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Time-dependent inactivation of steroid C17(20) lyase by 17β-cyclopropyl ether-substituted steroids
- Source :
- Bioorganic & Medicinal Chemistry Letters. 6:97-100
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Androstenes bearing a cyclopropyl group attached to the C-17β position with a heteroatom linker, designed as mechanism-based inhibitors of steroid C 17(20) lyase, were found to be potent, time-dependent inhibitors of this enzyme.
- Subjects :
- chemistry.chemical_classification
C17 20 lyase
Stereochemistry
medicine.medical_treatment
Organic Chemistry
Clinical Biochemistry
Heteroatom
Pharmaceutical Science
Ether
Lyase
Biochemistry
Steroid
chemistry.chemical_compound
Enzyme
chemistry
Drug Discovery
medicine
Molecular Medicine
Androstenes
Molecular Biology
Linker
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........7ea2b3228e504186ef90e7958913109b