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Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis
- Source :
- Expert review of clinical pharmacology. 6(5)
- Publication Year :
- 2013
-
Abstract
- Colorectal cancer is a major public health concern, ranking among the leading causes of cancer death in both men and women. Because of this continued burden there is a clear need for improved treatment, and more importantly prevention, of this disease. In recent years there is significant evidence to support the hypothesis that guanylyl cyclase C (GUCY2C) is a tumor suppressor in the intestine, and that the loss of hormone ligands for this receptor is an important step in the disease process. Thus, ligand replacement therapy has been proposed as a strategy to prevent colorectal cancer. Until recently this strategy was not clinically plausible; however, the recent regulatory approval of Linaclotide (LINZESS™, Forest Laboratories and Ironwood Pharmaceuticals, Inc.), an oral GUCY2C ligand, has raised the possibility of utilizing this strategy clinically to prevent colorectal cancer.
- Subjects :
- Oncology
medicine.medical_specialty
Receptors, Peptide
Colorectal cancer
Guanylin
Receptors, Enterotoxin
Disease
Pharmacology
Ligands
Article
Causes of cancer
chemistry.chemical_compound
Internal medicine
Drug Discovery
medicine
Animals
Anticarcinogenic Agents
Humans
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Receptor
Linaclotide
business.industry
General Medicine
Guanylate cyclase 2C
medicine.disease
chemistry
Receptors, Guanylate Cyclase-Coupled
Biomarker (medicine)
business
Colorectal Neoplasms
Peptides
Subjects
Details
- ISSN :
- 17512441
- Volume :
- 6
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Expert review of clinical pharmacology
- Accession number :
- edsair.doi.dedup.....aefa7ca3a5b4c73d961d1cbc0fe6504c