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Interactions between herpes simplex virus type 2 and human immunodeficiency virus type 1 infection in African women: opportunities for intervention.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2000 Oct; Vol. 182 (4), pp. 1090-6. Date of Electronic Publication: 2000 Sep 08. - Publication Year :
- 2000
-
Abstract
- Sexually transmitted diseases (STDs) are cofactors for human immunodeficiency virus (HIV) transmission, but the specific role of herpes simplex virus type 2 (HSV-2) is unclear. This study aimed to examine the in vivo relationships between HSV-2 and HIV-1 in 300 women in Bangui, Central African Republic. Sera were tested for syphilis, HIV-1, HSV-2 antibody, and levels of vitamins A and E. Genital specimens were tested for other STDs. HSV-2 DNA and HIV-1 RNA were quantified in cervicovaginal lavage. The prevalences of HSV-2 antibody (91% vs. 78%, P=.02), HSV-2 shedding (43% vs. 22%, P=. 003), and levels of HSV-2 DNA (P=.01) were all significantly higher among HIV-1-seropositive than among HIV-1-seronegative women. There was a significant correlation between genital HIV-1 RNA and HSV-2 DNA levels (P=.02) among the 23 women who were shedding HSV-2 DNA. If confirmed, such associations highlight the urgent need for HSV-2 control measures in populations at high risk of both infections.
- Subjects :
- Black People
Central African Republic epidemiology
Cervix Uteri microbiology
Cervix Uteri virology
Enzyme-Linked Immunosorbent Assay
Female
HIV Infections blood
HIV Infections prevention & control
Herpes Genitalis blood
Herpes Genitalis prevention & control
Humans
Prevalence
RNA, Viral blood
Sexually Transmitted Diseases complications
Sexually Transmitted Diseases diagnosis
Sexually Transmitted Diseases epidemiology
Vagina metabolism
Vagina microbiology
Vagina virology
Vaginal Smears
Viral Load
Virus Shedding
Vitamin A blood
Vitamin E blood
HIV Infections complications
HIV-1 isolation & purification
Herpes Genitalis complications
Herpesvirus 2, Human isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 182
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 10979904
- Full Text :
- https://doi.org/10.1086/315836