombi, Blessing, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Samiah, Alam, Tahiya, M Alanzi, Turki, B Albertson, Samuel, Elizabeth Alcalde-Rabanal, Jacqueline, Meles Alema, Niguse, Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alijanzadeh, Mehran, Alinia, Cyru, Alipour, Vahid, Mohamed Aljunid, Syed, Alla, Françoi, Allebeck, Peter, Almasi-Hashiani, Amir, Alonso, Jordi, M Al-Raddadi, Rajaa, A Altirkawi, Khalid, Alvis-Guzman, Nelson, J Alvis-Zakzuk, Nelson, Amini, Saeed, Amini-Rarani, Mostafa, Aminorroaya, Arya, Amiri, Fatemeh, L Amit, Arianna Maever, A Amugsi, Dickson, Gayle Herrera Amul, Gianna, Anderlini, Deanna, Liliana Andrei, Catalina, Andrei, Tudorel, Anjomshoa, Mina, Ansari, Fereshteh, Ansari, Iman, Ansari-Moghaddam, Alireza, T Antonio, Carl Abelardo, M Antony, Catherine, Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Arabloo, Jalal, Arab-Zozani, Morteza, Y Aravkin, Aleksandr, Ariani, Filippo, Ärnlöv, Johan, K Aryal, Krishna, Arzani, Afsaneh, Asadi-Aliabadi, Mehran, A Asadi-Pooya, Ali, Asghari, Babak, Ashbaugh, Charlie, Debalkie Atnafu, Desta, R Atre, Sachin, Ausloos, Floriane, Ausloos, Marcel, Paulina Ayala Quintanilla, Beatriz, Ayano, Getinet, Amogre Ayanore, Martin, Asmare Aynalem, Yared, Azari, Samad, Azarian, Ghasem, Nigussie Azene, Zelalem, Babaee, Ebrahim, Badawi, Alaa, Bagherzadeh, Mojtaba, Hossein Bakhshaei, Mohammad, Bakhtiari, Ahad, Balakrishnan, Senthilkumar, Balalla, Shivanthi, Balassyano, Shelly, Banach, Maciej, Chandra Banik, Palash, S Bannick, Marlena, Bante Bante, Agegnehu, Gebreegziabher Baraki, Adhanom, A Barboza, Miguel, Lyn Barker-Collo, Suzanne, M Barthelemy, Celine, Barua, Lingkan, Barzegar, Akbar, Basu, Sanjay, T Baune, Bernhard, Bayati, Mohsen, Bazmandegan, Gholamreza, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, K Bello, Aminu, G Bender, Rose, A Bennett, Derrick, B Bennitt, Fiona, M Bensenor, Isabela, P Benziger, Catherine, Berhe, Kidanemaryam, Bernabe, Eduardo, J Bertolacci, Gregory, Bhageerathy, Reshmi, Bhala, Neeraj, Bhandari, Dinesh, Bhardwaj, Pankaj, Bhattacharyya, Krittika, A Bhutta, Zulfiqar, Bibi, Sadia, H Biehl, Molly, Bikbov, Bori, Shahdaat Bin Sayeed, Muhammad, Biondi, Antonio, Minuye Birihane, Binyam, Bisanzio, Donal, Bisignano, Catherine, Kishore Biswas, Raaj, Bohlouli, Somayeh, Bohluli, Mehdi, Rao Rao Bolla, Srinivasa, Boloor, Archith, S Boon-Dooley, Alexandra, Borges, Guilherme, Maria Borzì, Antonio, Bourne, Rupert, J Brady, Oliver, Brauer, Michael, Brayne, Carol, K Breitborde, Nicholas J, Brenner, Hermann, Svitil Briant, Paul, M Briggs, Andrew, Ivanovich Briko, Nikolay, B Britton, Gabrielle, Bryazka, Dana, Buchbinder, Rachelle, R Bumgarner, Blair, Busse, Reinhard, A Butt, Zahid, Luciano Caetano Dos Santos, Florentino, LA Alberto Cámera, Lui, R Campos-Nonato, Ismael, Car, Josip, Cárdenas, Rosario, Carreras, Giulia, J Carrero, Juan, Carvalho, Felix, Mauricio Castaldelli-Maia, Joao, A Castañeda-Orjuela, Carlo, Castelpietra, Giulio, D Castle, Chri, Castro, Franz, Catalá-López, Ferrán, Causey, Kate, R Cederroth, Christopher, M Cercy, Kelly, Cerin, Ester, Singh Chandan, Joht, R Chang, Alex, J Charlson, Fiona, Kumar Chattu, Vijay, Chaturvedi, Sarika, Chimed-Ochir, Odgerel, Lee Chin, Ken, Youngwhan Cho, Daniel, Christensen, Hanne, Chu, Dinh-Toi, T Chung, Michael, M Cicuttini, Flavia, G Ciobanu, Liliana, Cirillo, Massimo, L Collins, Emma, Compton, Kelly, Conti, Sara, Angelo Cortesi, Paolo, Marisa Costa, Vera, Cousin, Ewerton, G Cowden, Richard, C Cowie, Benjamin, A Cromwell, Elizabeth, H Cross, Di, Stephen Crowe, Christopher, A Cruz, Jessica, Cunningham, Matthew, A Dahlawi, Saad M, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Mohammad Darwesh, Aso, Daryani, Ahmad, K Das, Jai, Das Gupta, Rajat, das Neves, José, Alberto Dávila-Cervantes, Claudio, Davletov, Kairat, De Leo, Diego, E Dean, France, K DeCleene, Nicole, Deen, Amanda, Degenhardt, Louisa, Paul Dellavalle, Robert, Mekonnen Demeke, Feleke, Getnet Demsie, Desalegn, Denova-Gutiérrez, Edgar, Dereje Dereje, Nebiyu, Dervenis, Nikolao, Desai, Rupak, Desalew, Assefa, Ayalew Dessie, Getenet, Dhamminda Dharmaratne, Samath, Prasad Dhungana, Govinda, Dianatinasab, Mostafa, Diaz, Daniel, Sadat Dibaji Forooshani, Zahra, V Dingels, Zachary, Ashworth Dirac, M, Djalalinia, Shirin, Thi Do, Hoa, Dokova, Klara, Dorostkar, Fariba, P Doshi, Chirag, Doshmangir, Leila, Douiri, Abdel, C Doxey, Matthew, Robert Driscoll, Tim, J Dunachie, Susanna, B Duncan, Bruce, Rodrigues Duraes, Andre, Wilder Eagan, Arielle, Ebrahimi Kalan, Mohammad, Edvardsson, David, R Ehrlich, Joshua, El Nahas, Nevine, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, Y Elgendy, Islam, Rashad Elhabashy, Hala, I El-Jaafary, Shaimaa, Rf Elyazar, Iqbal, Hassan Emamian, Mohammad, Emmons-Bell, Sophia, E Erskine, Holly, Eshrati, Babak, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esmaeilzadeh, Firooz, Esteghamati, Alireza, Estep, Kara, Etemadi, Arash, Esaiyas Etisso, Atkilt, Farahmand, Mohammad, Faraj, Anwar, Fareed, Mohammad, Faridnia, Roghiyeh, E Sá Farinha, Carla Sofia, Farioli, Andrea, Faro, Andre, Faruque, Mithila, Farzadfar, Farshad, Fattahi, Nazir, Fazlzadeh, Mehdi, L Feigin, Valery, Feldman, Rachel, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, J Ferrari, Alize, L Ferreira, Manuela, Filip, Irina, Fischer, Florian, L Fisher, Jame, Fitzgerald, Ryan, Flohr, Carsten, Sorio Flor, Luisa, A Foigt, Nataliya, Oluwatoyin Folayan, Morenike, M Force, Lisa, Fornari, Carla, Foroutan, Masoud, T Fox, Jack, Freitas, Marisa, Fu, Weijia, Fukumoto, Takeshi, M Furtado, João, M Gad, Mohamed, Gakidou, Emmanuela, C Galles, Natalie, Gallus, Silvano, Gamkrelidze, Amiran, L Garcia-Basteiro, Alberto, M Gardner, William, Sahiledengle Geberemariyam, Biniyam, Mekonnen Gebrehiwot, Abiyu, Bizuwork Gebremedhin, Ketema, Ayalew Ayalew Ayalew Gebreslassie, Assefa, Gershberg Hayoon, Anna, W Gething, Peter, Ghadimi, Maryam, Ghadiri, Keyghobad, Ghafourifard, Mansour, Ghajar, Alireza, Ghamari, Farhad, Ghashghaee, Ahmad, Ghiasvand, Hesam, Ghith, Nermin, Gholamian, Asadollah, Amir Gilani, Syed, Singh Gill, Paramjit, Gitimoghaddam, Mojgan, Giussani, Giorgia, Goli, Sriniva, Santiago Gomez, Ricardo, Vali Gopalani, Sameer, Gorini, Giuseppe, M Gorman, Taren, Chase Gottlich, Harrison, Goudarzi, Houman, C Goulart, Alessandra, Niegia Garcia Goulart, Bárbara, Grada, Ayman, Grivna, Michal, Grosso, Giuseppe, Ibrahim Mohialdeen Gubari, Mohammed, Chander Gugnani, Harish, Luiz Sena Guimaraes, Andre, Alves Guimarães, Rafael, Abdi Guled, Rashid, Guo, Gaorui, Guo, Yuming, Gupta, Rajeev, A Haagsma, Juanita, Haddock, Beatrix, Hafezi-Nejad, Nima, Hafiz, Abdul, Hagins, Hailey, M Haile, Lydia, J Hall, Brian, Halvaei, Iman, R Hamadeh, Randah, Hamagharib Abdullah, Kanaan, B Hamilton, Erin, Han, Chieh, Han, Hannah, J Hankey, Graeme, Maria Haro, Josep, D Harvey, Jame, I Hasaballah, Ahmed, Hasanzadeh, Amir, Hashemian, Maryam, Hassanipour, Soheil, Hassankhani, Hadi, J Havmoeller, Rasmu, J Hay, Roderick, I Hay, Simon, Hayat, Khezar, Heidari, Behnam, Heidari, Golnaz, Heidari-Soureshjani, Reza, Hendrie, Delia, J Henrikson, Hannah, J Henry, Nathaniel, Herteliu, Claudiu, Heydarpour, Fatemeh, R Hird, Thoma, W Hoek, Han, K Hole, Michael, Holla, Ramesh, Hoogar, Praveen, Dean Hosgood, H, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, G Hoy, Damian, Hsairi, Mohamed, Chia-Rong Hsieh, Vivian, Hu, Guoqing, M Huda, Tanvir, N Hugo, Fernando, K Huynh, Chantal, Hwang, Bing-Fang, C Iannucci, Vincent, Emmanuel Ibitoye, Segun, S Ikuta, Kevin, Stephen Ilesanmi, Olayinka, M Ilic, Irena, D Ilic, Milena, Raja Inbaraj, Leeberk, Ippolito, Helen, Sina Naghibi Irvani, Seyed, Mofizul Islam, M, Islam, Mdmohaimenul, Mohammed Shariful Islam, Sheikh, Islami, Farhad, Iso, Hiroyasu, Q Ivers, Rebecca, D Iwu, Chidozie C, Osamuyi Iyamu, Ihoghosa, Jaafari, Jalil, H Jacobsen, Kathryn, Jadidi-Niaragh, Farhad, Jafari, Hussain, Jafarinia, Morteza, Jahagirdar, Deepa, Ali Jahani, Mohammad, Jahanmehr, Nader, Jakovljevic, Mihajlo, Jalali, Amir, Jalilian, Farzad, L James, Spencer, Janjani, Hosna, Dilipkumar Janodia, Manthan, Upendra Jayatilleke, Achala, Jeemon, Panniyammakal, Jenabi, Ensiyeh, Prakash Jha, Ravi, Jha, Vivekanand, S Ji, John, Jia, Peng, John, Oommen, O John-Akinola, Yetunde, Owens Johnson, Catherine, Charlotte Johnson, Sarah, B Jonas, Jost, Joo, Tama, Joshi, Ankur, Jerzy Jozwiak, Jacek, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kalani, Hamed, Kalani, Rizwan, R Kalankesh, Leila, Kalhor, Rohollah, Kamiab, Zahra, Kanchan, Tanuj, Karami Matin, Behzad, Karch, André, Anisul Karim, Mohd, Eddin Karimi, Salah, Mullu Kassa, Getachew, J Kassebaum, Nichola, Vittal Katikireddi, Srinivasa, Kawakami, Norito, A Kayode, Gbenga, H Keddie, Suzanne, Keller, Cathleen, Kereselidze, Maia, Abdullatif Khafaie, Morteza, Khalid, Nauman, Khan, Maseer, Khatab, Khaled, M Khater, Mona, Nazli Khatib, Mahalaqua, Khayamzadeh, Maryam, Taghi Khodayari, Mohammad, Khundkar, Roba, Kianipour, Neda, Kieling, Christian, Kim, Daniel, Kim, Young-Eun, Jin Kim, Yun, W Kimokoti, Ruth, Kisa, Adnan, Kisa, Sezer, Kissimova-Skarbek, Katarzyna, Kivimäki, Mika, J Kneib, Cameron, Kristin Skrindo Knudsen, Ann, M Kocarnik, Jonathan, Kolola, Tufa, A Kopec, Jacek, Kosen, Soewarta, A Koul, Parvaiz, Koyanagi, Ai, A Kravchenko, Michael, Krishan, Kewal, J Krohn, Kri, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Anil Kumar, G, Kumar, Manasi, Kumar, Pushpendra, Kumar, Vivek, Kumaresh, Girikumar, P Kurmi, Om, Kusuma, Dian, Hmwe Kyu, Hmwe, La Vecchia, Carlo, Lacey, Ben, Kumar Lal, Dharmesh, Lalloo, Ratilal, O Lam, Jennifer, Hasan Lami, Fari, Landires, Iván, J Lang, Justin, Charles Lansingh, Van, Leigh Larson, Samantha, O Larsson, Ander, Lasrado, Savita, S Lassi, Zohra, Mei-Ming Lau, Kathryn, M Lavados, Pablo, V Lazarus, Jeffrey, R Ledesma, Jorge, H Lee, Paul, Wen Huey Lee, Shaun, E LeGrand, Kate, Leigh, Jame, Leonardi, Matilde, Lescinsky, Haley, Leung, Janni, Levi, Miriam, Lewington, Sarah, Li, Shanshan, Lim, Lee-Ling, Lin, Christine, Lin, Ro-Ting, Linehan, Christine, Linn, Shai, Liu, Hung-Chun, Liu, Shiwei, Liu, Zichen, J Looker, Katharine, D Lopez, Alan, D Lopukhov, Platon, Lorkowski, Stefan, A Lotufo, Paulo, D Lucas, Tim C, Lugo, Alessandra, Lunevicius, Raimunda, A Lyons, Ronan, Ma, Jianing, H MacLachlan, Jennifer, R Maddison, Emilie, Maddison, Ralph, Madotto, Fabiana, Walter Mahasha, Phetole, Thi Mai, Hue, Majeed, Azeem, Maled, Venkatesh, Maleki, Shokofeh, Malekzadeh, Reza, Carvalho Malta, Deborah, A Mamun, Abdullah, Manafi, Amir, Manafi, Navid, Manguerra, Helena, Mansouri, Borhan, Ali Mansournia, Mohammad, M Mantilla Herrera, Ana, C Maravilla, Joemer, Marks, Ashley, Rogerlândio Martins-Melo, Francisco, Martopullo, Ira, Zahra Masoumi, Seyedeh, Massano, João, Ballard Massenburg, Benjamin, Raj Mathur, Manu, K Maulik, Pallab, Mcalinden, Colm, J McGrath, John, Mckee, Martin, Mohan Mehndiratta, Man, Mehri, Fereshteh, M Mehta, Kala, Bigyananda Meitei, Wahengbam, N Memiah, Peter T, Mendoza, Walter, G Menezes, Ritesh, Worku Mengesha, Endalkachew, Berwo Mengesha, Meresa, Mereke, Alibek, Meretoja, Atte, J Meretoja, Tuomo, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Maria Michalek, Irmina, Mulatu Mihretie, Kebadnew, R Miller, Ted, J Mills, Edward, Mirica, Andreea, M Mirrakhimov, Erkin, Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei-Alavijeh, Mehdi, Temesgen Misganaw, Awoke, Mithra, Prasanna, Moazen, Babak, Moghadaszadeh, Masoud, Mohamadi, Efat, K Mohammad, Dara, Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadian-Hafshejani, Abdollah, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohammed, Shafiu, H Mokdad, Ali, Molokhia, Mariam, C Momen, Natalie, Monasta, Lorenzo, Mondello, Stefania, D Mooney, Meghan, Moosazadeh, Mahmood, Moradi, Ghobad, Moradi, Masoud, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Morales, Linda, Morawska, Lidia, Moreno Velásquez, Ilai, Morgado-da-Costa, Joana, Douglas Morrison, Shane, F Mosser, Jonathan, Mouodi, Simin, Meysam Mousavi, Seyyed, Mousavi Khaneghah, Amin, Otto Mueller, Ulrich, B Munro, Sandra, K Muriithi, Mose, Imran Musa, Kamarul, Muthupandian, Saravanan, Naderi, Mehdi, Jayaraman Nagarajan, Ahamarshan, Nagel, Gabriele, Naghshtabrizi, Behshad, Nair, Sanjeev, K Nandi, Anita, Nangia, Vinay, Richie Nansseu, Jobert, C Nayak, Vinod, Nazari, Javad, Negoi, Ionut, Irina Negoi, Ruxandra, Biresaw Netsere Netsere, Henok, W Ngunjiri, Josephine, Tat Nguyen, Cuong, Nguyen, Jason, Nguyen, Michele, Nguyen, Minh, Nichols, Emma, Nigatu, Dabere, T Nigatu, Yeshambel, Nikbakhsh, Rajan, R Nixon, Molly, A Nnaji, Chukwudi, Nomura, Shuhei, Norrving, Bo, Jacques Noubiap, Jean, Nowak, Christoph, Nunez-Samudio, Virginia, Oţoiu, Adrian, Oancea, Bogdan, M Odell, Christopher, Akpojene Ogbo, Felix, Oh, In-Hwan, Wandera Okunga, Emmanuel, Oladnabi, Morteza, T Olagunju, Andrew, Olubukunola Olusanya, Bolajoko, Olusegun Olusanya, Jacob, Morenike Oluwasanu, Mojisola, Omar Bali, Ahmed, Omer Omer, Muktar, L Ong, Kanyin, E Onwujekwe, Obinna, U Orji, Aislyn, M Orpana, Heather, Ortiz, Alberto, M Ostroff, Samuel, Otstavnov, Nikita, S Otstavnov, Stanislav, Øverland, Simon, O Owolabi, Mayowa, P A, Mahesh, Rao Padubidri, Jagadish, P Pakhare, Abhijit, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Pandey, Anamika, Park, Eun-Kee, G Kumari Parmar, Priya, Kumar Pasupula, Deepak, Kishor Patel, Sangram, J Paternina-Caicedo, Angel, Pathak, Ashish, Pathak, Mona, B Patten, Scott, C Patton, George, Paudel, Deepak, Pazoki Toroudi, Hamidreza, E Peden, Amy, Pennini, Alyssa, Christian Filipino Pepito, Veincent, K Peprah, Emmanuel, Pereira, Alexandre, M Pereira, David, Perico, Norberto, Quang Pham, Hai, R Phillips, Michael, M Pigott, David, Pilgrim, Thoma, M Pilz, Tessa, Pirsaheb, Meghdad, Plana-Ripoll, Oleguer, Plass, Dietrich, Narayan Pokhrel, Khem, V Polibin, Roman, Polinder, Suzanne, R Polkinghorne, Kevan, J Postma, Maarten, Pourjafar, Hadi, Pourmalek, Farshad, Pourmirza Kalhori, Reza, Pourshams, Akram, Poznańska, Anna, I Prada, Sergio, Ria Angga Pribadi, Dima, Pupillo, Elisabetta, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiee, Ata, Rafiei, Alireza, Raggi, Alberto, Rahimi-Movaghar, Afarin, Aziz Rahman, Muhammad, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Ramezanzadeh, Kiana, Lal Ranabhat, Chhabi, C Rao, Puja, J Rao, Sowmya, Rasella, Davide, Rastogi, Prateek, Rathi, Priya, Laith Rawaf, David, Rawaf, Salman, Rawal, Lal, Razo, Christian, Boston Redford, Sofia, C Reiner Jr, Robert, Reinig, Nickola, Bettay Reitsma, Marissa, Remuzzi, Giuseppe, Renjith, Vishnu, N Renzaho, Andre M, Resnikoff, Serge, Rezaei, Nima, Sadegh Rezai, Mohammad, Rezapour, Aziz, Rhinehart, Phoebe-Anne, Mohammad Riahi, Seyed, P Ribeiro, Antonio Luiz, Cury Ribeiro, Daniel, Ribeiro, Daniela, Rickard, Jennifer, S Roberts, Nicholas L, Roberts, Shaun, R Robinson, Stephen, Roever, Leonardo, Rolfe, Sam, Ronfani, Luca, Roshandel, Gholamreza, A Roth, Gregory, Rubagotti, Enrico, Fred Rumisha, Susan, Sabour, Siamak, S Sachdev, Perminder, Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeidi, Shahram, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Ali Sahraian, Mohammad, Mohammad Sajadi, S, Reza Salahshoor, Mohammad, Salamati, Payman, Salehi Zahabi, Saleh, Salem, Hosni, R Rashad Salem, Marwa, Salimzadeh, Hamideh, A Salomon, Joshua, Salz, Inbal, Samad, Zainab, M Samy, Abdallah, Sanabria, Juan, Francesco Santomauro, Damian, S Santos, Itamar, Vasco Santos, João, M Santric-Milicevic, Milena, Yegnanarayana Iyer Saraswathy, Sivan, Sarmiento-Suárez, Rodrigo, Sarrafzadegan, Nizal, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, N Sbarra, Alyssa, E Schaeffer, Lauren, Schiavolin, Silvia, Inês Schmidt, Maria, Elisabeth Schutte, Aletta, C Schwebel, David, Schwendicke, Falk, Muleta Senbeta, Anbissa, Senthilkumaran, Subramanian, G Sepanlou, Sadaf, Anne Shackelford, Katya, Shadid, Jamileh, Shahabi, Saeed, A Shaheen, Amira, Ali Shaikh, Masood, S Shalash, Ali, Shams-Beyranvand, Mehran, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomar, Sharara, Fablina, S Sheena, Brittney, Sheikhtaheri, Abba, S Shetty, Ranjitha, Shibuya, Kenji, Shibabaw Shiferaw, Wondimeneh, Shigematsu, Mika, Il Shin, Jae, Shiri, Rahman, Shirkoohi, Reza, G Shrime, Mark, Shuval, Kerem, Siabani, Soraya, Dora Sigfusdottir, Inga, Sigurvinsdottir, Rannveig, Pedro Silva, João, E Simpson, Kyle, Singh, Ambrish, A Singh, Jasvinder, Skiadaresi, Eirini, T Skou Skou, Søren, Yurievich Skryabin, Valentin, Sobngwi, Eugene, Sokhan, Anton, Soltani, Shahin, D Sorensen, Reed J, B Soriano, Joan, Bekele Sorrie, Muluken, N Soyiri, Ireneou, T Sreeramareddy, Chandrashekhar, D Stanaway, Jeffrey, A Stark, Benjamin, Cătălina Ştefan, Simona, Stein, Caroline, Steiner, Caitlyn, J Steiner, Timothy, A Stokes, Mark, Jacob Stovner, Lar, L Stubbs, Jacob, Sudaryanto, Agu, Babale Sufiyan, Mu'Awiyyah, Sulo, Gerhard, Sultan, Iyad, L Sykes, Bryan, O Sylte, Dillon, Szócska, Mikló, Tabarés-Seisdedos, Rafael, M Tabb, Karen, Kumar Tadakamadla, Santosh, Taherkhani, Amir, Tajdini, Masih, Takahashi, Ken, Taveira, Nuno, L Teagle, Whitney, Teame, Hirut, Tehrani-Banihashemi, Arash, Fseha Teklehaimanot, Berhane, Terrason, Sonyah, Tadesse Tessema, Zemenu, Raman Thankappan, Kavumpurathu, M Thomson, Azalea, Reza Tohidinik, Hamid, Tonelli, Marcello, Topor-Madry, Roman, E Torre, Anna, Touvier, Mathilde, Roberto Roberto Tovani-Palone, Marco, Xuan Tran, Bach, Travillian, Ravensara, E Troeger, Christopher, Clement Truelsen, Thoma, C Tsai, Alexander, Tsatsakis, Aristidi, Tudor Car, Lorainne, Tyrovolas, Stefano, Uddin, Riaz, Ullah, Saif, A Undurraga, Eduardo, Unnikrishnan, Bhaskaran, Vacante, Marco, Vakilian, Alireza, R Valdez, Pascual, Varughese, Santosh, Juhani Vasankari, Tommi, Vasseghian, Yasser, Venketasubramanian, Narayanaswamy, S Violante, Francesco, Vlassov, Vasily, Emil Vollset, Stein, Vongpradith, Avina, Vukovic, Ana, Vukovic, Rade, Waheed, Yasir, K Walters, Madgalene, Wang, Jiayu, Wang, Yafeng, Wang, Yuan-Pang, L Ward, Joseph, Watson, Alexandrea, Wei, Jingkai, G Weintraub, Robert, J Weiss, Daniel, Weiss, Jordan, Westerman, Ronny, L Whisnant, Joanna, A Whiteford, Harvey, Wiangkham, Taweewat, E Wiens, Kirsten, Wijeratne, Tissa, B Wilner, Lauren, Wilson, Shadrach, Wojtyniak, Bogdan, A Wolfe, Charles D, E Wool, Eve, Wu, Ai-Min, Wulf Hanson, Sarah, Yong Wunrow, Han, Xu, Gelin, Xu, Rixing, Yadgir, Simon, Hossein Yahyazadeh Jabbari, Seyed, Yamagishi, Kazumasa, Yaminfirooz, Mousa, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, A Yearwood, Jamal, Y Yeheyis, Toma, Gizachew Yeshitila, Yordano, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Yoosefi Lebni, Javad, Z Younis, Mustafa, Patrick Younker, Theodore, Yousefi, Zabihollah, Yousefifard, Mahmoud, Yousefinezhadi, Taraneh, Yousuf Yousuf, Abdilahi, Yu, Chuanhua, Yusefzadeh, Hasan, Zahirian Moghadam, Telma, Zaki, Leila, Bin Zaman, Sojib, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zangeneh, Alireza, Sergeevich Zastrozhin, Mikhail, Alemayehu Zewdie, Kaleab, Zhang, Yunquan, Zhang, Zhi-Jiang, T Zhao, Jeff, Zhao, Yingxi, Zheng, Peng, Zhou, Maigeng, Ziapour, Arash, M Zimsen, Stephanie R, Naghavi, Mohsen, L Murray, Christopher J, Tampere University, Tays Research Services, Health Sciences, Vos, T., Lim, S. S., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., Abolhassani, H., Aboyans, V., Abrams, E. M., Abreu, L. G., Abrigo, M. R. M., Abu-Raddad, L. J., Abushouk, A. I., Acebedo, A., Ackerman, I. N., Adabi, M., Adamu, A. A., Adebayo, O. M., Adekanmbi, V., Adelson, J. D., Adetokunboh, O. O., Adham, D., Afshari, M., Afshin, A., Agardh, E. E., Agarwal, G., Agesa, K. M., Aghaali, M., Aghamir, S. M. K., Agrawal, A., Ahmad, T., Ahmadi, A., Ahmadi, M., Ahmadieh, H., Ahmadpour, E., Akalu, T. Y., Akinyemi, R. O., Akinyemiju, T., Akombi, B., Al-Aly, Z., Alam, K., Alam, N., Alam, S., Alam, T., Alanzi, T. M., Albertson, S. B., Alcalde-Rabanal, J. E., Alema, N. M., Ali, M., Ali, S., Alicandro, G., Alijanzadeh, M., Alinia, C., Alipour, V., Aljunid, S. M., Alla, F., Allebeck, P., Almasi-Hashiani, A., Alonso, J., Al-Raddadi, R. M., Altirkawi, K. A., Alvis-Guzman, N., Alvis-Zakzuk, N. J., Amini, S., Amini-Rarani, M., Aminorroaya, A., Amiri, F., Amit, A. M. L., Amugsi, D. A., Amul, G. G. H., Anderlini, D., Andrei, C. L., Andrei, T., Anjomshoa, M., Ansari, F., Ansari, I., Ansari-Moghaddam, A., Antonio, C. A. T., Antony, C. M., Antriyandarti, E., Anvari, D., Anwer, R., Arabloo, J., Arab-Zozani, M., Aravkin, A. Y., Ariani, F., Arnlov, J., Aryal, K. K., Arzani, A., Asadi-Aliabadi, M., Asadi-Pooya, A. A., Asghari, B., Ashbaugh, C., Atnafu, D. D., Atre, S. R., Ausloos, F., Ausloos, M., Ayala Quintanilla, B. P., Ayano, G., Ayanore, M. A., Aynalem, Y. A., Azari, S., Azarian, G., Azene, Z. N., Babaee, E., Badawi, A., Bagherzadeh, M., Bakhshaei, M. H., Bakhtiari, A., Balakrishnan, S., Balalla, S., Balassyano, S., Banach, M., Banik, P. C., Bannick, M. S., Bante, A. B., Baraki, A. G., Barboza, M. A., Barker-Collo, S. L., Barthelemy, C. M., Barua, L., Barzegar, A., Basu, S., Baune, B. T., Bayati, M., Bazmandegan, G., Bedi, N., Beghi, E., Bejot, Y., Bello, A. K., Bender, R. G., Bennett, D. A., Bennitt, F. B., Bensenor, I. M., Benziger, C. P., Berhe, K., Bernabe, E., Bertolacci, G. J., Bhageerathy, R., Bhala, N., Bhandari, D., Bhardwaj, P., Bhattacharyya, K., Bhutta, Z. A., Bibi, S., Biehl, M. H., Bikbov, B., Bin Sayeed, M. S., Biondi, A., Birihane, B. M., Bisanzio, D., Bisignano, C., Biswas, R. K., Bohlouli, S., Bohluli, M., Bolla, S. R. R., Boloor, A., Boon-Dooley, A. S., Borges, G., Borzi, A. M., Bourne, R., Brady, O. J., Brauer, M., Brayne, C., Breitborde, N. J. K., Brenner, H., Briant, P. S., Briggs, A. M., Briko, N. I., Britton, G. B., Bryazka, D., Buchbinder, R., Bumgarner, B. R., Busse, R., Butt, Z. A., Caetano dos Santos, F. L., Camera, L. L. A., Campos-Nonato, I. R., Car, J., Cardenas, R., Carreras, G., Carrero, J. J., Carvalho, F., Castaldelli-Maia, J. M., Castaneda-Orjuela, C. A., Castelpietra, G., Castle, C. D., Castro, F., Catala-Lopez, F., Causey, K., Cederroth, C. R., Cercy, K. M., Cerin, E., Chandan, J. S., Chang, A. R., Charlson, F. J., Chattu, V. K., Chaturvedi, S., Chimed-Ochir, O., Chin, K. L., Cho, D. Y., Christensen, H., Chu, D. -T., Chung, M. T., Cicuttini, F. M., Ciobanu, L. G., Cirillo, M., Collins, E. L., Compton, K., Conti, S., Cortesi, P. A., Costa, V. M., Cousin, E., Cowden, R. G., Cowie, B. C., Cromwell, E. A., Cross, D. H., Crowe, C. S., Cruz, J. A., Cunningham, M., Dahlawi, S. M. A., Damiani, G., Dandona, L., Dandona, R., Darwesh, A. M., Daryani, A., Das, J. K., Das Gupta, R., das Neves, J., Davila-Cervantes, C. A., Davletov, K., De Leo, D., Dean, F. E., Decleene, N. K., Deen, A., Degenhardt, L., Dellavalle, R. P., Demeke, F. M., Demsie, D. G., Denova-Gutierrez, E., Dereje, N. D., Dervenis, N., Desai, R., Desalew, A., Dessie, G. A., Dharmaratne, S. D., Dhungana, G. P., Dianatinasab, M., Diaz, D., Dibaji Forooshani, Z. S., Dingels, Z. V., Dirac, M. A., Djalalinia, S., Do, H. T., Dokova, K., Dorostkar, F., Doshi, C. P., Doshmangir, L., Douiri, A., Doxey, M. C., Driscoll, T. R., Dunachie, S. J., Duncan, B. B., Duraes, A. R., Eagan, A. W., Ebrahimi Kalan, M., Edvardsson, D., Ehrlich, J. R., El Nahas, N., El Sayed, I., El Tantawi, M., Elbarazi, I., Elgendy, I. Y., Elhabashy, H. R., El-Jaafary, S. I., Elyazar, I. R., Emamian, M. H., Emmons-Bell, S., Erskine, H. E., Eshrati, B., Eskandarieh, S., Esmaeilnejad, S., Esmaeilzadeh, F., Esteghamati, A., Estep, K., Etemadi, A., Etisso, A. E., Farahmand, M., Faraj, A., Fareed, M., Faridnia, R., Farinha, C. S. E. S., Farioli, A., Faro, A., Faruque, M., Farzadfar, F., Fattahi, N., Fazlzadeh, M., Feigin, V. L., Feldman, R., Fereshtehnejad, S. -M., Fernandes, E., Ferrari, A. J., Ferreira, M. L., Filip, I., Fischer, F., Fisher, J. L., Fitzgerald, R., Flohr, C., Flor, L. S., Foigt, N. A., Folayan, M. O., Force, L. M., Fornari, C., Foroutan, M., Fox, J. T., Freitas, M., Fu, W., Fukumoto, T., Furtado, J. M., Gad, M. M., Gakidou, E., Galles, N. C., Gallus, S., Gamkrelidze, A., Garcia-Basteiro, A. L., Gardner, W. M., Geberemariyam, B. S., Gebrehiwot, A. M., Gebremedhin, K. B., Gebreslassie, A. A. A. A., Gershberg Hayoon, A., Gething, P. W., Ghadimi, M., Ghadiri, K., Ghafourifard, M., Ghajar, A., Ghamari, F., Ghashghaee, A., Ghiasvand, H., Ghith, N., Gholamian, A., Gilani, S. A., Gill, P. S., Gitimoghaddam, M., Giussani, G., Goli, S., Gomez, R. S., Gopalani, S. V., Gorini, G., Gorman, T. M., Gottlich, H. C., Goudarzi, H., Goulart, A. C., Goulart, B. N. G., Grada, A., Grivna, M., Grosso, G., Gubari, M. I. M., Gugnani, H. C., Guimaraes, A. L. S., Guimaraes, R. A., Guled, R. A., Guo, G., Guo, Y., Gupta, R., Haagsma, J. A., Haddock, B., Hafezi-Nejad, N., Hafiz, A., Hagins, H., Haile, L. M., Hall, B. J., Halvaei, I., Hamadeh, R. R., Hamagharib Abdullah, K., Hamilton, E. B., Han, C., Han, H., Hankey, G. J., Haro, J. M., Harvey, J. D., Hasaballah, A. I., Hasanzadeh, A., Hashemian, M., Hassanipour, S., Hassankhani, H., Havmoeller, R. J., Hay, R. J., Hay, S. I., Hayat, K., Heidari, B., Heidari, G., Heidari-Soureshjani, R., Hendrie, D., Henrikson, H. J., Henry, N. J., Herteliu, C., Heydarpour, F., Hird, T. R., Hoek, H. W., Hole, M. K., Holla, R., Hoogar, P., Hosgood, H. D., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hoy, D. G., Hsairi, M., Hsieh, V. C. -R., Hu, G., Huda, T. M., Hugo, F. N., Huynh, C. K., Hwang, B. -F., Iannucci, V. C., Ibitoye, S. E., Ikuta, K. S., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Inbaraj, L. R., Ippolito, H., Irvani, S. S. N., Islam, M. M., Islam, M., Islam, S. M. S., Islami, F., Iso, H., Ivers, R. Q., Iwu, C. C. D., Iyamu, I. O., Jaafari, J., Jacobsen, K. H., Jadidi-Niaragh, F., Jafari, H., Jafarinia, M., Jahagirdar, D., Jahani, M. A., Jahanmehr, N., Jakovljevic, M., Jalali, A., Jalilian, F., James, S. L., Janjani, H., Janodia, M. D., Jayatilleke, A. U., Jeemon, P., Jenabi, E., Jha, R. P., Jha, V., Ji, J. S., Jia, P., John, O., John-Akinola, Y. O., Johnson, C. O., Johnson, S. C., Jonas, J. B., Joo, T., Joshi, A., Jozwiak, J. J., Jurisson, M., Kabir, A., Kabir, Z., Kalani, H., Kalani, R., Kalankesh, L. R., Kalhor, R., Kamiab, Z., Kanchan, T., Karami Matin, B., Karch, A., Karim, M. A., Karimi, S. E., Kassa, G. M., Kassebaum, N. J., Katikireddi, S. V., Kawakami, N., Kayode, G. A., Keddie, S. H., Keller, C., Kereselidze, M., Khafaie, M. A., Khalid, N., Khan, M., Khatab, K., Khater, M. M., Khatib, M. N., Khayamzadeh, M., Khodayari, M. T., Khundkar, R., Kianipour, N., Kieling, C., Kim, D., Kim, Y. -E., Kim, Y. J., Kimokoti, R. W., Kisa, A., Kisa, S., Kissimova-Skarbek, K., Kivimaki, M., Kneib, C. J., Knudsen, A. K. S., Kocarnik, J. M., Kolola, T., Kopec, J. A., Kosen, S., Koul, P. A., Koyanagi, A., Kravchenko, M. A., Krishan, K., Krohn, K. J., Kuate Defo, B., Kucuk Bicer, B., Kumar, G. A., Kumar, M., Kumar, P., Kumar, V., Kumaresh, G., Kurmi, O. P., Kusuma, D., Kyu, H. H., La Vecchia, C., Lacey, B., Lal, D. K., Lalloo, R., Lam, J. O., Lami, F. H., Landires, I., Lang, J. J., Lansingh, V. C., Larson, S. L., Larsson, A. O., Lasrado, S., Lassi, Z. S., Lau, K. M. -M., Lavados, P. M., Lazarus, J. V., Ledesma, J. R., Lee, P. H., Lee, S. W. H., Legrand, K. E., Leigh, J., Leonardi, M., Lescinsky, H., Leung, J., Levi, M., Lewington, S., Li, S., Lim, L. -L., Lin, C., Lin, R. -T., Linehan, C., Linn, S., Liu, H. -C., Liu, S., Liu, Z., Looker, K. J., Lopez, A. D., Lopukhov, P. D., Lorkowski, S., Lotufo, P. A., Lucas, T. C. D., Lugo, A., Lunevicius, R., Lyons, R. A., Ma, J., Maclachlan, J. H., Maddison, E. R., Maddison, R., Madotto, F., Mahasha, P. W., Mai, H. T., Majeed, A., Maled, V., Maleki, S., Malekzadeh, R., Malta, D. C., Mamun, A. A., Manafi, A., Manafi, N., Manguerra, H., Mansouri, B., Mansournia, M. A., Mantilla Herrera, A. M., Maravilla, J. C., Marks, A., Martins-Melo, F. R., Martopullo, I., Masoumi, S. Z., Massano, J., Massenburg, B. B., Mathur, M. R., Maulik, P. K., Mcalinden, C., Mcgrath, J. J., Mckee, M., Mehndiratta, M. M., Mehri, F., Mehta, K. M., Meitei, W. B., Memiah, P. T. N., Mendoza, W., Menezes, R. G., Mengesha, E. W., Mengesha, M. B., Mereke, A., Meretoja, A., Meretoja, T. J., Mestrovic, T., Miazgowski, B., Miazgowski, T., Michalek, I. M., Mihretie, K. M., Miller, T. R., Mills, E. J., Mirica, A., Mirrakhimov, E. M., Mirzaei, H., Mirzaei, M., Mirzaei-Alavijeh, M., Misganaw, A. T., Mithra, P., Moazen, B., Moghadaszadeh, M., Mohamadi, E., Mohammad, D. K., Mohammad, Y., Mohammad Gholi Mezerji, N., Mohammadian-Hafshejani, A., Mohammadifard, N., Mohammadpourhodki, R., Mohammed, S., Mokdad, A. H., Molokhia, M., Momen, N. C., Monasta, L., Mondello, S., Mooney, M. D., Moosazadeh, M., Moradi, G., Moradi, M., Moradi-Lakeh, M., Moradzadeh, R., Moraga, P., Morales, L., Morawska, L., Moreno Velasquez, I., Morgado-da-Costa, J., Morrison, S. D., Mosser, J. F., Mouodi, S., Mousavi, S. M., Mousavi Khaneghah, A., Mueller, U. O., Munro, S. B., Muriithi, M. K., Musa, K. I., Muthupandian, S., Naderi, M., Nagarajan, A. J., Nagel, G., Naghshtabrizi, B., Nair, S., Nandi, A. K., Nangia, V., Nansseu, J. R., Nayak, V. C., Nazari, J., Negoi, I., Negoi, R. I., Netsere, H. B. N., Ngunjiri, J. W., Nguyen, C. T., Nguyen, J., Nguyen, M., Nichols, E., Nigatu, D., Nigatu, Y. T., Nikbakhsh, R., Nixon, M. R., Nnaji, C. A., Nomura, S., Norrving, B., Noubiap, J. J., Nowak, C., Nunez-Samudio, V., Otoiu, A., Oancea, B., Odell, C. M., Ogbo, F. A., Oh, I. -H., Okunga, E. W., Oladnabi, M., Olagunju, A. T., Olusanya, B. O., Olusanya, J. O., Oluwasanu, M. M., Omar Bali, A., Omer, M. O., Ong, K. L., Onwujekwe, O. E., Orji, A. U., Orpana, H. M., Ortiz, A., Ostroff, S. M., Otstavnov, N., Otstavnov, S. S., Overland, S., Owolabi, M. O., P A, M., Padubidri, J. R., Pakhare, A. P., Palladino, R., Pana, A., Panda-Jonas, S., Pandey, A., Park, E. -K., Parmar, P. G. K., Pasupula, D. K., Patel, S. K., Paternina-Caicedo, A. J., Pathak, A., Pathak, M., Patten, S. B., Patton, G. C., Paudel, D., Pazoki Toroudi, H., Peden, A. E., Pennini, A., Pepito, V. C. F., Peprah, E. K., Pereira, A., Pereira, D. M., Perico, N., Pham, H. Q., Phillips, M. R., Pigott, D. M., Pilgrim, T., Pilz, T. M., Pirsaheb, M., Plana-Ripoll, O., Plass, D., Pokhrel, K. N., Polibin, R. V., Polinder, S., Polkinghorne, K. R., Postma, M. J., Pourjafar, H., Pourmalek, F., Pourmirza Kalhori, R., Pourshams, A., Poznanska, A., Prada, S. I., Prakash, V., Pribadi, D. R. A., Pupillo, E., Quazi Syed, Z., Rabiee, M., Rabiee, N., Radfar, A., Rafiee, A., Rafiei, A., Raggi, A., Rahimi-Movaghar, A., Rahman, M. A., Rajabpour-Sanati, A., Rajati, F., Ramezanzadeh, K., Ranabhat, C. L., Rao, P. C., Rao, S. J., Rasella, D., Rastogi, P., Rathi, P., Rawaf, D. L., Rawaf, S., Rawal, L., Razo, C., Redford, S. B., Reiner, R. C., Reinig, N., Reitsma, M. B., Remuzzi, G., Renjith, V., Renzaho, A. M. N., Resnikoff, S., Rezaei, N., Rezai, M. S., Rezapour, A., Rhinehart, P. -A., Riahi, S. M., Ribeiro, A. L. P., Ribeiro, D. C., Ribeiro, D., Rickard, J., Roberts, N. L. S., Roberts, S., Robinson, S. R., Roever, L., Rolfe, S., Ronfani, L., Roshandel, G., Roth, G. A., Rubagotti, E., Rumisha, S. F., Sabour, S., Sachdev, P. S., Saddik, B., Sadeghi, E., Sadeghi, M., Saeidi, S., Safi, S., Safiri, S., Sagar, R., Sahebkar, A., Sahraian, M. A., Sajadi, S. M., Salahshoor, M. R., Salamati, P., Salehi Zahabi, S., Salem, H., Salem, M. R. R., Salimzadeh, H., Salomon, J. A., Salz, I., Samad, Z., Samy, A. M., Sanabria, J., Santomauro, D. F., Santos, I. S., Santos, J. V., Santric-Milicevic, M. M., Saraswathy, S. Y. I., Sarmiento-Suarez, R., Sarrafzadegan, N., Sartorius, B., Sarveazad, A., Sathian, B., Sathish, T., Sattin, D., Sbarra, A. N., Schaeffer, L. E., Schiavolin, S., Schmidt, M. I., Schutte, A. E., Schwebel, D. C., Schwendicke, F., Senbeta, A. M., Senthilkumaran, S., Sepanlou, S. G., Shackelford, K. A., Shadid, J., Shahabi, S., Shaheen, A. A., Shaikh, M. A., Shalash, A. S., Shams-Beyranvand, M., Shamsizadeh, M., Shannawaz, M., Sharafi, K., Sharara, F., Sheena, B. S., Sheikhtaheri, A., Shetty, R. S., Shibuya, K., Shiferaw, W. S., Shigematsu, M., Shin, J. I., Shiri, R., Shirkoohi, R., Shrime, M. G., Shuval, K., Siabani, S., Sigfusdottir, I. D., Sigurvinsdottir, R., Silva, J. P., Simpson, K. E., Singh, A., Singh, J. A., Skiadaresi, E., Skou, S. T. S., Skryabin, V. Y., Sobngwi, E., Sokhan, A., Soltani, S., Sorensen, R. J. D., Soriano, J. B., Sorrie, M. B., Soyiri, I. N., Sreeramareddy, C. T., Stanaway, J. D., Stark, B. A., Stefan, S. C., Stein, C., Steiner, C., Steiner, T. J., Stokes, M. A., Stovner, L. J., Stubbs, J. L., Sudaryanto, A., Sufiyan, M. B., Sulo, G., Sultan, I., Sykes, B. L., Sylte, D. O., Szocska, M., Tabares-Seisdedos, R., Tabb, K. M., Tadakamadla, S. K., Taherkhani, A., Tajdini, M., Takahashi, K., Taveira, N., Teagle, W. L., Teame, H., Tehrani-Banihashemi, A., Teklehaimanot, B. F., Terrason, S., Tessema, Z. T., Thankappan, K. R., Thomson, A. M., Tohidinik, H. R., Tonelli, M., Topor-Madry, R., Torre, A. E., Touvier, M., Tovani-Palone, M. R. R., Tran, B. X., Travillian, R., Troeger, C. E., Truelsen, T. C., Tsai, A. C., Tsatsakis, A., Tudor Car, L., Tyrovolas, S., Uddin, R., Ullah, S., Undurraga, E. A., Unnikrishnan, B., Vacante, M., Vakilian, A., Valdez, P. R., Varughese, S., Vasankari, T. J., Vasseghian, Y., Venketasubramanian, N., Violante, F. S., Vlassov, V., Vollset, S. E., Vongpradith, A., Vukovic, A., Vukovic, R., Waheed, Y., Walters, M. K., Wang, J., Wang, Y., Wang, Y. -P., Ward, J. L., Watson, A., Wei, J., Weintraub, R. G., Weiss, D. J., Weiss, J., Westerman, R., Whisnant, J. L., Whiteford, H. A., Wiangkham, T., Wiens, K. E., Wijeratne, T., Wilner, L. B., Wilson, S., Wojtyniak, B., Wolfe, C. D. A., Wool, E. E., Wu, A. -M., Wulf Hanson, S., Wunrow, H. Y., Xu, G., Xu, R., Yadgir, S., Yahyazadeh Jabbari, S. H., Yamagishi, K., Yaminfirooz, M., Yano, Y., Yaya, S., Yazdi-Feyzabadi, V., Yearwood, J. A., Yeheyis, T. Y., Yeshitila, Y. G., Yip, P., Yonemoto, N., Yoon, S. -J., Yoosefi Lebni, J., Younis, M. Z., Younker, T. P., Yousefi, Z., Yousefifard, M., Yousefinezhadi, T., Yousuf, A. Y., Yu, C., Yusefzadeh, H., Zahirian Moghadam, T., Zaki, L., Zaman, S. B., Zamani, M., Zamanian, M., Zandian, H., Zangeneh, A., Zastrozhin, M. S., Zewdie, K. A., Zhang, Y., Zhang, Z. -J., Zhao, J. T., Zhao, Y., Zheng, P., Zhou, M., Ziapour, A., Zimsen, S. R. M., Naghavi, M., Murray, C. J. L., Department of Public Health, Clinicum, Department of Neurosciences, HUS Comprehensive Cancer Center, Environmental Sciences, Public Health, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), Sálfræðideild (HR), Department of Psychology (RU), Samfélagssvið (HR), School of Social Sciences (RU), Háskólinn í Reykjavík, Reykjavik University, GBD 2019 Diseases and Injuries Collaborator, Violante FS, Department of Earth Observation Science, Faculty of Geo-Information Science and Earth Observation, and UT-I-ITC-ACQUAL

Subjects
Male, Life expectancy, Disability-Adjusted Life Year, Diseases, Disease, communicable disease, systematic analysis, Global Burden of Disease, 0302 clinical medicine, 80 and over, Medicine, 10. No inequality, Child, 11 Medical and Health Sciences, injuries, Aged, 80 and over, education.field_of_study, Sjúkdómar, DEMENTIA, FALLS, General Medicine, Forvarnir, 3. Good health, Child, Preschool, Human, GBD, Population health, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Humans, Global Burden of Disease Study, education, Aged, Spatial Analysis, Global burden, Disability, Prevention, DISABILITY, Infant, Spatial Analysi, Mortality rate, Global Burden of Disease, Diseases, Injuries, Systematic analysis, PREVENTION, Years of potential life lost, Risk factors, Disease study, ITC-ISI-JOURNAL-ARTICLE, RISK-FACTORS, Clinical Medicine, RA, Demography, Fötlun, Dánartíðni, Áhættuþættir, 030204 cardiovascular system & hematology, Risk Factors, Cause of Death, Global health, 030212 general & internal medicine, 1. No poverty, Disability-Adjusted Life Years, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, 3142 Public health care science, environmental and occupational health, Adolescent, Adult, Age Distribution, Female, Infant, Newborn, Young Adult, Lýðheilsa, CLINICAL-TRIALS, Population, Settore MED/01 - Statistica Medica, diseases, ITC-HYBRID, Heilbrigðisvísindi, General & Internal Medicine, Mortality, Preschool, Disease burden, business.industry, Risk Factor, Klinisk medicin, Newborn, purl.org/pe-repo/ocde/ford#3.02.00 [https], Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Áverkar, Systematic analysis, NA, business
Abstract

Publisher's version (útgefin grein), Background In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990-2010 time period, with the greatest annualised rate of decline occurring in the 0-9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10-24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10-24 years were also in the top ten in the 25-49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50-74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd., Research reported in this publication was supported by the Bill & Melinda Gates Foundation; the University of Melbourne; Queensland Department of Health, Australia; the National Health and Medical Research Council, Australia; Public Health England; the Norwegian Institute of Public Health; St Jude Children's Research Hospital; the Cardiovascular Medical Research and Education Fund; the National Institute on Ageing of the National Institutes of Health (award P30AG047845); and the National Institute of Mental Health of the National Institutes of Health (award R01MH110163). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders. The authors alone are responsible for the views expressed in this Article and they do not necessarily represent the views, decisions, or policies of the institutions with which they are affiliated, the National Health Service (NHS), the National Institute for Health Research (NIHR), the UK Department of Health and Social Care, or Public Health England; the United States Agency for International Development (USAID), the US Government, or MEASURE Evaluation; or the European Centre for Disease Prevention and Control (ECDC). This research used data from the Chile National Health Survey 2003, 2009-10, and 2016-17. The authors are grateful to the Ministry of Health, the survey copyright owner, for allowing them to have the database. All results of the study are those of the authors and in no way committed to the Ministry. The Costa Rican Longevity and Healthy Aging Study project is a longitudinal study by the University of Costa Rica's Centro Centroamericano de Poblacion and Instituto de Investigaciones en Salud, in collaboration with the University of California at Berkeley. The original pre-1945 cohort was funded by the Wellcome Trust (grant 072406), and the 1945-55 Retirement Cohort was funded by the US National Institute on Aging (grant R01AG031716). The principal investigators are Luis Rosero-Bixby and William H Dow and co-principal investigators are Xinia Fernandez and Gilbert Brenes. The accuracy of the authors' statistical analysis and the findings they report are not the responsibility of ECDC. ECDC is not responsible for conclusions or opinions drawn from the data provided. ECDC is not responsible for the correctness of the data and for data management, data merging and data collation after provision of the data. ECDC shall not be held liable for improper or incorrect use of the data. The Health Behaviour in School-Aged Children (HBSC) study is an international study carried out in collaboration with WHO/EURO. The international coordinator of the 1997-98, 2001-02, 2005-06, and 2009-10 surveys was Candace Currie and the databank manager for the 1997-98 survey was Bente Wold, whereas for the following surveys Oddrun Samdal was the databank manager. A list of principal investigators in each country can be found on the HBSC website. Data used in this paper come from the 2009-10 Ghana Socioeconomic Panel Study Survey, which is a nationally representative survey of more than 5000 households in Ghana. The survey is a joint effort undertaken by the Institute of Statistical, Social and Economic Research (ISSER) at the University of Ghana and the Economic Growth Centre (EGC) at Yale University. It was funded by EGC. ISSER and the EGC are not responsible for the estimations reported by the analysts. The Palestinian Central Bureau of Statistics granted the researchers access to relevant data in accordance with license number SLN2014-3-170, after subjecting data to processing aiming to preserve the confidentiality of individual data in accordance with the General Statistics Law, 2000. The researchers are solely responsible for the conclusions and inferences drawn upon available data. Data for this research was provided by MEASURE Evaluation, funded by USAID. The authors thank the Russia Longitudinal Monitoring Survey, conducted by the National Research University Higher School of Economics and ZAO Demoscope together with Carolina Population Center, University of North Carolina at Chapel Hill and the Institute of Sociology, Russia Academy of Sciences for making data available. This paper uses data from the Bhutan 2014 STEPS survey, implemented by the Ministry of Health with the support of WHO; the Kuwait 2006 and 2014 STEPS surveys, implemented by the Ministry of Health with the support of WHO; the Libya 2009 STEPS survey, implemented by the Secretariat of Health and Environment with the support of WHO; the Malawi 2009 STEPS survey, implemented by Ministry of Health with the support of WHO; and the Moldova 2013 STEPS survey, implemented by the Ministry of Health, the National Bureau of Statistics, and the National Center of Public Health with the support of WHO. This paper uses data from Survey of Health, Ageing and Retirement in Europe (SHARE) Waves 1 (DOI:10.6103/SHARE. w1.700), 2 (10.6103/SHARE.w2.700), 3 (10.6103/SHARE.w3.700), 4 (10.6103/SHARE.w4.700), 5 (10.6103/SHARE.w5.700), 6 (10.6103/SHARE.w6.700), and 7 (10.6103/SHARE.w7.700); see Borsch-Supan and colleagues (2013) for methodological details. The SHARE data collection has been funded by the European Commission through FP5 (QLK6-CT-2001-00360), FP6 (SHARE-I3: RII-CT-2006-062193, COMPARE: CIT5-CT-2005-028857, SHARELIFE: CIT4-CT-2006-028812), FP7 (SHARE-PREP: GA N degrees 211909, SHARE-LEAP: GA N degrees 227822, SHARE M4: GA N degrees 261982) and Horizon 2020 (SHARE-DEV3: GA N degrees 676536, SERISS: GA N degrees 654221) and by DG Employment, Social Affairs & Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the US National Institute on Aging (U01_AG09740-13S2, P01_AG005842, P01_AG08291, P30_AG12815, R21_AG025169, Y1-AG-4553-01, IAG_BSR06-11, OGHA_04-064, HHSN271201300071C), and from various national funding sources is gratefully acknowledged. This study has been realised using the data collected by the Swiss Household Panel, which is based at the Swiss Centre of Expertise in the Social Sciences. The project is financed by the Swiss National Science Foundation. The United States Aging, Demographics, and Memory Study is a supplement to the Health and Retirement Study (HRS), which is sponsored by the National Institute of Aging (grant number NIA U01AG009740). It was conducted jointly by Duke University and the University of Michigan. The HRS is sponsored by the National Institute on Aging (grant number NIA U01AG009740) and is conducted by the University of Michigan. This paper uses data from Add Health, a program project designed by J Richard Udry, Peter S Bearman, and Kathleen Mullan Harris, and funded by a grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 17 other agencies. Special acknowledgment is due to Ronald R Rindfuss and Barbara Entwisle for assistance in the original design. Information on how to obtain the Add Health data files is available on the Add Health website. No direct support was received from grant P01-HD31921 for this analysis. The data reported here have been supplied by the United States Renal Data System. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy or interpretation of the US Government. Collection of data for the Mozambique National Survey on the Causes of Death 2007-08 was made possible by USAID under the terms of cooperative agreement GPO-A-00-08-000_D3-00. This manuscript is based on data collected and shared by the International Vaccine Institute (IVI) from an original study IVI conducted. L G Abreu acknowledges support from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Brazil; finance code 001) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, a Brazilian funding agency). I N Ackerman was supported by a Victorian Health and Medical Research Fellowship awarded by the Victorian Government. O O Adetokunboh acknowledges the South African Department of Science and Innovation and the National Research Foundation. A Agrawal acknowledges the Wellcome Trust DBT India Alliance Senior Fellowship. S M Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. M Ausloos, C Herteliu, and A Pana acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. A Badawi is supported by the Public Health Agency of Canada. D A Bennett was supported by the NIHR Oxford Biomedical Research Centre. R Bourne acknowledges the Brien Holden Vision Institute, University of Heidelberg, Sightsavers, Fred Hollows Foundation, and Thea Foundation. G B Britton and I Moreno Velasquez were supported by the Sistema Nacional de Investigacion, SNI-SENACYT, Panama. R Buchbinder was supported by an Australian National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship. J J Carrero was supported by the Swedish Research Council (2019-01059). F Carvalho acknowledges UID/MULTI/04378/2019 and UID/QUI/50006/2019 support with funding from FCT/MCTES through national funds. A R Chang was supported by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases grant K23 DK106515. V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundacao para a Ciencia e Tecnologia, IP, under the Norma Transitaria DL57/2016/CP1334/CT0006. A Douiri acknowledges support and funding from the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care South London at King's College Hospital NHS Foundation Trust and the Royal College of Physicians, and support from the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. B B Duncan acknowledges grants from the Foundation for the Support of Research of the State of Rio Grande do Sul (IATS and PrInt) and the Brazilian Ministry of Health. H E Erskine is the recipient of an Australian NHMRC Early Career Fellowship grant (APP1137969). A J Ferrari was supported by a NHMRC Early Career Fellowship grant (APP1121516). H E Erskine and A J Ferrari are employed by and A M Mantilla-Herrera and D F Santomauro affiliated with the Queensland Centre for Mental Health Research, which receives core funding from the Queensland Department of Health. M L Ferreira holds an NHMRC Research Fellowship. C Flohr was supported by the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust. M Freitas acknowledges financial support from the EU (European Regional Development Fund [FEDER] funds through COMPETE POCI-01-0145-FEDER-029248) and National Funds (Fundacao para a Ciencia e Tecnologia) through project PTDC/NAN-MAT/29248/2017. A L S Guimaraes acknowledges support from CNPq. C Herteliu was partially supported by a grant co-funded by FEDER through Operational Competitiveness Program (project ID P_40_382). P Hoogar acknowledges Centre for Bio Cultural Studies, Directorate of Research, Manipal Academy of Higher Education and Centre for Holistic Development and Research, Kalaghatagi. F N Hugo acknowledges the Visiting Professorship, PRINT Program, CAPES Foundation, Brazil. B-F Hwang was supported by China Medical University (CMU107-Z-04), Taichung, Taiwan. S M S Islam was funded by a National Heart Foundation Senior Research Fellowship and supported by Deakin University. R Q Ivers was supported by a research fellowship from the National Health and Medical Research Council of Australia. M Jakovljevic acknowledges the Serbian part of this GBD-related contribution was co-funded through Grant OI175014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. P Jeemon was supported by a Clinical and Public Health intermediate fellowship (grant number IA/CPHI/14/1/501497) from the Wellcome Trust-Department of Biotechnology, India Alliance (2015-20). O John is a recipient of UIPA scholarship from University of New South Wales, Sydney. S V Katikireddi acknowledges funding from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_12017/13, MC_UU_12017/15), and the Scottish Government Chief Scientist Office (SPHSU13, SPHSU15). C Kieling is a CNPq researcher and a UK Academy of Medical Sciences Newton Advanced Fellow. Y J Kim was supported by Research Management Office, Xiamen University Malaysia (XMUMRF/2018-C2/ITCM/00010). K Krishan is supported by UGC Centre of Advanced Study awarded to the Department of Anthropology, Panjab University, Chandigarh, India. M Kumar was supported by K43 TW 010716 FIC/NIMH. B Lacey acknowledges support from the NIHR Oxford Biomedical Research Centre and the BHF Centre of Research Excellence, Oxford. J V Lazarus was supported by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III [ISCIII]/ESF, the EU [CP18/00074]). K J Looker thanks the NIHR Health Protection Research Unit in Evaluation of Interventions at the University of Bristol, in partnership with Public Health England, for research support. S Lorkowski was funded by the German Federal Ministry of Education and Research (nutriCARD, grant agreement number 01EA1808A). R A Lyons is supported by Health Data Research UK (HDR-9006), which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, NIHR (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation, and Wellcome Trust. J J McGrath is supported by the Danish National Research Foundation (Niels Bohr Professorship), and the Queensland Health Department (via West Moreton HHS). P T N Memiah acknowledges support from CODESRIA. U O Mueller gratefully acknowledges funding by the German National Cohort Study BMBF grant number 01ER1801D. S Nomura acknowledges the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K10082). A Ortiz was supported by ISCIII PI19/00815, DTS18/00032, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. These funding sources had no role in the writing of the manuscript or the decision to submit it for publication. S B Patten was supported by the Cuthbertson & Fischer Chair in Pediatric Mental Health at the University of Calgary. G C Patton was supported by an aNHMRC Senior Principal Research Fellowship. M R Phillips was supported in part by the National Natural Science Foundation of China (NSFC, number 81371502 and 81761128031). A Raggi, D Sattin, and S Schiavolin were supported by grants from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C Besta, Linea 4-Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). P Rathi and B Unnikrishnan acknowledge Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal. A L P Ribeiro was supported by Brazilian National Research Council, CNPq, and the Minas Gerais State Research Agency, FAPEMIG. D C Ribeiro was supported by The Sir Charles Hercus Health Research Fellowship (#18/111) Health Research Council of New Zealand. D Ribeiro acknowledges financial support from the EU (FEDER funds through the Operational Competitiveness Program; POCI-01-0145-FEDER-029253). P S Sachdev acknowledges funding from the NHMRC of Australia Program Grant. A M Samy was supported by a fellowship from the Egyptian Fulbright Mission Program. M M Santric-Milicevic acknowledges the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract number 175087). R Sarmiento-Suarez received institutional support from Applied and Environmental Sciences University (Bogota, Colombia) and ISCIII (Madrid, Spain). A E Schutte received support from the South African National Research Foundation SARChI Initiative (GUN 86895) and Medical Research Council. S T S Skou is currently funded by a grant from Region Zealand (Exercise First) and a grant from the European Research Council under the EU's Horizon 2020 research and innovation program (grant agreement number 801790). J B Soriano is funded by Centro de Investigacion en Red de Enfermedades Respiratorias, ISCIII. R Tabares-Seisdedos was supported in part by the national grant PI17/00719 from ISCIII-FEDER. N Taveira was partially supported by the European & Developing Countries Clinical Trials Partnership, the EU (LIFE project, reference RIA2016MC-1615). S Tyrovolas was supported by the Foundation for Education and European Culture, the Sara Borrell postdoctoral programme (reference number CD15/00019 from ISCIII-FEDER). S B Zaman received a scholarship from the Australian Government research training programme in support of his academic career., "Peer Reviewed"

Published
2020

47. Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

William M. Gardner, Rawlance Ndejjo, Govinda Prasad Dhungana, Fereshteh Ansari, Kathleen Pillsbury Hopf, João Pedro Silva, M. Mofizul Islam, Cong Zhu, Abdul Hafiz, Irmina Maria Michalek, Syed Mohamed Aljunid, Leonardo Roever, Mustefa Glagn, Davood Anvari, Tessa M. Pilz, Sameer Vali Gopalani, Joel M. Francis, Man Mohan Mehndiratta, Rakhi Dandona, Abbas Sheikhtaheri, Mansour Ghafourifard, Simon Øverland, David Laith Rawaf, Jaykaran Charan, Akram Pourshams, Mostafa Dianatinasab, Morteza Mahmoudi, Alton Lu, Alyssa N. Sbarra, Lorainne Tudor Car, Franz Castro, Hafiz Ansar Rasul Suleria, Luca Ronfani, Marina Pinheiro, Mehran Asadi-Aliabadi, Maziar Moradi-Lakeh, Hoa Thi Do, Whitney L. Teagle, Sofia Androudi, Carl Abelardo T. Antonio, Myron Anthony Godinho, Bhaskaran Unnikrishnan, Oluchi Ezekannagha, Getinet Ayano, Seyyed Shamsadin Athari, Dimas Ria Angga Pribadi, Kyle E. Simpson, Muluken Bekele Sorrie, Vivekanand Jha, Chukwuma David Umeokonkwo, Akshaya Srikanth Bhagavathula, Cuong Tat Nguyen, Amr Hassan, Akine Eshete Abosetugn, Hailay Abrha Gesesew, Anna V. Korotkova, Brijesh Sathian, Marcello Tonelli, Olatunde Aremu, Mohammad Reza Salahshoor, Juan Jesus Carrero, Cameron J. Kneib, Ravi Prakash Jha, David H. Shaw, Hossein Samadi Kafil, Tanuj Kanchan, Khezar Hayat, Hamid Sharifi, Morteza Shamsizadeh, Muktar Omer Omer, Fatemeh Amiri, Hamidreza Pazoki Toroudi, David Edvardsson, Xiu Ju George Zhao, Hannah Han, Leticia Avila-Burgos, Adam E. Berman, Jemal Abdu Mohammed, Thomas Pilgrim, Leila Doshmangir, Mu'awiyyah Babale Sufiyan, David M. Pigott, Hadi Hassankhani, Beatriz Paulina Ayala Quintanilla, Teklemariam Gultie, Arash Ziapour, Seyed Sina Naghibi Irvani, Ilse N. Dippenaar, Jean Jacques Noubiap, Emmanuela Gakidou, Abiyu Mekonnen Gebrehiwot, Maha El Tantawi, Xuefeng Liu, Zulfiqar A. Bhutta, Keyghobad Ghadiri, João Mauricio Castaldelli-Maia, Behzad Karami Matin, Yunquan Zhang, Vera Marisa Costa, Iyad Sultan, Mostafa Hosseini, Abdulaziz Khalid Abu Haimed, Haidong Wang, Kaleab Alemayehu Zewdie, Celine M. Barthelemy, Hosna Janjani, Bartosz Miazgowski, Jobert Richie Nansseu, Arianna Maever L. Amit, John S. Ji, Ata Rafiee, Maria Inês Schmidt, Alireza Rafiei, Somayeh Bohlouli, Joana Morgado-da-Costa, Huong Lan Thi Nguyen, Pradyumna Agasthi, Tiffany K. Gill, Martin McKee, Khaled Khatab, Jae Il Shin, Animut Tagele Tamiru, Giancarlo Logroscino, Hassan Abolhassani, Syed Saoud Zaidi, Sivan Yegnanarayana Iyer Saraswathy, Garumma Tolu Feyissa, Ahmad Daryani, Ziyad Al-Aly, Gebreamlak Gebremedhn Gebremeskel, Michael T. Chung, Amirhossein Sahebkar, Mehedi Hasan, Saeed Shahabi, Diep Ngoc Nguyen, Yohannes Kinfu, Nicholas L S Roberts, Jagadish Rao Padubidri, Mika Shigematsu, Lucero Cahuana-Hurtado, Deepa Jahagirdar, Islam Y. Elgendy, Erkin M. Mirrakhimov, Tanvir M. Huda, Fakher Rahim, Dara K. Mohammad, Yingxi Zhao, Ruxandra Irina Negoi, Vinod C. Nayak, Reinhard Busse, Andrew T. Leever, Muhammad Aziz Rahman, Kathryn Mei Ming Lau, Stefania Mondello, Vivian Chia-Rong Hsieh, Kris J. Krohn, Reza Rawassizadeh, Vishnu Renjith, Jianing Ma, Moses K. Muriithi, Mark G. Shrime, Mayowa O. Owolabi, Nobuyuki Horita, Seyed Hossein Yahyazadeh Jabbari, Daniel Y. Cho, Miloje Savic, Moslem Soofi, Iqbal R. F. Elyazar, Freweini Gebrearegay G. Tela, Jonathan F. Mosser, Palash Chandra Banik, Andre Rodrigues Duraes, Yuan-Pang Wang, Natalie C. Galles, Rashid Abdi Guled, Abdallah M. Samy, Hadi Pourjafar, Roman Topor-Madry, Ayesha Humayun, Leila Zaki, Nuworza Kugbey, Maryam Khayamzadeh, Naznin Hossain, Jiregna Darega Gela, Jordi Alonso, Ruth W Kimokoti, A. A. Fomenkov, Jalal Arabloo, Aletta E. Schutte, Biruk Wogayehu Taddele, Teklehaimanot Gereziher Haile, Diego Augusto Santos Silva, Seyed Mohammad Kazem Aghamir, Maciej Banach, Deanna Anderlini, Moses J. Bockarie, Saleem Muhammad Rana, Randah R. Hamadeh, Farhad Islami, Olalekan A. Uthman, S. Mohammad Sajadi, Francisco Rogerlândio Martins-Melo, Shankar M Bakkannavar, Kairat Davletov, Soraya Seedat, Alan D. Lopez, Masoud Behzadifar, Benjamin B. Massenburg, Santosh Varughese, Ingan Ukur Tarigan, Amin Soheili, Félix Carvalho, Yun Jin Kim, Catalina Liliana Andrei, Caleb Mackay Salpeter Irvine, Mojgan Gitimoghaddam, G Anil Kumar, Rasmus J. Havmoeller, Hiroyasu Iso, Atte Meretoja, Yasir Waheed, João M. Furtado, Christian Razo, Neeti Kapoor, Mowafa Househ, Rajaa Al-Raddadi, Mohammad Khammarnia, Santi Martini, Feng Sha, Marco Vacante, Jacek A. Kopec, Hunduma Amensisa Bojia, Jacob Olusegun Olusanya, Kate E. LeGrand, Nikolay Ivanovich Briko, Robert S. Bernstein, Arun Balachandran, Davoud Adham, Ahad Bakhtiari, Shafiu Mohammed, Leake G. Gebremeskel, Smita Pakhale, Ejaz Ahmad Khan, Daniel Cury Ribeiro, Yousef Mohammad, Bernhard T. Baune, Azeem Majeed, Luis Camera, Mohammad Ali Jahani, Hasan Yusefzadeh, Rahman Shiri, Massimo Cirillo, Nikita Otstavnov, Vahid Yazdi-Feyzabadi, Paolo Lauriola, Irfan Ullah, Aruna M Kamath, Maryam Mirzaei, Zabihollah Yousefi, Iman El Sayed, Mohammad Farahmand, Yetunde O. John-Akinola, Khem Narayan Pokhrel, Felix Akpojene Ogbo, Megan Knight, Nelson J. Alvis-Zakzuk, Teferi Mekonnen, Iván Landires, Robert G. Weintraub, Chukwudi A Nnaji, Lauren E. Schaeffer, Paulo A. Lotufo, Mehdi Naderi, Tomislav Mestrovic, André Faro, Mohsen Bayati, Raffaele Palladino, Shahin Soltani, Vladimir Andreevich Korshunov, Birhanu Geta Meharie, Mihajlo Jakovljevic, Abdiwahab Hashi, Olatunji O. Adetokunboh, Dejana Braithwaite, Sergio I. Prada, Bárbara Niegia Garcia de Goulart, Reza Pourmirza Kalhori, Jee-Young Jasmine Choi, Ernoiz Antriyandarti, Ronny Westerman, Meghdad Pirsaheb, Paul S. F. Yip, Mehdi Mirzaei-Alavijeh, Gebremariam Woldu, Rashmi Gupta, Onome Bright Oghenetega, Shane D. Morrison, Inga Dora Sigfusdottir, Marcel Ausloos, Mehdi Hosseinzadeh, Marcos Roberto Tovani-Palone, K M Shivakumar, Alireza Ansari-Moghaddam, Archith Boloor, Aidin Abedi, Binyam Minuye Birihane, Mohammad Ali Mansournia, Nihad A. Almasri, Simachew Animen Bante, Carlo Eduardo Medina-Solís, Leeberk Raja Inbaraj, Edgar Denova-Gutiérrez, Antonio Biondi, Valentin Yurievich Skryabin, Srinivasa Vittal Katikireddi, Sarika Chaturvedi, Francesco Saverio Violante, Abhay Gaidhane, George A. Mensah, Naohiro Yonemoto, Ahmad Ghashghaee, Ebrahim Babaee, Saman Esmaeilnejad, Sharath Burugina Nagaraja, Avina Vongpradith, Javad Nazari, Amir Khater, Michael K. Hole, Ben Lacey, Razique Anwer, Łukasz Szumowski, Ai Koyanagi, Rajesh Sagar, Ali Rajabpour-Sanati, Seyed M Karimi, Yordanos Gizachew Yeshitila, Mona Pathak, Nithin Kumar, Masoud Foroutan, Mehdi Fazlzadeh, Anusha Ganapati Bhat, Abbas Mosapour, Kebede Deribe, Nermin Ghith, Vaman Kulkarni, Sanjay Zodpey, Asadollah Gholamian, Mohammed Shannawaz, Nancy Fullman, Benn Sartorius, Giulio Castelpietra, Ghulam Mustafa, Silvia Schiavolin, Nelson Alvis-Guzman, Jeffrey D. Stanaway, Rafael Lozano, Christopher J L Murray, Guoqing Hu, Andrew M. Briggs, Ashish Badiye, Yousef Khader, Masoud Moghadaszadeh, Rahmatollah Moradzadeh, Valery L. Feigin, Claudia I. Mastrogiacomo, Emma Smith, Yasser Vasseghian, Saeed Amini, Asif Hanif, Achala Upendra Jayatilleke, Maryam Adabi, Sarah Wulf Hanson, Bhaskar Thakur, Ravi Mehrotra, Virginia Núñez-Samudio, Lalit Dandona, Segun Emmanuel Ibitoye, Simon I. Hay, Kiirithio N. Ngari, Obinna Onwujekwe, Deborah Carvalho Malta, Lorenzo Monasta, Neda Kianipour, Khurshid Alam, Luisa Sorio Flor, Priya Rathi, Ali Bijani, Khalid A Altirkawi, Jaimie Adelson, Hamed Zandian, Frank Tanser, Dharmesh Kumar Lal, John Everett Mumford, Morteza Oladnabi, Telma Zahirian Moghadam, Rodrigo Sarmiento-Suárez, Masoud Moradi, Maseer Khan, Mohammad Ali Sahraian, Amy E. Peden, Dhirendra N Sinha, Shanshan Li, Shailesh Advani, Behshad Naghshtabrizi, Matilde Leonardi, Lope H Barrero, Nicholas Steel, Dinh-Toi Chu, Claudio Alberto Dávila-Cervantes, Pushpendra Singh, Adrian Otoiu, Fabrizio Tediosi, Yonas Getaye Tefera, Pawan Faris, George C. Patton, Christopher Troeger, Mohammed Madadin, Jeffrey V. Lazarus, Paul H. Lee, Mohammad Amin Bahrami, Wondimeneh Shibabaw Shiferaw, Emmanuel Wandera Okunga, Biniyam Sahiledengle Geberemariyam, Samer Hamidi, Young-Ho Khang, Rufus Akinyemi, Farhad Jadidi-Niaragh, Godfrey Mutashambara Rwegerera, Naser Mohammad Gholi Mezerji, Rupak Desai, Eduardo Bernabé, Jamal A. Yearwood, Nima Rezaei, Emerito Jose A. Faraon, Vasily Vlassov, Stanislav S. Otstavnov, Reed J D Sorensen, Elena V. Gnedovskaya, Johan Ärnlöv, Mukhammad David Naimzada, Tahereh Javaheri, Tamer H. Farag, Paolo Cortesi, Gbenga A. Kayode, Lucas Guimarães Abreu, Manu Raj Mathur, Getie Lake Aynalem, Narayanaswamy Venketasubramanian, Doris V.V. Ortega-Altamirano, Giorgia Giussani, Liliana G Ciobanu, Suraj Bhattarai, Basema Saddik, Mustafa Z. Younis, Ensiyeh Jenabi, Ira Martopullo, Mohamed M. Gad, Kanyin L. Ong, Addisu Melese, Fotis Topouzis, Hanne Christensen, In-Hwan Oh, Arash Sarveazad, Shuhei Nomura, Peter Memiah, Sergej M. Ostojic, Santosh Kumar Tadakamadla, Dinesh Bhandari, Ahmed Omar Bali, Farahnaz Joukar, Arielle Wilder Eagan, Emma Elizabeth Spurlock, Ferrán Catalá-López, Caroline Stein, Jonathan M. Kocarnik, Stephen S Lim, Siamak Sabour, Kelly Compton, Shoaib Hassan, Rannveig Sigurvinsdottir, Claudiu Herteliu, Aso Mohammad Darwesh, Muluken Altaye Ayza, Angela Y. Chang, Leila R Kalankesh, Rafael Alves Guimarães, Abdollah Mohammadian-Hafshejani, Lal B. Rawal, Soewarta Kosen, Degena Bahrey Tadesse, Theo Vos, Paula Moraga, Soheil Hassanipour, Abdelrahman Ibrahim Abushouk, Oladimeji Adebayo, Mikk Jürisson, Tuomo J. Meretoja, Ireneous N. Soyiri, Carlo La Vecchia, Khalil Eskandari, Aziz Sheikh, Jagdish Khubchandani, James Leigh, Morteza Arab-Zozani, Sheikh Mohammed Shariful Islam, Stefan Kohler, Olayinka Stephen Ilesanmi, Kazumasa Yamagishi, Michele Romoli, Jasvinder A. Singh, Neeraj Bedi, Ivo Iavicoli, Alyssa Pennini, Subas Neupane, Emmanuel Peprah, Sojib Bin Zaman, Marwa Rashad Salem, Mohammed Ibrahim Mohialdeen Gubari, Ramesh Holla, Bayisa Abdissa Baye, Robert Ancuceanu, Eduarda Fernandes, Chandrashekhar T Sreeramareddy, Ettore Beghi, Quique Bassat, B Reshmi, Masood Ali Shaikh, Ionut Negoi, Peter Azzopardi, Florian Fischer, Kerem Shuval, Sorin Hostiuc, Hmwe H Kyu, Ver Bilano, Siddhesh Zadey, Davide Rasella, Vahid Alipour, Sowmya J. Rao, Radoslaw Sierpinski, Irina Filip, Michelle L. Bell, Malke Asaad, Ravensara S. Travillian, Christopher R. Cederroth, Rafael Tabarés-Seisdedos, Ashkan Afshin, Saqib Ali, Mahalaqua Nazli Khatib, Saad M.A. Dahlawi, Hedayat Abbastabar, Zahid A Butt, Sagun Paudel, Vahid Rashedi, B. Suresh Kumar Shetty, Thomas R. Hird, Shokofeh Maleki, Atif Amin Baig, Reza Heidari-Soureshjani, Shaun Wen Huey Lee, Jorge R. Ledesma, Ai-Min Wu, Fablina Sharara, Zemenu Tadesse Tessema, Ratilal Lalloo, Rohollah Kalhor, Rosario Cárdenas, Amir Radfar, Salime Goharinezhad, Fereshteh Mehri, Katarzyna Kissimova-Skarbek, Spencer A. Pease, Diana Silva, Amir Hossein Goudarzian, Samath D Dharmaratne, Darshan B B, Mariya Vladimirovna Titova, Dickson A. Amugsi, Lee Ling Lim, Agegnehu Bante, Charles D.A. Wolfe, Majid A Almadi, Seyed Mohammad Riahi, Nader Jahanmehr, Yuming Guo, Tauseef Ahmad, Platon D. Lopukhov, Takahiro Tabuchi, Nicholas J Kassebaum, Jacek Jerzy Jozwiak, Ritesh G. Menezes, Giovanni Damiani, Delia Hendrie, Mostafa Amini-Rarani, Sanjay Basu, Mohammad Hossein Bakhshaei, Gholamreza Roshandel, Borhan Mansouri, Enrico Rubagotti, Anurag Agrawal, Alireza Esteghamati, Paramjit Gill, Graeme J. Hankey, Mikhail Sergeevich Zastrozhin, Nima Hafezi-Nejad, Bruce Bartholow Duncan, Silvano Gallus, Jeevan Pereira, Ahamarshan Jayaraman Nagarajan, Giulia Carreras, Fariba Dorostkar, Pietro Ferrara, Andrea Farioli, Christoph Nowak, Ahmed I. Hasaballah, Vijay Kumar Chattu, Bolajoko O. Olusanya, Perminder S. Sachdev, Era Upadhyay, Tommi Vasankari, Susan M Sawyer, Adnan Kisa, Farshad Pourmalek, Kiomars Sharafi, Golnaz Heidari, Mohammad Abdollahi, Georges Nguefack-Tsague, Sajid Hameed, Sanni Yaya, Bach Xuan Tran, Ole Frithjof Norheim, Robert Kaba Alhassan, Morenike Oluwatoyin Folayan, Ismail Tareque, Phetole Walter Mahasha, Kewal Krishan, Soraya Siabani, Aleksandr Y. Aravkin, Helena Ullyartha Pangaribuan, Maryam Zamanian, Joshua A. Salomon, Bianca S. Zlavog, Vinay Nangia, Falk Schwendicke, Takeshi Fukumoto, Hung Chak Ho, Jordan Weiss, Maha Atout, Tariku Tesfaye Bekuma, Efat Mohamadi, Nikolaos Dervenis, Joan B. Soriano, Syed Amir Gilani, Victor Adekanmbi, Marina Karanikolos, Alberto Raggi, Michael R.M. Abrigo, Weijia Fu, Reza Shirkoohi, Aditya Prasad Dash, Peng Jia, Masoumeh Sadeghi, Ashraf Nabhan, Isabela M. Benseñor, Morteza Jafarinia, Joht Singh Chandan, Usman Iqbal, Amira Shaheen, Deepak Saxena, Lauren B. Wilner, Nataliya A. Foigt, Jeadran N. Malagón-Rojas, David C. Schwebel, Gail Davey, Milena Ilic, Josep Maria Haro, Peter Njenga Keiyoro, Stein Emil Vollset, Andrea Werdecker, Zahiruddin Quazi Syed, Yared Asmare Aynalem, Entezar Mehrabi Nasab, Yihun Mulugeta Alemu, Muhammad Ali, Mona M. Khater, Ehsan Sadeghi, Thirunavukkarasu Sathish, Pascual R. Valdez, Jennifer Rickard, Mark A. Stokes, Davide Sattin, Ewerton Cousin, Oliver J. Brady, Krittika Bhattacharyya, Mika Kivimäki, Andrew T Olagunju, Jost B. Jonas, Dian Kusuma, Goura Kishor Rath, Alberto Ortiz, Samad Azari, Nayu Ikeda, James L. Fisher, Peng Zheng, Elisabetta Pupillo, Pankaj Bhardwaj, Suzanne Lyn Barker-Collo, Riaz Uddin, Ester Cerin, Amir Taherkhani, Martin Amogre Ayanore, Richard G. Wamai, Anders Larsson, Josephine W. Ngunjiri, Hosni Salem, Hesham M. Al-Mekhlafi, Sharareh Eskandarieh, Taraneh Yousefinezhadi, Srikanta Banerjee, Yang Xie, Yuichiro Yano, Songhomitra Panda-Jonas, Themba G. Ginindza, Manasi Kumar, Babak Moazen, Bing-Fang Hwang, Cristiana Abbafati, Florentino Luciano Caetano dos Santos, Juan Sanabria, Milena Santric-Milicevic, Carla Sofia e.Sá Farinha, Samuel B. Albertson, Chieh Han, Parvaiz A Koul, Foad Abd-Allah, Mojisola Oluwasanu, Mihaela Hostiuc, Chinwe Juliana Iwu, Colm McAlinden, Mohsen Naghavi, Maarten J. Postma, Chhabi Lal Ranabhat, Jalil Jaafari, Walter Mendoza, Abdulaziz M. Almulhim, Magdalene K. Walters, Ali H. Mokdad, Andre M. N. Renzaho, Catherine M. Antony, Ken Lee Chin, Ali A. Asadi-Pooya, Daniel Diaz, Adrian Pana, Salman Rawaf, Gina Agarwal, Demelash Woldeyohannes Handiso, Savita Lasrado, Amir Almasi-Hashiani, Praveen Hoogar, Srinivasa Rao Bolla, Fares Alahdab, Om P Kurmi, Sonali Kochhar, Van C. Lansingh, François Alla, Ali Almasi, Till Bärnighausen, Michael A. Piradov, Zubair Kabir, Boris Bikbov, Philip B. Mitchell, Amin Mousavi Khaneghah, Yahya Safari, Anirudh Kotlo, Jan-Walter De Neve, Biagio Simonetti, Carlos A Castañeda-Orjuela, Kenji Shibuya, GBD 2019 Universal Health Coverage Collaborator, Violante FS, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), Department of Public Health, University of Helsinki, Clinicum, Neurologian yksikkö, HUS Neurocenter, HUS Comprehensive Cancer Center, Helsinki University Hospital Area, GBD 2019 Universal Health Coverage Collaborators, Lozano, Rafael, Fullman, Nancy, Mumford, John Everett, Knight, Megan, Barthelemy, Celine M, Abbafati, Cristiana, Abbastabar, Hedayat, Abd-Allah, Foad, Abdollahi, Mohammad, Abedi, Aidin, Abolhassani, Hassan, Abosetugn, Akine Eshete, Abreu, Lucas Guimarãe, Abrigo, Michael R M, Abu Haimed, Abdulaziz Khalid, Abushouk, Abdelrahman I, Adabi, Maryam, Adebayo, Oladimeji M, Adekanmbi, Victor, Adelson, Jaimie, Adetokunboh, Olatunji O, Adham, Davoud, Advani, Shailesh M, Afshin, Ashkan, Agarwal, Gina, Agasthi, Pradyumna, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Akinyemi, Rufus Olusola, Alahdab, Fare, Al-Aly, Ziyad, Alam, Khurshid, Albertson, Samuel B, Alemu, Yihun Mulugeta, Alhassan, Robert Kaba, Ali, Muhammad, Ali, Saqib, Alipour, Vahid, Aljunid, Syed Mohamed, Alla, Françoi, Almadi, Majid Abdulrahman Hamad, Almasi, Ali, Almasi-Hashiani, Amir, Almasri, Nihad A, Al-Mekhlafi, Hesham M, Almulhim, Abdulaziz M, Alonso, Jordi, Al-Raddadi, Rajaa M, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Amini, Saeed, Amini-Rarani, Mostafa, Amiri, Fatemeh, Amit, Arianna Maever L, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antonio, Carl Abelardo T, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Arabloo, Jalal, Arab-Zozani, Morteza, Aravkin, Aleksandr Y, Aremu, Olatunde, Ärnlöv, Johan, Asaad, Malke, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A, Ashbaugh, Charlie, Athari, Seyyed Shamsadin, Atout, Maha Moh'd Wahbi, Ausloos, Marcel, Avila-Burgos, Leticia, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Aynalem, Yared Asmare, Aynalem, Getie Lake, Ayza, Muluken Altaye, Azari, Samad, Azzopardi, Peter S, B, Darshan B, Babaee, Ebrahim, Badiye, Ashish D, Bahrami, Mohammad Amin, Baig, Atif Amin, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M, Balachandran, Arun, Balassyano, Shelly, Banach, Maciej, Banerjee, Srikanta K, Banik, Palash Chandra, Bante, Agegnehu Bante, Bante, Simachew Animen, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H, Bassat, Quique, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Baye, Bayisa Abdissa, Bedi, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Bekuma, Tariku Tesfaye Tesfaye, Bell, Michelle L, Bensenor, Isabela M, Berman, Adam E, Bernabe, Eduardo, Bernstein, Robert S, Bhagavathula, Akshaya Srikanth, Bhandari, Dinesh, Bhardwaj, Pankaj, Bhat, Anusha Ganapati, Bhattacharyya, Krittika, Bhattarai, Suraj, Bhutta, Zulfiqar A, Bijani, Ali, Bikbov, Bori, Bilano, Ver, Biondi, Antonio, Birihane, Binyam Minuye, Bockarie, Moses John, Bohlouli, Somayeh, Bojia, Hunduma Amensisa, Bolla, Srinivasa Rao Rao, Boloor, Archith, Brady, Oliver J, Braithwaite, Dejana, Briant, Paul Svitil, Briggs, Andrew M, Briko, Nikolay Ivanovich, Burugina Nagaraja, Sharath, Busse, Reinhard, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Cahuana-Hurtado, Lucero, Cámera, Luis Alberto, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Castro, Franz, Catalá-López, Ferrán, Causey, Kate, Cederroth, Christopher R, Cercy, Kelly M, Cerin, Ester, Chandan, Joht Singh, Chang, Angela Y, Charan, Jaykaran, Chattu, Vijay Kumar, Chaturvedi, Sarika, Chin, Ken Lee, Cho, Daniel Youngwhan, Choi, Jee-Young Jasmine, Christensen, Hanne, Chu, Dinh-Toi, Chung, Michael T, Ciobanu, Liliana G, Cirillo, Massimo, Comfort, Haley, Compton, Kelly, Cortesi, Paolo Angelo, Costa, Vera Marisa, Cousin, Ewerton, Dahlawi, Saad M A, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Darega Gela, Jiregna, Darwesh, Aso Mohammad, Daryani, Ahmad, Dash, Aditya Prasad, Davey, Gail, Dávila-Cervantes, Claudio Alberto, Davletov, Kairat, De Neve, Jan-Walter, Denova-Gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolao, Desai, Rupak, Dharmaratne, Samath Dhamminda, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, Dias da Silva, Diana, Diaz, Daniel, Dippenaar, Ilse N, Do, Hoa Thi, Dorostkar, Fariba, Doshmangir, Leila, Duncan, Bruce B, Duraes, Andre Rodrigue, Eagan, Arielle Wilder, Edvardsson, David, El Sayed, Iman, El Tantawi, Maha, Elgendy, Islam Y, Elyazar, Iqbal RF, Eskandari, Khalil, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Ezekannagha, Oluchi, Farag, Tamer, Farahmand, Mohammad, Faraon, Emerito Jose A, Farinha, Carla Sofia e Sá, Farioli, Andrea, Faris, Pawan Sirwan, Faro, Andre, Fazlzadeh, Mehdi, Feigin, Valery L, Fernandes, Eduarda, Ferrara, Pietro, Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Fisher, James L, Flor, Luisa Sorio, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Masoud, Francis, Joel Msafiri, Fu, Weijia, Fukumoto, Takeshi, Furtado, João M, Gad, Mohamed M, Gaidhane, Abhay Motiramji, Gakidou, Emmanuela, Galles, Natalie C, Gallus, Silvano, Gardner, William M, Geberemariyam, Biniyam Sahiledengle, Gebrehiwot, Abiyu Mekonnen, Gebremeskel, Leake G, Gebremeskel, Gebreamlak Gebremedhn, Gesesew, Hailay Abrha, Ghadiri, Keyghobad, Ghafourifard, Mansour, Ghashghaee, Ahmad, Ghith, Nermin, Gholamian, Asadollah, Gilani, Syed Amir, Gill, Paramjit Singh, Gill, Tiffany K, Ginindza, Themba G, Gitimoghaddam, Mojgan, Giussani, Giorgia, Glagn, Mustefa, Gnedovskaya, Elena V, Godinho, Myron Anthony, Goharinezhad, Salime, Gopalani, Sameer Vali, Goudarzian, Amir Hossein, Goulart, Bárbara Niegia Garcia, Gubari, Mohammed Ibrahim Mohialdeen, Guimarães, Rafael Alve, Guled, Rashid Abdi, Gultie, Teklemariam, Guo, Yuming, Gupta, Rajeev, Gupta, Rahul, Hafezi-Nejad, Nima, Hafiz, Abdul, Haile, Teklehaimanot Gereziher, Hamadeh, Randah R, Hameed, Sajid, Hamidi, Samer, Han, Chieh, Han, Hannah, Handiso, Demelash Woldeyohanne, Hanif, Asif, Hankey, Graeme J, Haro, Josep Maria, Hasaballah, Ahmed I, Hasan, Md Mehedi, Hashi, Abdiwahab, Hassan, Shoaib, Hassan, Amr, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J, Hay, Simon I, Hayat, Khezar, Heidari, Golnaz, Heidari-Soureshjani, Reza, Hendrie, Delia, Herteliu, Claudiu, Hird, Thomas R, Ho, Hung Chak, Hole, Michael K, Holla, Ramesh, Hollingsworth, Bruce, Hoogar, Praveen, Hopf, Kathleen Pillsbury, Horita, Nobuyuki, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsieh, Vivian Chia-rong, Hu, Guoqing, Huda, Tanvir M, Humayun, Ayesha, Hwang, Bing-Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ikeda, Nayu, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Inbaraj, Leeberk Raja, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, M Mofizul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Iso, Hiroyasu, Iwu, Chinwe Juliana, Iwu, Chidozie C D, Jaafari, Jalil, Jadidi-Niaragh, Farhad, Jafarinia, Morteza, Jahagirdar, Deepa, Jahani, Mohammad Ali, Jahanmehr, Nader, Jakovljevic, Mihajlo, Janjani, Hosna, Javaheri, Tahereh, Jayatilleke, Achala Upendra, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Jia, Peng, John-Akinola, Yetunde O, Jonas, Jost B, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Zubair, Kalankesh, Leila R, Kalhor, Rohollah, Kamath, Aruna M, Kanchan, Tanuj, Kapoor, Neeti, Karami Matin, Behzad, Karanikolos, Marina, Karimi, Seyed M, Kassebaum, Nicholas J, Katikireddi, Srinivasa Vittal, Kayode, Gbenga A, Keiyoro, Peter Njenga, Khader, Yousef Saleh, Khammarnia, Mohammad, Khan, Maseer, Khan, Ejaz Ahmad, Khang, Young-Ho, Khatab, Khaled, Khater, Amir M, Khater, Mona M, Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khubchandani, Jagdish, Kianipour, Neda, Kim, Young-Eun, Kim, Yun Jin, Kimokoti, Ruth W, Kinfu, Yohanne, Kisa, Adnan, Kissimova-Skarbek, Katarzyna, Kivimäki, Mika, Kneib, Cameron J, Kocarnik, Jonathan M, Kochhar, Sonali, Kohler, Stefan, Kopec, Jacek A, Korotkova, Anna V, Korshunov, Vladimir Andreevich, Kosen, Soewarta, Kotlo, Anirudh, Koul, Parvaiz A, Koyanagi, Ai, Krishan, Kewal, Krohn, Kris J, Kugbey, Nuworza, Kulkarni, Vaman, Kumar, G Anil, Kumar, Nithin, Kumar, Manasi, Kurmi, Om P, Kusuma, Dian, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Landires, Iván, Lansingh, Van Charle, Larsson, Anders O, Lasrado, Savita, Lau, Kathryn Mei-Ming, Lauriola, Paolo, Lazarus, Jeffrey V, Ledesma, Jorge R, Lee, Paul H, Lee, Shaun Wen Huey, Leever, Andrew T, Legrand, Kate E, Leigh, Jame, Leonardi, Matilde, Li, Shanshan, Lim, Stephen S, Lim, Lee-Ling, Liu, Xuefeng, Logroscino, Giancarlo, Lopez, Alan D, Lopukhov, Platon D, Lotufo, Paulo A, Lu, Alton, Ma, Jianing, Madadin, Mohammed, Mahasha, Phetole Walter, Mahmoudi, Morteza, Majeed, Azeem, Malagón-Rojas, Jeadran N, Maleki, Shokofeh, Malta, Deborah Carvalho, Mansouri, Borhan, Mansournia, Mohammad Ali, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, Massenburg, Benjamin Ballard, Mastrogiacomo, Claudia I, Mathur, Manu Raj, Mcalinden, Colm, Mckee, Martin, Medina-Solís, Carlo Eduardo, Meharie, Birhanu Geta, Mehndiratta, Man Mohan, Mehrabi Nasab, Entezar, Mehri, Fereshteh, Mehrotra, Ravi, Mekonnen, Teferi, Melese, Addisu, Memiah, Peter T N, Mendoza, Walter, Menezes, Ritesh G, Mensah, George A, Meretoja, Tuomo J, Meretoja, Atte, Mestrovic, Tomislav, Miazgowski, Bartosz, Michalek, Irmina Maria, Mirrakhimov, Erkin M, Mirzaei, Maryam, Mirzaei-Alavijeh, Mehdi, Mitchell, Philip B, Moazen, Babak, Moghadaszadeh, Masoud, Mohamadi, Efat, Mohammad, Yousef, Mohammad, Dara K, Mohammad Gholi Mezerji, Naser, Mohammadian-Hafshejani, Abdollah, Mohammed, Shafiu, Mohammed, Jemal Abdu, Mokdad, Ali H, Monasta, Lorenzo, Mondello, Stefania, Moradi, Masoud, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Morgado-da-Costa, Joana, Morrison, Shane Dougla, Mosapour, Abba, Mosser, Jonathan F, Mousavi Khaneghah, Amin, Muriithi, Moses K, Mustafa, Ghulam, Nabhan, Ashraf F, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naimzada, Mukhammad David, Nangia, Vinay, Nansseu, Jobert Richie, Nayak, Vinod C, Nazari, Javad, Ndejjo, Rawlance, Negoi, Ionut, Negoi, Ruxandra Irina, Neupane, Suba, Ngari, Kiirithio N, Nguefack-Tsague, George, Ngunjiri, Josephine W, Nguyen, Cuong Tat, Nguyen, Diep Ngoc, Nguyen, Huong Lan Thi, Nnaji, Chukwudi A, Nomura, Shuhei, Norheim, Ole F, Noubiap, Jean Jacque, Nowak, Christoph, Nunez-Samudio, Virginia, Otoiu, Adrian, Ogbo, Felix Akpojene, Oghenetega, Onome Bright, Oh, In-Hwan, Okunga, Emmanuel Wandera, Oladnabi, Morteza, Olagunju, Andrew T, Olusanya, Jacob Olusegun, Olusanya, Bolajoko Olubukunola, Oluwasanu, Mojisola Morenike, Omar Bali, Ahmed, Omer, Muktar Omer, Ong, Kanyin L, Onwujekwe, Obinna E, Ortega-Altamirano, Doris V V, Ortiz, Alberto, Ostojic, Sergej M, Otstavnov, Nikita, Otstavnov, Stanislav S, Øverland, Simon, Owolabi, Mayowa O, Padubidri, Jagadish Rao., Pakhale, Smita, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Pangaribuan, Helena Ullyartha, Pathak, Mona, Patton, George C, Paudel, Sagun, Pazoki Toroudi, Hamidreza, Pease, Spencer A, Peden, Amy E, Pennini, Alyssa, Peprah, Emmanuel K, Pereira, Jeevan, Pigott, David M, Pilgrim, Thoma, Pilz, Tessa M, Pinheiro, Marina, Piradov, Michael A, Pirsaheb, Meghdad, Pokhrel, Khem Narayan, Postma, Maarten J, Pourjafar, Hadi, Pourmalek, Farshad, Pourmirza Kalhori, Reza, Pourshams, Akram, Prada, Sergio I, Pribadi, Dimas Ria Angga, Pupillo, Elisabetta, Quazi Syed, Zahiruddin, Radfar, Amir, Rafiee, Ata, Rafiei, Alireza, Raggi, Alberto, Rahim, Fakher, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Rana, Saleem Muhammad, Ranabhat, Chhabi Lal, Rao, Sowmya J, Rasella, Davide, Rashedi, Vahid, Rath, Goura Kishor, Rathi, Priya, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Rawassizadeh, Reza, Razo, Christian, Renjith, Vishnu, Renzaho, Andre M N, Reshmi, Bhageerathy, Rezaei, Nima, Riahi, Seyed Mohammad, Ribeiro, Daniel Cury, Rickard, Jennifer, Roberts, Nicholas L S, Roever, Leonardo, Romoli, Michele, Ronfani, Luca, Roshandel, Gholamreza, Rubagotti, Enrico, Rwegerera, Godfrey M, Sabour, Siamak, Sachdev, Perminder S, Saddik, Basema, Sadeghi, Masoumeh, Sadeghi, Ehsan, Safari, Yahya, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S. Mohammad, Salahshoor, Mohammad Reza, Salem, Marwa R Rashad, Salem, Hosni, Salomon, Joshua, Samadi Kafil, Hossein, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saraswathy, Sivan Yegnanarayana Iyer, Sarmiento-Suárez, Rodrigo, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Savic, Miloje, Sawyer, Susan M, Saxena, Deepak, Sbarra, Alyssa N, Schaeffer, Lauren E, Schiavolin, Silvia, Schmidt, Maria Inê, Schutte, Aletta Elisabeth, Schwebel, David C, Schwendicke, Falk, Seedat, Soraya, Sha, Feng, Shahabi, Saeed, Shaheen, Amira A, Shaikh, Masood Ali, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomar, Sharara, Fablina, Sharifi, Hamid, Shaw, David H, Sheikh, Aziz, Sheikhtaheri, Abba, Shetty, B Suresh Kumar, Shibuya, Kenji, Shiferaw, Wondimeneh Shibabaw, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Shirkoohi, Reza, Shivakumar, K M, Shrime, Mark G, Shuval, Kerem, Siabani, Soraya, Sierpinski, Radoslaw, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, Diego Augusto Santo, Silva, João Pedro, Simonetti, Biagio, Simpson, Kyle E, Singh, Jasvinder A, Singh, Pushpendra, Sinha, Dhirendra Narain, Skryabin, Valentin Yurievich, Smith, Emma U R, Soheili, Amin, Soltani, Shahin, Soofi, Moslem, Sorensen, Reed J. D., Soriano, Joan B, Sorrie, Muluken Bekele, Soyiri, Ireneous N, Spurlock, Emma Elizabeth, Sreeramareddy, Chandrashekhar T, Stanaway, Jeffrey D, Steel, Nichola, Stein, Caroline, Stokes, Mark A, Sufiyan, Mu'awiyyah Babale, Suleria, Hafiz Ansar Rasul, Sultan, Iyad, Szumowski, Łukasz, Tabarés-Seisdedos, Rafael, Tabuchi, Takahiro, Tadakamadla, Santosh Kumar, Taddele, Biruk Wogayehu, Tadesse, Degena Bahrey, Taherkhani, Amir, Tamiru, Animut Tagele, Tanser, Frank C, Tareque, Md Ismail, Tarigan, Ingan Ukur, Teagle, Whitney L, Tediosi, Fabrizio, Tefera, Yonas Getaye Getaye, Tela, Freweini Gebrearegay, Tessema, Zemenu Tadesse, Thakur, Bhaskar, Titova, Mariya Vladimirovna, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Foti, Tovani-Palone, Marcos Roberto Roberto, Tran, Bach Xuan, Travillian, Ravensara, Troeger, Christopher E, Tudor Car, Lorainne, Uddin, Riaz, Ullah, Irfan, Umeokonkwo, Chukwuma David, Unnikrishnan, Bhaskaran, Upadhyay, Era, Uthman, Olalekan A, Vacante, Marco, Valdez, Pascual R, Varughese, Santosh, Vasankari, Tommi Juhani, Vasseghian, Yasser, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasily, Vollset, Stein Emil, Vongpradith, Avina, Vos, Theo, Waheed, Yasir, Walters, Magdalene K, Wamai, Richard G, Wang, Haidong, Wang, Yuan-Pang, Weintraub, Robert G, Weiss, Jordan, Werdecker, Andrea, Westerman, Ronny, Wilner, Lauren B, Woldu, Gebremariam, Wolfe, Charles D A, Wu, Ai-Min, Wulf Hanson, Sarah, Xie, Yang, Xu, Rixing, Yahyazadeh Jabbari, Seyed Hossein, Yamagishi, Kazumasa, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yearwood, Jamal A, Yeshitila, Yordanos Gizachew, Yip, Paul, Yonemoto, Naohiro, Younis, Mustafa Z, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yusefzadeh, Hasan, Zadey, Siddhesh, Zahirian Moghadam, Telma, Zaidi, Syed Saoud, Zaki, Leila, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zastrozhin, Mikhail Sergeevich, Zewdie, Kaleab Alemayehu, Zhang, Yunquan, Zhao, Xiu-Ju George, Zhao, Yingxi, Zheng, Peng, Zhu, Cong, Ziapour, Arash, Zlavog, Bianca S, Zodpey, Sanjay, Murray, Christopher J L, Lacey, B, Sartorius, B, Sálfræðideild (HR), Department of Psychology (RU), Samfélagssvið (HR), School of Social Sciences (RU), Háskólinn í Reykjavík, Reykjavik University, Lozano, R, Fullman, N, Mumford, J, Knight, M, Barthelemy, C, Abbafati, C, Abbastabar, H, Abd-Allah, F, Abdollahi, M, Abedi, A, Abolhassani, H, Abosetugn, A, Abreu, L, Abrigo, M, Abu Haimed, A, Abushouk, A, Adabi, M, Adebayo, O, Adekanmbi, V, Adelson, J, Adetokunboh, O, Adham, D, Advani, S, Afshin, A, Agarwal, G, Agasthi, P, Aghamir, S, Agrawal, A, Ahmad, T, Akinyemi, R, Alahdab, F, Al-Aly, Z, Alam, K, Albertson, S, Alemu, Y, Alhassan, R, Ali, M, Ali, S, Alipour, V, Aljunid, S, Alla, F, Almadi, M, Almasi, A, Almasi-Hashiani, A, Almasri, N, Al-Mekhlafi, H, Almulhim, A, Alonso, J, Al-Raddadi, R, Altirkawi, K, Alvis-Guzman, N, Alvis-Zakzuk, N, Amini, S, Amini-Rarani, M, Amiri, F, Amit, A, Amugsi, D, Ancuceanu, R, Anderlini, D, Andrei, C, Androudi, S, Ansari, F, Ansari-Moghaddam, A, Antonio, C, Antony, C, Antriyandarti, E, Anvari, D, Anwer, R, Arabloo, J, Arab-Zozani, M, Aravkin, A, Aremu, O, Ärnlöv, J, Asaad, M, Asadi-Aliabadi, M, Asadi-Pooya, A, Ashbaugh, C, Athari, S, Atout, M, Ausloos, M, Avila-Burgos, L, Ayala Quintanilla, B, Ayano, G, Ayanore, M, Aynalem, Y, Aynalem, G, Ayza, M, Azari, S, Azzopardi, P, B, D, Babaee, E, Badiye, A, Bahrami, M, Baig, A, Bakhshaei, M, Bakhtiari, A, Bakkannavar, S, Balachandran, A, Balassyano, S, Banach, M, Banerjee, S, Banik, P, Bante, A, Bante, S, Barker-Collo, S, Bärnighausen, T, Barrero, L, Bassat, Q, Basu, S, Baune, B, Bayati, M, Baye, B, Bedi, N, Beghi, E, Behzadifar, M, Bekuma, T, Bell, M, Bensenor, I, Berman, A, Bernabe, E, Bernstein, R, Bhagavathula, A, Bhandari, D, Bhardwaj, P, Bhat, A, Bhattacharyya, K, Bhattarai, S, Bhutta, Z, Bijani, A, Bikbov, B, Bilano, V, Biondi, A, Birihane, B, Bockarie, M, Bohlouli, S, Bojia, H, Bolla, S, Boloor, A, Brady, O, Braithwaite, D, Briant, P, Briggs, A, Briko, N, Burugina Nagaraja, S, Busse, R, Butt, Z, Caetano dos Santos, F, Cahuana-Hurtado, L, Cámera, L, Cárdenas, R, Carreras, G, Carrero, J, Carvalho, F, Castaldelli-Maia, J, Castañeda-Orjuela, C, Castelpietra, G, Castro, F, Catalá-López, F, Causey, K, Cederroth, C, Cercy, K, Cerin, E, Chandan, J, Chang, A, Charan, J, Chattu, V, Chaturvedi, S, Chin, K, Cho, D, Choi, J, Christensen, H, Chu, D, Chung, M, Ciobanu, L, Cirillo, M, Comfort, H, Compton, K, Cortesi, P, Costa, V, Cousin, E, Dahlawi, S, Damiani, G, Dandona, L, Dandona, R, Darega Gela, J, Darwesh, A, Daryani, A, Dash, A, Davey, G, Dávila-Cervantes, C, Davletov, K, De Neve, J, Denova-Gutiérrez, E, Deribe, K, Dervenis, N, Desai, R, Dharmaratne, S, Dhungana, G, Dianatinasab, M, Dias da Silva, D, Diaz, D, Dippenaar, I, Do, H, Dorostkar, F, Doshmangir, L, Duncan, B, Duraes, A, Eagan, A, Edvardsson, D, El Sayed, I, El Tantawi, M, Elgendy, I, Elyazar, I, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Esteghamati, A, Ezekannagha, O, Farag, T, Farahmand, M, Faraon, E, Farinha, C, Farioli, A, Faris, P, Faro, A, Fazlzadeh, M, Feigin, V, Fernandes, E, Ferrara, P, Feyissa, G, Filip, I, Fischer, F, Fisher, J, Flor, L, Foigt, N, Folayan, M, Fomenkov, A, Foroutan, M, Francis, J, Fu, W, Fukumoto, T, Furtado, J, Gad, M, Gaidhane, A, Gakidou, E, Galles, N, Gallus, S, Gardner, W, Geberemariyam, B, Gebrehiwot, A, Gebremeskel, L, Gebremeskel, G, Gesesew, H, Ghadiri, K, Ghafourifard, M, Ghashghaee, A, Ghith, N, Gholamian, A, Gilani, S, Gill, P, Gill, T, Ginindza, T, Gitimoghaddam, M, Giussani, G, Glagn, M, Gnedovskaya, E, Godinho, M, Goharinezhad, S, Gopalani, S, Goudarzian, A, Goulart, B, Gubari, M, Guimarães, R, Guled, R, Gultie, T, Guo, Y, Gupta, R, Hafezi-Nejad, N, Hafiz, A, Haile, T, Hamadeh, R, Hameed, S, Hamidi, S, Han, C, Han, H, Handiso, D, Hanif, A, Hankey, G, Haro, J, Hasaballah, A, Hasan, M, Hashi, A, Hassan, S, Hassan, A, Hassanipour, S, Hassankhani, H, Havmoeller, R, Hay, S, Hayat, K, Heidari, G, Heidari-Soureshjani, R, Hendrie, D, Herteliu, C, Hird, T, Ho, H, Hole, M, Holla, R, Hollingsworth, B, Hoogar, P, Hopf, K, Horita, N, Hossain, N, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Hsieh, V, Hu, G, Huda, T, Humayun, A, Hwang, B, Iavicoli, I, Ibitoye, S, Ikeda, N, Ilesanmi, O, Ilic, I, Ilic, M, Inbaraj, L, Iqbal, U, Irvani, S, Irvine, C, Islam, M, Islam, S, Islami, F, Iso, H, Iwu, C, Jaafari, J, Jadidi-Niaragh, F, Jafarinia, M, Jahagirdar, D, Jahani, M, Jahanmehr, N, Jakovljevic, M, Janjani, H, Javaheri, T, Jayatilleke, A, Jenabi, E, Jha, R, Jha, V, Ji, J, Jia, P, John-Akinola, Y, Jonas, J, Joukar, F, Jozwiak, J, Jürisson, M, Kabir, Z, Kalankesh, L, Kalhor, R, Kamath, A, Kanchan, T, Kapoor, N, Karami Matin, B, Karanikolos, M, Karimi, S, Kassebaum, N, Katikireddi, S, Kayode, G, Keiyoro, P, Khader, Y, Khammarnia, M, Khan, M, Khan, E, Khang, Y, Khatab, K, Khater, A, Khater, M, Khatib, M, Khayamzadeh, M, Khubchandani, J, Kianipour, N, Kim, Y, Kimokoti, R, Kinfu, Y, Kisa, A, Kissimova-Skarbek, K, Kivimäki, M, Kneib, C, Kocarnik, J, Kochhar, S, Kohler, S, Kopec, J, Korotkova, A, Korshunov, V, Kosen, S, Kotlo, A, Koul, P, Koyanagi, A, Krishan, K, Krohn, K, Kugbey, N, Kulkarni, V, Kumar, G, Kumar, N, Kumar, M, Kurmi, O, Kusuma, D, Kyu, H, La Vecchia, C, Lal, D, Lalloo, R, Landires, I, Lansingh, V, Larsson, A, Lasrado, S, Lau, K, Lauriola, P, Lazarus, J, Ledesma, J, Lee, P, Lee, S, Leever, A, Legrand, K, Leigh, J, Leonardi, M, Li, S, Lim, S, Lim, L, Liu, X, Logroscino, G, Lopez, A, Lopukhov, P, Lotufo, P, Lu, A, Ma, J, Madadin, M, Mahasha, P, Mahmoudi, M, Majeed, A, Malagón-Rojas, J, Maleki, S, Malta, D, Mansouri, B, Mansournia, M, Martini, S, Martins-Melo, F, Martopullo, I, Massenburg, B, Mastrogiacomo, C, Mathur, M, Mcalinden, C, Mckee, M, Medina-Solís, C, Meharie, B, Mehndiratta, M, Mehrabi Nasab, E, Mehri, F, Mehrotra, R, Mekonnen, T, Melese, A, Memiah, P, Mendoza, W, Menezes, R, Mensah, G, Meretoja, T, Meretoja, A, Mestrovic, T, Miazgowski, B, Michalek, I, Mirrakhimov, E, Mirzaei, M, Mirzaei-Alavijeh, M, Mitchell, P, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Mohammad, Y, Mohammad, D, Mohammad Gholi Mezerji, N, Mohammadian-Hafshejani, A, Mohammed, S, Mohammed, J, Mokdad, A, Monasta, L, Mondello, S, Moradi, M, Moradi-Lakeh, M, Moradzadeh, R, Moraga, P, Morgado-da-Costa, J, Morrison, S, Mosapour, A, Mosser, J, Mousavi Khaneghah, A, Muriithi, M, Mustafa, G, Nabhan, A, Naderi, M, Nagarajan, A, Naghavi, M, Naghshtabrizi, B, Naimzada, M, Nangia, V, Nansseu, J, Nayak, V, Nazari, J, Ndejjo, R, Negoi, I, Negoi, R, Neupane, S, Ngari, K, Nguefack-Tsague, G, Ngunjiri, J, Nguyen, C, Nguyen, D, Nguyen, H, Nnaji, C, Nomura, S, Norheim, O, Noubiap, J, Nowak, C, Nunez-Samudio, V, Otoiu, A, Ogbo, F, Oghenetega, O, Oh, I, Okunga, E, Oladnabi, M, Olagunju, A, Olusanya, J, Olusanya, B, Oluwasanu, M, Omar Bali, A, Omer, M, Ong, K, Onwujekwe, O, Ortega-Altamirano, D, Ortiz, A, Ostojic, S, Otstavnov, N, Otstavnov, S, Øverland, S, Owolabi, M, Padubidri, J, Pakhale, S, Palladino, R, Pana, A, Panda-Jonas, S, Pangaribuan, H, Pathak, M, Patton, G, Paudel, S, Pazoki Toroudi, H, Pease, S, Peden, A, Pennini, A, Peprah, E, Pereira, J, Pigott, D, Pilgrim, T, Pilz, T, Pinheiro, M, Piradov, M, Pirsaheb, M, Pokhrel, K, Postma, M, Pourjafar, H, Pourmalek, F, Pourmirza Kalhori, R, Pourshams, A, Prada, S, Pribadi, D, Pupillo, E, Quazi Syed, Z, Radfar, A, Rafiee, A, Rafiei, A, Raggi, A, Rahim, F, Rahman, M, Rajabpour-Sanati, A, Rana, S, Ranabhat, C, Rao, S, Rasella, D, Rashedi, V, Rath, G, Rathi, P, Rawaf, S, Rawaf, D, Rawal, L, Rawassizadeh, R, Razo, C, Renjith, V, Renzaho, A, Reshmi, B, Rezaei, N, Riahi, S, Ribeiro, D, Rickard, J, Roberts, N, Roever, L, Romoli, M, Ronfani, L, Roshandel, G, Rubagotti, E, Rwegerera, G, Sabour, S, Sachdev, P, Saddik, B, Sadeghi, M, Sadeghi, E, Safari, Y, Sagar, R, Sahebkar, A, Sahraian, M, Sajadi, S, Salahshoor, M, Salem, M, Salem, H, Salomon, J, Samadi Kafil, H, Samy, A, Sanabria, J, Santric-Milicevic, M, Saraswathy, S, Sarmiento-Suárez, R, Sarveazad, A, Sathian, B, Sathish, T, Sattin, D, Savic, M, Sawyer, S, Saxena, D, Sbarra, A, Schaeffer, L, Schiavolin, S, Schmidt, M, Schutte, A, Schwebel, D, Schwendicke, F, Seedat, S, Sha, F, Shahabi, S, Shaheen, A, Shaikh, M, Shamsizadeh, M, Shannawaz, M, Sharafi, K, Sharara, F, Sharifi, H, Shaw, D, Sheikh, A, Sheikhtaheri, A, Shetty, B, Shibuya, K, Shiferaw, W, Shigematsu, M, Shin, J, Shiri, R, Shirkoohi, R, Shivakumar, K, Shrime, M, Shuval, K, Siabani, S, Sierpinski, R, Sigfusdottir, I, Sigurvinsdottir, R, Silva, D, Silva, J, Simonetti, B, Simpson, K, Singh, J, Singh, P, Sinha, D, Skryabin, V, Smith, E, Soheili, A, Soltani, S, Soofi, M, Sorensen, R, Soriano, J, Sorrie, M, Soyiri, I, Spurlock, E, Sreeramareddy, C, Stanaway, J, Steel, N, Stein, C, Stokes, M, Sufiyan, M, Suleria, H, Sultan, I, Szumowski, Ł, Tabarés-Seisdedos, R, Tabuchi, T, Tadakamadla, S, Taddele, B, Tadesse, D, Taherkhani, A, Tamiru, A, Tanser, F, Tareque, M, Tarigan, I, Teagle, W, Tediosi, F, Tefera, Y, Tela, F, Tessema, Z, Thakur, B, Titova, M, Tonelli, M, Topor-Madry, R, Topouzis, F, Tovani-Palone, M, Tran, B, Travillian, R, Troeger, C, Tudor Car, L, Uddin, R, Ullah, I, Umeokonkwo, C, Unnikrishnan, B, Upadhyay, E, Uthman, O, Vacante, M, Valdez, P, Varughese, S, Vasankari, T, Vasseghian, Y, Venketasubramanian, N, Violante, F, Vlassov, V, Vollset, S, Vongpradith, A, Vos, T, Waheed, Y, Walters, M, Wamai, R, Wang, H, Wang, Y, Weintraub, R, Weiss, J, Werdecker, A, Westerman, R, Wilner, L, Woldu, G, Wolfe, C, Wu, A, Wulf Hanson, S, Xie, Y, Xu, R, Yahyazadeh Jabbari, S, Yamagishi, K, Yano, Y, Yaya, S, Yazdi-Feyzabadi, V, Yearwood, J, Yeshitila, Y, Yip, P, Yonemoto, N, Younis, M, Yousefi, Z, Yousefinezhadi, T, Yusefzadeh, H, Zadey, S, Zahirian Moghadam, T, Zaidi, S, Zaki, L, Zaman, S, Zamani, M, Zamanian, M, Zandian, H, Zastrozhin, M, Zewdie, K, Zhang, Y, Zhao, X, Zhao, Y, Zheng, P, Zhu, C, Ziapour, A, Zlavog, B, Zodpey, S, Murray, C, Tampere University, Health Sciences, 10922180 - Schutte, Aletta Elisabeth, Lozano, R., Fullman, N., Mumford, J. E., Knight, M., Barthelemy, C. M., Abbafati, C., Abbastabar, H., Abd-Allah, F., Abdollahi, M., Abedi, A., Abolhassani, H., Abosetugn, A. E., Abreu, L. G., Abrigo, M. R. M., Abu Haimed, A. K., Abushouk, A. I., Adabi, M., Adebayo, O. M., Adekanmbi, V., Adelson, J., Adetokunboh, O. O., Adham, D., Advani, S. M., Afshin, A., Agarwal, G., Agasthi, P., Aghamir, S. M. K., Agrawal, A., Ahmad, T., Akinyemi, R. O., Alahdab, F., Al-Aly, Z., Alam, K., Albertson, S. B., Alemu, Y. M., Alhassan, R. K., Ali, M., Ali, S., Alipour, V., Aljunid, S. M., Alla, F., Almadi, M. A. H., Almasi, A., Almasi-Hashiani, A., Almasri, N. A., Al-Mekhlafi, H. M., Almulhim, A. M., Alonso, J., Al-Raddadi, R. M., Altirkawi, K. A., Alvis-Guzman, N., Alvis-Zakzuk, N. J., Amini, S., Amini-Rarani, M., Amiri, F., Amit, A. M. L., Amugsi, D. A., Ancuceanu, R., Anderlini, D., Andrei, C. L., Androudi, S., Ansari, F., Ansari-Moghaddam, A., Antonio, C. A. T., Antony, C. M., Antriyandarti, E., Anvari, D., Anwer, R., Arabloo, J., Arab-Zozani, M., Aravkin, A. Y., Aremu, O., Arnlov, J., Asaad, M., Asadi-Aliabadi, M., Asadi-Pooya, A. A., Athari, S. S., Atout, M. M. W., Ausloos, M., Avila-Burgos, L., Ayala Quintanilla, B. P., Ayano, G., Ayanore, M. A., Aynalem, Y. A., Aynalem, G. L., Ayza, M. A., Azari, S., Azzopardi, P. S., B, D. B., Babaee, E., Badiye, A. D., Bahrami, M. A., Baig, A. A., Bakhshaei, M. H., Bakhtiari, A., Bakkannavar, S. M., Balachandran, A., Banach, M., Banerjee, S. K., Banik, P. C., Bante, A. B., Bante, S. A., Barker-Collo, S. L., Barnighausen, T. W., Barrero, L. H., Bassat, Q., Basu, S., Baune, B. T., Bayati, M., Baye, B. A., Bedi, N., Beghi, E., Behzadifar, M., Bekuma, T. T. T., Bell, M. L., Bensenor, I. M., Berman, A. E., Bernabe, E., Bernstein, R. S., Bhagavathula, A. S., Bhandari, D., Bhardwaj, P., Bhat, A. G., Bhattacharyya, K., Bhattarai, S., Bhutta, Z. A., Bijani, A., Bikbov, B., Bilano, V., Biondi, A., Birihane, B. M., Bockarie, M. J., Bohlouli, S., Bojia, H. A., Bolla, S. R. R., Boloor, A., Brady, O. J., Braithwaite, D., Briggs, A. M., Briko, N. I., Burugina Nagaraja, S., Busse, R., Butt, Z. A., Caetano dos Santos, F. L., Cahuana-Hurtado, L., Camera, L. A., Cardenas, R., Carreras, G., Carrero, J. J., Carvalho, F., Castaldelli-Maia, J. M., Castaneda-Orjuela, C. A., Castelpietra, G., Castro, F., Catala-Lopez, F., Cederroth, C. R., Cerin, E., Chandan, J. S., Chang, A. Y., Charan, J., Chattu, V. K., Chaturvedi, S., Chin, K. L., Cho, D. Y., Choi, J. -Y. J., Christensen, H., Chu, D. -T., Chung, M. T., Ciobanu, L. G., Cirillo, M., Compton, K., Cortesi, P. A., Costa, V. M., Cousin, E., Dahlawi, S. M. A., Damiani, G., Dandona, L., Dandona, R., Darega Gela, J., Darwesh, A. M., Daryani, A., Dash, A. P., Davey, G., Davila-Cervantes, C. A., Davletov, K., De Neve, J. -W., Denova-Gutierrez, E., Deribe, K., Dervenis, N., Desai, R., Dharmaratne, S. D., Dhungana, G. P., Dianatinasab, M., Dias da Silva, D., Diaz, D., Dippenaar, I. N., Do, H. T., Dorostkar, F., Doshmangir, L., Duncan, B. B., Duraes, A. R., Eagan, A. W., Edvardsson, D., El Sayed, I., El Tantawi, M., Elgendy, I. Y., Elyazar, I. R., Eskandari, K., Eskandarieh, S., Esmaeilnejad, S., Esteghamati, A., Ezekannagha, O., Farag, T., Farahmand, M., Faraon, E. J. A., Farinha, C. S. E. S., Farioli, A., Faris, P. S., Faro, A., Fazlzadeh, M., Feigin, V. L., Fernandes, E., Ferrara, P., Feyissa, G. T., Filip, I., Fischer, F., Fisher, J. L., Flor, L. S., Foigt, N. A., Folayan, M. O., Fomenkov, A. A., Foroutan, M., Francis, J. M., Fu, W., Fukumoto, T., Furtado, J. M., Gad, M. M., Gaidhane, A. M., Gakidou, E., Galles, N. C., Gallus, S., Gardner, W. M., Geberemariyam, B. S., Gebrehiwot, A. M., Gebremeskel, L. G., Gebremeskel, G. G., Gesesew, H. A., Ghadiri, K., Ghafourifard, M., Ghashghaee, A., Ghith, N., Gholamian, A., Gilani, S. A., Gill, P. S., Gill, T. K., Ginindza, T. G., Gitimoghaddam, M., Giussani, G., Glagn, M., Gnedovskaya, E. V., Godinho, M. A., Goharinezhad, S., Gopalani, S. V., Goudarzian, A. H., Goulart, B. N. G., Gubari, M. I. M., Guimaraes, R. A., Guled, R. A., Gultie, T., Guo, Y., Gupta, R., Hafezi-Nejad, N., Hafiz, A., Haile, T. G., Hamadeh, R. R., Hameed, S., Hamidi, S., Han, C., Han, H., Handiso, D. W., Hanif, A., Hankey, G. J., Haro, J. M., Hasaballah, A. I., Hasan, M. M., Hashi, A., Hassan, S., Hassan, A., Hassanipour, S., Hassankhani, H., Havmoeller, R. J., Hay, S. I., Hayat, K., Heidari, G., Heidari-Soureshjani, R., Hendrie, D., Herteliu, C., Hird, T. R., Ho, H. C., Hole, M. K., Holla, R., Hoogar, P., Hopf, K. P., Horita, N., Hossain, N., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Hostiuc, S., Househ, M., Hsieh, V. C. -R., Hu, G., Huda, T. M., Humayun, A., Hwang, B. -F., Iavicoli, I., Ibitoye, S. E., Ikeda, N., Ilesanmi, O. S., Ilic, M. D., Inbaraj, L. R., Iqbal, U., Irvani, S. S. N., Irvine, C. M. S., Islam, M. M., Islam, S. M. S., Islami, F., Iso, H., Iwu, C. J., Jaafari, J., Jadidi-Niaragh, F., Jafarinia, M., Jahagirdar, D., Jahani, M. A., Jahanmehr, N., Jakovljevic, M., Janjani, H., Javaheri, T., Jayatilleke, A. U., Jenabi, E., Jha, R. P., Jha, V., Ji, J. S., Jia, P., John-Akinola, Y. O., Jonas, J. B., Joukar, F., Jozwiak, J. J., Jurisson, M., Kabir, Z., Kalankesh, L. R., Kalhor, R., Kamath, A. M., Kanchan, T., Kapoor, N., Karami Matin, B., Karanikolos, M., Karimi, S. M., Kassebaum, N. J., Katikireddi, S. V., Kayode, G. A., Keiyoro, P. N., Khader, Y. S., Khammarnia, M., Khan, M., Khan, E. A., Khang, Y. -H., Khatab, K., Khater, A. M., Khater, M. M., Khatib, M. N., Khayamzadeh, M., Khubchandani, J., Kianipour, N., Kim, Y. J., Kimokoti, R. W., Kinfu, Y., Kisa, A., Kissimova-Skarbek, K., Kivimaki, M., Kneib, C. J., Kocarnik, J. M., Kochhar, S., Kohler, S., Kopec, J. A., Korotkova, A. V., Korshunov, V. A., Kosen, S., Kotlo, A., Koul, P. A., Koyanagi, A., Krishan, K., Krohn, K. J., Kugbey, N., Kulkarni, V., Kumar, G. A., Kumar, N., Kumar, M., Kurmi, O. P., Kusuma, D., Kyu, H. H., La Vecchia, C., Lacey, B., Lal, D. K., Lalloo, R., Landires, I., Lansingh, V. C., Larsson, A. O., Lasrado, S., Lau, K. M. -M., Lauriola, P., Lazarus, J. V., Ledesma, J. R., Lee, P. H., Lee, S. W. H., Leever, A. T., Legrand, K. E., Leigh, J., Leonardi, M., Li, S., Lim, S. S., Lim, L. -L., Liu, X., Logroscino, G., Lopez, A. D., Lopukhov, P. D., Lotufo, P. A., Lu, A., Ma, J., Madadin, M., Mahasha, P. W., Mahmoudi, M., Majeed, A., Malagon-Rojas, J. N., Maleki, S., Malta, D. C., Mansouri, B., Mansournia, M. A., Martini, S., Martins-Melo, F. R., Martopullo, I., Massenburg, B. B., Mastrogiacomo, C. I., Mathur, M. R., Mcalinden, C., Mckee, M., Medina-Solis, C. E., Meharie, B. G., Mehndiratta, M. M., Mehrabi Nasab, E., Mehri, F., Mehrotra, R., Mekonnen, T., Melese, A., Memiah, P. T. N., Mendoza, W., Menezes, R. G., Mensah, G. A., Meretoja, T. J., Meretoja, A., Mestrovic, T., Miazgowski, B., Michalek, I. M., Mirrakhimov, E. M., Mirzaei, M., Mirzaei-Alavijeh, M., Mitchell, P. B., Moazen, B., Moghadaszadeh, M., Mohamadi, E., Mohammad, Y., Mohammad, D. K., Mohammad Gholi Mezerji, N., Mohammadian-Hafshejani, A., Mohammed, S., Mohammed, J. A., Mokdad, A. H., Monasta, L., Mondello, S., Moradi, M., Moradi-Lakeh, M., Moradzadeh, R., Moraga, P., Morgado-da-Costa, J., Morrison, S. D., Mosapour, A., Mosser, J. F., Mousavi Khaneghah, A., Muriithi, M. K., Mustafa, G., Nabhan, A. F., Naderi, M., Nagarajan, A. J., Naghavi, M., Naghshtabrizi, B., Naimzada, M. D., Nangia, V., Nansseu, J. R., Nayak, V. C., Nazari, J., Ndejjo, R., Negoi, I., Negoi, R. I., Neupane, S., Ngari, K. N., Nguefack-Tsague, G., Ngunjiri, J. W., Nguyen, C. T., Nguyen, D. N., Nguyen, H. L. T., Nnaji, C. A., Nomura, S., Norheim, O. F., Noubiap, J. J., Nowak, C., Nunez-Samudio, V., Otoiu, A., Ogbo, F. A., Oghenetega, O. B., Oh, I. -H., Okunga, E. W., Oladnabi, M., Olagunju, A. T., Olusanya, J. O., Olusanya, B. O., Oluwasanu, M. M., Omar Bali, A., Omer, M. O., Ong, K. L., Onwujekwe, O. E., Ortega-Altamirano, D. V. V., Ortiz, A., Ostojic, S. M., Otstavnov, N., Otstavnov, S. S., Overland, S., Owolabi, M. O., Padubidri, J. R., Pakhale, S., Palladino, R., Pana, A., Panda-Jonas, S., Pangaribuan, H. U., Pathak, M., Patton, G. C., Paudel, S., Pazoki Toroudi, H., Pease, S. A., Peden, A. E., Pennini, A., Peprah, E. K., Pereira, J., Pigott, D. M., Pilgrim, T., Pilz, T. M., Pinheiro, M., Piradov, M. A., Pirsaheb, M., Pokhrel, K. N., Postma, M. J., Pourjafar, H., Pourmalek, F., Pourmirza Kalhori, R., Pourshams, A., Prada, S. I., Pribadi, D. R. A., Pupillo, E., Quazi Syed, Z., Radfar, A., Rafiee, A., Rafiei, A., Raggi, A., Rahim, F., Rahman, M. A., Rajabpour-Sanati, A., Rana, S. M., Ranabhat, C. L., Rao, S. J., Rasella, D., Rashedi, V., Rath, G. K., Rathi, P., Rawaf, S., Rawaf, D. L., Rawal, L., Rawassizadeh, R., Razo, C., Renjith, V., Renzaho, A. M. N., Reshmi, B., Rezaei, N., Riahi, S. M., Ribeiro, D. C., Rickard, J., Roberts, N. L. S., Roever, L., Romoli, M., Ronfani, L., Roshandel, G., Rubagotti, E., Rwegerera, G. M., Sabour, S., Sachdev, P. S., Saddik, B., Sadeghi, M., Sadeghi, E., Safari, Y., Sagar, R., Sahebkar, A., Sahraian, M. A., Sajadi, S. M., Salahshoor, M. R., Salem, M. R. R., Salem, H., Salomon, J., Samadi Kafil, H., Samy, A. M., Sanabria, J., Santric-Milicevic, M. M., Saraswathy, S. Y. I., Sarmiento-Suarez, R., Sartorius, B., Sarveazad, A., Sathian, B., Sathish, T., Sattin, D., Savic, M., Sawyer, S. M., Saxena, D., Sbarra, A. N., Schaeffer, L. E., Schiavolin, S., Schmidt, M. I., Schutte, A. E., Schwebel, D. C., Schwendicke, F., Seedat, S., Sha, F., Shahabi, S., Shaheen, A. A., Shaikh, M. A., Shamsizadeh, M., Shannawaz, M., Sharafi, K., Sharara, F., Sharifi, H., Shaw, D. H., Sheikh, A., Sheikhtaheri, A., Shetty, B. S. K., Shibuya, K., Shiferaw, W. S., Shigematsu, M., Shin, J. I., Shiri, R., Shirkoohi, R., Shivakumar, K. M., Shrime, M. G., Shuval, K., Siabani, S., Sierpinski, R., Sigfusdottir, I. D., Sigurvinsdottir, R., Silva, D. A. S., Silva, J. P., Simonetti, B., Simpson, K. E., Singh, J. A., Singh, P., Sinha, D. N., Skryabin, V. Y., Smith, E. U. R., Soheili, A., Soltani, S., Soofi, M., Sorensen, R. J. D., Soriano, J. B., Sorrie, M. B., Soyiri, I. N., Spurlock, E. E., Sreeramareddy, C. T., Stanaway, J. D., Steel, N., Stein, C., Stokes, M. A., Sufiyan, M. B., Suleria, H. A. R., Sultan, I., Szumowski, L., Tabares-Seisdedos, R., Tabuchi, T., Tadakamadla, S. K., Taddele, B. W., Tadesse, D. B., Taherkhani, A., Tamiru, A. T., Tanser, F. C., Tareque, M. I., Tarigan, I. U., Teagle, W. L., Tediosi, F., Tefera, Y. G. G., Tela, F. G., Tessema, Z. T., Thakur, B., Titova, M. V., Tonelli, M., Topor-Madry, R., Topouzis, F., Tovani-Palone, M. R. R., Tran, B. X., Travillian, R., Troeger, C. E., Tudor Car, L., Uddin, R., Ullah, I., Umeokonkwo, C. D., Unnikrishnan, B., Upadhyay, E., Uthman, O. A., Vacante, M., Valdez, P. R., Varughese, S., Vasankari, T. J., Vasseghian, Y., Venketasubramanian, N., Violante, F. S., Vlassov, V., Vollset, S. E., Vongpradith, A., Vos, T., Waheed, Y., Walters, M. K., Wamai, R. G., Wang, H., Wang, Y. -P., Weintraub, R. G., Weiss, J., Werdecker, A., Westerman, R., Wilner, L. B., Woldu, G., Wolfe, C. D. A., Wu, A. -M., Wulf Hanson, S., Xie, Y., Yahyazadeh Jabbari, S. H., Yamagishi, K., Yano, Y., Yaya, S., Yazdi-Feyzabadi, V., Yearwood, J. A., Yeshitila, Y. G., Yip, P., Yonemoto, N., Younis, M. Z., Yousefi, Z., Yousefinezhadi, T., Yusefzadeh, H., Zadey, S., Zahirian Moghadam, T., Zaidi, S. S., Zaki, L., Zaman, S. B., Zamanian, M., Zandian, H., Zastrozhin, M. S., Zewdie, K. A., Zhang, Y., Zhao, X. -J. G., Zhao, Y., Zheng, P., Zhu, C., Ziapour, A., Zlavog, B. S., Zodpey, S., and Murray, C. J. L.

Subjects
Index (economics), Servicios de Salud, SUSTAINABLE DEVELOPMENT GOALS, 030204 cardiovascular system & hematology, universal health coverage, sustaibale develpment goal, global burden of disease, performance, systematic analysis, Global Burden of Disease, 0302 clinical medicine, Universal Health Insurance, RA0421, 11. Sustainability, Per capita, Medical economics, Disease, 030212 general & internal medicine, 10. No inequality, 11 Medical and Health Sciences, effective coverage of health services, GBD 2019 Universal Health Coverage Collaborators, education.field_of_study, Public health, Medical care, Sjúkdómar, 4. Education, 1. No poverty, Health coverage, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Hälsovetenskaper, 3142 Public health care science, environmental and occupational health, Health services, 3. Good health, Global burden of disease, Health Expenditures, Humans, World Health Organization, Purchasing power parity, Scale (social sciences), Lýðheilsa, universal health coverag, CANCER SURVIVAL, ACCESS, Human, Heilsuhagfræði, medicine.medical_specialty, Health coverage, GBD, GBD, Universal health, GBD 2019, Population, Health expenditures, 3122 Cancers, Population health, 03 medical and health sciences, Health systems, Heilbrigðisvísindi, SDG 3 - Good Health and Well-being, General & Internal Medicine, Development economics, Health Sciences, medicine, Heilbrigðisstefna, Alþjóðaheilbrigðisstofnunin, QUALITY, Global Burden of Disease Study, education, PROGRESS, Disease burden, Health services accessibility, CARE, Heilbrigðisþjónusta, purl.org/pe-repo/ocde/ford#3.02.00 [https], Health Expenditure, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, 3121 General medicine, internal medicine and other clinical medicine, Morbility, Administración de los Servicios de Salud, Medical policy, Business, Heilbrigðiskerfi
Abstract

Publisher's version (útgefin grein), Background Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system level is important for understanding whether health services are aligned with countries' health profiles and are of sufficient quality to produce health gains for populations of all ages. Methods Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we assessed UHC effective coverage for 204 countries and territories from 1990 to 2019. Drawing from a measurement framework developed through WHO's GPW13 consultation, we mapped 23 effective coverage indicators to a matrix representing health service types (eg, promotion, prevention, and treatment) and five population-age groups spanning from reproductive and newborn to older adults (>= 65 years). Effective coverage indicators were based on intervention coverage or outcome-based measures such as mortality-to-incidence ratios to approximate access to quality care; outcome-based measures were transformed to values on a scale of 0-100 based on the 2.5th and 97.5th percentile of location-year values. We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. For three tests of validity (content, known-groups, and convergent), UHC effective coverage index performance was generally better than that of other UHC service coverage indices from WHO (ie, the current metric for SDG indicator 3.8.1 on UHC service coverage), the World Bank, and GBD 2017. We quantified frontiers of UHC effective coverage performance on the basis of pooled health spending per capita, representing UHC effective coverage index levels achieved in 2019 relative to country-level government health spending, prepaid private expenditures, and development assistance for health. To assess current trajectories towards the GPW13 UHC billion target-1 billion more people benefiting from UHC by 2023-we estimated additional population equivalents with UHC effective coverage from 2018 to 2023. Findings Globally, performance on the UHC effective coverage index improved from 45.8 (95% uncertainty interval 44.2-47.5) in 1990 to 60.3 (58.7-61.9) in 2019, yet country-level UHC effective coverage in 2019 still spanned from 95 or higher in Japan and Iceland to lower than 25 in Somalia and the Central African Republic. Since 2010, sub-Saharan Africa showed accelerated gains on the UHC effective coverage index (at an average increase of 2.6% [1.9-3.3] per year up to 2019); by contrast, most other GBD super-regions had slowed rates of progress in 2010-2019 relative to 1990-2010. Many countries showed lagging performance on effective coverage indicators for non-communicable diseases relative to those for communicable diseases and maternal and child health, despite non-communicable diseases accounting for a greater proportion of potential health gains in 2019, suggesting that many health systems are not keeping pace with the rising non-communicable disease burden and associated population health needs. In 2019, the UHC effective coverage index was associated with pooled health spending per capita (r=0.79), although countries across the development spectrum had much lower UHC effective coverage than is potentially achievable relative to their health spending. Under maximum efficiency of translating health spending into UHC effective coverage performance, countries would need to reach $1398 pooled health spending per capita (US$ adjusted for purchasing power parity) in order to achieve 80 on the UHC effective coverage index. From 2018 to 2023, an estimated 388.9 million (358.6-421.3) more population equivalents would have UHC effective coverage, falling well short of the GPW13 target of 1 billion more people benefiting from UHC during this time. Current projections point to an estimated 3.1 billion (3.0-3.2) population equivalents still lacking UHC effective coverage in 2023, with nearly a third (968.1 million [903.5-1040.3]) residing in south Asia. Interpretation The present study demonstrates the utility of measuring effective coverage and its role in supporting improved health outcomes for all people-the ultimate goal of UHC and its achievement. Global ambitions to accelerate progress on UHC service coverage are increasingly unlikely unless concerted action on non-communicable diseases occurs and countries can better translate health spending into improved performance. Focusing on effective coverage and accounting for the world's evolving health needs lays the groundwork for better understanding how close-or how far-all populations are in benefiting from UHC., Lucas Guimaraes Abreu acknowledges support from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (Capes) -Finance Code 001, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG). Olatunji O Adetokunboh acknowledges South African Department of Science & Innovation, and National Research Foundation. Anurag Agrawal acknowledges support from the Wellcome Trust DBT India Alliance Senior Fellowship IA/CPHS/14/1/501489. Rufus Olusola Akinyemi acknowledges Grant U01HG010273 from the National Institutes of Health (NIH) as part of the H3Africa Consortium. Rufus Olusola Akinyemi is further supported by the FLAIR fellowship funded by the UK Royal Society and the African Academy of Sciences. Syed Mohamed Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. Marcel Ausloos, Claudiu Herteliu, and Adrian Pana acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDSUEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. Till Winfried Barnighausen acknowledges support from the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. Juan J Carrero was supported by the Swedish Research Council (2019-01059). Felix Carvalho acknowledges UID/MULTI/04378/2019 and UID/QUI/50006/2019 support with funding from FCT/MCTES through national funds. Vera Marisa Costa acknowledges support from grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundacao para a Ciencia e a Tecnologia (FCT), IP, under the Norma TransitA3ria DL57/2016/CP1334/CT0006. Jan-Walter De Neve acknowledges support from the Alexander von Humboldt Foundation. Kebede Deribe acknowledges support by Wellcome Trust grant number 201900/Z/16/Z as part of his International Intermediate Fellowship. Claudiu Herteliu acknowledges partial support by a grant co-funded by European Fund for Regional Development through Operational Program for Competitiveness, Project ID P_40_382. Praveen Hoogar acknowledges the Centre for Bio Cultural Studies (CBiCS), Manipal Academy of Higher Education(MAHE), Manipal and Centre for Holistic Development and Research (CHDR), Kalghatgi. Bing-Fang Hwang acknowledges support from China Medical University (CMU108-MF-95), Taichung, Taiwan. Mihajlo Jakovljevic acknowledges the Serbian part of this GBD contribution was co-funded through the Grant OI175014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. Aruna M Kamath acknowledges funding from the National Institutes of Health T32 grant (T32GM086270). Srinivasa Vittal Katikireddi acknowledges funding from the Medical Research Council (MC_UU_12017/13 & MC_UU_12017/15), Scottish Government Chief Scientist Office (SPHSU13 & SPHSU15) and an NRS Senior Clinical Fellowship (SCAF/15/02). Yun Jin Kim acknowledges support from the Research Management Centre, Xiamen University Malaysia (XMUMRF/2018-C2/ITCM/0001). Kewal Krishan acknowledges support from the DST PURSE grant and UGC Center of Advanced Study (CAS II) awarded to the Department of Anthropology, Panjab University, Chandigarh, India. Manasi Kumar acknowledges support from K43 TW010716 Fogarty International Center/NIMH. Ben Lacey acknowledges support from the NIHR Oxford Biomedical Research Centre and the BHF Centre of Research Excellence, Oxford. Ivan Landires is a member of the Sistema Nacional de InvestigaciA3n (SNI), which is supported by the Secretaria Nacional de Ciencia Tecnologia e Innovacion (SENACYT), Panama. Jeffrey V Lazarus acknowledges support by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III/ESF, European Union [CP18/00074]). Peter T N Memiah acknowledges CODESRIA; HISTP. Subas Neupane acknowledges partial support from the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital. Shuhei Nomura acknowledges support from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K10082). Alberto Ortiz acknowledges support by ISCIII PI19/00815, DTS18/00032, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. These funding sources had no role in the writing of the manuscript or the decision to submit it for publication. George C Patton acknowledges support from a National Health & Medical Research Council Fellowship. Marina Pinheiro acknowledges support from FCT for funding through program DL 57/2016 -Norma transitA3ria. Alberto Raggi, David Sattin, and Silvia Schiavolin acknowledge support by a grant from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C Besta, Linea 4 -Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). Daniel Cury Ribeiro acknowledges support from the Sir Charles Hercus Health Research Fellowship -Health Research Council of New Zealand (18/111). Perminder S Sachdev acknowledges funding from the NHMRC Australia. Abdallah M Samy acknowledges support from a fellowship from the Egyptian Fulbright Mission Program. Milena M Santric-Milicevic acknowledges support from the Ministry of Education, Science and Technological Development of the Republic of Serbia (Contract No. 175087). Rodrigo Sarmiento-Suarez acknowledges institutional support from University of Applied and Environmental Sciences in Bogota, Colombia, and Carlos III Institute of Health in Madrid, Spain. Maria Ines Schmidt acknowledges grants from the Foundation for the Support of Research of the State of Rio Grande do Sul (IATS and PrInt) and the Brazilian Ministry of Health. Sheikh Mohammed Shariful Islam acknowledges a fellowship from the National Heart Foundation of Australia and Deakin University. Aziz Sheikh acknowledges support from Health Data Research UK. Kenji Shibuya acknowledges Japan Ministry of Education, Culture, Sports, Science and Technology. Joan B Soriano acknowledges support by Centro de Investigacion en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Rafael Tabares-Seisdedos acknowledges partial support from grant PI17/00719 from ISCIII-FEDER. Santosh Kumar Tadakamadla acknowledges support from the National Health and Medical Research Council Early Career Fellowship, Australia. Marcello Tonelli acknowledges the David Freeze Chair in Health Services Research at the University of Calgary, AB, Canada., "Peer Reviewed"

Published
2020

48. Imidazolium labelling permits the sensitive mass-spectrometric detection of

Author

Yao-Yao, Zhang, Mattia, Ghirardello, Ting, Wang, Ai-Min, Lu, Li, Liu, Josef, Voglmeir, and M Carmen, Galan

Subjects
Chemistry, Limit of Detection, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Imidazoles, Humans, Lactose, Glycosides, Acetylglucosamine, Amination
Abstract

A novel imidazolium derivative (GITag) shows superior ionisation and consequently allows increased mass spectrometric detection capabilities of oligosaccharides and N-glycans. Here we demonstrate that human serum samples can be directly labelled by GITag on a MALDI target plate, abrogating prevalently required sample pretreatment or clean-up steps., A novel imidazolium derivative (GITag) shows superior ionisation and therefore allows increased mass spectrometric detection capabilities, herein demonstrated by directly labelling human serum N-glycans without sample pretreatment or cleanup steps.

Published
2021

49. Genomic profiling of a patient with quadruple synchronous colorectal cancer: a case report

Author

Junjie Sun, Hengxue Lin, Tianliang Bai, Xiongjie Jia, Ai-Min Zhang, Tao Zhang, and Xinyu Peng

Subjects
Male, Pathology, medicine.medical_specialty, Colorectal cancer, Rectum, Case Report, RC799-869, Adenocarcinoma, Neoplasms, Multiple Primary, Synchronous colorectal cancer, Carcinoma, Medicine, Ascending colon, Humans, Retrospective Studies, Intraepithelial neoplasia, business.industry, Gastroenterology, Sigmoid colon, General Medicine, Genomics, Diseases of the digestive system. Gastroenterology, Middle Aged, medicine.disease, Primary tumor, digestive system diseases, Oxaliplatin, medicine.anatomical_structure, Quadruple, Next-generation sequencing, Heterogeneity, business, Colorectal Neoplasms, medicine.drug
Abstract

Background Synchronous colorectal cancer (SCRC) is featured by the presence of multiple primary tumor lesions in a single patient at initial diagnosis. It is less common with the prevalence of approximately 3.5% among colorectal cancer (CRC). Some studies of SCRC have been performed in patients with two tumor lesions. However, SCRC cases with three or more tumor lesions were rare and remained to be investigated. Case presentation In this case report, we presented a 56-year-old male SCRC case with quadruple tumor lesions which is rarely seen in clinical practice. After laparoscopic radical resection of sigmoid carcinoma and partial rectum resection, the four tumor samples were subjected to pathological evaluation and next-generation sequencing (NGS) based genetic profiling. The four tumor lesions included two adenocarcinomas with moderate differentiation at sigmoid colon and rectum respectively, a grade 1 neuroendocrine tumor (NET) at rectum and a high-grade intraepithelial neoplasia at ascending colon. Each tumor exhibited distinct histology types and mutation profiles. After surgical resection, the patient remained disease-free after four cycles of chemotherapy with oxaliplatin and capecitabine (XELOX). Conclusions The tumor lesions in this case showed different pathological and genetic features which indicats the heterogeneity of SCRC. The genomic profilling might provide novel insights to understand SCRC at molecular level.

Published
2021

50. High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes

Author

Zhenghua Hong, Yifeng Shi, Ai-Min Wu, Yifei Zhou, Yan Lin, Xiang-Yang Wang, Liaojun Sun, Jiaoxiang Chen, Yaosen Wu, Zhenxuan Shao, Naifeng Tian, Libin Ni, Ben Wang, and Xiaolei Zhang

Subjects
Senescence, Cancer Research, Immunology, Endogeny, AMP-Activated Protein Kinases, medicine.disease_cause, Article, Diabetes Complications, Acetylcysteine, Mice, Cellular and Molecular Neuroscience, Chondrocytes, Downregulation and upregulation, Autophagy, Diabetes Mellitus, medicine, Animals, Humans, Bone, QH573-671, Chemistry, Endocrine system and metabolic diseases, AMPK, Cell Biology, Ribonucleotides, Aminoimidazole Carboxamide, Cell biology, Oxidative Stress, Glucose, Apoptosis, Hyperglycemia, Cytology, Oxidative stress, medicine.drug
Abstract

Diabetes (DB) is a risk factor for osteoarthritis progression. High glucose (HG) is one of the key pathological features of DB and has been demonstrated to induce apoptosis and senescence in chondrocytes. Autophagy is an endogenous mechanism that can protect cells against apoptosis and senescence. The effects of HG on autophagy in cells including chondrocytes have been studied; however, the results have been inconsistent. The current study aimed to elucidate the underlying mechanisms, which could be associated with the contrasting outcomes. The present study revealed that HG can induce apoptosis and senescence in chondrocytes, in addition to regulating autophagy dynamically. The present study demonstrated that HG can cause oxidative stress in chondrocytes and suppress the AMPK pathway in a dose-dependent manner. Elimination of oxidative stress by Acetylcysteine, also called N-acetyl cysteine (NAC), downregulated autophagy and alleviated HG-stimulated apoptosis and senescence, while activation of the AMPK signaling pathway by AICAR not only upregulated autophagy but also alleviated HG-stimulated apoptosis and senescence. A combined treatment of NAC and AICAR was superior to treatment with either NAC or AICAR. The study has demonstrated that HG can suppress autophagy through the AMPK pathway and induce autophagy via oxidative stress in chondrocytes.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results