Neurophysiological mechanisms of cancer-induced bone pain

Graphical abstract
Highlights • The development of scientific research in CIBP was elaborated in a complete and clear perspective. • The possible mechanisms, including the new achievements in central sensitization, glial cell activation, acid environment, of CIBP were reviewed. • Several key molecules and treatments as well as the potential targets and promising therapies were also briefly reviewed. • The challenges we faced and the future directions are also summarized and elaborated.
Background Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditions and the complexity of neuropathic pain, related mechanisms have been continuously supplemented but have not been perfected. Aim of Review Therefore, the current review highlights the latest progress in basic research on the field and proposes potential therapeutic targets, representative drugs and upcoming therapies. Key Scientific Concepts of Review Notably, factors such as central sensitization, neuroinflammation, glial cell activation and an acidic environment are considered to be related to neuropathic pain in CIBP. Nonetheless, further research is needed to ascertain the mechanism of CIBP in order to develop highly effective drugs. Moreover, more attention needs to be paid to the care of patients with advanced cancer.