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Your search keyword '"bis-iridoid glycoside"' showing total 3 results
Start Over Descriptor "bis-iridoid glycoside" Topic chemistry
3 results on '"bis-iridoid glycoside"'

1. Nine Unique Iridoids and Iridoid Glycosides From Patrinia scabiosaefolia

Author

Zhenhua Liu, Yun Niu, Li Zhou, Lijun Meng, Sitan Chen, Mengke Wang, Jiangmiao Hu, and Wenyi Kang

Subjects
Patrinia scabiosaefolia, iridoid, iridoid glycoside, bis-iridoid glycoside, cytotoxic activity, Chemistry, QD1-999
Abstract

Patrinia scabiosaefolia is a medical and edible Chinese herb with high nutritional and medicinal value. The continuing study of its chemical constituents led to the discovery of nine unique iridoids and iridoid glycosides, including three new iridoids (1-3) and six previously unknown irioid glycosides (5-10), and one known compound (4). Among them, compound 1 was a deformed iridoid, while compounds 3, 5-7, and 10 formed a new ring in their skeletons which was uncommon in this genus. For compound 3, the new ring existed between C-3 and C-10, while a 1,3-dioxane appeared between C-7 and C-10 in compounds 5-7 and 10. Moreover, compound 10 was a bis-iridoid glycoside, which was the first reported in P. scabiosaefolia. And the sugar of irioid glycosides (5-10) was glucose at C-11, except in 9 which had a 5-deoxyglucose moiety. All their structures were confirmed based on the extensive spectroscopic analysis, including IR, UV, HR-ESI-MS, ECD, and 1D- and 2D-NMR experiments. Their cytotoxic activities against HL-60, A-549, SMMC-7721, MCF-7, SW480 were also tested.

Published
2021
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2. New iridoids from the roots of Valeriana dioscoridis Sm

Author

Judit Hohmann, Hasan Kırmızıbekmez, Péter Bérdi, Norbert Kúsz, István Zupkó, Kırmızıbekmez, H., Kúsz, N., Bérdi, P., Zupkó, I., Hohmann, J., and Yeditepe Üniversitesi

Subjects
Turkey, Flavonoid, Phytochemicals, Antiproliferative activity, 01 natural sciences, Caprifoliaceae, Valeriana dioscoridis, Plant Roots, HeLa, Valerian, Drug Discovery, Humans, MTT assay, Iridoids, Pharmacology, chemistry.chemical_classification, Bis-iridoid glycoside, Plants, Medicinal, Traditional medicine, biology, Molecular Structure, 010405 organic chemistry, Phytosterol, Glycoside, General Medicine, Nuclear magnetic resonance spectroscopy, biology.organism_classification, Antineoplastic Agents, Phytogenic, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Valeriana, HeLa Cells
Abstract

Four new iridoids (1–4), together with three known iridoids (5–7), one known flavonoid glycoside, three phenolic acids and one phytosterol were isolated from the roots of Valeriana dioscoridis. Their structures were elucidated by means of NMR spectroscopy and mass spectrometry. This is the first report on the phytochemical composition of the non-volatile constituents of V. dioscoridis and the occurrence of a bis-iridoid glycoside in the genus Valeriana. The antiproliferative effects of the iridoids (1–7) were evaluated against three human cancer cell lines of gynacological origin (HeLa, A2780 and T47D) at 10, 30 and 60 µM concentrations, using the MTT assay and they elicited modest antiproliferative activity when compared to the reference agent, cisplatin. © 2018 Elsevier B.V. GINOP-2.3.2-15-2016-0001 2 Financial support from the Economic Development and Innovation Operative Programme GINOP-2.3.2-15-2016-0001 2 are gratefully acknowledged.

Published
2018

3. New Lignans and Iridoid Glycosides from Dipsacus asper Wall

Author

Guo-Xu Ma, Guang-Zhong Tu, Huagang Hu, Wenhua Huang, Xinguang Sun, Bao-Lin Guo, Gang Ding, and Dawei Zhang

Subjects
Iridoid Glycosides, Stereochemistry, Dipsacus asper, Human immunodeficiency virus (HIV), Pharmaceutical Science, HIV Integrase, medicine.disease_cause, Plant Roots, Article, Analytical Chemistry, lcsh:QD241-441, Dipsacus asper Wall, lcsh:Organic chemistry, Cell Wall, Drug Discovery, medicine, Organic chemistry, HIV Integrase Inhibitors, Physical and Theoretical Chemistry, chemistry.chemical_classification, bis-iridoid glycoside, biology, Organic Chemistry, lignans, Glycoside, Dipsacaceae, Integrase, chemistry, Chemistry (miscellaneous), HIV-1, biology.protein, Molecular Medicine, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

Six new compounds, including four new lignans, dipsalignan A (1), B–D (3–5), and two new bis-iridoid glycoside dimmers, dipsanosides M (7) and N (8), together with two known compounds (2) and (6), have been isolated from the roots of Dipsacus asper Wall. Their structures were established on the basis of spectroscopic data (MS, 1D, 2D NMR, and CD) and chemical methods. All the isolated compounds were tested against human immunodeficiency virus-1 (HIV-1) integrase inhibition activities, and only compounds 1, 2, 7, and 8 displayed weak activities.

Published
2015

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