1. Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer
- Author
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Sonia A. Allen, James M. Angelastro, Alexey Tomilov, Thomas K. Sears, Sandipan Datta, Gino A Cortopassi, Kevin D. Woolard, and Jose Sandoval
- Subjects
0301 basic medicine ,Cell Survival ,Antineoplastic Agents ,Cetylpyridinium ,Pharmacology ,Cetylpyridinium chloride ,Cell Line ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,AMP-activated protein kinase ,medicine ,Animals ,Humans ,Inducer ,Protein kinase A ,Molecular Biology ,biology ,Adenylate Kinase ,Cancer ,AMPK ,Glioma ,Cell Biology ,medicine.disease ,Metformin ,030104 developmental biology ,chemistry ,Mitochondrial biogenesis ,Anti-Infective Agents, Local ,Hepatocytes ,Neoplastic Stem Cells ,biology.protein ,Molecular Medicine ,030217 neurology & neurosurgery ,medicine.drug - Abstract
AMP-activated protein kinase (AMPK) is a eukaryotic energy sensor and protector from mitochondrial/energetic stress that is also a therapeutic target for cancer and metabolic disease. Metformin is an AMPK inducer that has been used in cancer therapeutic trials. Through screening we isolated cetylpyridinium chloride (CPC), a drug known to dose-dependently inhibit mitochondrial complex 1, as a potent and dose-dependent AMPK stimulator. Mitochondrial biogenesis and bioenergetics changes have also been implicated in glioblastoma, which is the most aggressive form of brain tumors. Cetylpyridinium chloride has been administered in humans as a safe drug-disinfectant for several decades, and we report here that under in vitro conditions, cetylpyridinium chloride kills glioblastoma cells in a dose dependent manner at a higher efficacy compared to current standard of care drug, temozolomide.
- Published
- 2020