1. Receptor guanylyl cyclase (RGC) family in GtoPdb v.2021.3
- Author
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Lincoln R. Potter, Johannes-Peter Stasch, Michael Russwurm, Peter Brouckaert, John C. Burnett, John Garthwaite, Andreas Friebe, Scott A. Waldman, Annie Beuve, Adrian J. Hobbs, Michaela Kuhn, Doris Koesling, and Harald H.H.W. Schmidt
- Subjects
chemistry.chemical_classification ,Enzyme ,Chemistry ,Cell surface receptor ,Grueneberg ganglion ,Endogeny ,Mammalian genome ,Receptor ,Intestinal epithelium ,Guanylate cyclase ,Cell biology - Abstract
The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP). GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grueneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors.
- Published
- 2021