1. Herpes Simplex Virus Type-2 Cervicovaginal Shedding Among Women Living With HIV-1 and Receiving Antiretroviral Therapy in Burkina Faso: An 8-Year Longitudinal Study.
- Author
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Low AJ, Nagot N, Weiss HA, Konate I, Kania D, Segondy M, Meda N, van de Perre P, and Mayaud P
- Subjects
- Adolescent, Adult, Burkina Faso epidemiology, DNA, Viral isolation & purification, Female, HIV Infections drug therapy, HIV Infections epidemiology, Herpes Genitalis epidemiology, Humans, Linear Models, Odds Ratio, Young Adult, Anti-HIV Agents therapeutic use, HIV Infections complications, Herpes Genitalis complications, Herpes Genitalis virology, Herpesvirus 2, Human physiology, Virus Shedding physiology
- Abstract
Background: The impact of antiretroviral therapy (ART) on herpes simplex virus type-2 (HSV-2) replication is unclear. The aim of this study was to assess factors associated with cervicovaginal HSV-2 DNA shedding and genital ulcer disease (GUD) in a cohort of women living with human immunodeficiency virus type-1 (HIV-1) in Burkina Faso., Methods: Participants were screened for cervicovaginal HSV-2 DNA, GUD, cervicovaginal and systemic HIV-1 RNA, and reproductive tract infections every 3-6 months over 8 years. Associations with HSV-2 shedding and quantity were examined using random-effects logistic and linear regression, respectively., Results: Of the 236 women with data on HSV-2 shedding, 151 took ART during the study period. Cervicovaginal HSV-2 DNA was detected in 42% of women (99 of 236) in 8.2% of visits (151 of 1848). ART was associated with a reduction in the odds of HSV-2 shedding, which declined for each year of ART use (odds ratio [OR], 0.74; 95% confidence interval [CI], .59-.92). In the multivariable model, the impact of ART was primarily associated with suppression of systemic HIV-1 RNA (adjusted OR, 0.32; 95% CI, .15-.67). A reduction in the odds of GUD was also observed during ART, mainly in those with HIV-1 suppression (adjusted OR, 0.53; 95% CI, .25-1.11)., Conclusions: ART is strongly associated with a decrease in cervicovaginal HSV-2 shedding, and the impact was sustained over several years., (© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Published
- 2016
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