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The patent application by inventor Herriot Tabuteau focuses on methods of administering solriamfetol to lactating women to reduce potential adverse events in infants fed breast milk from treated subjects. The invention involves orally administering solriamfetol at specific doses and timing to minimize exposure and adverse effects in infants. The methods aim to treat disorders such as narcolepsy, excessive daytime sleepiness, obstructive sleep apnea, attention deficit hyperactivity disorder, cognitive impairment, or binge eating disorder in lactating women while safeguarding infant health. [Extracted from the article]

The patent application by Ting Therapeutics LLC focuses on methods for preventing and treating hearing loss, particularly sensorineural hearing loss caused by noise exposure. The application highlights the use of pharmaceutical compositions containing various therapeutically active agents, such as Afatinib, to protect inner ear cells from damage and prevent hearing loss. The invention aims to address the lack of clinically proven medications for hearing loss and offers potential solutions for individuals experiencing sensorineural hearing loss. The application emphasizes the need for innovative approaches to combat hearing loss due to noise exposure. [Extracted from the article]

Researchers from Northwestern University have conducted a study on hearing loss during chemotherapy, a common but often underestimated side effect affecting millions of cancer patients worldwide. The study highlights the prevalence, mechanisms, and potential protective measures against chemotherapy-induced ototoxicity, focusing on the primary symptoms of hearing loss, tinnitus, vertigo, and dizziness. The research emphasizes the need for a comprehensive understanding of this issue and discusses potential strategies for hearing protection against cisplatin ototoxicity. [Extracted from the article]

A recent report from the Department of Oncology in Paris, France, discusses the challenges in treating salivary gland cancers due to their histological diversity. The study focused on systemic treatments for recurrent or metastatic salivary gland cancer, highlighting the importance of individualized treatment based on histology and specific receptor blockage. The research emphasized the impact of treatment response on overall survival, with different histological subtypes showing varying effectiveness to different therapies. This systematic review underscores the need for tailored treatments based on histological subtype for improved outcomes in patients with salivary gland cancer. [Extracted from the article]

A recent study conducted at the University of Manchester focused on the potential prevention of iatrogenic sensorineural hearing loss in neonatal units due to aminoglycoside exposure. The study found that most neonatal units in the UK use aminoglycosides as first-line antibiotic agents, putting infants with a specific genetic variant at risk. The researchers suggest integrating point-of-care genetic testing into neonatal septic screening pathways to address this issue. For more information, the full article can be accessed through Frontiers in Pediatrics. [Extracted from the article]

A recent study conducted in Karnataka, India, focused on the aerobic bacteriology of active chronic otitis media and its antibiotic susceptibility patterns among patients in Vijayapura. The research found that Pseudomonas aeruginosa was the most common organism isolated, with a high sensitivity to Amikacin and Piperacillin. The study highlighted the importance of understanding microbial predominance and antibiotic susceptibility in treating Chronic Suppurative Otitis Media, a common childhood disease in India. [Extracted from the article]

The article discusses the genetic basis of obstructive sleep apnea (OSA) and the persistent excessive daytime sleepiness (EDS) experienced by some patients even after treatment. The study explores the interaction between genetic markers and EDS in relation to OSA severity, identifying new genetic targets such as CCDC3, MARCHF1, and MED31. The research suggests potential therapeutic considerations for excessively sleepy OSA patients, including connections to insulin resistance, thiamine deficiency, and resveratrol use. The study is based on a large-scale genome-wide analysis involving over 11,500 samples from diverse populations. [Extracted from the article]

A study conducted at Shaoyang University in Hunan, People's Republic of China, focused on the role of serum aquaporin 8 (AQP8) expression in evaluating the degree of hydrolabyrinth and predicting prognosis in patients with Meniere's disease. The research involved 105 patients with Meniere's disease and 102 healthy subjects as the control group. Results showed that serum AQP8 mRNA levels were significantly higher in the Meniere's disease group, particularly in patients with severe hydrops, and were associated with predicting poor prognosis. The study concluded that AQP8 mRNA is linked to the degree of hydrolabyrinth in Meniere's disease patients and is crucial in prognosis prediction. [Extracted from the article]

A recent study conducted at the University of Sao Paulo (USP) focused on the audiological characterization of individuals with Cornelia de Lange Syndrome (CdLS). The research included 13 individuals with confirmed diagnoses, aged between 3 and 26 years. The study found that 62.5% of participants had mild hearing loss, with a predominance of bilateral conductive hearing loss. The research also identified changes in tympanometry and acoustic reflexes, indicating middle-ear impairments in individuals with CdLS. [Extracted from the article]

A recent study conducted at Government Medical College in Kerala, India, focused on the impact of adenotonsillectomy on the quality of life of children with obstructive sleep apnea (OSA). The study involved 43 children aged 4 to 12 years who underwent the surgery, with results showing a significant improvement in quality of life postoperatively. The research highlighted the importance of addressing OSA in children to improve sleep quality and overall well-being. [Extracted from the article]

The University of Texas Medical Branch conducted a study on opioid prescribing trends following thyroidectomy and parathyroidectomy before and after the 2021 American Academy of Otolaryngology-Head and Neck Surgery guidelines. The research found that there was an immediate decrease in opioid prescriptions for thyroid surgery after the guideline change, but the change was not sustained over time. However, there was a gradual decrease in opioid prescriptions for parathyroidectomy over time. This study provides valuable insights into the impact of prescription guidelines on opioid prescribing trends in surgical procedures. [Extracted from the article]

A recent study published by a researcher from Sloan Kettering Institute explores the use of Extended Reality (XR) technologies in otolaryngology-head and neck surgery (OHNS) beyond the operating room. The scoping review evaluates how XR can be applied for patient education, physician training, and interdisciplinary communication in OHNS. While the study identifies gaps in the existing literature and highlights the potential benefits of XR in improving patient comprehension and communication among surgical teams, more robust research is needed to fully assess its clinical value. Ongoing research aims to optimize the integration of XR technology into clinical practice to enhance education and patient care in OHNS. [Extracted from the article]

Researchers at Phoenix Children's Hospital are conducting a prospective observational study comparing revision palatoplasty and pharyngoplasty for the treatment of velopharyngeal insufficiency in individuals aged 3-23 with a history of repaired cleft palate. The study aims to enroll 528 participants across 12 hospitals in the US and Canada, with primary outcomes focused on resolving hypernasality and secondary outcomes on obstructive sleep apnea. The study, funded by NIH, is expected to be the largest and most comprehensive investigation of VPI surgery outcomes to date, with recruitment ongoing until 2025 and results expected by 2026. [Extracted from the article]

A recent study conducted at Fattouma Bourguiba Hospital in Tunisia focused on the management of chronic rhinosinusitis with nasal polyps (CRSwNP) through endoscopic sinus surgery (ESS). The study, which included 280 patients, found a recurrence rate of 20.7% and identified non-compliance with postoperative medication, specifically topical steroids, as a significant factor in recurrence. The research concluded that ESS is an effective treatment for CRSwNP, but highlighted the importance of postoperative medication compliance in reducing recurrence rates. [Extracted from the article]