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The article discusses the use of an explainable machine-learning model to classify culprit calcified carotid plaque in embolic stroke of undetermined source (ESUS). The study focuses on the importance of plaque vulnerability factors such as intraplaque hemorrhage, lipid-rich-necrotic-core, perivascular adipose tissue, and calcification morphology. By incorporating noncalcified plaque components and calcification features with the SHapley Additive exPlanations (SHAP) framework, the model can accurately classify calcified carotid plaques as culprit or non-culprit, providing explanations for its decisions and identifying potential thresholds for high-risk features. The research aims to improve clinical interpretability and accuracy in plaque classification using machine-learning approaches. [Extracted from the article]

RapidAI has been recognized by Frost & Sullivan with the 2024 Company of the Year Award for its AI-based stroke imaging solutions. The company offers a comprehensive suite of AI solutions that improve operational efficiencies and patient outcomes in stroke care. RapidAI's advanced imaging and workflow solutions enable faster and more accurate triage, transfer, and treatment decisions, ultimately leading to better patient outcomes. Through its commitment to innovation and clinical rigor, RapidAI has solidified its leadership in the global healthcare industry, serving thousands of hospitals in over 100 countries. [Extracted from the article]

A study conducted at Zhuhai People's Hospital in China explored the association between enlarged perivascular spaces (EPVSs) and early acute ischemic stroke with cognitive impairment (EAIS-CI). The research found that EPVSs, particularly in the basal ganglia, were linked to cognitive impairment severity in stroke patients. Factors such as low education level, EPVS severity, white matter hyperintensities, and brain atrophy were identified as significant markers for EAIS-CI diagnosis and assessment. The study provides valuable insights for clinicians in predicting cognitive impairment after acute ischemic stroke. [Extracted from the article]

Recent research from Nanjing University of Chinese Medicine explores the mechanisms by which acupuncture improves motor function after a stroke through neuroplasticity, as revealed by magnetic resonance imaging techniques. The study highlights the importance of MRI technology in identifying abnormal brain activities accurately and discusses additional techniques like diffusion kurtosis imaging and neurite orientation dispersion and density imaging for observing post-stroke motor neural injuries. The findings aim to enhance doctors' understanding of neural pathways and motor deficits in ischemic stroke, potentially leading to the development of targeted therapies. The research has been peer-reviewed and provides valuable insights into the potential benefits of acupuncture in stroke rehabilitation. [Extracted from the article]

The Institute of Higher Nervous Activity and Neurophysiology has released a dataset of over 50 hours of near infrared spectroscopy (NIRS) recordings from stroke patients controlling a brain-computer interface. Fifteen stroke patients participated in 237 motor imagery brain-computer interface sessions, providing valuable data for evaluating signal processing techniques in patients with cerebrovascular accidents. The research aims to assess the effectiveness of various NIRS signal processing and analysis techniques in stroke patients, offering insights into hemodynamic responses and BCI performance. For more information, the full article is available in Scientific Data, published by Nature Portfolio. [Extracted from the article]

A study conducted by researchers at Zhengzhou University in China proposed a new imaging-etiologic classification system for acute ischemic stroke with large vascular occlusion based on MRI and pathogenesis. The classification system achieved a high positive rate and demonstrated excellent validity and reliability in identifying vascular occlusion and revealing the underlying causes of stroke. This approach could potentially improve the management of acute ischemic stroke with large vascular occlusion by facilitating more targeted endovascular treatment interventions. [Extracted from the article]

A recent study from Chung Shan Medical University explores the relationship between obstructive sleep apnea (OSA), hypertension, and a specific genetic variant (rs6843082) as risk factors for stroke. The research found that individuals with OSA and hypertension, along with the rs6843082 genotype (GA + AA), had a significantly higher risk for stroke compared to those without hypertension. The study suggests that OSA may be a risk factor for stroke in individuals with certain genetic predispositions and comorbidities. For more information, the full article can be accessed for free at the provided link. [Extracted from the article]

A recent study conducted at Brigham and Women's Hospital focused on atrial fibrillation (AF) and extracranial systemic embolic events (SEE). The study analyzed data from 71,683 patients randomized to NOAC vs. warfarin to assess the risks of SEE. The findings indicated that standard dose NOAC was more effective than warfarin in preventing SEE in AF patients, with a 29% reduction in risk. SEE, although less frequent than ischemic stroke in AF patients, were associated with significant morbidity and mortality, often requiring surgical or percutaneous intervention. [Extracted from the article]

Researchers from Chiba University Graduate School of Medicine conducted a study on atrial fibrillation (AF) and percutaneous left atrial appendage closure (LAAC) outcomes, focusing on sex differences in Japanese patients. The study found that female patients were older, thinner, and less likely to have diabetes compared to male patients. Additionally, pulmonary embolism was more common in females after LAAC, highlighting the importance of considering sex differences in antithrombotic management post-procedure. The research concluded that LAAC was feasible and safe for both genders, but emphasized the need for careful attention when discontinuing anticoagulants in female patients. [Extracted from the article]

Researchers at South China University of Technology conducted a retrospective observational study comparing single arterial cannulation via the axillary artery with double arterial cannulation via the axillary and femoral artery for patients undergoing cardiopulmonary bypass for acute type A aortic surgery. The study found that single axillary cannulation was associated with shorter durations of cardiopulmonary bypass and intensive care unit and hospital stays, with no significant difference in mortality compared to double arterial cannulation. The research was peer-reviewed and published in Perfusion, providing valuable insights for surgical treatment of acute type A aortic dissection. [Extracted from the article]

A recent study conducted at the University of Pecs examined the outcomes of acute ischemic stroke patients with large vessel occlusion who underwent mechanical thrombectomy with or without prior intravenous thrombolysis. The study found that patients who received bridging therapy (IVT followed by MT) had a higher rate of functional independence and lower mortality compared to those who underwent direct mechanical thrombectomy. These findings support current guidelines recommending bridging therapy for eligible stroke patients and contribute to the ongoing clinical debate on the topic. For more information, the full article can be accessed at the Neurology International journal website. [Extracted from the article]

Researchers at Besancon University Hospital in France conducted a study on mechanical thrombectomy for acute ischemic stroke, focusing on the optimal size of aspiration catheters in relation to arterial diameter. They found that a higher diameter ratio between the catheter and the occluded artery was associated with a higher rate of successful recanalization. The study suggests that selecting aspiration catheters based on this ratio could increase the success rate of mechanical thrombectomy procedures. Further research is recommended to specify the optimal ratio. [Extracted from the article]

Worcester Polytechnic Institute (WPI) researcher Yihao Zheng is leading a project to develop real-time imaging technology for stroke treatment by focusing on blood clots in the brain. The technology involves a fiber-optic probe that uses light and advanced calculations to determine the characteristics of a blood clot, aiding doctors in making decisions during clot removal procedures. This four-year project, funded by a grant from the National Science Foundation, aims to improve the success rate of thrombectomies and reduce complications associated with stroke treatment. Collaborating with researchers from various institutions, Zheng's team is working on a slender fiber-optic probe that will gather data on the clot's chemical composition and predict how it would respond to mechanical forces, ultimately enhancing healthcare for stroke patients. [Extracted from the article]

A report from Huazhong University of Science and Technology in Wuhan, China, discusses two cases of children with cryptogenic stroke associated with patent foramen ovale (PFO). The children underwent PFO closure, resulting in relief of neurologic symptoms and no recurrence after follow-up. The research suggests that while most children with PFO do not require intervention, some cases of PFO and cryptogenic stroke may benefit from closure of the foramen ovale. [Extracted from the article]

A recent report from Genoa, Italy, discusses the high mortality and disability rates associated with arterial ischemic stroke (AIS) in children. The main causes of AIS in children include congenital heart disease, cervical arterial dissection, and intracranial arteriopathies. The research emphasizes the need for defining diagnostic protocols and treatment options for pediatric AIS, highlighting the importance of early intervention and specialized care for young stroke patients. [Extracted from the article]

A recent study conducted by the Department of Physiotherapy explored the association between depression and adherence to upper limb exercises among community-dwelling stroke survivors. The research found that post-stroke depression significantly impacts exercise adherence, with moderate depression leading to lower adherence rates. The study suggests that incorporating mental health support into stroke rehabilitation could enhance upper limb motor recovery outcomes. For more information, the full article can be accessed through Health Science Reports. [Extracted from the article]

A recent study conducted at Florida State University has explored the use of superparamagnetic iron oxide nanoparticle-labeled extracellular vesicles for magnetic resonance imaging of ischemic stroke. The research highlights the potential of extracellular vesicles derived from human mesenchymal stem cells as a promising alternative for stroke treatment. By labeling these vesicles with nanoparticles and utilizing MRI, the study demonstrated enhanced contrast and improved outcomes in delivery and stroke recovery. This peer-reviewed research provides valuable insights into the development of innovative therapies for cerebrovascular diseases like stroke. [Extracted from the article]

A recent study conducted at the University of Tunku Abdul Rahman explored the relationship between recovery locus of control (RLOC) and health-related quality of life (HRQoL) among chronic stroke survivors. The study found that while respondents exhibited high RLOC scores, there was no significant relationship between RLOC scores and the EQ5D-5L index score, indicating that other factors may play a more critical role in influencing HRQoL among chronic stroke survivors. This research sheds light on the importance of addressing individual beliefs about health status in post-stroke rehabilitation to optimize recovery outcomes and improve quality of life. [Extracted from the article]

A recent study conducted by the Chinese Academy of Medical Sciences focused on the clinical and prognostic characteristics of acute Branch Atheromatous Disease (BAD)-related stroke. The study, which enrolled 476 patients from 20 Chinese hospitals, found that BAD-related stroke presents distinct demographic, clinical, and prognostic features, with a high incidence of early neurological deterioration and a low risk of stroke recurrence. The research highlighted the need for further high-quality studies to determine optimal acute-phase treatment strategies for BAD-related stroke. [Extracted from the article]

Researchers from the University of Basel conducted a study on the association between lower extremity physical function and physical activity after ischemic stroke. The study, part of the MOBITEC-Stroke project, found that better initial lower extremity physical function and higher improvements in function over time were linked to increased physical activity levels post-stroke. The findings suggest that interventions focusing on maintaining and enhancing lower extremity physical function could positively impact physical activity levels in stroke survivors. The research was supported by the Swiss National Science Foundation and published in SAGE Open Medicine. [Extracted from the article]

Researchers from Prince Sattam Bin Abdulaziz University conducted a study on the feasibility of using video game-based trunk exercises for rehabilitation in chronic stroke survivors. The study involved ten participants who completed 18 intervention sessions over 6-8 weeks. The findings suggest that the Valedo system is feasible for delivering trunk exercises to chronic stroke survivors, with participants reporting some physical and cognitive challenges but overall feeling that the exercises were safe. The research highlights the importance of considering various factors when implementing this type of intervention in the future. [Extracted from the article]

A study conducted at Zhengzhou University in the People's Republic of China focused on the T-cell receptor repertoire in patients with ischemic stroke. The research aimed to understand the biological function of T lymphocytes by analyzing the TCR repertoire in patients who had experienced an acute ischemic stroke. The findings suggest that both immunosuppression and enhanced antigen-specific T-cell response may exist in the periphery of acute ischemic stroke patients, which could potentially lead to novel therapeutic interventions for regulating neuroinflammation and the overall immune response after a stroke. [Extracted from the article]

A study conducted by Capital Medical University in Beijing, China, explored the impact of statins on ischemic stroke outcomes beyond low-density lipoprotein cholesterol (LDL-C) levels. The research, which included over 800,000 patients, found that statins reduced in-hospital mortality and stroke severity, with the effects persisting even after matching for LDL-C levels. The study suggests that statins may have neuroprotective effects in addition to their lipid-lowering properties, emphasizing the importance of considering these factors in stroke treatment. [Extracted from the article]

A recent study conducted at the University Health Network in Toronto, Canada, explored the perspectives and expectations of stroke survivors using egocentric cameras to monitor hand function at home. The research found that stroke survivors perceived the cameras as easy to use and beneficial for rehabilitation purposes, with high acceptance for future use. However, concerns such as discomfort, self-consciousness, and privacy of others need to be managed when using wearable cameras in public settings. The study was supported by the Heart & Stroke Foundation of Canada and published in Disability and Rehabilitation Assistive Technology. [Extracted from the article]

A study conducted at the University of Southern Florida examined the role of mural cell-derived laminin-alpha 5 in intracerebral hemorrhage (ICH). The research found that there was a minimal role of mural cell-derived laminin-alpha 5 in ICH, contrasting with its detrimental role in ischemic stroke. This study suggests that mural cell-derived laminin-alpha 5 may have distinct functions in different diseases. The research was supported by the National Institutes of Health (NIH) and has been peer-reviewed. [Extracted from the article]

A recent study conducted at the University of California Irvine explored the correlation between sensor-acquired reachable workspace (RWS) and activities of daily living (ADL) function in stroke patients. The research found a moderately strong correlation between reachable workspace and ADL function, indicating that improvements in reachable workspace were associated with improvements in ADL function during stroke rehabilitation. This study highlights the potential of sensor-acquired 3D motion analysis as an alternative method to assess ADL function in stroke patients. [Extracted from the article]

Researchers at Guangzhou University of Chinese Medicine conducted a study to explore the causal relationship between ischemic stroke and epilepsy, specifically generalized epilepsy. Using Mendelian randomization analysis, they found a causal link between ischemic stroke and the risk of generalized epilepsy, but not focal epilepsy. The study also identified diastolic blood pressure and BMI as factors with a causal relationship to epilepsy risk. This research provides genetic evidence that can help stratify the risk of post-stroke epilepsy. [Extracted from the article]

A recent study conducted at the University of Miami Miller School of Medicine focused on the impact of discharge communication on the achievement of lifestyle and behavioral changes post-stroke. The research found that patients who reported sufficient discharge communication were more likely to achieve recommended positive behaviors and activities within 30 days post-stroke hospitalization. The study emphasized the importance of quality communication in ensuring a successful transition of care for stroke patients, particularly from hospital to home or rehabilitation facilities. [Extracted from the article]

Researchers at University Hospital Frankfurt conducted a study on stroke patients with large-vessel occlusion to investigate the relationship between pial collateral supply and carotid stenosis. The study found no significant difference in the prevalence of high-grade carotid stenosis between patients with good collateral supply and those with poor collateral supply. The research highlighted the importance of MRI-based collateral assessment in determining stroke severity, ischemic core volume, and early functional outcomes. Further exploration of demographic and clinical variables affecting pial collateral supply in stroke patients is recommended for future studies. [Extracted from the article]

Researchers at North China University of Science and Technology conducted a study on the impact of unilateral resistance training (URT) on preventing sarcopenia in stroke patients. The study involved 77 stroke survivors and found that URT significantly improved hand grip strength, muscle thickness, upper limb functionality, and psychological well-being in the intervention group compared to the control group. The research concluded that URT can mitigate muscle atrophy, prevent sarcopenia, enhance upper limb function, and improve overall quality of life for stroke patients. The study was published in Scientific Reports and was supported by The Health Commission of Hebei Province. [Extracted from the article]

A study published in Blood Weekly discusses the use of intra-arterial Deoxyribonuclease therapy in aged mice with acute ischemic stroke (AIS). The therapy showed promising results in improving cerebral blood flow, reducing neurological deficits, and decreasing cerebral infarct volume in the mice. The study suggests that direct intra-arterial DNase therapy may be a potential treatment option for improving outcomes in aged individuals with large vessel occlusion strokes. [Extracted from the article]

A recent study conducted at the University of the Ryukyus explored the association between obesity, metabolic health status, and cerebral small vessel disease in stroke-free individuals. The research found that abdominal and general obesity alone were not linked to higher total SVD scores, but unhealthy metabolic components, such as high blood pressure and hyperglycemia, were significant risk factors for SVD. The study involved 6088 participants and concluded that metabolic health status plays a crucial role in the development of cerebral small vessel disease. [Extracted from the article]

The article discusses the development of a quantitative mass spectrometry imaging (MSI) workflow for spatial metabolomics using isotopically labeled yeast extract as internal standards. The study demonstrates the ability to quantify hundreds of metabolites and lipids in brain and kidney tissue, and applies this approach to map metabolic changes in a stroke model. The research reveals remote metabolic remodeling in the ipsilateral sensorimotor cortex post-stroke, highlighting the importance of using internal standards for accurate visualization of metabolic differences. This preprint has not yet undergone peer review. [Extracted from the article]

The article discusses the use of fMRI graph analysis to predict dynamic balance state and recovery following a stroke. It highlights the impact of stroke on neural tissue and the resulting sensory-motor disabilities in adults. The study suggests that global features are more informative than local features in predicting recovery, with a reported accuracy of 85% for recovery level and 76% for dynamic balance state. The research aims to contribute to clinical goal setting and mapping the neural substrates of dynamic balance. [Extracted from the article]

The article discusses the relationship between excitotoxicity, Golgi stability, and neuroprotection in the context of ischemic stroke. Researchers are exploring the use of a neuroprotective peptide, MTFL457, to prevent the downregulation of the TrkB-FL receptor induced by excitotoxicity, which can lead to Golgi fragmentation and neuronal death. The study suggests that preserving the function of the TrkB-FL receptor and Golgi stability could be crucial in protecting against stroke and other neurodegenerative diseases associated with excitotoxicity. The research is available as a preprint and has not yet undergone peer review. [Extracted from the article]

A study published in Health & Medicine Week explores the role of Reduced Folate Carrier 1 (RFC1) in exacerbating blood-brain barrier breakdown during ischemic stroke in adult mice. The research suggests that RFC1, known for transporting folates across the blood-brain barrier, may play a significant role in the brain's response to ischemic injury. By suppressing RFC1 protein levels, the study found an increase in blood-brain barrier leakage during ischemia, highlighting the potential importance of RFC1 in the pathophysiology of ischemic stroke. The findings support evidence from human studies and emphasize the dynamic nature of RFC1 protein levels in the acute phases of ischemic stroke. [Extracted from the article]

The article discusses a study that aimed to uncover genetic and modifiable factors that mediate the effect of education level on the risk of stroke. The research found that higher education level was associated with a reduced risk of stroke, and identified factors such as instant coffee intake, never smoking status, and various health indicators as significant mediators in this relationship. The study suggests that interventions targeting these mediators could potentially reduce the risk of stroke, highlighting new therapeutic possibilities. [Extracted from the article]

The article discusses a systematic review and network meta-analysis of 201 studies evaluating thrombectomy devices and combination therapies in acute ischemic stroke. The study compares the safety and efficacy of different devices and therapies, with the TREVO device showing the highest efficacy for functional recovery and successful recanalization. The findings suggest that contemporary stent-retriever device technology is the most effective option for improving outcomes in acute stroke care, emphasizing the importance of selecting the most effective and safest thrombectomy device. [Extracted from the article]

A recent study from Morehouse School of Medicine in Atlanta, Georgia, explores the role of the cholesterol metabolic enzyme Cyp46a1 and its metabolite 24s-hydroxycholesterol in ischemic stroke. The research suggests that targeting Cyp46a1 or 24s-hydroxycholesterol could lead to new strategies for stroke intervention. The study, funded by the National Institutes of Health, provides insights into a potential mechanism that impacts stroke outcomes. [Extracted from the article]

A recent study published in Drug Week explores the effects of Ding-Zhi-Xiao-Wan decoction (DZXW) on vascular dementia (VD) in mice. Researchers from the Department of Rheumatology found that DZXW alleviated mitochondrial autophagy in VD mice through the PI3K/Akt/mTOR pathway, improving cognitive function and memory retention. The study highlights the potential neuroprotective effects of DZXW in treating VD, offering insights into traditional Chinese medicine compounds for neurological disorders. For more information, the full article can be accessed through the publisher Elsevier. [Extracted from the article]

A recent study published in Oakland, California, highlights the importance of addressing psychosocial health issues after a stroke event. The research emphasizes the need for enhanced screening, assessment, supportive services, and education to ensure that patients receive necessary treatment and care. The study calls for more inclusive nursing interventions that consider the impact of structural racism and care disparities, focusing on individuals with recurrent strokes and preexisting psychosocial conditions. [Extracted from the article]

A recent study conducted at the University of Miami focused on the impact of long-term anticoagulation therapy on in-hospital outcomes for patients with atrial fibrillation (AF) who experienced acute ischemic stroke. The study found that patients on anticoagulation had decreased in-hospital mortality, stroke severity, and complications such as bleeding compared to those not on anticoagulation. This research, which has been peer-reviewed, provides valuable insights into the benefits of anticoagulation therapy for AF patients with acute ischemic stroke. [Extracted from the article]

A recent study from the Heart Rhythm Management Centre focused on atrial fibrillation patients with persistent leaks following the Watchman device implantation. The research compared the effectiveness of half-dose non-vitamin K oral anticoagulants (HD-NOAC) versus antiplatelet therapy (APT) in preventing thromboembolic events. Results showed that HD-NOAC was associated with a significantly lower rate of thromboembolic events compared to APT, but discontinuation of HD-NOAC increased the risk of stroke. This study provides valuable insights into the management of atrial fibrillation patients with post-Watchman leaks. [Extracted from the article]

A recent study from the University of Glasgow examined the incidence and outcomes of early cardiovascular complications in patients following intracerebral hemorrhage (ICH). The research found that the development of stroke-heart syndrome following ICH was associated with poorer outcomes compared to ICH patients without this complication. The study, which analyzed data from the Virtual International Stroke Trials Archive, highlighted the importance of recognizing and addressing cardiovascular complications in patients with ICH. [Extracted from the article]

The article discusses a phase III clinical trial, NCT06658197, comparing the efficacy and safety of two thrombolytic agents, tenecteplase and alteplase, for treating acute large vessel occlusive stroke within 4.5 hours of symptom onset. The trial aims to assess functional independence at 90 days post-randomization as the primary outcome measure. The study involves 850 participants and is set to be completed by June 1, 2027, with Xuanwu Hospital in Beijing as the primary investigator. [Extracted from the article]

A clinical trial, NCT06663657, is being conducted to compare the effects of cognitive sensorimotor exercises versus task-oriented training on balance, gait, and activities of daily living in chronic stroke patients. The trial involves 40 participants with chronic stroke who will be randomized into two intervention groups receiving different types of training for 8 weeks. Assessment tools such as the Berg Balance Scale, Dynamic Gait Index, and Modified Barthel Index will be used to evaluate the outcomes. The study aims to provide insights into the effectiveness of these interventions in improving functional abilities in stroke patients. [Extracted from the article]

The article discusses a clinical trial, NCT06663709, focusing on the impact of the BRACE protocol on balance, cognition, and mobility among stroke patients. The study aims to compare the effects of BRACE and task-oriented training on these aspects in stroke patients through a randomized control trial with two experimental groups. The trial is currently recruiting participants in Pakistan and is set to be completed by March 10, 2025. [Extracted from the article]

A recent 12-year cohort study conducted at Sichuan University in China examined the long-term outcomes among different subtypes of ischemic stroke patients. The study found that patients with cardio-embolism subtype had the highest mortality risk, while those with small artery occlusion subtype showed more favorable prognostic outcomes in terms of functional recovery. The research suggests that treatment options should be carefully considered for different ischemic stroke subtypes to optimize patient outcomes and improve stroke care effectiveness. [Extracted from the article]

A recent study conducted at the IRCCS Institute of Neurological Sciences in Bologna, Italy, focused on the effectiveness of focal mechanical vibration therapy in post-stroke rehabilitation. The research reviewed six randomized controlled trials and found that focal vibration therapy led to significant reductions in spasticity and improvements in motor function for most patients. While the short-term benefits are promising, further research with larger sample sizes is needed to confirm its long-term efficacy and optimal treatment parameters. The study suggests that focal vibration therapy could be an effective adjunct in post-stroke rehabilitation, particularly for reducing spasticity and improving motor function. [Extracted from the article]

A recent study conducted by researchers at Soongsil University focused on the impact of early rhythm control (ERC) on reducing the risk of ischemic stroke in cancer survivors with atrial fibrillation (AF). The study, which included over 591,000 patients, found that the ERC group had a lower risk of stroke compared to the usual care group, regardless of cancer history. The researchers concluded that an integrated approach incorporating appropriate rhythm control strategies should be considered for cancer survivors with newly diagnosed AF. The study was published in the European Heart Journal and can be accessed for free online. [Extracted from the article]