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New Therapies for Lowering Triglyceride-Rich Lipoproteins

Authors :
Wen-Liang Song
Robert S. Rosenson
Aleesha Shaik
Source :
Journal of the American College of Cardiology. 78:1817-1830
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Emerging evidence suggests that elevated concentrations of triglyceride-rich lipoprotein remnants (TRLs) derived from hepatic and intestinal sources contribute to the risk of atherosclerotic cardiovascular events. Natural selection studies support a causal role for elevated concentrations of remnant cholesterol and the pathways contributing to perturbations in metabolic pathways regulating TRLs with an increased risk of atherosclerotic cardiovascular disease events. New therapies targeting select catalytic pathways in TRL metabolism reduce atherosclerosis in experimental models, and concentrations of TRLs in patients with a vast range of triglyceride levels. Clinical trials with inhibitors of angiopoietin-like 3 protein and apolipoprotein C-III will be required to provide further guidance on the potential contribution of these emerging therapies in the paradigm of cardiovascular risk management in patients with elevated remnant cholesterol.

Details

ISSN :
07351097
Volume :
78
Database :
OpenAIRE
Journal :
Journal of the American College of Cardiology
Accession number :
edsair.doi...........ae0ecae9606f6696b21d2ef63eb8a5a0