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Effect of HSV-2 on population-level trends in HIV incidence in Uganda between 1990 and 2007.
- Source :
-
Tropical medicine & international health : TM & IH [Trop Med Int Health] 2013 Oct; Vol. 18 (10), pp. 1257-66. - Publication Year :
- 2013
-
Abstract
- Objective: To assess the long-term effects of population-level HSV-2 infection on HIV incidence.<br />Methods: Data from a population-based cohort in south-western Uganda were used to estimate HIV incidence from 1990 to 2007. Stored blood samples were tested for HSV-2, and the impact of HSV-2 prevalence and incidence on HIV incidence was estimated by calculating population attributable fractions (PAFs). The association between population-level annual HIV incidence and annual HSV-2 incidence/prevalence was analysed using linear regression.<br />Results: HIV incidence declined over time among men, from 8.72/1000 person-years (pyr) in 1990 to 4.85/1000 pyr in 2007 (P-trend <0.001). In contrast, there was no decline in HIV incidence among women (4.86/1000 pyr in 1990 to 6.74/1000 pyr in 2007, P-trend = 0.18). PAFs of incident HIV attributable to HSV-2 were high (60% in males; 70% in females). There was no evidence of an association between long-term trends in HIV incidence and HSV-2 prevalence or incidence.<br />Conclusion: Assuming a causal relationship, a substantial proportion of new HIV infections in this population are attributable to HSV-2. The study did not find an effect of HSV-2 prevalence/incidence on trends in HIV incidence. HIV incidence did not vary much during the study period. This may partly explain the lack of association.<br /> (© 2013 John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1365-3156
- Volume :
- 18
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Tropical medicine & international health : TM & IH
- Publication Type :
- Academic Journal
- Accession number :
- 24016032
- Full Text :
- https://doi.org/10.1111/tmi.12176