1. Post‐treatment serum Wisteria floribunda agglutinin‐positive mac‐2‐binding protein level is a useful predictor of hepatocellular carcinoma development after hepatitis C virus eradication
- Author
-
Shunsuke Sato, Yuji Ikeda, Sho Sato, Hironori Tsuzura, Yuji Kita, Daishi Kabemura, Noboru Yatagai, Nozomi Amano, Yuji Shimada, Takuya Genda, and Ayato Murata
- Subjects
hepatitis C virus ,medicine.medical_specialty ,Hepatitis C virus ,Wisteria floribunda agglutinin‐positive mac‐2‐binding protein ,RC799-869 ,medicine.disease_cause ,interferon‐based therapy ,Gastroenterology ,Interferon ,interferon‐free therapy ,Internal medicine ,Medicine ,Wisteria floribunda agglutinin ,direct‐acting antiviral drug ,Hepatology ,Receiver operating characteristic ,biology ,business.industry ,Hazard ratio ,Original Articles ,hepatocellular carcinoma ,Diseases of the digestive system. Gastroenterology ,Wisteria floribunda ,biology.organism_classification ,medicine.disease ,digestive system diseases ,Hepatocellular carcinoma ,Original Article ,sustained virological response ,business ,Mac 2 binding protein ,medicine.drug - Abstract
Aims Recent advances of direct‐acting antiviral drugs for hepatitis C virus (HCV) have dramatically improved the sustained virologic response (SVR) rate, but hepatocellular carcinoma (HCC) development rarely occurs even in patients who achieve an SVR. Wisteria floribunda agglutinin‐positive mac‐2‐binding protein (WFA+‐M2BP) was recently developed as a noninvasive biomarker of liver fibrosis. However, the association between the WFA+‐M2BP level and HCC development after the achievement of an SVR is unclear. Methods and Results We examined the association between WFA+‐M2BP and HCC development in 522 HCV patients who achieved an SVR (Interferon [IFN]‐based therapy, n = 228; IFN‐free therapy, n = 294). Multivariate analysis revealed that a high WFA+‐M2BP level at SVR week 24 after treatment (SVR24) (hazard ratio [HR] = 1.215, P = 0.020), low platelet counts (HR = 0.876, P = 0.037), and old age (HR = 1.073, P = 0.012) were independent risk factors for HCC development regardless of the treatment regimen. Receiver operator characteristics curve analysis revealed that a WFA+‐M2BP level at SVR24 of ≥1.62 cut‐off index (COI) was the cut‐off value for the prediction of HCC development (adjusted HR = 12.565, 95% CI 3.501–45.092, P, The assessment of liver fibrosis using the WFA+‐M2BP level at SVR24 is a useful predictor of HCC development after HCV eradication even in the IFN‐free therapy era.
- Published
- 2021