4 results on '"Van Tong H"'
Search Results
2. LRRK2 and RIPK2 variants in the NOD 2-mediated signaling pathway are associated with susceptibility to Mycobacterium leprae in Indian populations.
- Author
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Marcinek P, Jha AN, Shinde V, Sundaramoorthy A, Rajkumar R, Suryadevara NC, Neela SK, van Tong H, Balachander V, Valluri VL, Thangaraj K, and Velavan TP
- Subjects
- Alleles, Female, Haplotypes genetics, Haplotypes immunology, Humans, India epidemiology, Leprosy epidemiology, Leprosy immunology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Male, Nod2 Signaling Adaptor Protein immunology, Polymorphism, Genetic genetics, Polymorphism, Genetic immunology, Protein Serine-Threonine Kinases immunology, Receptor-Interacting Protein Serine-Threonine Kinase 2 immunology, Signal Transduction immunology, Th1 Cells immunology, Genetic Predisposition to Disease, Leprosy genetics, Mycobacterium leprae, Nod2 Signaling Adaptor Protein genetics, Protein Serine-Threonine Kinases genetics, Receptor-Interacting Protein Serine-Threonine Kinase 2 genetics, Signal Transduction genetics
- Abstract
In recent years, genome wide association studies have discovered a large number of gene loci that play a functional role in innate and adaptive immune pathways associated with leprosy susceptibility. The immunological control of intracellular bacteria M. leprae is modulated by NOD2-mediated signaling of Th1 responses. In this study, we investigated 211 clinically classified leprosy patients and 230 ethnically matched controls in Indian population by genotyping four variants in NOD2 (rs9302752A/G), LRRK2 (rs1873613A/G), RIPK2 (rs40457A/G and rs42490G/A). The LRRK2 locus is associated with leprosy outcome. The LRRK2 rs1873613A minor allele and respective rs1873613AA genotypes were significantly associated with an increased risk whereas the LRRK2 rs1873613G major allele and rs1873613GG genotypes confer protection in paucibacillary and leprosy patients. The reconstructed GA haplotypes from RIPK2 rs40457A/G and rs42490G/A variants was observed to contribute towards increased risk whereas haplotypes AA was observed to confer protective role. Our results indicate that a possible shared mechanisms underlying the development of these two clinical forms of the disease as hypothesized. Our findings confirm and validates the role of gene variants involved in NOD2-mediated signalling pathways that play a role in immunological control of intracellular bacteria M. leprae.
- Published
- 2013
- Full Text
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3. Mannose-binding lectin and susceptibility to schistosomiasis.
- Author
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Antony JS, Ojurongbe O, van Tong H, Ouf EA, Engleitner T, Akindele AA, Sina-Agbaje OR, Adeyeba AO, Kremsner PG, and Velavan TP
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Child, Child, Preschool, Cohort Studies, Female, Humans, Male, Mannose-Binding Lectin deficiency, Middle Aged, Nigeria, Young Adult, Genetic Predisposition to Disease, Mannose-Binding Lectin blood, Mannose-Binding Lectin genetics, Schistosomiasis haematobia immunology
- Abstract
Background: Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis., Methods: We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium-infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis., Results: MBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The -550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes -550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03)., Conclusions: In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis.
- Published
- 2013
- Full Text
- View/download PDF
4. Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis.
- Author
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Ouf EA, Ojurongbe O, Akindele AA, Sina-Agbaje OR, Van Tong H, Adeyeba AO, Kremsner PG, Kun JF, and Velavan T
- Subjects
- Adolescent, Adult, Aged, Animals, Child, Child, Preschool, Cross-Sectional Studies, Female, Haplotypes, Humans, Male, Middle Aged, Nigeria, Promoter Regions, Genetic, Real-Time Polymerase Chain Reaction, Young Adult, Ficolins, Genetic Predisposition to Disease, Lectins blood, Lectins genetics, Polymorphism, Single Nucleotide, Schistosoma haematobium immunology, Schistosomiasis genetics
- Abstract
Background: Human ficolin-2 (L-ficolins) encoded by the FCN2 gene are pattern-recognition proteins involved in innate immunity and are associated with several infectious diseases., Methods: A Nigerian cohort of 168 Schistosoma haematobium-infected individuals and 192 healthy controls were examined for functional single-nucleotide polymorphisms in the promoter region (-986G>A, -602G>A, -4A>G) and in exon 8 (+6424G>T) using real-time polymerase chain reaction., Results: The FCN2 -986A and -4G alleles were significantly associated with the occurrence of schistosomiasis (P = .0004 for -986G>A; P = .0001 for -4A>G). The heterozygous genotypes (P = .0006 for -986G>A; P = .0002 for -4A>G) were observed to be a risk factor for susceptibility to schistosomiasis, whereas the homozygous genotypes of major alleles (P = .0002 for -986G>A; P = .0001 for -4A>G) were observed to shield against schistosomiasis. The haplotype AGGG (P = .0002) was observed to be a risk factor for susceptibility to schistosomiasis compared with controls, and the haplotype GGAG (P = .04) was observed to confer protection compared with patients. Ficolin-2 serum level was significantly higher in controls (P < .005) and in controls with GGAG haplotypes (P < .0001)., Conclusions: Our findings demonstrate that FCN2 promoter variants (-986G>A and -4A>G) influence ficolin-2 serum levels and susceptibility to schistosomiasis.
- Published
- 2012
- Full Text
- View/download PDF
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