Drug-filled nanocapsule helps make immunotherapy more effective in mice.

To achieve that goal, the team developed a treatment encapsulating an enzyme called lactate oxidase into a tiny nanocapsule that reduces lactate levels and releases hydrogen peroxide in the tumor. Keywords: Anions; Bioengineering; Biomolecular Engineering; Bionanotechnology; Biotechnology; Cancer; Chemicals; Drug Delivery Systems; Drugs and Therapies; Electrolytes; Elements; Emerging Technologies; Engineering; Enzymes and Coenzymes; Gases; Genetics; Health and Medicine; Hydrogen; Hydrogen Peroxide; Immunotherapy; Inorganic Chemicals; Ions; Nanobiotechnology; Nanocapsules; Nanotechnology; Oncology; Organic Chemicals; Oxidase; Oxides; Peroxides; Reactive Oxygen Species; Solid Cancer; University of California - Los Angeles Health Sciences EN Anions Bioengineering Biomolecular Engineering Bionanotechnology Biotechnology Cancer Chemicals Drug Delivery Systems Drugs and Therapies Electrolytes Elements Emerging Technologies Engineering Enzymes and Coenzymes Gases Genetics Health and Medicine Hydrogen Hydrogen Peroxide Immunotherapy Inorganic Chemicals Ions Nanobiotechnology Nanocapsules Nanotechnology Oncology Organic Chemicals Oxidase Oxides Peroxides Reactive Oxygen Species Solid Cancer University of California - Los Angeles Health Sciences 287 287 1 10/24/23 20231024 NES 231024 2023 OCT 24 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- UCLA researchers have developed a new treatment method using a tiny nanocapsule to help boost the immune response, making it easier for the immune system to fight and kill solid tumors. "Moreover, this dual-action approach improved the success of a specific type of cancer immunotherapy treatment called immune checkpoint blockade and we believe it could be an effective strategy to help make cancer immunotherapy more effective.". [Extracted from the article]