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40 results on '"Biomolecular engineering"'

1. Probing the acyl carrier protein–Enzyme interactions within terminal alkyne biosynthetic machinery

Author

Su, Michael, Zhu, Xuejun, and Zhang, Wenjun

Subjects
Chemical Engineering, Engineering, 2.1 Biological and endogenous factors, Aetiology, biochemical engineering, metabolic engineering, Biochemicals, Bioengineering, Biofuels, Biomolecular Engineering, Food, Resources Engineering and Extractive Metallurgy, Chemical engineering
Abstract

The alkyne functionality has attracted much interest due to its diverse chemical and biological applications. We recently elucidated an acyl carrier protein (ACP)-dependent alkyne biosynthetic pathway, however, little is known about ACP interactions with the alkyne biosynthetic enzymes, an acyl-ACP ligase (JamA) and a membrane-bound bi-functional desaturase/acetylenase (JamB). Here, we showed that JamB has a more stringent interaction with ACP than JamA. In addition, site directed mutagenesis of a non-cognate ACP significantly improved its compatibility with JamB, suggesting a possible electrostatic interaction at the ACP-JamB interface. Finally, error-prone PCR and screening of a second non-cognate ACP identified hot spots on the ACP that are important for interacting with JamB and yielded mutants which were better recognized by JamB. Our data thus not only provide insights into the ACP interactions in alkyne biosynthesis, but it also potentially aids in future combinatorial biosynthesis of alkyne-tagged metabolites for chemical and biological applications.

Published
2018

2. NYU Tandon researchers create microchips capable of detecting and diagnosing diseases.

Abstract

NYU Tandon researchers have developed microchips capable of detecting multiple diseases from a single cough or air sample, revolutionizing healthcare diagnostics. These microchips use field-effect transistors (FETs) to detect biological markers and offer faster results, simultaneous testing for multiple diseases, and immediate data transmission to healthcare providers. The researchers are exploring new ways to modify FET surfaces to enable parallel detection of multiple pathogens, with breakthrough technology like thermal scanning probe lithography (tSPL) showing promise in achieving this goal. The study, supported by industry partners, demonstrates the potential for creating portable diagnostic devices that could be used in various settings, from hospitals to homes. [Extracted from the article]

Published
2025

3. Patent Issued for Engineered gyri-like mutein aptamers, and related methods (USPTO 12104201).

Abstract

Crosslife Technologies Inc. has been issued a patent for engineered gyri-like mutein aptamers, which are non-native variant proteins designed from the Gyrl-like family of proteins. These aptamers, known as GYRAPTs or GYRYZYMEs, can bind to various target organic molecules and function as on/off bioswitches. The patent outlines methods for creating these aptamers through rational mutagenesis or mutant library screening, highlighting their potential applications in molecular imaging, diagnostics, and therapeutics. The Gyrl-like proteins used as scaffolds for these aptamers are small-molecule binding proteins found in prokaryotes and eukaryotes, offering a versatile platform for designing novel biotechnological tools. [Extracted from the article]

Published
2024

4. Researchers develop affordable, rapid blood test for brain cancer.

Abstract

Researchers at the University of Notre Dame have developed an automated device that can diagnose glioblastoma, a fast-growing and incurable brain cancer, in less than an hour. The device uses a biochip that utilizes electrokinetic technology to detect biomarkers, specifically active Epidermal Growth Factor Receptors (EGFRs), which are overexpressed in certain cancers like glioblastoma. The biochip is able to distinguish between active and non-active EGFRs and is sensitive and selective in detecting active EGFRs on extracellular vesicles from blood samples. The device has the potential to be adapted for detecting other types of biological nanoparticles and biomarkers for different diseases. [Extracted from the article]

Published
2024

5. Electrochemical biosensing interfaced with cell-free synthetic biology.

Author

Wang, Baoguo, Zhao, Jinming, Zhang, Jiayin, Wei, Tianxiang, Han, Kun, and Gao, Tao

Subjects
*BIOENGINEERING, *SYNTHETIC biology, *MICROBIAL fuel cells, *ELECTRONIC equipment, *ENGINEERING, *BIOSENSORS, *ELECTRODES
Abstract

Synthetic biology's multiscale approaches to biosensing facilitate biological detection across diverse environments, leading to the development of advanced bio/electronic devices that convert biological events into electrical signals. Electrochemical biosensors are particularly promising due to their cost-effectiveness, ease of fabrication, and potential for miniaturization. Cell-free synthetic biology (CFSB) utilizes cell-free biological components to engineer and mimic the behavior, functions, and characteristics of cell systems, providing versatile approaches to bioengineering beyond cellular contexts. Engineering electrode surface with the principles of CFSB systems may represent a cutting-edge research direction for electrochemical biosensing, potentially solving bioanalytical issues of selectivity, sensitivity, and biocompatibility. This review highlights the latest trends in creating biosensing electrodes with CFSB components, as categorized by transcriptional, translational, and novel CFSB types. It provides a comprehensive analysis of the benefits and challenges of engineering CFSB components on electrode surfaces, aiming to inspire the future integration of CFSB technologies into electrochemical biosensing research. • Description of the role of cell-free synthetic biology (CFBS) system for bioelectronic surface engineering. • Categorizing and discussing advantages and challenges the CFSB systems for the development of electrochemical biosensors. • Providing new insights on biomolecular engineering of electrode surface for enhanced bioanalytical performance. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Solving an age-old mystery about crystal formation.

Abstract

A recent publication in PNAS by Peter Vekilov, a researcher at the University of Houston, has shed light on the process of crystal formation and how molecules become a part of them. Vekilov's research utilized advanced experimental techniques to uncover that incorporation into crystal kinks occurs in two steps, with an intermediate state playing a crucial role in the stability and growth of crystals. This discovery challenges previous theories and could aid in understanding the influence of small parts in a liquid on the shapes of natural crystals. The findings have implications for various fields, including bioengineering, nanobiotechnology, and emerging technologies. [Extracted from the article]

Published
2024

7. The importance and future of biochemical engineering

Author

Timothy A. Whitehead, Amanda M. Lewis, Christina Chan, Chien-Ting Li, E. Terry Papoutsakis, Michael J. Betenbaugh, Scott Banta, William E. Bentley, Steffen Schaffer, Rashmi Kshirsagar, Michael C. Jewett, Mattheos A. G. Koffas, Douglas S. Clark, Ian Wheeldon, Laura Segatori, Costas D. Maranas, Beth Junker, Corinne A. Hoesli, and Kristala L. J. Prather

Subjects
0106 biological sciences, 0301 basic medicine, Engineering, Research areas, business.industry, Emerging technologies, Bioengineering, Biomolecular engineering, Biochemistry, 01 natural sciences, Applied Microbiology and Biotechnology, Article, 03 medical and health sciences, 030104 developmental biology, 010608 biotechnology, Humans, Engineering ethics, business, Biotechnology, Grand Challenges
Abstract

© 2020 Wiley Periodicals LLC Today's Biochemical Engineer may contribute to advances in a wide range of technical areas. The recent Biochemical and Molecular Engineering XXI conference focused on “The Next Generation of Biochemical and Molecular Engineering: The role of emerging technologies in tomorrow's products and processes”. On the basis of topical discussions at this conference, this perspective synthesizes one vision on where investment in research areas is needed for biotechnology to continue contributing to some of the world's grand challenges.

Published
2020
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8. Mitochondrial protein plays key role in glioblastoma and therapeutic resistance.

Subjects
MITOCHONDRIAL proteins, BRAIN tumors, GLIOBLASTOMA multiforme
Abstract

Out of 577 samples, they found that the CHCHD2 genes had higher expression in tumor cells, compared to non-tumor tissue, and was higher in advanced cases of glioblastoma. Keywords: Animal Science; Bioengineering; Biomolecular Engineering; Bionanotechnology; Biotechnology; Cancer; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign; Drugs and Therapies; Emerging Technologies; Engineering; Genetics; Glioblastomas; Health and Medicine; Mitochondrial Proteins; Nanobiotechnology; Nanotechnology; Oncology; Therapeutics; Therapy EN Animal Science Bioengineering Biomolecular Engineering Bionanotechnology Biotechnology Cancer Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign Drugs and Therapies Emerging Technologies Engineering Genetics Glioblastomas Health and Medicine Mitochondrial Proteins Nanobiotechnology Nanotechnology Oncology Therapeutics Therapy 607 607 1 10/30/23 20231030 NES 231030 2023 OCT 31 (NewsRx) -- By a News Reporter-Staff News Editor at Veterinary Week -- Glioblastoma is the most common type of brain tumor that affects adults and, unfortunately, still remains incurable. [Extracted from the article]

Published
2023

9. Drug-filled nanocapsule helps make immunotherapy more effective in mice.

Abstract

To achieve that goal, the team developed a treatment encapsulating an enzyme called lactate oxidase into a tiny nanocapsule that reduces lactate levels and releases hydrogen peroxide in the tumor. Keywords: Anions; Bioengineering; Biomolecular Engineering; Bionanotechnology; Biotechnology; Cancer; Chemicals; Drug Delivery Systems; Drugs and Therapies; Electrolytes; Elements; Emerging Technologies; Engineering; Enzymes and Coenzymes; Gases; Genetics; Health and Medicine; Hydrogen; Hydrogen Peroxide; Immunotherapy; Inorganic Chemicals; Ions; Nanobiotechnology; Nanocapsules; Nanotechnology; Oncology; Organic Chemicals; Oxidase; Oxides; Peroxides; Reactive Oxygen Species; Solid Cancer; University of California - Los Angeles Health Sciences EN Anions Bioengineering Biomolecular Engineering Bionanotechnology Biotechnology Cancer Chemicals Drug Delivery Systems Drugs and Therapies Electrolytes Elements Emerging Technologies Engineering Enzymes and Coenzymes Gases Genetics Health and Medicine Hydrogen Hydrogen Peroxide Immunotherapy Inorganic Chemicals Ions Nanobiotechnology Nanocapsules Nanotechnology Oncology Organic Chemicals Oxidase Oxides Peroxides Reactive Oxygen Species Solid Cancer University of California - Los Angeles Health Sciences 287 287 1 10/24/23 20231024 NES 231024 2023 OCT 24 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- UCLA researchers have developed a new treatment method using a tiny nanocapsule to help boost the immune response, making it easier for the immune system to fight and kill solid tumors. "Moreover, this dual-action approach improved the success of a specific type of cancer immunotherapy treatment called immune checkpoint blockade and we believe it could be an effective strategy to help make cancer immunotherapy more effective.". [Extracted from the article]

Published
2023

10. Lehigh University researchers make sand that flows uphill.

Abstract

Bioengineering, Biomolecular Engineering, Bionanotechnology, Biotechnology, Emerging Technologies, Engineering, Lehigh University, Nanobiotechnology, Nanotechnology Keywords: Bioengineering; Biomolecular Engineering; Bionanotechnology; Biotechnology; Emerging Technologies; Engineering; Lehigh University; Nanobiotechnology; Nanotechnology EN Bioengineering Biomolecular Engineering Bionanotechnology Biotechnology Emerging Technologies Engineering Lehigh University Nanobiotechnology Nanotechnology 2542 2542 1 10/03/23 20231006 NES 231006 2023 OCT 6 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Engineering researchers at Lehigh University have discovered that sand can actually flow uphill. [Extracted from the article]

Published
2023

11. With $5 million grant, the Welch Center for Advanced Bioactive Materials Crystallization is formed at University of Houston.

Abstract

Keywords: Bioengineering; Biomolecular Engineering; Bionanotechnology; Biotechnology; Chemical Engineering; Chemistry; Emerging Technologies; Engineering; Nanobiotechnology; Nanoparticles; Nanotechnology; University of Houston EN Bioengineering Biomolecular Engineering Bionanotechnology Biotechnology Chemical Engineering Chemistry Emerging Technologies Engineering Nanobiotechnology Nanoparticles Nanotechnology University of Houston 1703 1703 1 09/25/23 20230929 NES 230929 2023 SEP 29 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Jeffrey Rimer, Abraham E. Dukler Professor of Chemical Engineering, known globally for his seminal breakthroughs that control crystals to help treat malaria and kidney stones, has been awarded an inaugural $5 million Catalyst for Discovery Program Grant from The Welch Foundation, to establish the Welch Center for Advanced Bioactive Materials Crystallization. Bioengineering, Biomolecular Engineering, Bionanotechnology, Biotechnology, Chemical Engineering, Chemistry, Emerging Technologies, Engineering, Nanobiotechnology, Nanoparticles, Nanotechnology, University of Houston. [Extracted from the article]

Published
2023

12. Celebrating excellence: Inaugural cohort of UH-Chevron Energy Graduate Fellows.

Abstract

Keywords: Bioengineering; Biomolecular Engineering; Bionanotechnology; Biotechnology; Chemical Engineering; Chemicals; Clean Energy; Deep Learning; Elements; Emerging Technologies; Energy; Energy Generation; Energy Industry; Engineering; Environment; Environmental Engineering; Gases; Geophysics; Hospitals; Hydrogen; India; Inorganic Chemicals; Machine Learning; Mathematics; Nanobiotechnology; Nanotechnology; Oil & Gas; Petroleum Engineering; Physics; Politics; Renewable Energy; Science And Engineering; Sustainability Research; Sustainable Energy; University of Houston EN Bioengineering Biomolecular Engineering Bionanotechnology Biotechnology Chemical Engineering Chemicals Clean Energy Deep Learning Elements Emerging Technologies Energy Energy Generation Energy Industry Engineering Environment Environmental Engineering Gases Geophysics Hospitals Hydrogen India Inorganic Chemicals Machine Learning Mathematics Nanobiotechnology Nanotechnology Oil & Gas Petroleum Engineering Physics Politics Renewable Energy Science And Engineering Sustainability Research Sustainable Energy University of Houston 1030 1030 1 09/11/23 20230917 NES 230917 2023 SEP 17 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Letter on the CDC & FDA -- University of Houston, the Energy University, is proud to introduce the inaugural cohort of UH-Chevron Energy Graduate Fellows - eight graduate students who are actively involved in innovative energy-related research across the UH campus. The potential impact of this research extends to renewable energy generation, electric power transmission and advanced scientific applications, all of which contribute to a sustainable clean energy future. [Extracted from the article]

Published
2023

13. Human pangenome reference will enable more complete and equitable understanding of genomic diversity.

Abstract

Creating the pangenome The pangenome was made possible through the development of advanced computational techniques to align the multiple genome sequences into one, usable reference in a structure called a pangenome graph. Because of the methods used in this project, all of the genomes within the pangenome reference are of extremely high quality and accuracy, covering more than 99 percent of each human genome with more than 99 percent accuracy. [Extracted from the article]

Published
2023

14. Enhancing at-home COVID tests with glow-in-the dark materials.

Subjects
SARS-CoV-2, COVID-19 testing
Abstract

Bioengineering, Biomolecular Engineering, Bionanotechnology, Biotechnology, COVID-19, Coronavirus, Diagnostics and Screening, Emerging Technologies, Engineering, Nanotechnology, RNA Viruses, SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2, Technology, University of Houston, Nanobiotechnology, Viral, Virology Keywords: Bioengineering; Biomolecular Engineering; Bionanotechnology; Biotechnology; COVID-19; Coronavirus; Diagnostics and Screening; Emerging Technologies; Engineering; Nanobiotechnology; Nanotechnology; RNA Viruses; SARS-CoV-2; Severe Acute Respiratory Syndrome Coronavirus 2; Technology; University of Houston; Viral; Virology EN Bioengineering Biomolecular Engineering Bionanotechnology Biotechnology COVID-19 Coronavirus Diagnostics and Screening Emerging Technologies Engineering Nanobiotechnology Nanotechnology RNA Viruses SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2 Technology University of Houston Viral Virology 18 18 1 03/23/23 20230320 NES 230320 2023 MAR 24 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx COVID-19 Weekly -- Researchers at the University of Houston are using glow-in-the-dark materials to enhance and improve rapid COVID-19 home tests. If you've taken an at-home COVID-19 or pregnancy test, then you've taken what is scientifically called a lateral flow assay (LFA) test, a diagnostic tool widely used because of its rapid results, low cost and ease of operation. [Extracted from the article]

Published
2023

15. 10th Royan Institute's International Summer School on 'Molecular Biomedicine: From Diagnostics to Therapeutics'

Author

Arezoo Rasti, Saeed Mohebbi, Piter J. Bosma, Parisa Torabi, Jafar Kiani, Mehdi Shamsara, Maryam Ghotbaddini, Sadegh Babashah, Farnoush Faridbod, Samira Gholami, Hamid Sadeghi-Abandansari, Vahid Khoddami, Morteza Hosseini, Sara Amjadian, Faezeh Shekari, Mohammad Kazemi-Ashtiani, Sharif Moradi, Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, AGEM - Endocrinology, metabolism and nutrition, and AGEM - Inborn errors of metabolism

Subjects
Engineering, Schools, business.industry, molecular biomedicine, Early detection, Biomolecular engineering, biomolecular engineering, General Biochemistry, Genetics and Molecular Biology, molecular diagnosis, Humans, Engineering ethics, prognosis, business, early detection, Biomedicine
Published
2020

21. Star-shaped block polymers as a molecular biomaterial for nanomedicine development

Author

Yuyang Jiang, Lin Mei, and Si-Shen Feng

Subjects
Engineering, Polymers, business.industry, Biomedical Engineering, Medicine (miscellaneous), Biomaterial, Bioengineering, Nanotechnology, Biomolecular engineering, Biodegradable Plastics, Development, Cancer nanotechnology, Anticancer drug, Polyethylene Glycols, Nanomedicine, Block (telecommunications), Humans, Nanoparticles, General Materials Science, business
Abstract

Si-Shen Feng Author for correspondence: Department of Chemical & Biomolecular Engineering, Department of Bioengineering, & Nanoscience & Nanotechnology Initiative (NUSNNI/NanoCore), National University of Singapore, Block E3, 05–29, 2 Engineering Drive 3, 117576, Singapore Tel.: +65 6576 3835 Fax: +65 6779 1936 chefess@nus.edu.sg Star-shaped block polymers as a molecular biomaterial for nanomedicine development

Published
2014
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24. Designing biological systems: Systems Engineering meets Synthetic Biology

Author

Kai Sundmacher, Michael Mangold, and Sascha Rollié

Subjects
Engineering, business.industry, Applied Mathematics, General Chemical Engineering, Scale (chemistry), Systems biology, Biomolecular engineering, General Chemistry, Industrial and Manufacturing Engineering, Synthetic biology, Systems engineering, System integration, Identification (biology), Biosystems engineering, Complex systems biology, business
Abstract

Synthetic Biology offers qualitatively new perspectives on the benefits of industrially harnessed biological processes. The ability to modify and reprogramme natural biology increases the scope of tailored bioprocesses and yields attractive prospects beyond conventional Biotechnology. The present review summarises the major achievements and categorises them according to a hierarchy of system levels. Similar structures are known in the engineering sciences and might prove useful for the future development of Synthetic Biology. The hierarchy encompasses several levels of detail. Biological (macro-)molecules present the most detailed level (parts), followed by compartmentalised or non-compartmentalised modules (devices). In the next level, parts and devices are combined into functional cells and further into cellular communities. The manifold interactions between biological entities of the same hierarchical level or between different levels are accounted for by networks, primarily metabolic pathways and regulatory circuits. Networks of different types are represented as a superordinate hierarchical level that achieves full system integration. On all these levels, extensive and sound scientific foundations exist regarding experimental but also theoretical methods. These have led to diverse manifestations of Synthetic Biology on the parts and devices levels. Investigations involving synthetic components on the systems scale represent the most difficult and remain limited in number. A main challenge lies with the quantitative prediction of interactions between different entities across different scales. Systems-theoretical approaches provide important tools to analyse complex biological behaviour and can support the design of artificial biological systems. A promising strategy is seen in an efficient modularisation that reduces biological systems to a limited set of functional modules with well-characterised interfaces. For the design of synthetic biological systems the interactions across these interfaces should be standardised to reduce complexity. Yet, the identification of modules and standardised interaction routes remains a non-trivial problem. Furthermore, an appropriate platform that efficiently describes replication and evolutionary processes has to be developed in order to extend the achievements of Synthetic Biology into designed biological processes.

Published
2012
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25. Biomolecular engineering at interfaces

Author

Annette F. Dexter, Lizhong He, and Anton P. J. Middelberg

Subjects
Engineering, Interface (Java), business.industry, Applied Mathematics, General Chemical Engineering, Biomolecular engineering, Nanotechnology, General Chemistry, Laboratory scale, Industrial and Manufacturing Engineering, Field (computer science), Systems engineering, Interaction problem, business, Scale effect
Abstract

A broad review of technologically focused work concerning biomolecules at interfaces is presented. The emphasis is on developments in interfacial biomolecular engineering that may have a practical impact in bioanalysis, tissue engineering, emulsion processing or bioseparations. We also review methods for fabrication in an attempt to draw out those approaches that may be useful for product manufacture, and briefly review methods for analysing the resulting interfacial nanostructures. From this review we conclude that the generation of knowledge and-innovation at the nanoscale far exceeds our ability to translate this innovation into practical outcomes addressing a market need, and that significant technological challenges exist. A particular challenge in this translation is to understand how the structural properties of biomolecules control the assembled architecture, which in turn defines product performance, and how this relationship is affected by the chosen manufacturing route. This structure-architecture-process-performance (SAPP) interaction problem is the familiar laboratory scale-up challenge in disguise. A further challenge will be to interpret biomolecular self- and directed-assembly reactions using tools of chemical reaction engineering, enabling rigorous manufacturing optimization of self-assembly laboratory techniques. We conclude that many of the technological problems facing this field are addressable using tools of modem chemical and biomolecular engineering, in conjunction with knowledge and skills from the underpinning sciences. (c) 2005 Elsevier Ltd. All rights reserved.

Published
2006
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26. Technology trends 2004

Author

A. Applewhite and J. Kumagai

Subjects
ComputingMilieux_GENERAL, Engineering, Engineering management, Globalization, business.industry, Information technology, Biomolecular engineering, Electrical and Electronic Engineering, business, ComputingMilieux_MISCELLANEOUS, Technology forecasting
Abstract

Biomolecular engineering is hot, the tech sector is turning around, and the United States will continue to dominate high-tech R&D in the coming decade. So say the IEEE Fellows in the second annual 2004 IEEE Technology Leaders Survey.

Published
2004
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27. Chemical biotechnology: microbial solutions to global change

Author

Wilfred Chen and Huimin Zhao

Subjects
Engineering, business.industry, Biomedical Engineering, Rational design, Chemical biology, Bioengineering, Biomolecular engineering, Protein engineering, Directed evolution, Genome engineering, Biotechnology, Metabolic engineering, Synthetic biology, Biochemical engineering, business
Abstract

Huimin Zhao is a professor of Chemical and Biomolecular Engineering at the University of Illinois at Urbana-Champaign and the holder of Centennial Chair. His research interests encompass many different aspects of synthetic biology and chemical biology. They include directed evolution and rational design of proteins and pathways, novel approaches for protein, pathway, and genome engineering, the molecular genetics and enzymology of natural product biosynthesis, the fundamental aspects of biocatalysis, and the use of protein engineering and metabolic engineering methods in designing platform organisms including E. coli and S. cerevisiae for the synthesis of important chemicals, antibiotics, and biofuels from renewable feedstocks.

Published
2008
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28. Research Frontiers in Bioinspired Energy: Molecular-Level Learning from Natural Systems: A Workshop

Author

Dorothy Zolandz

Subjects
Outreach, Engineering, Molecular level, Multidisciplinary approach, business.industry, Information sharing, Energy (esotericism), Mechanical engineering, Natural (music), Biomolecular engineering, business, Data science, Discipline
Abstract

An interactive, multidisciplinary, public workshop, organized by a group of experts in biochemistry, biophysics, chemical and biomolecular engineering, chemistry, microbial metabolism, and protein structure and function, was held on January 6-7, 2011 in Washington, DC. Fundamental insights into the biological energy capture, storage, and transformation processes provided by speakers was featured in this workshop which included topics such as microbes living in extreme environments such as hydrothermal vents or caustic soda lakes (extremophiles) provided a fascinating basis for discussing the exploration and development of new energy systems. Breakout sessions and extended discussions among the multidisciplinary groups of participants in the workshop fostered information sharing and possible collaborations on future bioinspired research. Printed and web-based materials that summarize the committee's assessment of what transpired at the workshop were prepared to advance further understanding of fundamental chemical properties of biological systems within and between the disciplines. In addition, webbased materials (including two animated videos) were developed to make the workshop content more accessible to a broad audience of students and researchers working across disciplinary boundaries. Key workshop discussion topics included: Exploring and identifying novel organisms; Identifying patterns and conserved biological structures in nature; Exploring and identifying fundamental properties and mechanisms of knownmore » biological systems; Supporting current, and creating new, opportunities for interdisciplinary education, training, and outreach; and Applying knowledge from biology to create new devices and sustainable technology.« less

Published
2012
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31. BIOINFORMATICS EDUCATION AT KEIO UNIVERSITY

Author

Yasubumi Sakakibara

Subjects
Engineering, business.industry, Biomolecular engineering, General Medicine, Computational biology, Bioinformatics, business
Abstract

This article gives short view on bioinformatics education at Keio university.

Published
2007
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34. Subtractive Etching of Cu with Hydrogen-Based Plasmas

Author

Galit Levitin, Fangyu Wu, and Dennis W. Hess

Subjects
Engineering, Fabrication, Subtractive color, Hydrogen, chemistry, business.industry, Etching (microfabrication), Georgia tech, chemistry.chemical_element, Nanotechnology, Biomolecular engineering, Plasma, business
Abstract

Due to the inability to form volatile etch products at temperatures less than 180 oC, the damascene process has been the prevailing patterning technology for copper. A simple, hydrogen (H2) plasma-based, low temperature etch process was developed to allow an alternative method to damascene technology. Cu thin films were etched by a H2 plasma in an inductively coupled plasma (ICP) reactor at temperatures below room temperature (10 oC). This process achieved anisotropic Cu features and an etch rate of ~13 nm/min. Ion bombardment was a contributor to Cu removal, since the etch rates were essentially proportional to the platen power with a constant coil power. However, lower etch rates of Cu were observed in an Ar plasma than in the H2 plasma, despite the fact that Ar is a more efficient sputter gas. Based on Cu etch rates and patterning results, the etch process involve both chemical and physical characteristics.

Published
2010
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35. Biofabrication to build the biology–device interface

Author

Yi Liu, Gary W. Rubloff, Reza Ghodssi, James N. Culver, William E. Bentley, Gregory F. Payne, and Eunkyoung Kim

Subjects
Engineering, business.industry, Interface (computing), Biomedical Engineering, Biocompatible Materials, Bioengineering, Nanotechnology, Biomolecular engineering, General Medicine, Biochemistry, Toolbox, Biological materials, Electronics, Medical, Biomaterials, Interfacing, Systems engineering, Humans, Electronics, business, Molecular Biology, Electronic systems, Biotechnology, Biofabrication
Abstract

The last century witnessed spectacular advances in both microelectronics and biotechnology yet there was little synergy between the two. A challenge to their integration is that biological and electronic systems are constructed using divergent fabrication paradigms. Biology fabricates bottom-up with labile components, while microelectronic devices are fabricated top-down using methods that are 'bio-incompatible'. Biofabrication--the use of biological materials and mechanisms for construction--offers the opportunity to span these fabrication paradigms by providing convergent approaches for building the bio-device interface. Integral to biofabrication are stimuli-responsive materials (e.g. film-forming polysaccharides) that allow directed assembly under near physiological conditions in response to device-imposed signals. Biomolecular engineering, through recombinant technology, allows biological components to be endowed with information for assembly (e.g. encoded in a protein's amino acid sequence). Finally, self-assembly and enzymatic assembly provide the mechanisms for construction over a hierarchy of length scales. Here, we review recent advances in the use of biofabrication to build the bio-device interface. We anticipate that the biofabrication toolbox will expand over the next decade as more researchers enlist the unique construction capabilities of biology. Further, we look forward to observing the application of this toolbox to create devices that can better diagnose disease, detect pathogens and discover drugs. Finally, we expect that biofabrication will enable the effective interfacing of biology with electronics to create implantable devices for personalized and regenerative medicine.

Published
2010
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37. European initiatives in the improvement of agricultural plants and microorganisms by genetic engineering

Author

Diter von Wettstein

Subjects
Engineering, business.industry, Agriculture, Order (business), Bioengineering, Biomolecular engineering, business, Environmental planning, Biotechnology
Abstract

On 9 and 10 October 1984 the European Communities' program in biomolecular engineering of crop plants and associated microorganisms met at the Carlsberg Laboratory in order to assess research progress, discuss future plans and coordinate efforts. Major trends and highlights apparent from the presentations are discussed here 1,2 .

Published
1984
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38. Review of Achievements of Sector 1 Second Generation Bio-reactors

Author

H. J. Grande

Subjects
Engineering, Corn stover, Membrane reactor, business.industry, Bioreactor, Biomolecular engineering, Sucrose phosphorylase, Pulp and paper industry, business
Abstract

The final contractors meeting of the Biomolecular Engineering programme in the sector “Second Generation Bioreactors” has taken place on 7–9 April in Compiegne. At this meeting the results were discussed and evaluated. The conclusions reached and the final reports are the basis for this review.

Published
1986
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