ChemInform Abstract: Time-Dependent Inactivation of Steroid C17(20) Lyase by 17β- Cyclopropyl Ether-Substituted Steroids

Authors :: Marie E. Laughlin
Philip M. Weintraub
Angela L. Marquart
Thomas R. Blohm
Cynthia A. Gates
Norton P. Peet
Michael R. Angelastro
Source :: ChemInform. 27
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: Androstenes bearing a cyclopropyl group attached to the C-17β position with a heteroatom linker, designed as mechanism-based inhibitors of steroid C 17(20) lyase, were found to be potent, time-dependent inhibitors of this enzyme.

Subjects :: chemistry.chemical_classification
Chemistry
Stereochemistry
C17 20 lyase
medicine.medical_treatment
Heteroatom
Ether
General Medicine
Lyase
Steroid
chemistry.chemical_compound
Enzyme
medicine
Androstenes
Linker

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