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New Lignans and Iridoid Glycosides from Dipsacus asper Wall
- Source :
- Molecules, Vol 20, Iss 2, Pp 2165-2175 (2015), Molecules, Volume 20, Issue 2, Pages 2165-2175
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- Six new compounds, including four new lignans, dipsalignan A (1), B–D (3–5), and two new bis-iridoid glycoside dimmers, dipsanosides M (7) and N (8), together with two known compounds (2) and (6), have been isolated from the roots of Dipsacus asper Wall. Their structures were established on the basis of spectroscopic data (MS, 1D, 2D NMR, and CD) and chemical methods. All the isolated compounds were tested against human immunodeficiency virus-1 (HIV-1) integrase inhibition activities, and only compounds 1, 2, 7, and 8 displayed weak activities.
- Subjects :
- Iridoid Glycosides
Stereochemistry
Dipsacus asper
Human immunodeficiency virus (HIV)
Pharmaceutical Science
HIV Integrase
medicine.disease_cause
Plant Roots
Article
Analytical Chemistry
lcsh:QD241-441
Dipsacus asper Wall
lcsh:Organic chemistry
Cell Wall
Drug Discovery
medicine
Organic chemistry
HIV Integrase Inhibitors
Physical and Theoretical Chemistry
chemistry.chemical_classification
bis-iridoid glycoside
biology
Organic Chemistry
lignans
Glycoside
Dipsacaceae
Integrase
chemistry
Chemistry (miscellaneous)
HIV-1
biology.protein
Molecular Medicine
Two-dimensional nuclear magnetic resonance spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 20
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....b44184929e1b7defc8a3511cdae0fd4b