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New iridoids from the roots of Valeriana dioscoridis Sm
- Source :
- Fitoterapia. 130
- Publication Year :
- 2018
-
Abstract
- Four new iridoids (1–4), together with three known iridoids (5–7), one known flavonoid glycoside, three phenolic acids and one phytosterol were isolated from the roots of Valeriana dioscoridis. Their structures were elucidated by means of NMR spectroscopy and mass spectrometry. This is the first report on the phytochemical composition of the non-volatile constituents of V. dioscoridis and the occurrence of a bis-iridoid glycoside in the genus Valeriana. The antiproliferative effects of the iridoids (1–7) were evaluated against three human cancer cell lines of gynacological origin (HeLa, A2780 and T47D) at 10, 30 and 60 µM concentrations, using the MTT assay and they elicited modest antiproliferative activity when compared to the reference agent, cisplatin. © 2018 Elsevier B.V. GINOP-2.3.2-15-2016-0001 2 Financial support from the Economic Development and Innovation Operative Programme GINOP-2.3.2-15-2016-0001 2 are gratefully acknowledged.
- Subjects :
- Turkey
Flavonoid
Phytochemicals
Antiproliferative activity
01 natural sciences
Caprifoliaceae
Valeriana dioscoridis
Plant Roots
HeLa
Valerian
Drug Discovery
Humans
MTT assay
Iridoids
Pharmacology
chemistry.chemical_classification
Bis-iridoid glycoside
Plants, Medicinal
Traditional medicine
biology
Molecular Structure
010405 organic chemistry
Phytosterol
Glycoside
General Medicine
Nuclear magnetic resonance spectroscopy
biology.organism_classification
Antineoplastic Agents, Phytogenic
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry
Valeriana
HeLa Cells
Subjects
Details
- ISSN :
- 18736971
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....74ecee4e9799df88f4e95b1b37c6bfe3