1. 1H-magnetic resonance spectroscopy lipoprotein profile in patients with chronic heart failure versus matched controls
- Author
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Josep Lupón, Núria Alonso, Didac Mauricio, Albert Teis, Antoni Bayes-Genis, Marcelino Bermúdez-López, Nuria Amigo, Esmeralda Castelblanco, Germán Cediel, Pau Codina, Josep Julve, Montse Guardiola, Josep Franch, and J. Ribalta
- Subjects
medicine.medical_specialty ,education.field_of_study ,medicine.drug_class ,Cholesterol ,business.industry ,Population ,General Medicine ,Nuclear magnetic resonance spectroscopy ,medicine.disease ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,Heart failure ,Ambulatory ,medicine ,Natriuretic peptide ,lipids (amino acids, peptides, and proteins) ,education ,business ,Body mass index ,Lipoprotein - Abstract
INTRODUCTION AND OBJECTIVES Advanced lipoprotein phenotyping is a better predictor of atherosclerotic cardiovascular risk than cholesterol concentration alone. Lipoprotein profiling in heart failure (HF) is incompletely characterized. We aimed to describe the lipoprotein profile in patients with chronic HF compared with a matched control population. METHODS This cross-sectional study was performed from May 2006 to April 2014 and included ambulatory patients with chronic HF. Lipid concentrations and the size of main lipoprotein fractions (high-density lipoprotein [HDL], low-density lipoprotein [LDL], and very low-density lipoprotein) and the particle concentration of their 3 subfractions (large, medium and small) were assessed using 1H magnetic resonance spectroscopy. RESULTS The 429 included patients with chronic HF were compared with 428 matched controls. Patients with chronic HF had lower total cholesterol and lower mean LDL (1115 vs 1352 nmol/L; P
- Published
- 2022