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Mannose-binding lectin and susceptibility to schistosomiasis.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2013 Jun 01; Vol. 207 (11), pp. 1675-83. Date of Electronic Publication: 2013 Feb 28. - Publication Year :
- 2013
-
Abstract
- Background: Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis.<br />Methods: We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium-infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis.<br />Results: MBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The -550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes -550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03).<br />Conclusions: In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis.
- Subjects :
- Adolescent
Adult
Aged
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Female
Humans
Male
Mannose-Binding Lectin deficiency
Middle Aged
Nigeria
Young Adult
Genetic Predisposition to Disease
Mannose-Binding Lectin blood
Mannose-Binding Lectin genetics
Schistosomiasis haematobia immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 207
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23448728
- Full Text :
- https://doi.org/10.1093/infdis/jit081