Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis.

Authors :: Antunes Andrade F
Goeldner Eibofner I
Pieczarka C
van Tong H
Sena L
Skare T
Ramos da Rosa Utiyama S
Jose de Messias-Reason I
P Velavan T
Source :: International journal of immunogenetics [Int J Immunogenet] 2021 Jun; Vol. 48 (3), pp. 260-265. Date of Electronic Publication: 2021 Mar 01.
Publication Year :: 2021
Abstract: The complement receptor of the immunoglobulin superfamily (CRIg, encoded by the VSIG4 gene) is a macrophage receptor involved in the clearance of immune complexes and autologous cells. Our results suggest that the VSIG4 rs1044165T allele is a risk factor for severe functional status of rheumatoid arthritis in women, possibly by affecting VSIG4 gene expression.<br /> (© 2021 John Wiley & Sons Ltd.)

Subjects :: Adolescent
Adult
Aged
Alleles
Arthritis, Rheumatoid epidemiology
Arthritis, Rheumatoid pathology
Brazil epidemiology
Humans
Middle Aged
Polymorphism, Single Nucleotide genetics
Young Adult
Arthritis, Rheumatoid genetics
Genetic Association Studies
Genetic Predisposition to Disease
Receptors, Complement genetics

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