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Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics
- Source :
- Toxins, Toxins, Vol 2, Iss 8, Pp 2028-2054 (2010)
- Publication Year :
- 2010
- Publisher :
- MDPI AG, 2010.
-
Abstract
- Heat-stable toxins (STs) produced by enterotoxigenic bacteria cause endemic and traveler’s diarrhea by binding to and activating the intestinal receptor guanylyl cyclase C (GC-C). Advances in understanding the biology of GC-C have extended ST from a diarrheagenic peptide to a novel therapeutic agent. Here, we summarize the physiological and pathophysiological role of GC-C in fluid-electrolyte regulation and intestinal crypt-villus homeostasis, as well as describe translational opportunities offered by STs, reflecting the unique characteristics of GC-C, in treating irritable bowel syndrome and chronic constipation, and in preventing and treating colorectal cancer.
- Subjects :
- Receptors, Peptide
Health, Toxicology and Mutagenesis
Guanylin
Bacterial Toxins
Molecular Sequence Data
lcsh:Medicine
Receptors, Enterotoxin
colorectal cancer
Review
Enterotoxin
Biology
guanylin
Toxicology
Irritable Bowel Syndrome
Enterotoxins
chemistry.chemical_compound
medicine
Animals
Humans
Amino Acid Sequence
guanylyl cyclase C
Irritable bowel syndrome
heat-stable enterotoxins (STa)
Neoplasm Staging
hormone insufficiency
Escherichia coli Proteins
lcsh:R
uroguanylin
targeted delivery
Guanylate cyclase 2C
medicine.disease
hormone replacement therapy
Biomarker
Diarrhea
Receptors, Guanylate Cyclase-Coupled
chemistry
Immunology
tumor vaccine
biomarker
medicine.symptom
Signal transduction
Colorectal Neoplasms
Peptides
Constipation
Signal Transduction
Uroguanylin
Subjects
Details
- ISSN :
- 20726651
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Toxins
- Accession number :
- edsair.doi.dedup.....a59d7bd09e7bddfa0744e23fe83f88f0